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| 1 | Update in version 2021 of CSCO guidelines for colorectal cancer from version 2020显示文摘Colorectal cancer(CRC) is one of the major cancers threatening life and health of Chinese residents. According to the latest data released by the National Cancer Center in2015(1), there were 387,000 new cases and 187,100 deaths of CRC in China, accounting for 9.87% and 8.01% of all malignancies. The first version of the Chinese Society of Clinical Oncology(CSCO) guidelines was released in April2017, and has been updated annually based on the latest clinical research data and the availability of new drugs(2-4). Here, we present the main updates of the 2021 version compared to 2020 version. | Caixia Dong Yuwei Ding Shanshan Weng Guichao Li Yanqing Huang Hanguang Hu Zhen Zhang Suzhan Zhang Ying Yuan | 2021 | Chinese Journal of Cancer Research2021，33，3： | 19 |
| 2 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 3 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 4 | MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B显示文摘Pathological cardiac hypertrophy serves as a significant foundation for cardiac dysfunction and heart failure. Recently, growing evidence has revealed that microRNAs(miRNAs) play multiple roles in biological processes and participate in cardiovascular diseases. In the present research, we investigate the impact of miRNA-34 c-5 p on cardiac hypertrophy and the mechanism involved. The expression of miR-34 c-5 p was proved to be elevated in heart tissues from isoprenaline(ISO)-infused mice. ISO also promoted miR-34 c-5 p level in primary cultures of neonatal rat cardiomyocytes(NRCMs). Transfection with miR-34 c-5 p mimic enhanced cell surface area and expression levels of foetal-type genes atrial natriuretic factor(Anf) and β-myosin heavy chain(β-Mhc) in NRCMs. In contrast, treatment with miR-34 c-5 p inhibitor attenuated ISO-induced hypertrophic responses. Enforced expression of miR-34 c-5 p by tail intravenous injection of its agomir led to cardiac dysfunction and hypertrophy in mice, whereas inhibiting miR-34 c-5 p by specific antagomir could protect the animals against ISO-triggered hypertrophic abnormalities. Mechanistically, miR-34 c-5 p suppressed autophagic flux in cardiomyocytes, which contributed to the development of hypertrophy. Furthermore, the autophagy-related gene 4 B(ATG4 B) was identified as a direct target of miR-34 c-5 p, and miR-34 c-5 p was certified to interact with 3’untranslated region of Atg4 b mRNA by dual-luciferase reporter assay. miR-34 c-5 p reduced the expression of ATG4 B, thereby resulting in decreased autophagy activity and induction of hypertrophy. Inhibition of miR-34 c-5 p abolished the detrimental effects of ISO by restoring ATG4 B and increasing autophagy. In conclusion, our findings illuminate that miR-34 c-5 p participates in ISO-induced cardiac hypertrophy, at least partly through suppressing ATG4 B and autophagy. It suggests that regulation of miR-34 c-5 p may offer a new way for handling hypertrophy-related cardiac dysfunction. | Yuhong Zhang Yanqing Ding Min Li Jing Yuan Youhui Yu Xueying Bi Huiqi Hong Jiantao Ye Peiqing Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 5 | Efect of growth rate on characteristic lengths of microstructure in directionally solidiied Ti-46Al-2Cr-2Nb-0.2B alloy显示文摘The microstructure of TiAl based alloys is sensitive to growth rates.In this paper,Bridgman directional solidification of Ti-46Al-2Cr-2Nb-0.2B(at.