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| 1 | Intratidal and neap-spring variations of suspended sediment concentrations and sediment transport processes in the North Branch of the Changjiang Estuary显示文摘Profiles of tidal current and suspended sediment concentration(SSC) were measured in the North Branch of the Changjiang Estuary from neap tide to spring tide in April 2010. The measurement data were analyzed to determine the characteristics of intratidal and neap-spring variations of SSC and suspended sediment transport. Modulated by tidal range and current speed, the tidal mean SSC increased from 0.5 kg/m3 in neap tide to 3.5 kg/m3 in spring tide. The intratidal variation of the depth-mean SSC can be summarized into three types: V-shape variation in neap tide, M-shape and mixed M-V shape variation in medium and spring tides. The occurrence of these variation types is controlled by the relative intensity and interaction of resuspension, settling and impact of water exchange from the rise and fall of tide. In neap tide the V-shape variation is mainly due to the dominant effect of the water exchange from the rise and fall of tide. During medium and spring tides, resuspension and settling processes become dominant. The interactions of these processes, together with the sustained high ebb current and shorter duration of low-tide slack, are responsible for the M-shape and M-V shape SSC variation. Weakly consolidated mud and high current speed cause significant resuspension and remarkable flood and ebb SSC peaks. Settling occurs at the slack water periods to cause SSC troughs and formation of a thin fluff layer on the bed. Fluxes of water and suspended sediment averaged over the neap-spring cycle are all seawards, but the magnitude and direction of tidal net sediment flux is highly variable. | LI Zhanhai LI Michael Z DAI Zhijun ZHAO Fangfang LI Jiufa | 2015 | Acta Oceanologica Sinica2015，34，1： | 9 |
| 2 | Isolation and phylogenetic study of Rift Valley fever virus from the first imported case to China显示文摘Dear Editor,Rift Valley fever(RVF)is an anthropozoonosis caused by Rift Valley fever virus(RVFV).RVFV belongs to the Phlebovirus genus in the family Bunyaviridae,which is circulating among ruminants.Human infection with RVFV is generally asymptomatic,however,minority of patients develop severe RVF diseases like encephalitis | Yongxia Shi Kui Zheng Xiaobo Li Liqiang Li Shufen Li Jinmin Ma Jun Dai Jingkai Ji Shuai Yuan Haorong Lu Jiandong Li Fangfang Sun Xun Xu Jicheng Huang | 2017 | Virologica Sinica2017，32，3： | 4 |
| 3 | Liquid-liquid phase separation in human health and diseases显示文摘Emerging evidence suggests that liquid-liquid phase separation(LLPS)represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells(also known as biomolecular condensates or droplets).Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases.In this review,we describe our current understanding of LLPS and summarize its physiological functions.We further describe the role of LLPS in the development of human diseases.Additionally,we review the recently developed methods for studying LLPS.Although LLPS research is in its infancy-but is fast-growing-it is clear that LLPS plays an essential role in the development of pathophysiological conditions.This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries. | Bin Wang Lei Zhang Tong Dai Ziran Qin Huasong Lu Long Zhang Fangfang Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 4 |
| 4 | A systematic review of SARS-CoV-2 vaccine candidates显示文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m2(day 1),gemcitabine 1 g/m2(days 1 and 8)and oxaliplatin 130 mg/m2(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy. | Yetian Dong Tong Dai Yujun Wei Long Zhang Min Zheng Fangfang Zhou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 5 | Alterations in microbiota of patients with COVID-19:potential mechanisms and therapeutic interventions显示文摘The global coronavirus disease 2019(COVID-19)pandemic is currently ongoing.It is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).A high proportion of COVID-19 patients exhibit gastrointestinal manifestations such as diarrhea,nausea,or vomiting.Moreover,the respiratory and gastrointestinal tracts are the primary habitats of human microbiota and targets for SARS-CoV-2 infection as they express angiotensin-converting enzyme-2(ACE2)and transmembrane protease serine 2(TMPRSS2)at high levels.There is accumulating evidence that the microbiota are significantly altered in patients with COVID-19 and post-acute COVID-19 syndrome(PACS). | Bin Wang Lei Zhang Yongqiang Wang Tong Dai Ziran Qin Fangfang Zhou Long Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 3 |
