|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Update in version 2021 of CSCO guidelines for colorectal cancer from version 2020显示文摘Colorectal cancer(CRC) is one of the major cancers threatening life and health of Chinese residents. According to the latest data released by the National Cancer Center in2015(1), there were 387,000 new cases and 187,100 deaths of CRC in China, accounting for 9.87% and 8.01% of all malignancies. The first version of the Chinese Society of Clinical Oncology(CSCO) guidelines was released in April2017, and has been updated annually based on the latest clinical research data and the availability of new drugs(2-4). Here, we present the main updates of the 2021 version compared to 2020 version. | Caixia Dong Yuwei Ding Shanshan Weng Guichao Li Yanqing Huang Hanguang Hu Zhen Zhang Suzhan Zhang Ying Yuan | 2021 | Chinese Journal of Cancer Research2021，33，3： | 19 |
| 2 | Synthesis and Characterization of Condensed Polynuclear Aromatic Resin Derived from Ethylene Tar显示文摘As a kind of low-cost and readily available industrial byproduct, ethylene tar (ET) was for the first time utilized for the preparation of heat-resistant condensed polynuclear aromatic resin (COPNAR). The basic properties of ET and the resulted COPNAR were characterized by FT-IR, 1H-NMR, TGA and elemental analysis. The test results showed that ET with high aromatic content (>50%) was suitable for the synthesis of COPNAR with superior heat resistance. The average molecular structure of ET was obtained by means of the improved Brown-Ladner method, and the reaction mechanism was considered as an acid-catalyzed positive ion-typed polymerization. Our findings have provided a new route to develop ET into technology-added heat-resistant resins. | Wu Mingbo Shi Yangyang Li Shibin Wang Yuwei Tan Minghui Wang Ding Zheng Jingtang Tsubaki Noritatsu | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，4： | 7 |
| 3 | Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2显示文摘Phosphatidylinositol 3 磷酸盐(PI3P ) 在小囊的 trafficking,细胞器生物的续生说和 autophagy 起必要作用。二班 III phosphatidylinositol 3-kinase (PI3KC3 ) 建筑群在哺乳动物, ATG14L 建筑群(PI3KC3-C1 ) 和 UVRAG 建筑群(PI3KC3-C2 ) 被识别了。PI3KC3-C1 为 autophagosome 生物的续生说是关键的,并且 PI3KC3-C2 涉及各种各样的膜 trafficking 事件。这里,我们在亚纳米分辨率报导人的 PI3KC3-C1 和 PI3KC3-C2 的 cryo 他们结构。二结构与不同特征分享普通塑造 L 的全面体系结构。他们检查直接表明 PI3KC3-C1 在类脂化合物单层上站起来,与 ATG14L 蝙蝠领域和 VPS34 C 终端领域(CTD ) 联系膜。生物化学的解剖显示 ATG14L 蝙蝠领域负责膜抛锚,而 VPS34 的 CTD 决定取向。而且, PI3KC3-C2 比 PI3KC3-C1 更微弱地绑在包含 PI liposomes 和净化的 endoplasmic 蜂窝胃(嗯) 泡,被 ATG14L 明确地决定的一个性质打领域。在里面 vivo 嗯本地化分析显示蝙蝠领域被要求为嗯 PI3KC3 的本地化。我们建议不同类脂化合物绑定能力是在 autophagy 区分 PI3KC3-C1 和 PI3KC3-C2 的函数的关键因素。 | Meisheng Ma Jun-Jie Liu Nan Li Yuwei Huang Na Ta Yang Chen Hua Fu Ming-Da Ye Yuehe Ding Weijiao Huang Jia Wang Meng-Qiu Dong Li Yu Hong-Wei Wang | 2017 | Cell Research2017，27，8： | 7 |
| 4 | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models显示文摘 | Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu | 2017 | Cell Research2017，27，12： | 5 |
| 5 | Modulating the optical and electrical properties of MAPbBr_(3) single crystals via voltage regulation engineering and application in memristors显示文摘Defect density is one of the most significant characteristics of perovskite single crystals(PSCs)that determines their optical and electrical properties,but few strategies are available to tune this property.Here,we demonstrate that voltage regulation is an efficient method to tune defect density,as well as the optical and electrical properties of PSCs.A three-step carrier transport model of MAPbBr_(3) PSCs is proposed to explore the defect regulation mechanism and carrier transport dynamics via an applied bias.Dynamic and steady-state photoluminescence measurements subsequently show that the surface defect density,average carrier lifetime,and photoluminescence intensity can be efficiently tuned by the applied bias.In