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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | Developing controllable hypermutable Clostridium cells through manipulating its methyl-directed mismatch repair system显示文摘Development of controllable hypermutable cells can greatly benefit understanding and harnessing microbial evolution.However,there have not been any similar sys-tems developed for Clostridium,an important bacterial genus.Here we report a novel two-step strategy for de-veloping controllable hypermutable cells of Clostridium acetobutylicum,an important and representative indus-trial strain.Firstly,the mutS/L operon essential for methyl-directed mismatch repair(MMR)activity was inactivated from the genome of C.acetobutylicum to generate hy-permutable cells with over 250-fold increased mutation rates.Secondly,a proofreading control system carrying an inducibly expressed mutS/L operon was constructed.The hypermutable cells and the proofreading control system were integrated to form a controllable hypermut-able system SMBMutC,of which the mutation rates can be regulated by the concentration of anhydrotetracycline(aTc).Duplication of the miniPthl-tetR module of the proof-reading control system further signifi cantly expanded the regulatory space of the mutation rates,demonstrating hypermutable Clostridium cells with controllable mutation rates are generated.The developed C.acetobutylicum strain SMBMutC2 showed higher survival capacities than the control strain facing butanol-stress,indicating greatly increased evolvability and adaptability of the controllable hypermutable cells under environmental challenges. | Guodong Luan Zhen Cai Fuyu Gong Hongjun Dong Zhao Lin Yanping Zhang Yin Li | 2013 | Protein & Cell2013，4，11： | 4 |
| 3 | Regulation of 1, 4, 5-triphosphate receptor channel gating dynamics by mutant presenilin in Alzheimer's disease cells显示文摘 | Fang Wei Xiang Li Meichun Cai Yanping Liu Peter Jung Jianwei Shuai | 2017 | Frontiers of physics2017，12，3： | 4 |
| 4 | Direct demonstration of carrier distribution and recombination within step-bunched UV-LEDs显示文摘AlGaN-based solid state UV emitters have many advantages over conventional UV sources. However, UV-LEDs still suffer from numerous challenges, including low quantum efficiency compared to their blue LED counterparts. One of the inherent reasons is a lack of carrier localization effect inside fully miscible AlGaN alloys. In the pursuit of phase separation and carrier localization inside the active region of AlGaN UV-LED, utilization of highly misoriented substrates proves to be useful, yet the carrier distribution and recombination mechanism in such structures has seldom been reported. In this paper, a UV-LED with step-bunched surface morphology was designed and fabricated, and the internal mechanism of high internal quantum efficiency was studied in detail. The correlation between microscale current distribution and surface morphology was provided, directly demonstrating that current prefers to flow through the step edges of the epitaxial layers. Experimental results were further supported by numerical simulation. It was found that efficient radiative recombination centers were formed in the inclined quantum well regions. A schematic three-dimensional energy band structure of the multiple quantum wells(MQWs) across the step was proposed and helps in further understanding the luminescence behavior of LEDs grown on misoriented substrates. Finally, a general principle to achieve carrier localization was proposed, which is valid for most ternary Ⅲ-Ⅴ semiconductors exhibiting phase separation. | HOUQIANG XU JIEAN JIANG LI CHEN JASON HOO LONG YAN SHIPING GUO CAI SHEN YANPING WEI HUA SHAO ZI-HUI ZHANG WEI GUO JICHUN YE | 2021 | Photonics Research2021，9，5： | 2 |
| 5 | Wendan decoction improves learning and memory deficits in a rat model of schizophrenia显示文摘An experimental model of schizophrenia was established using dizocilpine (MK-801). Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results revealed that the latency of schizophrenia model rats to escape from the hidden platform in the Morris water maze was significantly shortened after administration of Wendan decoction or clozapine. In addition, the treated rats crossed the platform significantly more times than the untreated model rats. Moreover, the rate of successful long-term potentiation induction in the Wendan decoction group and clozapine group were also obviously increased compared with the model group, and the population spike peak latency was significantly shortened. These experimental findings suggest that Wendan decoction can improve the learning and memory ability of schizophrenic rats to the same extent as clozapine treatment. | Cuiping Yang Changchun Cai Xiaojin Yang Yanping Yang Zhigang Zhou Jianhua Liu Heping Ye HongjiaoWan | 2012 | Neural Regeneration Research2012，7，15： | 2 |
