|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome显示文摘OBJECTIVE:To observe the curative effect of a recipe for warming the kidney and fortifying the spleen on diarrhea-predominant irritable bowel syndrome(IBS-D).METHODS:This multi-center,double-blind,randomized,and controlled trial included 240 patients that met the inclusion criterion and were then divided into two groups of 120.Patients in the treatment group(group A)took modified Sishen Wan orally for warming the kidney and fortifying the spleen and patients in the control group(group B)took a placebo,Chao Maiya,for 4 weeks.28 days after withdrawal,there was a 6-month follow-up to observe patient recurrence condition.The total effective rate,curative effect,and recurrence rate were evaluated after treatment.RESULTS:There was statistical difference(P<0.01)between the two groups in total effective rate(92.24%in the treatment group and 49.07%in the control group),in curative effect of TCM syndrome(90.52%and 47.22%,respectively),and in the recurrence rate(15.79%and 56.86%,respectively)within6 months after treatment.CONCLUSION:Modified Sishen Wan,for warming the kidney and fortifying the spleen,can effectively treat IBS-D and better control its recurrence. | Xiaolan Su Yanping Tang Jing Zhang Yuebin Dong Wei Wei Yibing Bai Yong Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 22 |
| 2 | Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats显示文摘Orexin neurons within the lateral hypothalamus play a crucial role in the promotion and maintenance of arousal. Studies have strongly suggested that orexin neurons are an important target in endogenous adenosine-regulated sleep homeostasis. Orexin A induces a robust increase in the firing activity of orexin neurons, while adenosine has an inhibitory effect. Whether the excitatory action of orexins in the lateral hypothalamus actually promotes wakefulness and reverses the sleep-producing effect of adenosine in vivo is less clear. In this study,electroencephalographic and electromyographic recordings were used to investigate the effects of orexin A and adenosine on sleep and wakefulness in rats. We found that microinjection of orexin A into the lateral hypothalamus increased wakefulness with a concomitant reduction of sleep during the first 3 h of post-injection recording, and this was completely blocked by a selective antagonist for orexin receptor 1,SB 334867. The enhancement of wakefulness also occurred after application of the excitatory neurotransmitter glutamate in the first 3 h post-injection. However, in the presence of the NMDA receptor antagonist APV, orexin A did not induce any change of sleep and wakefulness in the first 3 h.Further, exogenous application of adenosine into the lateral hypothalamus induced a marked increase of sleep in the first 3-h post-injection. No significant change in sleep and wakefulness was detected after adenosine application followed by orexin A administration into the same brain area. These findings suggest that the sleep-promoting action of adenosine can be reversed by orexin A applied to the 丨ate「a丨 hypothalamus, perhaps by exciting giutamatergic input to orexin neurons via the action0 f orexin receptor | Yanping Cun Lin Tang Jie Yan Chao He Yang Li Zhian Hu Jianxia Xia | 2014 | Neuroscience Bulletin2014，30，5： | 8 |
| 3 | A NOTE ON JACOBI SPECTRAL-COLLOCATION METHODS FOR WEAKLY SINGULAR VOLTERRA INTEGRAL EQUATIONS WITH SMOOTH SOLUTIONS显示文摘这个工作涉及光谱为第二种类型与的 Volterra 不可分的方程的 Jacobi 搭配方法一形式弱单个(t - s )-- 伪当内在的答案是足够地光滑的时,集中分析被执行在[陈与唐, J。Comput。Appl。数学, 233 (2009 ) , pp。938-950 ] ;由于技术原因,结果被限制为 0 < 渭 < 1/2。在这个工作,我们将改进结果到一般盒子 0 < 渭 < 1 并且当光滑的答案被包含时,证明数字错误在无穷和加权的标准指数地腐烂。[从作者抽象] | Yanping Chen Xianjuan Li Tao Tang | 2013 | Journal of Computational Mathematics2013，31，1： | 8 |