%)alloy was carried out at a constant temperature gradient(G)to investigate the effects of various growth rates(v)on characteristic lengths(primary dendritic arm spacing,secondary dendritic arm spacing and lamellar spacing)of the microstructure.Results show that under the experimental conditions of G=18 K·mm-1and v=15μm·s-1to 70μm·s-1,the primary phase of directionally solidified Ti-46Al-2Cr-2Nb-0.2B alloy isαphase,the values of primary dendritic arm spacing(λl),secondary dendritic arm spacing(λ2)and lamellar spacing(λla)decrease with the increase in growth rate.The results were compared with theoretical models and similar experimental results of TiAl based alloys.The Bouchard-Kirkaldy model agrees well with the relationship between primary dendritic arm spacing and growth rate obtained in the experiment;the relationship between them can be expressed byλl=758.6v-0.39.The relationship between the secondary dendritic arm spacing and the growth rate can be expressed byλ2=113.9v-0.45,while the relationship between the lamellar spacing and growth rate can be expressed byλla=22.88v-0.94. | Zhang Yuan Li Xinzhong Guo Jingjie Su Yanqing Fu Hengzhi | 2013 | China Foundry2013，10，5： | 3 |
| 6 | The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention显示文摘Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis. | Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li | 2022 | Bone Research2022，10，2： | 3 |
| 7 | EVAPORATION BEHAVIOR OF COMPONENTS IN Ti-15-3 MELT DURING ISM PROCESS显示文摘INTRODUCTIONMetastableβtitaniumaloysarenowfindingprogresivelymoreapplications,especialyowingtotheirgoodformingproperties[1].T... | Guo, Jingjie Liu, Yuan Su, Yanqing Ding, Hongsheng Jia, Jun | 1998 | 中国有色金属学会会刊:英文版1998，8，4： | 2 |
| 8 | Coarsening Manner and Microstructure Evolution of Al-In Hypermonotectic Alloy during Rapidly Cooling Process显示文摘A numerical model reflecting the real physical processes well has been developed to predict the coarsening manner of the second phase droplets and the microstructural evolution under the common action of nucleation, diffusional growth, colliding coagulation during rapid cooling Al-ln hypermonotectic alloys. The model reflects the real physical processes well and is also applicable to other immiscible alloys. | Yuan LIU, Jingjie GUO, Jun JIA, Yanqing SU, Hongsheng DING, Jiuzhou ZHAO and Xiang XUESchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | 2002 | Journal of Materials Science & Technology2002，18，3： | 2 |
| 9 | Dielectr ic barr ier discharge plasma-assisted modification of g-C_(3)N_(4)/Ag_(2)O/TiO_(2)-NRs composite enhanced photoelectrocatalytic activity显示文摘Dielectric barrier discharge(DBD)plasma applied as surface treatment technology was employed for the modification of Ag_(2)O and graphitic carbon nitride(g-C_(3)N_(4))powders.Subsequently,the pretreated powders were sequentially loaded onto TiO_(2)nanorods(TiO_(2)-NRs)via electro-deposition,followed by calcination at N_(2)atmosphere.The results indicated that at the optimal plasma discharge time of 5 min for modification of g-C_(3)N_(4)and Ag_(2)O,photocurrent density of ternary composite was 6 times to bare TiO_(2)-NRs under UV-visible light irradiation.Phenol was degraded by using DBD plasma-modified g-C_(3)N_(4)/Ag_(2)O/TiO_(2)-NRs electrode to analyze the photoelectrocatalytic performance.The removal rate of phenol for g-C_(3)N_(4)-5/Ag_(2)O-5/TiO_(2)-NRs electrode was about 3.07 times to that for TiO_(2)-NRs electrode.During active species scavengers'analysis,superoxide radicals and hydroxyl radicals were the main oxidation active species for pollutants degradation.A possible electron-hole separation and transfer mechanism of ternary composite with high photoelectrocatalytic performance was proposed. | Yupei Long Chenchen Yuan Xiaomin Wang Dongyan Jin Hong Zhou Qiongyin Wang Chenyang Lu Yuqi Chen Yanqing Cong Qi Wang Yi Zhang | 2021 | Journal of Environmental Sciences2021，33，6： | 2 |
| 10 | Electrochemical behaviors of co-deposited Pb/Pb–MnO 2 composite anode in sulfuric acid solution – Tafel and EIS investigations显示文摘 | Yanqing Lai Yuan Li Liangxing Jiang Wang Xu Xiaojun Lv Jie Li Yexiang Liu | 2012 | Journal of Electroanalytical Chemistry2012，，： | 2 |