| 6 | Effect of current emission abatement strategies on air quality improvement in China:A case study of Baotou,a typical industrial city in Inner Mongolia显示文摘The national Air Pollution Prevention and Control Action Plan required significant decreases in PM_(2.5) levels over China.To explore more effective emission abatement strategies in industrial cities,a case study was conducted in Baotou to evaluate the current national control measures.The total emissions of SO_2,NO_X,PM_(2.5) and NMVOC(non-methane volatile organic compounds) in Baotou were 211.2 Gg,156.1 Gg,28.8 Gg,and 48.5 Gg,respectively in 2013,and they would experience a reduction of 30.4%,26.6%,15.1%,and 8.7%,respectively in 2017 and 39.0%,32.0%,24.4%,and 12.9%,respectively in2020.The SO_2,NO_Xand PM_(2.5) emissions from the industrial sector would experience a greater decrease,with reductions of 37%,32.7 and 24.3%,respectively.From 2013 to 2020,the concentrations of SO_2,NO_2,and PM_(2.5) are expected to decline by approximately 30%,10% and 14.5%,respectively.The reduction rate of SNA(sulfate,nitrate and ammonium)concentrations was significantly higher than that of PM_(2.5) in 2017,implying that the current key strategy toward controlling air pollutants from the industrial sector is more powerful for SNA.Although air pollution control measures implemented in the industrial sector could greatly reduce total emissions,constraining the emissions from lower sources such as residential coal combustion would be more effective in decreasing the concentration of PM_(2.5) from 2017 to 2020.These results suggest that even for a typical industrial city,the reduction of PM_(2.5) concentrations not only requires decreases in emissions from the industrial sector,but also from the low emission sources.The seasonal variation in sulfate concentration also showed that emission from coal-burning is the key factor to control during the heating season. | Xionghui Qiu Lei Duan Siyi Cai Qian Yu Shuxiao Wang Fahe Chai Jian Gao Yanping Li Zhaoming Xu | 2017 | Journal of Environmental Sciences2017，29，7： | 2 |
| 7 | Reactive Effect of Low Intensity He-Ne Laser upon Damaged Ultrastructure of Human Erythrocyte Membrane in Fenton System by Atomic Force Microscopy显示文摘发现 modulating 的机制有低紧张 He-Ne 激光行动的红血球的 deform 能力,我们在人的红血球的超微结构上学习了低紧张 He-Ne 激光的效果膜。红血球在暴露他们到低紧张 He-Ne 激光前从 aFenton 反应系统与自由激进分子一起被对待。损坏红血球膜的超微结构被原子力量显微镜学检验。结果证明红血球膜变得很不平,膜的表面上的分子在与自由激进分子一起对待以后集合了进不同大小尺寸的粒子。在非照耀的组和 He-Ne 激光比较分子的粒子的会众的度照耀( 9 mW 和 18 mW )组织,我们发现在激光的分子的粒子的平均尺寸照耀组在非照耀的组是比那小的,显示低紧张激光让了修理功能到红血球膜的损坏由自由激进分子生产了。 | Yanhong CU Zhouyi GUO Yanping ZHAO Ying ZHENG Yanfang QIAO Jiye CAI Songhao LIU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 2 |
| 8 | Rationally designed Ta_(3)N_(5)/BiOCl S-scheme heterojunction with oxygen vacancies for elimination of tetracycline antibiotic and Cr(Ⅵ):Performance,toxicity evaluation and mechanism insight显示文摘S-scheme heterojunction photocatalysts have been the“stars”in the field of photocatalysis.Herein,a novel S-scheme heterojunction of Ta_(3)N_(5)/BiOCl with oxygen vacancies(OVs)was fabricated via a facile method.The charge separation and transport mechanism of this Ta_(3)N_(5)/BiOCl S-scheme heterojunction was verified by the analyses of band energy structures,active species,photoelectric behaviors and DFT theoretical calculation.Compared with Ta_(3)N_(5)and BiOCl,the Ta_(3)N_(5)/BiOCl unveils substantially upgraded photocatalytic property under visible light,and the photocatalytic efficiency for removal of tetracycline(TC)and hexavalent chromium(Cr(VI))reaches 89.6%and 91.6%,respectively.The substantial enhancement of the photocatalytic activity is attributed to the synergistic effect of the S-scheme hetero-structure and oxygen vacancies,which improves the visible-light absorption,while promoting the spatial separation of charge carriers with the optimum redox capacity,thereby boosting the production of active species for catalytic reactions.The TC degradation pathway is deduced and the toxicity evolution of TC is appraised using the QSAR method.In a nutshell,this work gives a deep understanding of the photocatalytic mechanism based on Ta_(3)N_(5)/BiOCl as well as presents a newfangled thought for developing highly efficient S-scheme heterojunction photocatalysts for water decontamination. | Shijie Li Mingjie Cai Chunchun Wang Yanping Liu Neng Li Peng Zhang Xin Li | 2022 | Journal of Materials Science & Technology2022，，28： | 2 |