| 4 | The effects of air temperature and precipitation on the net primary productivity in China during the early 21st century显示文摘Research on how terrestrial ecosystems respond to climate change can reveal the complex interactions between vegetation and climate,net primary productivity (NPP),an important vegetation parameter and ecological indicator,fluctuates within any given ecological environment or regional carbon budget.In this study, spatial interpolation was used to generate a spatial dataset, with 1-km spatial resolution,with meteorological data from 736 observation stations across China.An improved CASA model was used to simulate NPP over the period of 2001-2013 by taking into account land-cover change in every year during the same period.We propose the grid- based spatial patterns and dynamics of annual NPP,annual average temperature,and annual total precipitation based on the model.We also used the model to demonstrate the spatial correlation between NPP,temperature,and pre- cipitation in the study area with special focus on the impact of climate change in the early 21st century.Results showed that the spatial pattern of NPP over all of China is characterized by higher values in the southeast and lower values in the northwest.The spatial pattern of temperature indicates substantial latitudinal differences across the country,and the spatial pattem of precipitation shows a ribbon of decline from the southeast coast to the northwest inland.Most areas show an upward trend in NPP. Temperatures appear to decrease across the country during the global warming hiatus (1998-2008),and are accom- panied by an increase in precipitation over most regions.The correlation between NPP and annual average temperature is weak.Alternatively,NPP and annual total precipitation are positively correlated in northern and central China at a coefficient above 0.64(p <0.01)yet negatively correlated in the eastem parts of the Qinghai- Tibet Plateau and Sichuan Basin.Results can provide useful information for improving parameters for calibra- tion of the terrestrial ecosystem process model. | Qianfeng WANG Jingyu ZENG Song LENG Bingxiong FAN Jia TANG Cong JIANGs Yi HUANG Qing ZHANG Yanping QU Wnlin WANG Wei SHUI | 2018 | Frontiers of Earth Science2018，12，4： | 6 |
| 5 | Abnormal strain changes observed by a borehole strainmeter at Guza Station before the Ms7. 0 Lushan earthquake显示文摘Several days before the Ms7.0 Lushan earthquake,the YRY-4 borehole Strainmeter at Guza Station recorded prominent abnormal changes.The strain anomalies are very striking on the smooth background of several years’recording after the Wenchuan earthquake.However,because construction in the town of Guza has been undergoing rapid development in recent years,many factors have interfered with observations at the station.Whether or not the observed strain changes before the Lushan earthquake were affected by any of the sources of interference becomes a question that must be answered.Among the likely sources of interference,apartment construction,sportsground reconstruction,and tunnel cutting can be excluded by analyzing the morphological characteristic of the anomalies.The two remaining most possible sources are road construction in front of the station and the water level change of the nearby Dadu River caused by water filling into and discharging from an upstream reservoir.Through field investigation,comparison of the correlation between the strain and the seismographic recordings,comparison of the correlation between the strain and the Dadu River flow recordings,and analysis of the strain anomaly characteristics,we conclude that the abnormal changes observed at Guza Station cannot be attributed to either of these two sources but should be related to the Lushan earthquake. | Qiu Zehua Yang Guang Tang Lei Guo Yanping Zhang Baohong | 2013 | Geodesy and Geodynamics2013，4，3： | 4 |
