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| 1 | Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD显示文摘We characterized a unique group of patients with neuromyelitis optica spectrum disorder(NMOSD) who carried autoantibodies of aquaporin-4(AQP4) and myelin-oligodendrocyte glycoprotein(MOG). Among the 125 NMOSD patients, 10(8.0%) were AQP4- and MOG-ab double positive, and 14(11.2%) were MOG-ab single positive. The double-positive patients had a multiphase disease course with a high annual relapse rate(P=0.0431), and severe residual disability(P<0.0001). Of the double-positive patients, 70% had MS-like brain lesions, more severe edematous, multifocal regions on spinal magnetic resonance imaging(MRI), pronounced decreases of retinal nerve fiber layer thickness and atrophy of optic nerves. In contrast, patients with only MOG-ab had a higher ratio of monophasic disease course and mild residual disability. Spinal cord MRI illustrated multifocal cord lesions with mild edema, and brain MRIs showed more lesions around lateral ventricles. NMOSD patients carrying both autoantibodies to AQP4 and MOG existed and exhibited combined features of prototypic NMO and relapsing-remitting form of MS, whereas NMOSD with antibodies to MOG only exhibited an 'intermediate' phenotype between NMOSD and MS. Our study suggests that antibodies against MOG might be pathogenic in NMOSD patients and that determination of anti-MOG antibodies maybe instructive for management of NMOSD patients. | Yaping Yan Yujing Li Ying Fu Li Yang Lei Su Kaibin Shi Minshu Li Qiang Liu Aimee Borazanci Yaou Liu Yong He Jeffrey L Bennett Timothy L Vollmer Fu-Dong Shi | 2016 | Science China(Life Sciences)2016，59，12： | 20 |
| 2 | Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors显示文摘 | Zhu, Jie Ming, Chang Fu, Xin Duan, Yaou Duc Anh Hoang Rutgard, Jeffrey Zhang, Runze Wang, Wenqiu Hou, Rui Zhang, Daniel Zhang, Edward Zhang, Charlotte Hao, Xiaoke Xiong, Wenjun Zhang, Kang | 2017 | Cell Research2017，27，6： | 11 |
| 3 | The Coix Genome Provides Insights into Panicoideae Evolution and Papery Hull Domestication显示文摘Coix is a grass crop domesticated as early as the Neolithic era.It is still widely cultivated for both highly nutritional food and medicinal use.However,the genetic study and breeding of this crop are hindered by the lack of a sequenced genome.Here,we report de novo sequencing and assembly of the 1619-Mb genome of Coix,and annotation of 75.39%repeats and 39629 protein-coding genes.Comparative genomics analysis showed that Coix is more closely related to sorghum than maize,but intriguingly only Coix and maize had a recent genome duplication event,which was not detected in sorghum.We further constructed a genetic map and mapped several important traits,especially the strength of hull.Selection of papery hull(thin:easy dehulling)from the stony hull(thick:difficult dehulling)in wild progenitors was a key step in Coix domestication.The papery hull makes seed easier to process and germinate.Anatomic and global transcriptome analysis revealed that the papery hull is a result of inhibition of cell division and wall biogenesis.We also successfully demonstrated that seed hull pressure resistance is controlled by two major quantitative trait loci(QTLs),which are associated with hull thickness and color,respectively.The two QTLs were further fine mapped within intervals of 250 kb and 146 kb,respectively.These resources provide a platform for evolutionary studies and will facilitate molecular breeding of this important crop. | Chao Guo Yanan Wang Aiguo Yang Jun He Chaowen Xiao Shanhua Lv Fengming Han Yibing Yuan Yuan Yuan Xiaolong Dong Juan Guo YawenYang-Hailan Liu Ningzhi Zuo Yaxi Hu Kangxu Zhao Zhengbo Jiang Xing Wang Tingting Jiang Yaou Sherf Moju Cao Yuan Wang Zhaobo Long Tingzhao Rong Luqi Huang Shufeng Zhou | 2020 | Molecular Plant2020，13，2： | 11 |