| 6 | The interactions between cGAS-STING pathway and pathogens显示文摘Cytosolic DNA is an indicator of pathogen invasion or DNA damage.The cytosolic DNA sensor cyclic guanosine monophosphateadenosine monophosphate(cGAMP)synthase(cGAS)detects DNA and then mediates downstream immune responses through the molecule stimulator of interferon genes(STING,also known as MITA,MPYS,ERIS and TMEM173).Recent studies focusing on the roles of the cGAS-STING pathway in evolutionary distant species have partly sketched how the mammalian cGAS-STING pathways are shaped and have revealed its evolutionarily conserved mechanism in combating pathogens.Both this pathway and pathogens have developed sophisticated strategies to counteract each other for their survival.Here,we summarise current knowledge on the interactions between the cGAS-STING pathway and pathogens from both evolutionary and mechanistic perspectives.Deeper insight into these interactions might enable us to clarify the pathogenesis of certain infectious diseases and better harness the cGAS-STING pathway for antimicrobial methods. | Zhangliang Cheng Tong Dai Xuelin He Zhengkui Zhang Feng Xie Shuai Wang Long Zhang Fangfang Zhou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 7 | Physical structure and vertical distribution of chlorophyll a in winter sea ice from the northwestern Weddell Sea, Antarctica显示文摘The investigation on sea-ice biology in combination with physics, chemistry and ecology was carried out in the northwestern Weddell Sea, Antarctica, during the cruise ANT/XX III-7 on board POLARSTERN in the austral winter (August-October) in 2006. The distribution of chlorophyll a was measured and related to sea ice texture. The mean concentrations of chlorophyll a in the sea ice varied considerably with ice texture. The concentration of chlorophyll a per core ranged from 2.10– 84.40 μg/dm 3 with a mean of 16.56 μg/dm 3 . And the value of R (chlorophyll a / gross chlorophyll) ranged from 0.79–0.83. These high winter chlorophyll values indicate that primary production is considerable and confirms that there is significant primary production in Antarctic sea ice during winter. Thus this constitutes a major proportion of southern ocean primary production and carbon flux before the sea ice retreats. | DAI Fangfang WANG Zipan YAN Xiaojun LI Zhijun ALLHUSEN Erika DIECKMANN Gerhard | 2010 | Acta Oceanologica Sinica2010，29，3： | 2 |
| 8 | The role of a drug-loaded poly(lactic co-glycolic acid)(PLGA) copolymer stent in the treatment of ovarian cancer显示文摘Objectives:Cisplatin(CDDP)is a widely used and effective basic chemotherapeutic drug for the treatment of a variety of tumors,including ovarian cancer.However,adverse side effects and acquired drug resistance are observed in the clinical application of CDDP.Identifying a mode of administration that can alleviate side effects and reduce drug resistance has become a promising strategy to solve this problem.Methods:In this study,3 D printing technology was used to prepare a CDDP-poly(lactic-co-glycolic acid)(CDDP-PLGA)polymer compound stent,and its physicochemical properties and cytotoxicity were evaluated both in vitro and in vivo.Results:The CDDP-PLGA stent had a significant effect on cell proliferation and apoptosis and clearly decreased the size of subcutaneous tumors in nude mice,whereas the systemic side effects were mild compared with those of intraperitoneal CDDP injection.Compared with the control group,CDDP-PLGA significantly increased the mRNA and protein levels of p-glycoprotein(P<0.01;P<0.01)and decreased vascular endothelial growth factor mRNA(P<0.05)and protein levels(P<0.01),however,CDDP-PLGA significantly decreased the mR NA and protein levels of p-glycoprotein(P<0.01;P<0.01)and vascular endothelial growth factor(P<0.01;P<0.01),which are associated with chemoresistance,in subcutaneous tumor tissue.Immunohistochemistry assay results revealed that,in the CDDP-PLGA group,the staining of the proliferation-related genes Ki67 and PCNA were lightly,and the apoptosis-related gene caspase-3 stained deeply.Conclusions:PLGA biomaterials loaded with CDDP,as compared with the same amount of free CDDP,showed good efficacy in terms of cytotoxicity,as evidenced by changes in apoptosis.Continuous local CDDP release can decrease the systemic side effects of this drug and the occurrence of drug resistance and angiogenesis,and improve the therapeutic effect.This new approach may be an effective strategy for the local treatment of epithelial ovarian cancer. | Yanqing Wang Xiaoyin Qiao Xiao Yang Mengqin Yuan Shu Xian Li Zhang Dongyong Yang Shiyi Liu Fangfang Dai Zhikai Tan Yanxiang Cheng | 2020 | Cancer Biology & Medicine2020，17，1： | 2 |
