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| 1 | A 2-kb Mycovirus Converts a Pathogenic Fungus into a Beneficial Endophyte for Brassica Protection and Yield Enhancement显示文摘Mycoviruses are viruses that infect fungi,and hypovirulence-associated mycoviruses have the potential to control fungal diseases.However,it is unclear how mycovirus-mediated hypovirulent strains live and survive in the field,and no mycovirus has been applied for field crop protection.In this study,we found that a previously identified small DNA mycovirus(SsHADV-1)can convert its host,Sclerotinia sclerotiorum,from a typical necrotrophic pathogen to a beneficial endophytic fungus.SsHADV-1 downregulates the expression of key pathogenicity factor genes in S.sclerotiorum during infection.When growing in rapeseed,the SsHADV-1-infected strain DT-8 significantly regulates the expression of rapeseed genes involved in defense,hormone signaling,and circadian rhythm pathways.As a result,plant growth is promoted and disease resistance is enhanced.Field experiments showed that spraying DT-8 at the early flowering stage can reduce the disease severity of rapeseed stem rot by 67.6%and improve yield by 14.9%.Moreover,we discovered that SsHADV-1 could also infect other S.sclerotiorum strains on DT-8-inoculated plants and that DT-8 could be recovered from dead plants.These findings suggest that the mycoviruses may have the ability to shape the origin of endophytism.Our discoveries suggest that mycoviruses may influence the origin of endophytism and may also offer a novel strategy for disease control in which mycovirus-infected strains are used to improve crop health and release mycoviruses into the field. | Hongxiang Zhang Jiatao Xie Yanping Fu Jiasen Cheng Zheng Qu Zhenzhen Zhao Shufen Cheng Tao Chen Bo Li Qianqian Wang Xinqiang Liu Binnian Tian David B.Collinge Daohong Jiang | 2020 | Molecular Plant2020，13，10： | 9 |
| 2 | The effects of air temperature and precipitation on the net primary productivity in China during the early 21st century显示文摘Research on how terrestrial ecosystems respond to climate change can reveal the complex interactions between vegetation and climate,net primary productivity (NPP),an important vegetation parameter and ecological indicator,fluctuates within any given ecological environment or regional carbon budget.In this study, spatial interpolation was used to generate a spatial dataset, with 1-km spatial resolution,with meteorological data from 736 observation stations across China.An improved CASA model was used to simulate NPP over the period of 2001-2013 by taking into account land-cover change in every year during the same period.We propose the grid- based spatial patterns and dynamics of annual NPP,annual average temperature,and annual total precipitation based on the model.We also used the model to demonstrate the spatial correlation between NPP,temperature,and pre- cipitation in the study area with special focus on the impact of climate change in the early 21st century.Results showed that the spatial pattern of NPP over all of China is characterized by higher values in the southeast and lower values in the northwest.The spatial pattern of temperature indicates substantial latitudinal differences across the country,and the spatial pattem of precipitation shows a ribbon of decline from the southeast coast to the northwest inland.Most areas show an upward trend in NPP. Temperatures appear to decrease across the country during the global warming hiatus (1998-2008),and are accom- panied by an increase in precipitation over most regions.The correlation between NPP and annual average temperature is weak.Alternatively,NPP and annual total precipitation are positively correlated in northern and central China at a coefficient above 0.64(p <0.01)yet negatively correlated in the eastem parts of the Qinghai- Tibet Plateau and Sichuan Basin.Results can provide useful information for improving parameters for calibra- tion of the terrestrial ecosystem process model. | Qianfeng WANG Jingyu ZENG Song LENG Bingxiong FAN Jia TANG Cong JIANGs Yi HUANG Qing ZHANG Yanping QU Wnlin WANG Wei SHUI | 2018 | Frontiers of Earth Science2018，12，4： | 6 |
