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| 1 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 2 | Degree sums and path-factors in graphs 显示文摘 | Tian Feng and Wei Bing | 2001 | Graphs and Combinatorics2001，17，1： | 1 |
| 3 | Degree Sums and Path-Factors in Graphs显示文摘 | Yaojun Chen Feng Tian Bing Wei | 2001 | Graphs and Combinatorics2001，，1： | 1 |
| 4 | Novel Percutaneous Radiofrequency Ablation of Portal Vein Tumor Thrombus: Safety and Feasibility显示文摘 | Malkhaz Mizandari Guokun Ao Yaojun Zhang Xi Feng Qiang Shen Minshan Chen WanYee Lau Joanna Nicholls Long Jiao Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，1： | 1 |
| 5 | Methane and nitrous oxide emissions from direct-seeded and seedling- transplanted rice paddies in southeast China显示文摘 | Liu Shuwei Zhang Yaojun Lin Feng | 2014 | Plant Soil2014，374，12： | 1 |
| 6 | Degree Sums and Path-Factors in Graphs显示文摘 | Yaojun Chen Feng Tian Bing Wei | 2001 | Graphs and Combinatorics2001，，1： | 1 |
| 7 | Enhancement by IL-18 of the protective effect of a Schistosoma japonicum 26<ce:hsp sp='0.25'/>kDa GST plasmid DNA vaccine in mice显示文摘 | Feng Wei Quan Liu Shengyan Gao Limin Shang Yujia Zhai Jingtao Men Li Jiang Xing-Quan Zhu Zhiqiang Fu Yaojun Shi Zhiping Xia Jiaojiao Lin | 2008 | Vaccine2008，，33： | 1 |
| 8 | 乳腺癌新辅助化疗前后HER-2表达的变化(英文)显示文摘Objective:The aim of this study was to study changes of HER-2 expression after neoadjuvant chemotherapy in the breast cancer cases.Methods:One hundred and thirty-seven female patients with primary breast cancers,who received neoadjuvant chemotherapy,underwent core needle puncture and Mammotome biopsy before chemotherapy,and the biopsy results were used as the basis of histological diagnosis,fluorescence in situ hybridization (FISH) was performed to test HER2 status of tumor tissues before and after chemotherapy.All patients underwent FEC,TE,or AC neoadjuvant chemotherapy of 2-6 cycles before surgery.Results:Twenty-two patients were positive according to FISH test among 137 preoperative patients,8 patients achieved pathological complete remission after chemotherapy (three HER-2 positive patients and five negative patients),91 patients achieved partial remission,24 patients were stable,and 14 cases were invalid.Twenty-two patients were positive according to FISH test (8 patients with pathological complete remission did not undergo test),and positive patients still expressed positively after chemotherapy before neoadjuvant chemotherapy.Three negative patients were converted to be positive,and changes before and after chemotherapy had no statistical difference (P>0.05).Conclusion:Neoadjuvant chemotherapy makes no influence on patients with HER-2 positive expression,while patients with negative expression can be converted to be positive,but without significant difference. | Yaojun Feng Xinhong Wu Cuiping Pan Juan Xu Wei Zhong Jun Shao Biao Ma | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，8： | 1 |
| 9 | Micro-size picosecond-duration fast neutron source driven by a laser-plasma wakefield electron accelerator显示文摘A pulsed fast neutron source is critical for applications of fast neutron resonance radiography and fast neutron absorption spectroscopy.However,due to the large transversal source size(of the order of mm)and long pulse duration(of the order of ns)of traditional pulsed fast neutron sources,it is difficult to realize high-contrast neutron imaging with high spatial resolution and a fine absorption spectrum.Here,we experimentally present a micro-size ultra-short pulsed neutron source by a table-top laser-plasma wakefield electron accelerator driving a photofission reaction in a thin metal converter.A fast neutron source with source size of approximately 500μm and duration of approximately 36 ps has been driven by a tens of MeV,collimated,micro-size electron beam via a hundred TW laser facility.This micro-size ultra-short pulsed neutron source has the potential to improve the energy resolution of a fast neutron absorption spectrum dozens of times to,for example,approximately 100 eV at 1.65 MeV,which could be of benefit for high-quality fast neutron imaging and deep understanding of the theoretical model of neutron physics. | Yaojun Li Jie Feng Wenzhao Wang Junhao Tan Xulei Ge Feng Liu Wenchao Yan Guoqiang Zhang Changbo Fu Liming Chen | 2022 | High Power Laser Science and Engineering2022，10，5： | 0 |