| 6 | Relation of loudness to loudness just noticeable difference of tone显示文摘A relation of loudness to loudness just noticeable difference (JND) is derived based on signal detection theory and the hypothesis that loudness is the nerve spike count in the duration of T, and the spike rate distribution of stable tonal stimulus is a stable normal stochastic process. The relation suggests that ratio of loudness JND to loudness of tone is independent of intensity, which can explain well experimental results about the relation of intensity JND to intensity of tone, especially those that could not be explained before such as the Weber fraction hump at the moderate level and the near miss to Weber’s law. | LONG Zhangcai TANG Chaoqun (Department of Physics, Huazhong University of Science & Technology Wuhan 430074) ZHANG Yanping (Affiliated Hospital of Huazhong University of Science and Technology Wuhan 430074) LONG Xianming (Wuhan general logistic hospital | 2000 | Chinese Journal of Acoustics2000，19，3： | 4 |
| 7 | The strain seismograms of P- and S-waves of a local event recorded by four-gauge borehole strainmeter显示文摘At a sampling rate of 100 samples per second,the YRY-4 four-gauge borehole strainmeters(FGBS) are capable of recording transient strains caused by seismic waves such as P and S waves or strain seismograms. At such a high sampling rate, data from the YRY-4 strainmeters demonstrate fairly satisfactory self-consistency. The strain tensor seismograms demonstrate the senses of motion of P waves, that is, the type of seismic wave travels in the direction of the maximum normal strain change. The observed strain patterns of S waves significantly differ from those of P waves and should contain information about the source mechanism. Spectrum analysis shows that the strain seismograms are consistent with conventional broadband seismograms from the same site. | Zehua Qiu Shunliang Chi Zhenming Wang Seth Carpenter Lei Tang Yanping Guo Guang Yang | 2015 | Earthquake Science2015，28，3： | 4 |
| 8 | Selective recovery of Cu^2+ and Ni^2+ from wastewater using bioelectrochemical system显示文摘作为 bioelectrochemical 系统,微生物引起的燃料房间(MFC ) 和微生物引起的电解房间(MEC ) 被开发有选择地恢复 Cu < 啜 class= “ a-plus-plus ” >2+ 和 Ni < 啜 class= “ a-plus-plus ” > 从废水的 2+ 个 离子。废水在系统的阴极房间被对待,在哪个 Cu < 啜 class= “ a-plus-plus ” >2+ 和 Ni < 啜 class= “ a-plus-plus ” >2+ 个 离子被分别地使用 MFC 和 MEC 移开。在起始的 Cu < 啜 class= “ a-plus-plus ” > 500 mg 瀠牥散瑮条 ? 景漠瑵異 ? 慶畬 ? 景椠摮獵牴 ? 湩敶瑳摥戠 ? 的 2+ 集中潈杮? 湯 ?? 捡潡 ? 慔睩湡愠摮愠牢慯? 攠敮杲 ? 牰捩 ? 湡 ? 湩敶瑳敭瑮漠 ? 諗棔娹驺硴超 _ 捥湨汯杯捩污愠瑣癩瑩敩 ? 潦 ? 湩畤瑳祲挠畯摬戠 ? 潰獳扩敬挠湯牴扩瑵牯 ? 湡 ? 牤癩牥 ? 潴琠敨椠摮獵牴慩? 湥牥祧攠晦捩敩据? | Haiping LUO Bangyu QIN Guangli LIU Renduo ZHANG Yabo TANG Yanping HOU | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 4 |
| 9 | Cloning of Porcine Lactoferrin Gene and Construction of Expression System in Recombinant Lactobacillus显示文摘Lactobacillus was selected as a bacterial carrier for expression of N-lobe of porcine lactoferrin(PLF N) . A pair of primers was designed with Oligo6.0 and used to amplify PLF N gene. It was in accordance with the characters of translational fusions from gene and expression vector plasmid. A 1 077 bp fragment of the gene from PLF was cloned from mammary gland tissue of the lactating sow on the third day by RT-PCR;the gene was connected with the vector plasmid pPG612.1 and transformed into the host strain JM109. The recombinant expression vector plasmid pPG612-PLF N was created and identified by using plasmid extraction,PCR,restriction enzyme digestion and sequence analysis. The recombinant plasmid was transformed into Lactobacillus casei ATCC393,Lactobacillus plantarum KLDS 1.0344,Lactobacillus paracasei KLDS 1.0652 and Lactobacillus pentosus KLDS1.0413 by electroporation,and produced the recombinant strains of pPG612-PLF N /L. casei,pPG612-PLF N /L. plantarum,pPG612-PLF N /L. paracasei and pPG612-PLF N /L. pentosus,respectively. The results indicated that PLF N gene had inserted into the expression vectors and achieved multiple Lactobacillus expression systems. It electes the base for the expression and production of recombinant porcine lactoferrin in Lactobacillus. | ZONG Xiaolin HA Zhuo ZHAO Lili LIU Diqiu QIAO Xinyuan JIANG Yanping GE Junwei LI Yijing TANG Lijie | 2011 | Journal of Northeast Agricultural University(English Edition)2011，18，4： | 3 |