| 9 | Multifunctional hydrotalcite-derived K/MnMgAlO catalysts used for soot combustion, NOx storage and simultaneous soot–NOx removal显示文摘 | Qian Li Ming Meng Fangfang Dai Yuqing Zha Yaning Xie Tiandou Hu Jing Zhang | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 10 | In vivo biocompatibility and degradability of a Zn-Mg-Fe alloy osteosynthesis system显示文摘Zinc is generally considered to be one of the most promising materials to be used in biodegradable implants,and many zinc alloys have been optimized to improve implant biocompatibility,degradation,and mechanical properties.However,long-term degradation leads to the prolonged presence of degradation products,which risks foreign body reactions.Herein,we investigated the in vivo biocompatibility and degradation of a biodegradable Zn-Mg-Fe alloy osteosynthesis system in the frontal bone,mandible,and femur in beagles for 1 year.Results of the routine blood,biochemical,trace element,and histological analyses of multiple organs,peripheral blood CD4/CD8a levels,and serum interleukin 2 and 4 levels showed good biocompatibility of the Zn-Mg-Fe alloy.Zinc content analysis revealed zinc accumulation in adjacent bone tissue,but not in the liver,kidney,and spleen,which was related to the degradation of the Zn-Mg-Fe alloy.The alloy demonstrated a uniform slowing degradation rate in vivo.No degradation differences in the frontal bone,mandible,and femur were observed.The degradation products included zinc oxide[ZnO],zinc hydroxide[Zn(OH)_(2)],hydrozincite[Zn_(5)(OH)_(6)(CO_(3))_(2)],and hopeite[Zn_(3)(PO_(4))_(2)⋅4H_(2)O].The good biocompatibility and degradation properties of the Zn-Mg-Fe alloy render it a very attractive osteosynthesis system for clinical applications. | Xiaoxi Shao Xiang Wang Fangfang Xu Taiqiang Dai Jack G.Zhou Jiang Liu Kun Song Lei Tian Bin Liu Yanpu Liu | 2022 | Bioactive Materials2022，7，1： | 1 |
| 11 | HPLC Fingerprint Chromatogram of Tetracera asiatica Produced in Guangxi显示文摘[Objectives] To establish fingerprint chromatogram of Tetracera asiatica and provide basis for controlling and assessing the quality of Tetracera asiatica.[Methods] The high-performance liquid chromatography( HPLC) method was used. Phenomenex C18( 5 μm,4. 6 ×250 mm),acetonitrile-0. 1% phosphoric acid water,gradient elution,flow rate 1 m L/min,detection wavelength 214 nm,and column temperature 25 ℃. The fingerprint chromatogram of 10 batches of samples of Tetracera asiatica was determined for similarity comparison. [Results] It established HPLC fingerprint chromatogram of Tetracera asiatica produced in Guangxi,determined a total of 13 common fingerprint peaks. The similarity of 10 batches of Tetracera asiatica was > 0. 9.[Conclusions] The method is rapid and accurate and can provide references for assessing the quality of Tetracera asiatica. | Fangfang DA Zhonghua DAI Hua ZHU Jianbei TENG | 2017 | Medicinal Plant2017，8，4： | 1 |
| 12 | Performance of Ce substituted hydrotalcite-derived mixed oxide catalysts Co 2.5 Mg 0.5 Al 1<ce:hsp sp='0.12'/>?<ce:hsp sp='0.12'/> x % Ce x % O used for soot combustion and simultaneous NO x -soot removal显示文摘 | Fangfang Dai Ming Meng Yuqing Zha Zhaoqiang Li Tiandou Hu Yaning Xie Jing Zhang | 2012 | Fuel Processing Technology2012，，： | 1 |
| 13 | Comparable outcomes but higher risks of prolonged viral RNA shedding duration and secondary infection in cancer survivors with COVID-19: A multi-center, matched retrospective cohort study显示文摘Results Sixty-one cancer survivors and 183 matched non-cancer patients were screened from 2,828 COVID-19 infected patients admitted to 4 hospitals in Wuhan,China.The median ages of the cancer survivor cohort and non-cancer patient cohort were 64.0(55.0–73.0)and 64.0(54.0–73.5),respectively(P=0.909).Cancer survivors reported a higher incidence of symptom onset than non-cancer patients.Fever(80.3%vs.65.0%;P=0.026)was the most prevalent symptom,followed by cough(65.6%vs.37.7%;P<0.001),myalgia,and fatigue(45.9%vs.13.6%;P<0.001).The risks of the development of severe events(adjusted hazard ratio[AHR]=1.25;95%confidence interval[CI]:0.76–2.06;P=0.378)and mortality(relative risk[RR]=0.90,95%CI:0.79–1.04;P=0.416)in the cancer survivor cohort were comparable to those of the matched non-cancer patient cohort.However,the cancer survivor cohort showed a higher incidence of secondary infection(52.5%vs.30.1%;RR=1.47,95%CI:1.11–1.95;P=0.002)and