| 4 | Genome assembly of the maize inbred line A188 provides a new reference genome for functional genomics显示文摘The current assembled maize genomes cannot represent the broad genetic diversity of maize germplasms.Acquiring more genome sequences is critical for constructing a pan-genome and elucidating the linkage between genotype and phenotype in maize.Here we describe the genome sequence and annotation of A188,a maize inbred line with high phenotypic variation relative to other lines,acquired by single-molecule sequencing and optical genome mapping.We assembled a 2210-Mb genome with a scaffold N50 size of 11.61 million bases(Mb),compared to 9.73 Mb for B73 and 10.2 Mb for Mo17.Based on the B73_Ref Gen_V4 genome,295 scaffolds(2084.35 Mb,94.30%of the final genome assembly)were anchored and oriented on ten chromosomes.Comparative analysis revealed that~30%of the predicted A188 genes showed large structural divergence from B73,Mo17,and W22 genomes,which causes high protein divergence and may lead to phenotypic variation among the four inbred lines.As a line with high embryonic callus(EC)induction capacity,A188 provides a convenient tool for elucidating the molecular mechanism underlying the formation of EC in maize.Combining our new A188 genome with previously reported QTL and RNA sequencing data revealed eight genes with large structural variation and two differentially expressed genes playing potential roles in maize EC induction. | Fei Ge Jingtao Qu Peng Liu Lang Pan Chaoying Zou Guangsheng Yuan Cong Yang Guangtang Pan Jianwei Huang Langlang Ma Yaou Shen | 2022 | The Crop Journal2022，10，1： | 2 |
| 5 | Genetic architecture of maize yield traits dissected by QTL mapping and GWAS in maize显示文摘The study of yield traits can reveal the genetic architecture of grain yield for improving maize production.In this study, an association panel comprising 362 inbred lines and a recombinant inbred line population derived from X178 × 9782 were used to identify candidate genes for nine yield traits. High-priority overlap(HPO) genes, which are genes prioritized in a genome-wide association study(GWAS), were investigated using coexpression networks. The GWAS identified 51 environmentally stable SNPs in two environments and 36 pleiotropic SNPs, including three SNPs with both attributes. Seven hotspots containing 41 trait-associated SNPs were identified on six chromosomes by permutation. Pyramiding of superior alleles showed a highly positive effect on all traits, and the phenotypic values of ear diameter and ear weight consistently corresponded with the number of superior alleles in tropical and temperate germplasm. A total of 61 HPO genes were detected after trait-associated SNPs were combined with the coexpression networks. Linkage mapping identified 16 environmentally stable and 16 pleiotropic QTL.Seven SNPs that were located in QTL intervals were assigned as consensus SNPs for the yield traits.Among the candidate genes predicted by our study, some genes were confirmed to function in seed development. The gene Zm00001 d016656 encoding a serine/threonine protein kinase was associated with five different traits across multiple environments. Some genes were uniquely expressed in specific tissues and at certain stages of seed development. These findings will provide genetic information and resources for molecular breeding of maize grain yield. | Xiao Zhang Zhiyong Ren Bowen Luo Haixu Zhong Peng Ma Hongkai Zhang Hongmei Hu Yikai Wang Haiying Zhang Dan Liu Ling Wu Zhi Nie Yonghui Zhu Wenzhu He Suzhi Zhang Shunzong Su Yaou Shen Shibin Gao | 2022 | The Crop Journal2022，10，2： | 2 |
| 6 | Cloning and characterization of miRNAs from maize seedling roots under low phosphorus stress显示文摘 | Zhiming Zhang Haijian Lin Yaou Shen Jian Gao Kui Xiang Li Liu Haiping Ding Guangsheng Yuan Hai Lan Shufeng Zhou Maojun Zhao Shibin Gao Tingzhao Rong Guangtang Pan | 2012 | Molecular Biology Reports2012，，8： | 1 |
| 7 | Fast surface interpolation using multiresolution wavelet transform显示文摘 | Yaou M H Chang W T | 1994 | IEEE Trans Pattern Anal Maeh Intell1994，16，7： | 1 |
| 8 | MiR-143 enhances adipogenic differentiation of 3T3-L1 cells through targeting the coding region of mouse pleiotrophin显示文摘 | Can Yi Wei-dong Xie Fu Li Qing Lv Jie He Jiangbin Wu Dayong Gu Naihan Xu Yaou Zhang | 2011 | FEBS Letters2011，，： | 1 |
| 9 | Cloning and expression profiles of yak lipoprotein lipase gene显示文摘 | Yi Ding Yaou Xu Yaqiu Lin Yu Yue Suyu Jin Yuping Li Yucai Zheng | 2012 | Journal of Applied Animal Research2012，，4： | 1 |