| 10 | Superconvergence analysis of fully discrete finite element methods for semilinear parabolic optimal control problems显示文摘 | Yuelong TANG Yanping CHEN | 2013 | Frontiers of Mathematics in China2013，8，2： | 3 |
| 11 | Can nanoparticles and nano-protein interactions bring a bright future for insulin delivery?显示文摘Insulin therapy plays an essential role in the treatment of diabetes mellitus.However,frequent injections required to effectively control the glycemic levels lead to substantial inconvenience and low patient compliance.In order to improve insulin delivery,many efforts have been made,such as developing the nanoparticles (NPs)-based release systems and oral insulin.Although some improvements have been achieved,the ultimate results are still unsatisfying and none of insulin-loaded NPs systems have been approved for clinical use so far.Recently,nano?protein interactions and protein corona formation have drawn much attention due to their negative influence on the in vivo fate of NPs systems.As the other side of a coin,such interactions can also be used for constructing advanced drug delivery systems.Herein,we aim to provide an insight into the advance and flaws of various NPs-based insulin delivery systems.Particularly,an interesting discussion on nano?protein interactions and its potentials for developing novel insulin delivery systems is initiated. | Ting Zhang James Zhenggui Tang Xiaofan Fei Yanping Li Yi Song Zhiyong Qian Qiang Peng | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 3 |
| 12 | Phenotypic characterization of patients with activated PI3Kδ syndrome 1 presenting with features of systemic lupus erythematosus显示文摘Activated phosphoinositide 3-kinase d syndrome 1(APDS1)is a primary immunode-ficiency disease caused by gain-of-function mutations in PIK3CD.Clinical features of autoimmune disease have been reported in patients with APDS1.In this study,we reported three patients with APDS1 presenting with systemic lupus erythematosus(SLE)phenotype.The clinical manifestations included recurrent respiratory tract infection,lymphoproliferation,Coombs-positive hemolytic anemia,decreased complement fractions,positive antinuclear antibodies,renal complications related to SLE associated diseases,which met the clinical spectrum of APDS1 and the classification criteria of SLE.The immunological phenotype included an inversion in the CD4:CD8 ratio,an increase in both non-circulating Tfh CD4^(+)memory T and circulating Tfh populations,a low level of recent thymic emigrant T cells,overexpression of CD57 on T cells,and a decrease in B cells with fewer antibody class switch recombination.These phenotypes detected in patients with APDS1 presenting with SLE were resemble that in patients with APDS1 presenting without SLE.Meanwhile,we described the effect of glucocorticoids and rapamycin therapy on patients with APDS1.The phosphorylation of S6 at Ser235/236 was inhibited in patients with APDS1 who underwent glucocorticoids therapy,including two who presented with SLE phenotype.The phosphorylation of AKT at Ser473 and phosphorylation of S6 at Ser235/236 were inhibited in other patients with APDS1 who underwent rapamycin therapy.Here,we showed the coexistence of immunodeficiency and SLE phenotype in APDS1,and the inhibition of rapamycin in activated Akt-mTOR signaling pathway. | Yanping Wang Qiuyun Yang Xuemei Chen Wenjing Tang Lina Zhou Zhi Chen Yunfei An Zhiyong Zhang Xuemei Tang Xiaodong Zhao | 2021 | Genes & Diseases2021，8，6： | 3 |