| 9 | 3D printed fiber-optic nanomechanical bioprobe显示文摘Ultrasensitive nanomechanical instruments,e.g.atomic force microscopy(AFM),can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological processes.However,these instruments are limited because of their size and complex feedback system.In this study,we demonstrate a miniature fiber optical nanomechanical probe(FONP)that can be used to detect the mechanical properties of single cells and in vivo tissue measurements.A FONP that can operate in air and in liquids was developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser two-photon polymerization nanolithography.To realize stiffness matching of the FONP and sample,a strategy of customizing the microcantilever’s spring constant according to the sample was proposed based on structure-correlated mechanics.As a proof-of concept,three FONPs with spring constants varying from 0.421 N m^(−1)to 52.6 N m^(−1)by more than two orders of magnitude were prepared.The highest microforce sensitivity was 54.5 nmμN^(−1)and the detection limit was 2.1 nN.The Young’s modulus of heterogeneous soft materials,such as polydimethylsiloxane,muscle tissue of living mice,onion cells,and MCF-7 cells,were successfully measured,which validating the broad applicability of this method.Our strategy provides a universal protocol for directly programming fiber-optic AFMs.Moreover,this method has no special requirements for the size and shape of living biological samples,which is infeasible when using commercial AFMs.FONP has made substantial progress in realizing basic biological discoveries,which may create new biomedical applications that cannot be realized by current AFMs. | Mengqiang Zou Changrui Liao Yanping Chen Lei Xu Shuo Tang Gaixia Xu Ke Ma Jiangtao Zhou Zhihao Cai Bozhe Li Cong Zhao Zhourui Xu Yuanyuan Shen Shen Liu Ying Wang Zongsong Gan Hao Wang Xuming Zhang Sandor Kasas Yiping Wang | 2023 | International Journal of Extreme Manufacturing2023，5，1： | 1 |
| 10 | MicroRNA-132 ag- gravates epileptiform discharges via suppression of BDNF/ TrkB signaling in cultured hippocampal neurons显示文摘 | Lei Xiang Yanping Ren Hao Cai | 2015 | Brain Res2015，6，： | 1 |
| 11 | Macroscopic Electromagnetic Cooperative Network‑Enhanced MXene/Ni Chains Aerogel‑Based Microwave Absorber with Ultra‑Low Matching Thickness显示文摘Electromagnetic cooperative strategy has been presented as a mainstream approach that can effectively optimize the matching thickness of dielectric loss dominant system.However,it is still challenging for dielectric–magnetic loss coexisting-type absorber to develop electromagnetic wave(EMW)performance with ultra-low matching thickness(≤1 mm).Breaking the limitation of traditional electromagnetic response at microscopic/mesoscopic scale,a ficus microcarpa-like magnetic aerogel with macroscopical electromagnetic cooperative effect was fabricated through highly oriented self-assembly engineering.The highly oriented Ni chains with unique macroscopic morphology(~1 cm in length)were achieved via a special magnetic field-induced growth.Strong magnetic coupling was observed in the Ni chains confirmed by the micromagnetic simulation.The deductive calculation validates that maintaining high value of electromagnetic parameters at high frequencies is the prerequisites of ultrathin absorber.The electromagnetic cooperative networks with uninterrupted and dual pathways spread through the entire aerogel skeleton,resulting in the impressive permittivity even at high frequencies.Consequently,the aerogel exhibits a remarkable EMW performance at an ultrathin thickness of 1 mm.Thus,based on the modulation of electromagnetic parameters,this work proposed a macroscopic ordered structure with the electromagnetic cooperative effect useful to develop a suitable strategy for achieving ultrathin EMW absorbers. | Fei Pan Yanping Rao Dan Batalu Lei Cai Yanyan Dong Xiaojie Zhu Yuyang Shi Zhong Shi Yaowen Liu Wei Lu | 2022 | Nano-Micro Letters2022，14，8： | 1 |