a prolonged viral RNA shedding duration(32 days[IQR 26.0–46.0]vs.24.0 days[IQR 18.0–33.0];AHR=0.54;95%CI:0.38–0.80;P<0.05).Conclusion Compared to non-cancer patients,cancer survivors with COVID-19 exhibited a higher incidence of secondary infection,a prolonged period of viral shedding,but comparable risks of the development of severe events and mortality.It is helpful for clinicians to take tailored measures to treat cancer survivors with COVID-19. | Hui Peng Sheng Wang Qi Mei Yuhong Dai Jian Li Ming Li Kathrin Halfter Xueyan Jiang Qin Huang Lei Wang Wei Wei Ru Liu Zhen cao Motuma Yigezu Daba Fangfang Wang Bingqing Zhou Hong Qiu Xianglin Yuan | 2020 | Oncology and Translational Medicine2020，6，6： | 1 |
| 14 | Protein N-myristoylation:functions and mechanisms in control of innate immunity显示文摘Protein N-myristoylation is an important fatty acylation catalyzed by N-myristoyltransferases(NMTs),which are ubiquitous enzymes in eukaryotes.Specifically,attachment of a myristoyl group is vital for proteins participating in various biological functions,including signal transduction,cellular localization,and oncogenesis.Recent studies have revealed unexpected mechanisms indicating that protein N-myristoylation is involved in host defense against microbial and viral infections.In this review,we describe the current understanding of protein N-myristoylation(mainly focusing on myristoyl switches)and summarize its crucial roles in regulating innate immune responses,including TLR4-dependent inflammatory responses and demyristoylation-induced innate immunosuppression during Shigella flexneri infection.Furthermore,we examine the role of myristoylation in viral assembly,intracellular host interactions,and viral spread during human immunodeficiency virus-1(HIV-1)infection.Deeper insight into the relationship between protein N-myristoylation and innate immunity might enable us to clarify the pathogenesis of certain infectious diseases and better harness protein N-myristoylation for new therapeutics. | Bin Wang Tong Dai Wenhuan Sun Yujun Wei Jiang Ren Long Zhang Mengdi Zhang Fangfang Zhou | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 15 | The way of SARS-CoV-2 vaccine development:success and challenges显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of coronavirus disease 2019(COVID-19).To halt the pandemic,multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rollout worldwide.With novel SARS-CoV-2 variants emerging and circulating widely,whether the original vaccines that were designed based on the wild-type SARS-CoV-2 were effective against these variants has been a contentious discussion.Moreover,some studies revealed the long-term changes of immune responses post SARS-CoV-2 infection or vaccination and the factors that might impact the vaccine-induced immunity.Thus,in this review,we have summarized the influence of mutational hotspots on the vaccine efficacy and characteristics of variants of interest and concern.We have also discussed the reasons that might result in discrepancies in the efficacy of different vaccines estimated in different trials.Furthermore,we provided an overview of the duration of immune responses after natural infection or vaccination and shed light on the factors that may affect the immunity induced by the vaccines,such as special disease conditions,sex,and pre-existing immunity,with the aim of aiding in combating COVID-19 and distributing SARS-CoV-2 vaccines under the prevalence of diverse SARS-CoV-2 variants. | Yetian Dong Tong Dai Bin Wang Lei Zhang Ling-hui Zeng Jun Huang Haiyan Yan Long Zhang Fangfang Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 16 | Hesperetin attenuates mitochondria-dependent apoptosis in lipopolysaccharide-inducedH9C2 cardiomyocytes显示文摘 | Zheng Yang Yuan Liu Wei Deng Jia Dai Fangfang Li Yuan Yuan Qingqing Wu Heng Zhou Zhouyan Bian Qizhu Tang | 2014 | Molecular Medicine Reports2014，，5： | 1 |