| 11 | Stress Distribution in the Cruciform Specimen under Transverse Tension Stress for SiC/Ti-6Al-4V Composites显示文摘The cruciform specimen was selected to obtain the transverse tensile behavior of SiC fiber reinforced titanium matrix composites. Moreover, the means of combining the unilaterally coupled finite element method with the transverse tensile test was developed to evaluate the interfacial normal bond strength of composites. The results showed that the initial non-linearity in the transverse stress-strain curve of SiC/Ti-6Al-4V occurs at the stress of 350 MPa. The means of combining the unilaterally coupled finite element method with the transverse tensile test is an effective method to predict the interfacial normal bond strength of composites. In addition, the interface failure mechanism of composites was analyzed in detail. | Yang Yanqing Yuan Meini Li Jiankang Huang Bin Luo Xian | 2009 | 稀有金属材料与工程2009，38，A03： | 2 |
| 12 | Partial anammox achieved in full scale biofilm process for typical domestic wastewater treatment显示文摘The slow initiation of anammox for treating typical domestic wastewater and the relatively high footprint of wastewater treatment infrastructures are major concerns for practical wastewater treatment systems.Herein,a 300 m^(3)/d hybrid biofilm reactor(HBR)process was developed and operated with a short hydraulic retention time(HRT)of 8 h.The analysis of the bacterial community demonstrated that anammox were enriched in the anoxic zone of the HBR process.The percentage abundance of Candidatus Brocadia in the total bacterial community of the anoxic zone increased from 0 at Day 1 to 0.33%at Day 130 and then to 2.89%at Day 213.Based upon the activity of anammox bacteria,the removal of ammonia nitrogen(NH_(4)^(+)-N)in the anoxic zone was approximately 15%.This showed that the nitrogen transformation pathway was enhanced in the HBR system through partial anammox process in the anoxic zone.The final effluent contained 12 mg/L chemical oxygen demand(COD),0.662 mg/L NH_(4)^(+)-N,7.2 mg/L total nitrogen(TN),and 6 mg/L SS,indicating the effectiveness of the HBR process for treating real domestic wastewater. | Feng Hou Ting Zhang Yongzhen Peng Xiaoxin Cao Hongtao Pang Yanqing Shao Xianchun Lu Ju Yuan Xi Chen Jin Zhang | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 2 |
| 13 | The role of a drug-loaded poly(lactic co-glycolic acid)(PLGA) copolymer stent in the treatment of ovarian cancer显示文摘Objectives:Cisplatin(CDDP)is a widely used and effective basic chemotherapeutic drug for the treatment of a variety of tumors,including ovarian cancer.However,adverse side effects and acquired drug resistance are observed in the clinical application of CDDP.Identifying a mode of administration that can alleviate side effects and reduce drug resistance has become a promising strategy to solve this problem.Methods:In this study,3 D printing technology was used to prepare a CDDP-poly(lactic-co-glycolic acid)(CDDP-PLGA)polymer compound stent,and its physicochemical properties and cytotoxicity were evaluated both in vitro and in vivo.Results:The CDDP-PLGA stent had a significant effect on cell proliferation and apoptosis and clearly decreased the size of subcutaneous tumors in nude mice,whereas the systemic side effects were mild compared with those of intraperitoneal CDDP injection.Compared with the control group,CDDP-PLGA significantly increased the mRNA and protein levels of p-glycoprotein(P<0.01;P<0.01)and decreased vascular endothelial growth factor mRNA(P<0.05)and protein levels(P<0.01),however,CDDP-PLGA significantly decreased the mR NA and protein levels of p-glycoprotein(P<0.01;P<0.01)and vascular endothelial growth factor(P<0.01;P<0.01),which are associated with chemoresistance,in subcutaneous tumor tissue.Immunohistochemistry assay results revealed that,in the CDDP-PLGA group,the staining of the proliferation-related genes Ki67 and PCNA were lightly,and the apoptosis-related gene caspase-3 stained deeply.Conclusions:PLGA biomaterials loaded with CDDP,as compared with the same amount of free CDDP,showed good efficacy in terms of cytotoxicity,as evidenced by changes in apoptosis.Continuous local CDDP release can decrease the systemic side effects of this drug and the occurrence of drug resistance and angiogenesis,and improve the therapeutic effect.This new approach may be an effective strategy for the local treatment of epithelial ovarian cancer. | Yanqing Wang Xiaoyin Qiao Xiao Yang Mengqin Yuan Shu Xian Li Zhang Dongyong Yang Shiyi Liu Fangfang Dai Zhikai Tan Yanxiang Cheng | 2020 | Cancer Biology & Medicine2020，17，1： | 2 |