| 3 | Efficacy and safety of rasagiline in Chinese patients with early Parkinson’s disease:a randomized, double-blind,parallel,placebo-controlled,fixed-dose study显示文摘Background:Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson’s disease(PD)treatment,but its effectiveness on Chinese patients is unclear.This study aimed to evaluate the efficacy and safety of rasagiline monotherapy in Chinese patients with early PD.Methods:A 26-weeks,randomized,double-blind,placebo-controlled study has been performed at 15 sites in China and enrolled outpatients(≥35 years old)with idiopathic PD without a history of using any dopaminergic drugs.Participants were randomized 1:1 to receive rasagiline 1 mg once daily or placebo.The primary endpoint was the change of the Unified Parkinson’s Disease Rating Scale(UPDRS)total score from baseline to 26 weeks treatment.Secondary endpoints included changes in UPDRS subscale scores from part Ⅰ to Ⅲ.Health status was assessed with the PD Questionnaire(PDQ)-39 and EuroQol-Five-Dimension(EQ-5D)questionnaire.Safety profile was collected until 30 weeks after randomization.Results:A total of 130 patients(n=65/group)were recruited,and 127(rasagiline,n=64;placebo,n=63)were included in the full analysis set.Baseline characteristics were comparable between the two groups.The decrease in the mean UPDRS total score was greater in the rasagiline group than in the placebo group(−3.18±0.95 vs.−0.18±0.98,P=0.025),and the mean UPDRS part I non-motor symptoms score(−0.54±0.15 vs.-0.08±0.15,P=0.003)were significantly decreased in the rasagiline group compared with placebo treated patients.An improvement trend was observed in the active treatment group for the subscales evaluation with parts Ⅱ and Ⅲ,while the difference to placebo was not statistically significant.Life quality assessed by the EQ-5D visual analog scale improved in the rasagiline group but worsened in placebo treated patients.The overall incidence of treatment-emergent adverse events(AEs)was slightly lower in the rasagiline group(41.5%)than in the placebo group(46.2%).Conclusions:Rasagiline is effective,safe,and well tolerated as monotherapy for the treatment of Chinese PD patients. | Zhenxin Zhang Jian Wang Shengdi Chen Chunfeng Liu Baorong Zhang Rong Peng Shenggang Sun Xiangru Sun Gang Zhao Qiumin Qu Yansheng Li Suiqiang Zhu Xiaoping Pan Ming Shao Yanping Wang | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 4 | Applications,of fluorescence lifetime imaging in clinical medicine显示文摘Fluorescence lifetime is not only associated with the molecular structure f fuorophores,but alsostrongly depends on the environment around them,which llows fuorescence lifetime imagingmicroscopy(FLIM)to be used as a tool for precise measurement of the cell or tisue microenvironment,This review introduces the basic principle of fuorescence lifetime imagingtechnology and its application in clinical medicine,including research and diagnosis of diseases inskin,brain,eyes,mouth,bone,blood vessels and cavity organs,and drug evaluation.As anoninvasive,nontoxic and nonionizing radiation technique,FLIM demonstrates excellent per-formance with high sensitivity and specificity,which allows to determine precise position of thelesion and,thus,has good potential for application in biomedical research and clinical diagnosis. | Zhanwen Wang Yanping Zheng Deqiang Zhao Ziwei Zhao Lixin Liu Artem Pliss Feiqi Zhu Jun Liu Junle Qu Ping Luan | 2018 | Journal of Innovative Optical Health Sciences2018，，1： | 1 |
| 5 | Study on CA-CFAR Algorithm Based on Normalization Processing of Background Noise for HI of Optical Fiber显示文摘 | Yanping WANG Dandan QU Chao ZHAO Dan YANG | 2018 | Photonic Sensors2018，8，4： | 1 |
| 6 | A comprehensive static model for COREX process显示文摘 | QU Yingxia ZOU Zongshu XIAO Yanping | 2012 | Transactions of the Iron and Steel Institute of Japan2012，52，12： | 1 |
| 7 | Effects of eggshell addition on calcium-deficient acid soils contaminated with heavy metals显示文摘在这研究,水条件完成(泛滥,湿,或干燥)并且蛋壳剂量( 0 , 0.1 , 1.0 ,和 10.0 g/kg 土壤,分别地)在 pH 变化上,内容无法获得重金属的状态,重金属的形式,并且在与重金属污染的酸土壤的可得到的滋养的元素钙( Ca )分别地被调查。土壤样品连续地在室内被栽培并且由毒性分析了特征的沥滤参考(BCR ) 的过程和社区局顺序的抽取过程。结果证明蛋壳的增加能有效地改进酸土壤的 pH 并且增加它到中立水平。而且,内容无法获得重金属 Cu, Zn,和 Cd 的状态显著地增加了。而且,当土壤与 1.0 g/kg 蛋壳在充满的条件下面被栽培时,无法获得 Cu, Zn,和 Cd 的状态增加了大多数,并且这些重金属被转变成剩余状态。在另一方面, Ca 的可得到的状态的数量与 1.0 g/kg 蛋壳的增加从 73.34 mg/kg 增加了到 432.19,它显示蛋壳的增加戏剧性地改进了 Ca 的可得到的状态。因此,蛋壳能改善它有效地导致了授精的可得到的重金属和改进的减少的土壤环境。简言之,这研究显示蛋壳的增加将是为与重金属污染的酸地土壤的补习的一个新潜在的方法。 | Weiqi Luo Yanping Ji Lu Qu Zhi Dang Yingying Xie Chengfang Yang Xueqin Tao Jianmin Zhou Guining Lu | 2018 | Frontiers of Environmental Science & Engineering2018，12，3： | 1 |