| 13 | Clinical assessment and genomic landscape of a consanguineous family with three Kallmann syndrome descendants显示文摘尽管引起 Kallmann 症候群(KS ) 的一些基因被传统的连接分析和候选人基因技术识别了,症候群是在遗体糟糕理解的病人的多数的分子的病原学。在这份报纸,我们在场对与三个 KS 后代一起的一个同宗的汉中国家庭的临床的评价。从一个染色体宽的观点理解 KS 的分子的病原学,我们用 Affymetrix 染色体宽的人的 SNP 数组在这个家庭调查了结构的变化的染色体宽的侧面 6.0 站台。结果表明三个影响个人在染色体 1p21.1, 2q32.2, 8q21.13, 14q21.2 和 Xp22.31 上有普通拷贝数字变体(microdeletions ) 。而且, Xp22.31 上的拷贝数字变体位于 KAL1 的 intron,它引起 X 连接 KS。二 PCR 试金在这些区域上被执行验证用薄片获得的结果。另外,在这个区域的 genomic microdeletions 在 29 个汉中国分散的 KS 案例之一和四个另外的家庭案例之一中,然而并非用 26 汉汉语被验证分散的 normosmic 自发的 hypogonadotropic 性腺机能减退案例和 100 无关的汉汉语正常控制。我们的结果提供新奇卓见进对 KS 的分子的病原学的某些拷贝数字变体的相对贡献并且为进一步的研究产生有趣的候选人区域的一张表。 | Shilin Zhang Yanping Tang Tao Wang Jun Yang Ke Rao Lingyun Zhao Wenzhen Zhu Xianghu Meng Shaogang Wang Jihong Liu Weimin Yang Zhangqun Ye | 2011 | Asian Journal of Andrology2011，13，1： | 3 |
| 14 | Multiple-Instance Learning with Instance Selection via Constructive Covering Algorithm显示文摘Multiple-Instance Learning(MIL) is used to predict the unlabeled bags' label by learning the labeled positive training bags and negative training bags. Each bag is made up of several unlabeled instances. A bag is labeled positive if at least one of its instances is positive, otherwise negative. Existing multiple-instance learning methods with instance selection ignore the representative degree of the selected instances. For example, if an instance has many similar instances with the same label around it, the instance should be more representative than others. Based on this idea, in this paper, a multiple-instance learning with instance selection via constructive covering algorithm(MilCa) is proposed. In MilCa, we firstly use maximal Hausdorff to select some initial positive instances from positive bags, then use a Constructive Covering Algorithm(CCA) to restructure the structure of the original instances of negative bags. Then an inverse testing process is employed to exclude the false positive instances from positive bags and to select the high representative degree instances ordered by the number of covered instances from training bags. Finally, a similarity measure function is used to convert the training bag into a single sample and CCA is again used to classification for the converted samples. Experimental results on synthetic data and standard benchmark datasets demonstrate that MilCa can decrease the number of the selected instances and it is competitive with the state-of-the-art MIL algorithms. | Yanping Zhang Heng Zhang Huazhen Wei Jie Tang Shu Zhao | 2014 | Tsinghua Science and Technology2014，19，3： | 2 |
| 15 | A single-center retrospective study on epidemiological and Traditional Chinese Medicine syndrome characteristics of 21010 patients with reflux/heartburn symptoms显示文摘OBJECTIVE:To provide a basis for the clinical identification of true and false reflux,integrated traditional Chinese and Western medicine,and psychosomatic treatment,we conducted a retrospective study of the etiology and epidemiological and Traditional Chinese Medicine(TCM) syndrome characteristics of patients with reflux/heartburn symptoms.METHODS:The 210 10 patients with reflux/heartburn treated at Tianjin Nankai Hospital from January 1,2016,to December 31,2019,were divided into four groups according to their pathogenesis.Sex,age,course of disease,incidence rate,gastroscopy,24-h p Himpedance,esophageal manometry,Hamilton Anxiety Scale(HAMA)/Hamilton Depression Scale(HAMD) score,8-week proton pump inhibitor(PPI) treatment effect,and TCM syndrome characteristics were statistically analyzed.RESULTS:A total of 21010 patients(8864 men and 12146 women),with reflux/heartburn symptoms were screened,including 6284(29.9%) patients with reflux esophagitis(RE),10427(49.6%) patients with nonerosive reflux esophagitis(NERD),2430(11.6%) patients with reflux hypersensitivity(RH),and 1870(8.9%) patients with functional heartburn(FH).The incidence of the disease