| 17 | Characterization of 3D DNA Assemblies Using Cryogenic Electron Microscopy显示文摘DNA nanotechnology utilizes DNA double strands as building units for self-assembly of DNA nanostructures.The specific base-pairing interaction between DNA molecules is the basis of these assemblies.After decades of development,this technology has been able to construct complex and programmable structures.With the increase in delicate nature and complexity of the synthesized nanostructures,a characterization technology that can observe these structures in three dimensions has become necessary,and developing such a technology is considerably challenging.DNA assemblies have been studied using different characterization methods including atomic force microscopy(AFM),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).However,the three-dimensional(3D)DNA assemblies always collapse locally due to the dehydration during the drying process.Cryogenic electron microscopy(cryo-EM)can overcome the challenge by maintaining three-dimensional morphologies of the cryogenic samples and reconstruct the 3D models from cryogenic samples accordingly by collecting thousands of two-dimensional(2D)projection images,which can restore their original morphologies in solution.Here,we have reviewed several typical cases of 3D DNA-assemblies and highlighted the applications of cryo-EM in characterization of these assemblies.By comparing with some other characterization methods,we have shown how cryo-EM promoted the development of structural characterization in the field of DNA nanotechnology. | WANG Mingyang DUAN Jialin DAI Lizhi XIN Xiaodong WANG Fangfang LI Zheng TIAN Ye | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 18 | Content Determination of Total Flavonoids in Tetracera asiatica from 10 Different Production Areas in Guangxi显示文摘[Objectives] To determine the content of total flavonoids in Tetracera asiatica from different production areas in Guangxi and provide a basis for improving the quality standards of crude drug. [Methods] Using 50% ethanol as extractor,NaNO_2-Al(NO_3)_3-NaOH as chromogenic system and rutin as the reference substance,the content of total flavonoids from the crude drug was determined. [Results] A method for determining the content of total flavonoids was established,the content of total flavonoids was 11.35-21.35 mg·g^(-1),and the average content was 17.64 mg·g^(-1). [Conclusions] The method had high repeatability and stability,and the method was simple,rapid and sensitive and suitable for quantitative analysis. | Fangfang DA Zhonghua DAI Hua ZHU | 2017 | Medicinal Plant2017，8，5： | 0 |
| 19 | Research Situation of Polysaccharides of Dendrobii Officinalis Caulis显示文摘This study was conducted to investigate the changes of polysaccharides content in Dendrobii Officinalis Caulis and its pharmacological action. The results showed that different growth years,different periods,different habitats and different external factors had influences on the change of polysaccharide content in Dendrobii Officinalis Caulis. Dendrobii Officinalis Caulis has certain effects of enhancing immunity,resisting fatigue and oxidation,promoting digestion and salivation secretion,reducing blood sugar and blood pressure,resisting tumor and liver injury,and relaxing bowels. Dendrobii Officinalis Caulis polysaccharides are the main effective components in Dendrobii Officinalis Caulis. The control of Dendrobii Officinalis Caulis polysaccharide content is of great significance to the assurance of the yield and quality of Dendrobii Officinalis Caulis material. | Hua ZHU Liuyuan FAN Zhonghua DAI Jianbei TENG Fangfang DA Peng LI Pingfeng LI | 2017 | Agricultural Biotechnology2017，6，6： | 0 |
| 20 | Functions of Plant Growth Substances in the Growth of Dendrobium officinale Kimura et Migo显示文摘[Objectives] To study the effects of plant growth substance on the growth and development of Dendrobium officinale Kimura et Migo. [Methods] Comparative methods were applied to study the effects of plant growth substance on the growth and development of D. officinale Kimura et Migo. [Results] Plant growth regulators play an important role in the process of tissue culture rapid propagation of D. officinale Kimura et Migo,and the main regulatory pathways are as follows.( i) Plant growth regulators promote the growth and development of D. officinale Kimura et Migo through regulating the changes of its endogenous hormones.( ii) Plant growth regulators affect the accumulation of polysaccharide content in D. officinale Kimura et Migo through regulating the changes in chlorophyll content and enzymes involved in sucrose metabolism.( iii) Plant growth regulators can increase the activity of antioxidant enzymes of D. officinale Kimura et Migo,to increase its stress resistance. [Conclusions]Using molecular biology techniques,combined with the changes of plant hormones in D. officinale Kimura et Migo,and analysis on key enzyme in the synthesis of plant hormones and gene expression,it is feasible to study the rules o changes in the content of active content of D. officinale Kimura et Migo. | Hua ZHU Peng LI Zhonghua DAI Liuyuan FAN Fangfang DA Miao ZHANG Li LONG | 2018 | Medicinal Plant2018，9，2： | 0 |
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