particular,when the regulation voltage is 20 V(electrical poling intensity is 0.167 Vμm^(−1)),the surface defect density of MAPbBr_(3) PSCs is reduced by 24.27%,the carrier lifetime is prolonged by 32.04%,and the PL intensity is increased by 112.96%.Furthermore,a voltage-regulated MAPbBr_(3) PSC memristor device shows an adjustable multiresistance,weak ion migration effect and greatly enhanced device stability.Voltage regulation is a promising engineering technique for developing advanced perovskite optoelectronic devices. | Jun Xing Chen Zhao Yuting Zou Wenchi Kong Zhi Yu Yuwei Shan Qingfeng Dong Ding Zhou Weili Yu Chunlei Guo | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 6 | Clinical characteristics and risk factors for mortality in cancer patients with COVID-19显示文摘Patients with cancer are at increased risk of severe infections.From a cohort including 3060 patients with confirmed COVID-19,109(3.4%)cancer patients were included in this study.Among them,23(21.1%)patients died in the hospital.Cancer patients,especially those with hematological malignancies(41.6%),urinary carcinoma(35.7%),malignancies of the digestive system(33.3%),gynecological malignancies(20%),and lung cancer(14.3%),had a much higher mortality than patients without cancer.A total of 19(17.4%)cancer patients were infected in the hospital.The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients.Multivariate Cox regression analysis indicated that a Nutritional Risk Screening(NRS2002)score≥3(adjusted hazard ratio(HR)11.00;95%confidence interval(CI)4.60–26.32;P<0.001),high-risk type(adjusted HR 18.81;95%CI 4.21–83.93;P<0.001),tumor stage IV(adjusted HR 4.26;95%CI 2.34–7.75;P<0.001),and recent adjuvant therapy(<1 month)(adjusted HR 3.16;95%CI 1.75–5.70;P<0.01)were independent risk factors for in-hospital death after adjusting for age,comorbidities,D-dimer,and lymphocyte count.In conclusion,cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer.Cancer patients with high-risk tumor,NRS2002 score≥3,advanced tumor stage,and recent adjuvant therapy(<1 month)may have high risk of mortality. | Junnan Liang Guannan Jin Tongtong Liu Jingyuan Wen Ganxun Li Lin Chen Wei Wang Yuwei Wang Wei Liao Jia Song Zeyang Ding Xiao-ping Chen Bixiang Zhang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 7 | Green‑Solvent Processed Blade‑Coating Organic Solar Cells with an Efficiency Approaching 19%Enabled by Alkyl‑Tailored Acceptors显示文摘Power-conversion-efficiencies(PCEs)of organic solar cells(OSCs)in laboratory,normally processed by spin-coating technology with toxic halogenated solvents,have reached over 19%.However,there is usually a marked PCE drop when the bladecoating and/or green-solvents toward large-scale printing are used instead,which hampers the practical development of OSCs.Here,a new series of N-alkyl-tailored small molecule acceptors named YR-SeNF with a same molecular main backbone are developed by combining selenium-fused central-core and naphthalene-fused endgroup.Thanks to the N-alkyl engineering,NIR-absorbing YR-SeNF series show different crystallinity,packing patterns,and miscibility with polymeric donor.The studies exhibit that the molecular packing,crystallinity,and vertical distribution of active layer morphologies are well optimized by introducing newly designed guest acceptor associated with tailored N-alkyl chains,providing the improved charge transfer dynamics and stability for the PM6:L8-BO:YRSeNF-based OSCs.As a result,a record-high PCE approaching 19%is achieved in the blade-coating OSCs fabricated from a greensolvent o-xylene with high-boiling point.Notably,ternary OSCs offer robust operating stability under maximum-power-point tracking and well-keep>80%of the initial PCEs for even over 400 h.Our alkyl-tailored guest acceptor strategy provides a unique approach to develop green-solvent and blade-coating processed high-efficiency and operating stable OSCs,which paves a way for industrial development. | Hairui Bai Ruijie Ma Wenyan Su Top Archie Dela Pea Tengfei Li Lingxiao Tang Jie Yang Bin Hu Yilin Wang Zhaozhao Bi Yueling Su Qi Wei Qiang Wu Yuwei Duan Yuxiang Li Jiaying Wu Zicheng Ding Xunfan Liao Yinjuan Huang Chao Gao Guanghao Lu Mingjie Li Weiguo Zhu Gang Li Qunping Fan Wei Ma | 2023 | Nano-Micro Letters2023，15，12： | 1 |