was higher in women than in men(P <0.0001).The ranking of the incidence of anxiety and depression in these four groups was FH > RH > NERD > RE(P < 0.0001).There were more women than men in the groups with anxiety and more men than women in the groups with depression(P < 0.0001),and there was no significant difference in the distribution of anxiety and depression between men and women(P = 0.5689).There were significant differences in TCM syndrome characteristics between NERD,RE,and functional esophageal diseases(P < 0.01).The highest proportion of functional esophageal disease TCM symptoms was Qi stagnation and phlegm obstruction syndrome(36.16%),and there was no significant difference between RH and FH.The effective rates of PPI treatment at 8 weeks in patients in the RE,NERD,RH,and FH groups were 89%,72%,54%,and 0%,respectively.RE was classified into grades A,B,C,and D according to the Los Angeles grading system.The ranking of the incidence of these four grades was A > B > C > D(P < 0.0001).The effective rates of PPI treatment at 8 weeks were 91%,81%,69%,and 63% in patients with grade A,B,C,and D RE,respectively(P < 0.0001).The highest proportion of TCM syndrome types of NERD and RE was the stagnated heat syndrome in the liver and stomach syndrome,38.99% and 33.90%,respectively.CONCLUSION:Reflux/heartburn symptoms are relatively common in middle-aged women,and NERD is the most common etiology,followed by RE,RH,and FH.The most common TCM syndrome characteristics in NERD and RE were stagnated heat syndrome in the liver and stomach syndrome,and Qi stagnation and phlegm obstruction syndrome in functional esophageal diseases.Most patients with reflux/heartburn symptoms also experienced anxiety and depression. | TANG Yanping LI Peicai LIU Xi LIU Lei GONG Yanxia WEI Xiaodong LIU Lina YANG Li | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 2 |
| 16 | Hyperactive PI3Kδ predisposes naive T cells to activation via aerobic glycolysis programs显示文摘Activated phosphoinositide 3-kinaseδsyndrome(APDS)is an autosomal-dominant combined immunodeficiency disorder resulting from pathogenic gain-of-function(GOF)mutations in the PIK3CD gene.Patients with APDS display abnormal T cell homeostasis.However,the mechanisms by which PIK3CD GOF contributes to this feature remain unknown.Here,with a cohort of children with PIK3CD GOF mutations from multiple regions of China and a corresponding CRISPR/Cas9 gene-edited mouse model,we reported that hyperactive PI3Kδdisrupted TNaive cell homeostasis in the periphery by intrinsically promoting the growth,proliferation,and activation of TNaive cells.Our results showed that PIK3CD GOF resulted in loss of the quiescence-associated gene expression profile in naive T cells and promoted naive T cells to overgrow,hyperproliferate and acquire an activated functional status.Naive PIK3CD GOF T cells exhibited an enhanced glycolytic capacity and reduced mitochondrial respiration in the resting or activated state.Blocking glycolysis abrogated the abnormal splenic T cell pool and reversed the overactivated phenotype induced by PIK3CD GOF in vivo and in vitro.These results suggest that enhanced aerobic glycolysis is required for PIK3CD GOF-induced overactivation of naive T cells and provide a potential therapeutic approach for targeting glycolysis to treat patients with APDS as well as other immune disorders. | Yanjun Jia Qiuyun Yang Yanping Wang Wenyan Li Xuemei Chen Tao Xu Zhirui Tian Minxuan Feng Liang Zhang Wenjing Tang Na Tian Lina Zhou Wenxia Song Xiaodong Zhao | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 17 | Zeolite templated carbon nanodots for broadband ultrafast pulsed fiber laser generation显示文摘Carbon nanodots(C-dots) with a uniform size of about 2 nm are synthesized via in situ pyrolysis of n-propylamine that is confined in the nanochannels of zeolite Linde Type A(LTA). The as-synthesized