| 10 | 前哨淋巴结活检在不同期别乳腺癌新辅助化疗后的意义(英文)显示文摘Objective: We aimed to study the success and false negative rate of sentinel lymph node biopsy(SLNB) in different clinical stages breast cancer patients being carried out with neoadjuvant chemotherapy(NAC), and the clinical significance of SLNB, we conducting this trial. Methods: One hunderd and thirty-seven cases were enrolled in this clinical research from March 2003 to March 2007. All of the patients' sentinel lymph nodes were detected with99mTc-Dx and methylene blue. There were 61 patients with stage T1–2 N0 M0 carried SLNB without NAC(group A), 76 cases were carried out NAC 3–4 cycles before SLNB, including 39 T2–4 N0–1 M0 cases(group B) and 27 T2–4 N2–3 M0 cases(group C). The success and false negative rate of SLNB were analysed with chi-square test. Results: In group A, the successful and false negative rate of SLNB were 92.31%(36/39), 8.57%(3/35), and in group B and C were 92.31%(36/39), 8.57%(3/35) and 74.07 %(20/27), 18.52 %(5/27), respectively. The successful rate of group C decreased and false negative rate increased significantly compared with group A and B(P < 0.05), but group A and B had no significant difference(P > 0.05). Conclusion: The SLNB can accurately predict lymph node status of axillary lymph node in N0–1 stage patients with NAC, but in N2–3 stage patients the success rate decreased and false rate increased negative significantly. | Juan Xu Xinhong Wu Yaojun Feng Feng Yuan Wei Fan | 2013 | The Chinese-German Journal of Clinical Oncology2013，12，11： | 0 |
| 11 | 卵巢切除联合依西美坦治疗绝经前激素受体阳性晚期难治性乳腺癌(英文)显示文摘Objective: Taking tamoxifen orally is the main endocrine therapy of the premenopausal breast cancer with positive hormone receptor,but numerous patients developed to be advanced refractory breast cancer because of drug resistance.Our study investigated a role of the combination of bilateral oophorectomy and exemestane in the management of advanced refractory breast cancer.Methods: The bilateral oophorectomy was carried out in 17 patients.One week after the operation,exemestane was taken orally (25 mg/d).The median time to progression (TTP),the median survival time and the survival rate were calculated using Kaplan-Meier methods.Results: Seventeen patients age ranged from 26 to 44 years (median,36 years) were treated with an overall response rate of 64.70%,TTP was 8 months and the median survival time was 31 months.The survival rate of 1-year,3 years and 5 years was 88.24%,64.71%,29.41%,respectively.There have no grade III/IV side effects appeared.Conclusion: Bilateral oophorectomy combined with exemestane is safe and effective for advanced refractory premenopausal breast cancer with positive hormone receptor and it is well-tolerated. | Xinhong Wu Yaojun Feng Juan Xu Yiping Gong Biao Ma | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，1： | 0 |
| 12 | Effects of second-order dispersion of ultrashort laser pulse on stimulated Raman scattering显示文摘The influence of second-order dispersion(SOD)on stimulated Raman scattering(SRS)in the interaction of an ultrashort intense laser with plasma was investigated.More significant backward SRS was observed with the increase of the absolute value of SOD(|ψ2|).The integrated intensity of the scattered light is positively correlated to the driver laser pulse duration.Accompanied by the side SRS,filaments with different angles along the laser propagation direction were observed in the transverse shadowgraph.A model incorporating Landau damping and above-threshold ionization was developed to explain the SOD-dependent angular distribution of the filaments. | Yanqing Deng Dongning Yue Mufei Luo Xu Zhao Yaojun Li Xulei Ge Feng Liu Suming Weng Min Chen Xiaohui Yuan Jie Zhang | 2022 | High Power Laser Science and Engineering2022，10，6： | 0 |
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