| 14 | Coarsening mode and microstructure evolution of Al–In hypermonotectic alloy during rapidly cooling process显示文摘 | Guo Jingjie Liu Yuan Jia Jun Su Yanqing Ding Hongsheng Zhao Jiuzhou Xue Xiang | 2001 | Scripta Materialia2001，，10： | 1 |
| 15 | Electrochemical behaviors of co-deposited Pb/Pb-MnO2 composite anode insulphuric acid solution-Tafel and EIS investigations 显示文摘 | Lai Yanqing Li Yuan Jiang Liangxing Xu Wang Lv Xiaojun Li Jie Liu Yexiang | 2012 | Journal of Electroanalytical Chemistry2012，671，： | 1 |
| 16 | Component Evaporation of Ti-15-3 Melt during ISM Processing显示文摘How to control melt composition is the key for getting high quality alloy melt. The paper made the following efforts: (1) The activity coefficients in Ti-15-3 melt have been calculated. (2) Taking advantage of the activity coefficients, the evaporation losses of components in Ti-15-3 melt during ISM process have been studied. The calculated results show that there is a critical vacuum degree (about 1.33 Pa) during melting process. | Yanqing SU Jingjie GUO HongSheng DING Songqing LIU Yuan LIU GuiZhong LIU and Jun JIA National Key Laboratory of Precision Hot Processing of Metals, Harbin institute of Technology, Harbin 150001, China | 2001 | Journal of Materials Science & Technology2001，17，1： | 1 |
| 17 | OPTIMIZATION OF PROCESSING PARAMETERS DURING ISM PROCESS OF Ti-15-3显示文摘INTRODUCTIONTheISMisoneofthebestmeltingprocesformeltingreactivealoys,suchastitaniumalloys,Ti3Albasedaloys,TiAlbasedaloysan... | Guo, Jingjie Su, Yanqing Liu, Yuan Ren, Zhijiang Jia, Jun | 1999 | 中国有色金属学会会刊:英文版1999，9，1： | 1 |
| 18 | Effect of properties of SiC fibers on longitudinal tensile behavior of SiCf/Ti-6Al-4V composites 显示文摘 | Li Jiankang Yang Yanqing Yuan Meini | 2008 | Trans Nonferrous Met Soc China2008，18，3： | 1 |
| 19 | Demonstration of 85%pump depletion and 10-6 noise content in quasi-parametric chirped-pulse amplification显示文摘Full pump depletion corresponds to the upper limit of the generated signal photons relative to the pump pulse;this allows the highest peak power to be produced in a unit area of ultraintense laser amplifiers.In practical systems based on optical parametric chirped-pulse amplification,however,the typical pump depletion is only~35%.Here,we report quasi-parametric chirped-pulse amplification(QPCPA)with a specially designed 8-cm-thick Sm∶YCOB crystal that highly dissipates the idler and hence improves pump depletion.We demonstrate 56%QPCPA energy efficiency for an 810-nm signal converted from a 532-nm pump,or equivalently 85%pump depletion.As another advantage,such a record high depletion greatly suppresses the parametric superfluorescence noise in QPCPA to only~1.5×10-6 relative to the amplified signal energy.These results pave the way to beyond the ten-petawatt peak power of the currently most intense lasers. | Jingui Ma Kainan Xiong Peng Yuan Xiaoniu Tu Jing Wang Guoqiang Xie Yanqing Zheng Liejia Qian | 2022 | Light(Science & Applications)2022，11，10： | 1 |
| 20 | A MOLD MATERIAL USED FOR TITANIUM-ALUMINUM ALLOY-CALCIA显示文摘AMOLDMATERIALUSEDFORTITANIUMALUMINUMALLOY—CALCIA①GuoJingjie,SuYanqing,LiuYuan,DingHongsheng,RenZhijiangandJiaJunSchoolofMate... | Guo Jingjie, Su Yanqing, Liu Yuan, Ding Hongsheng, Ren Zhijiang and Jia JunSchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, P. R. China | 1998 | 中国有色金属学会会刊:英文版1998，8，2： | 1 |
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