| 12 | HPV16 E6蛋白与hDaxx的相互作用及其对HeLa细胞凋亡的影响(英文)显示文摘Objective: To study the interaction of human papillomavirus type 16 (HPV16 E6) protein and human death domain associated protein (hDaxx) and its effect on apoptosis of HeLa cells to provide the experimental basis for exploring the oncogenic mechanism of HPV16 E6 protein. Methods: Recombinant vector of pGADT7/E6 or pGBKT7/hDaxx was con- structed. The interaction of E6 protein and hDaxx was detected by yeast two-hybrid system. Their expression in yeast was detected by Western blotting. The eukaryotic plasmids of E6 and hDaxx were co-transfected into HeLa cells. Apoptosis was induced by 5-FU. The apoptotic rate was measured by flow cytometry (FCM). Results: E6 protein had intracellular interaction with hDaxx. The apoptotic rate was rising with the increase in the transfection quantity of pcDNA3.1 (-) / hDaxx in pcDNA3.1 (-) /E6 and pcDNA3.1 (-) / hDaxx co-transfected cells. The difference was significant ( P < 0. 01). Conclusion: There is intracellular interaction between HPV16 E6 protein and hDaxx. The over-expression of hDaxx can increase the sensitivity of E6 protein positive HeLa cells to 5-FU. The effect was in a dose dependent manner. HPV16 E6 protein inhibited the apoptosis of HeLa cells by interacting with hDaxx. | Aitao He Xin Wang Cuiming Zhu Hengling Cai Yanping Wan | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，12： | 1 |
| 13 | Nitric oxide-mediated immunosuppressive effect of Human amniotic membrane-derived mesenchymal stem cells on the viability and migration of microglia显示文摘 | Ke Yan Run Zhang Lei Chen Fanfan Chen Yi Liu Lingmei Peng Haitao Sun Weiyi Huang Chengmei Sun Bingke Lv Feng Li Yingqian Cai Yanping Tang Yuxi Zou Mouxuan Du Lingsha Qin Hengzhu Zhang Xiaodan Jiang | 2014 | Brain Research2014，，： | 1 |
| 14 | Decarburization mechanism of RH-MFB refining process显示文摘The overall decarburization mechanism can be divided into the decarburization in bulk molten steel and float- ing of CO against static pressure, the decarburization on the surface of argon bubbles and splashing particles. On the basis of each conception the RH-MFB decarburization mathematical model has been built according to the thermodynamic and mass conservation principle, and contributions of every decarburization mechanism were discussed and analyzed. | Chuanji Han Liqun Ai Bosong Liu Jun Zhang Yanping Bao Kaike Cai | 2006 | Journal of University of Science and Technology Beijing2006，13，3： | 1 |
| 15 | Engineering stress tolerance of Escherichia coli by stress‐induced mutagenesis (SIM)‐based adaptive evolution显示文摘 | Linjiang Zhu Zhen Cai Yanping Zhang Yin Li | 2014 | Biotechnology Journal2014，，1： | 1 |
| 16 | The effect of increased atmospheric temperature and CO_2 concentration during crop growth on the chemical composition and in vitro rumen fermentation characteristics of wheat straw显示文摘This experiment was c onducted to investigate the effects of increased atmospheric temperature and CO_2concentration during crop growth on the chemical composition and in vitro rumen fermentation characteristics of wheat straw.The field experiment was carried out from November 2012 to June 2013 at Changshu(31°32'93 'N,120°41'88' E) agro-ecological experimental station.A total of three treatments were set.The concentration of CO_2was increased to 500 umol/mol in the first treatment(CO_2 group).The temperature was increased by 2 ℃ in the second treatment(TEM group) and the concentration of CO_2 and temperature were both increased in the third treatment(CO_2 + TEM group).The mean temperature and concentration of CO_2 in control group were 10.5 ℃ and413 umol/mol.At harvesting,the wheat straws were collected and analyzed for chemical composition and in vitro digestibility.Results showed that dry matter was significantly increased in all three treatments.Ether extracts and neutral detergent fiber were significantly increased in TEM and CO_2 + TEM groups.Crude protein was significantly decreased in CO_2 + TEM group.In vitro digestibility analysis of wheat straw revealed that gas production was significantly decreased in CO_2 and CO_2 + TEM groups.Methane production was significantly decreased in TEM and CO_2 + TEM groups.Ammonia nitrogen and microbial crude protein were significantly decreased in all three treatments.Total volatile fatty acids were significantly decreased in CO_2 and CO_2 + TEM groups.In conclusion,the chemical composition of the wheat straw was affected by temperature and CO_2 and the in vitro digestibility of wheat straw was reduced,especially in the combined treatment of temperature and CO_2. | Xiangyu He Yanping Wu Min Cai Chunlong Mu Weihong Luo Yanfen Cheng Weiyun Zhu | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 1 |