| 10 | A non-ischemic forearm exercise test for the screening of patients with exer cise intolerance显示文摘 | Hogrel JY Laforêt P Ben Yaou R | 2001 | Neurology2001，56，12： | 1 |
| 11 | Cystatin C Deficiency Increases Elastic Lamina Degradation and Aortic Dilatation in Apolipoprotein E–Null Mice显示文摘 | Galina K. Sukhova Bing Wang Peter Libby Jie-Hong Pan Yaou Zhang Anders Grubb Kenneth Fang Harold A. Chapman Guo-Ping Shi | 2005 | Circulation Research2005，，3： | 1 |
| 12 | MicroRNA-21 in Scleroderma Fibrosis and its Function in TGF-β- Regulated Fibrosis-Related Genes Expression显示文摘 | Honglin Zhu Hui Luo Yisha Li Yaou Zhou Ying Jiang Jin Chai Xianzhong Xiao Yunhui You Xiaoxia Zuo | 2013 | Journal of Clinical Immunology2013，，6： | 1 |
| 13 | Clinical and gene- tic heterogeneity in laminopathies 显示文摘 | Bertrand AT Chikhaoui K Yaou RB | 2011 | Biochem Soc Trans2011，39，6： | 1 |
| 14 | Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone显示文摘 | Huang Hsu-Shan Chiou Jeng-Fong Fong Yaou | 2003 | Journal of Medicinal Chemistry2003，46，15： | 1 |
| 15 | miR-181a and inflammation: miRNA homeostasis response to inflammatory stimuli in vivo显示文摘 | Weidong Xie Zhongxin Li Mengnan Li Naihan Xu Yaou Zhang | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
| 16 | cDNA microarray analysis of gene expression profiles in human fibroblast cells irradiated with red light显示文摘 | Yaou Zhang Shipeng Song | 2003 | The Journal of Investigative Dermatology2003，120，： | 1 |
| 17 | Association mapping for root system architecture traits under two nitrogen conditions in germplasm enhancement of maize doubled haploid lines显示文摘Root system architecture(RSA)contributes to nitrogen(N)uptake and utilization in maize.In this study,a germplasm enhancement of maize double haploid population of 226 lines genotyped with 61,634 SNPs was used to investigate the genetic basis of RSA under two N levels using a genome-wide association study(GWAS).GLM+PCA,FarmCPU,and MLM models were utilized to balance false positives and false negatives.In total,33 and 51 significant SNP-trait associations were detected under high and low N conditions,respectively.Under high N,SNP S9_2483543 was detected by all models.Linkage disequilibrium(LD)regions of some SNPs overlapped with the intervals of QTL for RSA and N response that were detected in previous studies.In particular,several known genes,Rtcs,Rtcl,Rtcl,and Ms44,were located in the LD regions of S1_9992325,S9_151726472,S9_154381179,and S4_197073985,respectively.Among the candidate genes identified by this study,GRMZM2G139811,GRMZM2G314898,GRMZM2G054050,GRMZM2G173682,GRMZM2G470914,GRMZM2G462325,GRMZM2G416184,and GRMZM2G064302 were involved in seedling,seed,and root system development or N metabolism in Arabidopsis or rice.The markers identified in this study can be used for marker-assisted selection of RSA traits to improve nitrogen use efficiency in maize breeding,and the candidate genes will contribute to further understanding of the genetic basis of RSA under diverse N conditions. | Langlang Ma Chunyan Qing Ursula Frei Yaou Shen Thomas Lübberstedt | 2020 | The Crop Journal2020，8，2： | 1 |
| 18 | The Vagus Nerve and Nicotinic Receptors Involve Inhibition of HMGB1 Release and Early Pro - inflammatory Cytokines Function in Collagen - Induced Arthritis 显示文摘 | LI Tong ZUO Xiao- xiao ZHOU Yaou | 2010 | Journal of Clinical Immunology2010，30，2： | 1 |
| 19 | 一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统显示文摘文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OCT(光学相干断层扫描)成像技术是最常用的诊断技术之一。 | Daniel S.Kermany Michael Goldbaum Wenjia Cai Carolina C.S.Valentim Huiying Liang Sally L.Baxter Alex McKeown Ge Yang Xiaokang Wu Fangbing Yan Justin Dong Made K.Prasadha Jacqueline Pei Magdalene Y.L.Ting Jie Zhu Christina Li Sierra Hewett Jason Dong Ian Ziyar Alexander Shi Runze Zhang Rui Hou William Shi Xin Fu Yaou Duan Viet A.N. Huu Cindy Wen Edward D. Zhang Charlotte L. Zhang Oulan Li Xiaobo Wang Michael A. Singer Xiaodong Sun Jie Xu Ali Tafreshi M. Anthony Lewis Huimin Xia 张康 | 2019 | 科学新闻2019，0，2： | 1 |
| 20 | A Novel Ensemble of Classifiers for Microarray Data Classification显示文摘 | Chen Yuehui Zhao Yaou | 2008 | Applied Soft Computing2008，12，8： | 1 |
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