| 8 | A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis显示文摘Objective:In some patients with adenomatous polyposis,an identifiable pathogenic variant of known associated genes cannot be found.Researchers have studied this for decades;however,few new genes have been identified.Methods:Adenomatous polyposis coli(APC)negative polyposis patients were identified through next-generation sequencing and multiplex ligation-dependent probe amplification.Then,whole-exome sequencing(WES)was used to determine candidate genes harboring pathogenic variants.Functional experiments were performed to explore their effects.Subsequently,using Sanger sequencing,we found other polyposis patients carrying variants of the DUOX2 gene,encoding dual oxidase 2,and analyzed them.Results:From 88 patients with suspected familial adenomatous polyposis,25 unrelated APC negative polyposis patients were identified.Based on the WES results of 3 patients and 2 healthy relatives from a family,the germline nonsense variant(c.1588 A>T;p.K530 X)of the DUOX2 gene was speculated to play a decisive role in the pedigree in relation to adenomatous polyposis.During functional experiments,we observed that the truncated protein,h Duox2 K530,was overexpressed in the adenoma in a carrier of the DUOX2 nonsense variant,causing abnormal cell proliferation through endoplasmic reticulum(ER)retention.In addition,we found two unrelated APC negative patients carrying DUOX2 missense variants(c.3329 G>A,p.R1110 Q;c.4027 C>T,p.L1343 F).Given the results of the in silico analysis,these two missense variants might exert a negative influence on the function of h Duox2.Conclusions:To our knowledge,this is the first study that reports the possible association of DUOX2 germline variants with adenomatous polyposis.With an autosomal dominant inheritance,it causes ER retention,inducing an unfolded protein response. | Mengyuan Yang Yingxin Zhao Yuwei Ding Juan Wang Yinuo Tan Dong Xu Ying Yuan | 2021 | Cancer Biology & Medicine2021，18，1： | 1 |
| 9 | Free axisymmetrie vibration of transversely isotropic piezo- electric circular plates显示文摘 | Ding Haojiang Xu Rongqiao Chi Yuwei | 1999 | Int J Solid & Stru1999，36，： | 1 |
| 10 | Organometallic perovskite single crystals grown on lattice-matched substrate for photodetection显示文摘In this work,we demonstrate that an organometallic perovskite(OP)single crystal for effective photodetection can be grown on a gold(Au)-decorated substrate using liquid phase epitaxy.The covered gold could both control the shape of the epitaxial layer and act as its electrodes.An MAPbCl3 single crystal and an MAPbBr1.5Cl1.5 single crystal were used as the substrate and the epitaxial layer,respectively.The device,with an Au-perovskite-Au structure,can be fully characterized.Due to the high-quality epitaxial layer,the maximum external quantum efficiency(EQE)value is over 60%under the voltage of20 V.In addition,the response speed can reach 200 and 500 ns(ns)rise and fall,respectively.Our work provides an effective and promising method to fabricate efficient perovskite-based photodetectors. | Xin Wang Yuwei Li Yubing Xu Yuzhu Pan Yao Wua Guanwen Li Wei Zhang Shuyi Ding Jing Chen Wei Lei Dewei Zhao | 2020 | Nano Materials Science2020，2，3： | 0 |