| 8 | Probing Safety Problems of China's Small and Medium Size Chemical Enterprises显示文摘Ⅰ.The status quo and problems of small and medium chemical enterprises According to the National Bureau of Statistics,China has 27 091 petroleum andchemical enterprises | Liu Yanping Qu Funian Chen Jiufang Ren Dianzhong Tian Min, the Chemicals Registration Center of the State Administration of Work Safety | 2008 | China Chemical Reporter2008，，36： | 0 |
| 9 | Identification of a novel methylated nucleoside in Schizosac-charomyces pombe U6 snRNA显示文摘By using the method of reverse transcription at different dNTP concentrations, a novel methylated nucleoside, Am64, has been identified from Schizosaccharomyces pombe U6 snRNA, and a higher ordered structure repressing the passage of reverse transcriptase at the 5’ end of U6 snRNA has been demonstrated. | Hui Zhou Lianghu Qu Yanping Du Weixin Zhou | 2000 | Chinese Science Bulletin2000，45，14： | 0 |
| 10 | Deep learning autofluorescence-harmonic microscopy显示文摘Laser scanning microscopy has inherent tradeoffs between imaging speed,field of view(FOV),and spatial resolution due to the limitations of sophisticated mechanical and optical setups,and deep learning networks have emerged to overcome these limitations without changing the system.Here,we demonstrate deep learning autofluorescence-harmonic microscopy(DLAM)based on self-alignment attention-guided residual-in-residual dense generative adversarial networks to close the gap between speed,FOV;and quality.Using the framework,we demonstrate label-free large-field multimodal imaging of clinicopathological tissues with enhanced spatial resolution and running time advantages.Statistical quality assessments show that the attention-guided residual dense conneaions minimize the persistent noise,distortions,and scanning fringes that degrade the autofluorescence-harmonic images and avoid reconstruction artifaas in the output images.With the advantages of high contrast,high fidelity,and high speed in image reconstruction,DLAM can act as a powerful tool for the noninvasive evaluation of diseases,neural activity,and embryogenesis. | Binglin Shen Shaowen Liu Yanping Li Ying Pan Yuan Lu Rui Hu Junle Qu Liwei Liu | 2022 | Light(Science & Applications)2022，11，4： | 0 |
| 11 | Adjunct rasagiline to treat Parkinson’s disease with motor fluctuations:a randomized,double-blind study in China显示文摘Background:The use of adjunct rasagiline in levodopa-treated patients with Parkinson’s disease and motor fluctuations is supported by findings from large-scale clinical studies.This study is to investigate the efficacy and safety of adjunct rasagiline in Chinese patients with Parkinson’s disease,as a product registration study.Methods:This 16-week,randomized,double-blind,parallel-group,multicenter,placebo-controlled study of rasagiline 1 mg/day included levodopa-treated patients with Parkinson’s disease and motor fluctuations.The primary efficacy endpoint was mean change from baseline in total daily OFF time over 16 weeks.Secondary endpoints were Clinical Global Impressions–Improvement(CGI-I),and change in Unified Parkinson’s Disease Rating Scale(UPDRS)Activities of daily living(ADL)and Motor scores.Patient well-being(EQ-5D),and the frequency of adverse events were also assessed.Results:In total,324 levodopa-treated patients were randomized to rasagiline 1 mg/day(n=165)or placebo(n=159).Over 16 weeks,rasagiline statistically significantly reduced the mean[95% confidence interval]total daily OFF time versus placebo(−0.5 h[−0.92,−0.07];p=0.023).There were also statistically significant improvements versus placebo in CGI-I(−0.4 points[−0.61,−0.22];p<0.001),UPDRS-ADL OFF(−1.0 points[−1.75,−0.27];p=0.008),and UPDRS-Motor ON(−1.6 points[−3.05,−0.14];p=0.032)scores,as well as the EQ-5D utility index(p<0.05).Rasagiline was safe and well tolerated.Conclusions:In levodopa-treated Chinese patients with Parkinson’s disease and motor fluctuations,adjunct rasagiline 1 mg/day statistically significantly reduced OFF time,and improved daily function and overall well-being,versus placebo.Consistent with findings in other countries,adjunct rasagiline was proven efficacious and well tolerated in Chinese patients. | Zhenxin Zhang Ming Shao Shengdi Chen Chunfeng Liu Rong Peng Yansheng Li Jian Wang Suiqiang Zhu Qiumin Qu Xiaoying Zhang Haibo Chen Xiangru Sun Yanping Wang Shenggang Sun Baorong Zhang Jimei Li Xiaoping Pan Gang Zhao | 2018 | Translational Neurodegeneration2018，7，1： | 0 |