C-dots@LTA composite shows nonlinear optical saturable absorption properties in a broad wavelength band and can be used as saturable absorber(SA) to generate ultrafast pulsed fiber lasers. By inserting a zeolite LTA single crystal hosting C-dots into the fiber laser cavity, mode-locked fiber lasers with long-term operation stability at 1.5 μm and 1 μm are achieved. These results show that the C-dots@LTA are a promising SA material for ultrafast pulsed fiber laser generation in a broad wavelength band. To the best of our knowledge, this is the first demonstration of a C-dots@LTA-based mode-locked fiber laser. | XINTONG XU JIAQI CHEN WENTAO SHI DALIN SUN SHAOWEN CHU LANG SUN WENFEI ZHANG YANPING CHEN JIANPANG ZHAI SHUANGCHEN RUAN ZIKANG TANG | 2019 | Photonics Research2019，7，10： | 2 |
| 18 | 3D printed fiber-optic nanomechanical bioprobe显示文摘Ultrasensitive nanomechanical instruments,e.g.atomic force microscopy(AFM),can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological processes.However,these instruments are limited because of their size and complex feedback system.In this study,we demonstrate a miniature fiber optical nanomechanical probe(FONP)that can be used to detect the mechanical properties of single cells and in vivo tissue measurements.A FONP that can operate in air and in liquids was developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser two-photon polymerization nanolithography.To realize stiffness matching of the FONP and sample,a strategy of customizing the microcantilever’s spring constant according to the sample was proposed based on structure-correlated mechanics.As a proof-of concept,three FONPs with spring constants varying from 0.421 N m^(−1)to 52.6 N m^(−1)by more than two orders of magnitude were prepared.The highest microforce sensitivity was 54.5 nmμN^(−1)and the detection limit was 2.1 nN.The Young’s modulus of heterogeneous soft materials,such as polydimethylsiloxane,muscle tissue of living mice,onion cells,and MCF-7 cells,were successfully measured,which validating the broad applicability of this method.Our strategy provides a universal protocol for directly programming fiber-optic AFMs.Moreover,this method has no special requirements for the size and shape of living biological samples,which is infeasible when using commercial AFMs.FONP has made substantial progress in realizing basic biological discoveries,which may create new biomedical applications that cannot be realized by current AFMs. | Mengqiang Zou Changrui Liao Yanping Chen Lei Xu Shuo Tang Gaixia Xu Ke Ma Jiangtao Zhou Zhihao Cai Bozhe Li Cong Zhao Zhourui Xu Yuanyuan Shen Shen Liu Ying Wang Zongsong Gan Hao Wang Xuming Zhang Sandor Kasas Yiping Wang | 2023 | International Journal of Extreme Manufacturing2023，5，1： | 1 |
| 19 | First reported fatal Morganella morganii infections in chickens显示文摘 | ZHAO Changguang TANG Na WU Yanping | 2012 | Veterinary Microbiology2012，156，34： | 1 |
| 20 | Recovery Type A Posteriori Error Estimates of Fully Discrete Finite Element Methods for General Convex Parabolic Optimal Control Problems显示文摘This paper is concerned with recovery type a posteriori error estimates of fully discrete finite element approximation for general convex parabolic optimal control problems with pointwise control constraints.The time discretization is based on the backward Euler method.The state and the adjoint state are approximated by piecewise linear functions and the control is approximated by piecewise constant functions.We derive the superconvergence properties of finite element solutions.By using the superconvergence results,we obtain recovery type a posteriori error estimates.Some numerical examples are presented to verify the theoretical results. | Yuelong Tang Yanping Chen | 2012 | Numerical Mathematics(Theory,Methods and Applications)2012，5，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员