| 11 | CSCO guidelines for metastatic colorectal cancer:personalized medicine in clinical practice显示文摘Colorectal cancer(CRC)is the second most common cancer in China,the morbidity and mortality rates of which are rapidly increasing1,2.Among newly-diagnosed CRC patients,20%have metastatic disease at the time of presentation and an additional 25%present with localized disease and will subsequently develop metastases3.The treatment of metastatic colorectal cancer(mCRC)is gradually moving towards the era of precision therapy,which involves guided treatment based on individual genetic characteristics4.Since the first edition of the Chinese Society of Clinical Oncology(CSCO)guidelines was published in 2017,the guidelines have been updated annually according to the latest clinical trial findings5-9.Herein we summarize how the CSCO guidelines enable tailor-made treatments of mCRC with different molecular characteristics(Figure 1). | Mengyuan Yang Ziheng Xu Mi Mi Yuwei Ding Yuefen Pan Ying Yuan Weijing Sun Shanshan Weng | 2023 | Cancer Biology & Medicine2023，20，9： | 0 |
| 12 | Differentiation of the Agonists and Antagonists of the α7 Nicotinic Acetylcholine Receptor显示文摘Theα7 nicotinic acetylcholine receptors(nAChRs)are widely expressed in the central and peripheral nervous systems and are important drug targets for the treatment of neurological diseases.However,differentiation of the agonists and antagonists of the nAChR is difficult.In this study we aimed to develop a reliable and efficient computational approach for differentiation of the agonists from the antagonists of the nAChR based on a systematical analysis of 123 ligands(87 agonists,12 partial agonists,and 24 antagonists)binding with the extracellular domain of theα7 n AChR chimera.Our results suggest that the ligand size and ligand binding affinity cannot differentiate the agonists from the antagonists of the nAChR.The ligand efficiency that considers both ligand binding affinity and size for the agonists is overall more left shifted in comparison to the antagonists,but the values of the ligand efficiency still cannot differentiate the agonists from the antagonists unless the values are either relatively high(more than-0.3 kcal mol^-1)or relatively low(less than-0.45 kcal mol^-1).Our results suggest that accurate prediction of the agonist or antagonist of the nAChR is challenging and the ligand innate configuration has to be considered as an extra for differentiation of the agonists from the antagonists of the nAChR. | WU Guanzhao XU Qingliang BAO Yilei LIU Yuwei LI Qian FANG Zhengyu FU Jingyi DING Yuhang LIANG Zhiqing JIANG Tao YU Rilei | 2019 | Journal of Ocean University of China2019，18，5： | 0 |
| 13 | Author Correction:Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and-C2显示文摘We apologize for errors that we inadvertently introduced in Fig.4C and Supplementary infoirnation,Figs.S5F,S4E and S6C,of the paper published online on July 21*2017.The bands of Ha-P150_C2-BATsw in Fig.4C,/,a-Beclin1_C1/,in Supplementary information,Fig.S5F,and'a-P150_C2+6%PI(4,5)P2'in Supplementary information,Fig.S6C were incorrectly cropped from the original western blot images.The labeling of'a-VPS34—VPS34 ACTD'and'0-VPS34—ATGML ABATs'in Supplementary information,Fig.S4E were flipped.The corrected figures are provided below. | Meisheng Ma Jun-Jie Liu Yan Li Yuwei Huang Na Ta Yang Chen Hua Fu Ming-Da Ye Yuehe Ding Weijiao Huang Jia Wang Meng-Qiu Dong Li Yu and Hong-Wei Wang | 2020 | Cell Research2020，30，6： | 0 |
| 14 | Erratum to A truncated protein product of the germline variant of the DU0X2 gene leads to adenomatous polyposis显示文摘In the published paper1,the author's organization information on page 215 contained errors.The author information has been updated to correct the errors.The errors do not affect the conclusions of this article.We apologize for the errors and for any confusion they may have caused. | Mengyuan Yang Yingxin Zhao Yuwei Ding Juan Wang Yinuo Tan Dong Xu Ying Yuan | 2022 | Cancer Biology & Medicine2022，19，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员