| 12 | ATP结合人ABCF1的晶体结构显示ABC蛋白的独特构象显示文摘文章简介ABCF1具有两个序列相似的结构域,且构象非常活跃且不稳定,解析其结构的难度相对较大。为获得ABC家族蛋白ATP结合中间态的结构,课题组针对ABCF1的柔性进行了多轮克隆和结晶条件的设计和筛选,从而获得了ABCF1与ATP结合的中间状态结构复合物晶体. | Lu Qu Yan Jiang Chongyun Cheng Dong Wu Bing Meng Zhenrong Chen Yanping Zhu Neil Shaw 欧阳松应 刘志杰 | 2019 | 科学新闻2019，0，2： | 0 |
| 13 | Evaluation of repeated exposure systemic toxicity test of PVC with new plasticizer on rats via dual parenteral routes显示文摘Systemic toxicity caused by repeated exposure to both polar and nonpolar leachables of di(2-ethylhexyl)-1,2-cyclohexane plasticized polyvinyl chloride(PVC)was evaluated with dual routes of parenteral administration method on rats in the study.Experimental group and control group were designed by researchers.Tail intravenous injection with 0.9%sodium chloride injection extracts and intraperitoneal injection with corn oil extracts were conducted to the experimental rats while tail intravenous injection with 0.9%sodium chloride Injection and intraperitoneal injection with corn oil were conducted to the control rats.After 14 days,blood specimens were collected for clinical pathology(hematology and clinical chemistry)analysis.Selected organs were weighed and a histopathological examination was conducted.As a result,compared with the control animals,there were no toxicity-related changes on the parameters above.The results show that the rats do not show obvious systemic toxicity reaction caused by repeated exposure with dual routes of parenteral administration method on rats after administration with both polar and nonpolar exacts of di(2-ethylhexyl)-1,2-cyclohexane plasticized PVC simultaneously up for 14 days. | Li Hou Chunguang Fan Chenghu Liu Qiujin Qu ChunrenWang Yanping Shi | 2018 | Regenerative Biomaterials2018，5，1： | 0 |
| 14 | Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling显示文摘Light adaptation enables the vertebrate visual system to operate over a wide range of ambient illumination.Regulation of phototransduction in photoreceptors is considered a major mechanism underlying light adaptation.However,various types of neurons and glial cells exist in the retina,and whether and how all retinal cells interact to adapt to light/dark conditions at the cellular and molecular levels requires systematic investigation.Therefore,we utilized single-cell RNA sequencing to dissect retinal cell-type-specific transcriptomes during light/dark adaptation in mice.The results demonstrated that,in addition to photoreceptors,other retinal cell types also showed dynamic molecular changes and specifically enriched signaling pathways under light/dark adaptation.Importantly,Müller glial cells(MGs)were identified as hub cells for intercellular interactions,displaying complex cell‒cell communication with other retinal cells.Furthermore,light increased the transcription of the deiodinase Dio2 in MGs,which converted thyroxine(T4)to active triiodothyronine(T3).Subsequently,light increased T3 levels and regulated mitochondrial respiration in retinal cells in response to light conditions.As cones specifically express the thyroid hormone receptor Thrb,they responded to the increase in T3 by adjusting light responsiveness.Loss of the expression of Dio2 specifically in MGs decreased the light responsive ability of cones.These results suggest that retinal cells display global transcriptional changes under light/dark adaptation and that MGs coordinate intercellular communication during light/dark adaptation via thyroid hormone signaling. | Min Wei Yanping Sun Shouzhen Li Yunuo Chen Longfei Li Minghao Fang Ronghua Shi Dali Tong Jutao Chen Yuqian Ma Kun Qu Mei Zhang Tian Xue | 2023 | Protein & Cell2023，14，8： | 0 |
| 15 | Probing Safety Problems of China's Small and Medium Size Chemical Enterprises | Liu Yanping,Qu Funian,Chen Jiufang,Ren Dianzhong,Tian Min, the Chemical Registry Center of the State Administration of Work Safety | 2009 | China Chemical Reporter2009，，2： | 0 |
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