| 17 | Ta_(3)N_(5)/CdS Core–Shell S‑scheme Heterojunction Nanofibers for Efficient Photocatalytic Removal of Antibiotic Tetracycline and Cr(VI):Performance and Mechanism Insights显示文摘Ta_(3)N_(5)/CdS core–shell S-scheme heterojunction nanofibers are fabricated by in situ growing CdS nanodots on Ta_(3)N_(5) nanofib-ers via a simple wet-chemical method.These Ta_(3)N_(5)/CdS nanofibers not only affords superior photocatalytic tetracycline degradation and mineralization performance,but also cause an efficient photocatalytic Cr(VI)reduction performance.The creation of favorable core–shell fiber-shaped S-scheme hetero-structure with tightly contacted interface and the maximum interface contact area promises the effective photo-carrier disintegration and the optimal photo-redox capacity synchronously,thus leading to the preeminent photo-redox ability.Some critical environmental factors on the photo-behavior of Ta_(3)N_(5)/CdS are also evaluated in view of the complexity of the authentic aquatic environment.The degradation products of tetracycline were confirmed by HPLC–MS analyses.Furthermore,the effective decline in eco-toxicity of TC intermediates is confirmed by QSAR calculation.This work provides cutting-edge guidelines for the design of high-performance Ta_(3)N_(5)-based S-scheme heterojunction nanofibers for environment restoration. | Shijie Li Mingjie Cai Chunchun Wang Yanping Liu | 2023 | Advanced Fiber Materials2023，5，3： | 1 |
| 18 | Using Traveltime Tomography to Reconstruct Electrical Conductivity显示文摘UsingTraveltimeTomographytoReconstructElectricalConductivityMaNing,HuZhengyi,CaiQin,WangYanpingColegeofElectronicInformation... | Ma Ning Hu Zhengyi Cai Qin Wang Yanping | 1997 | Wuhan University Journal of Natural Sciences1997，2，1： | 0 |
| 19 | Enhancing Photovoltaic Performance of Nonfused-Ring Electron Acceptors via Asymmetric End-Group Engineering and Noncovalently Conformational Locks显示文摘By employing the asymmetric end-group engineering,an asymmetric nonfused-ring electron acceptor(NFREA)was designed and synthesized.Compared with the symmetric analogs(NoCA-17 and NoCA-18),NoCA-19 possesses broader light absorption range,more coplanarπ-conjugated backbone,and appropriate crystallinity according to the experimental and theoretical results.The organic solar cells based on J52:NoCA-19 exhibited a power conversion efficiency as high as 12.26%,which is much higher than those of J52:NoCA-17(9.50%)and J52:NoCA-18(11.77%),mainly due to more efficient exciton dissociation,better and balanced charge mobility,suppressed recombination loss,shorter charge extraction time,longer charge carrier lifetimes,and more favorable blend film morphology.These findings demonstrate the great potential of asymmetric end-group engineering in exploring low-cost and high-performance NFREAs. | Bo Liu Congqi Li Xiaobin Gu Yinghui Han Zhixiang Wei Yunhao Cai Xin Zhang Hui Huang Yanping Huo | 2024 | Chinese Journal of Chemistry2024，42，5： | 0 |
| 20 | Fenton-reaction-triggered metabolism of acetaminophen for enhanced cancer therapy显示文摘Acetaminophen(APAP), a classic nonsteroidal anti-inflammatory drug(NSAID), has attracted much attention due to the overdose-induced hepatotoxicity in the past several decades. N-Acetyl-p-benzoquinone imine(NAPQI), the P450-dependent metabolism of APAP, leads to GSH depletion, protein binding, mitochondrial oxidative stress, and eventually the liver injury. Herein, we develop a Fe-based metal-organic framework(MOF) to deliver and transform acetaminophen into toxic “chemo” drug through the cascade reaction for enhanced cancer therapy. In the acidic tumor microenvironment, the Fe-based MOF collapses and releases abundant Fe ions to generate hydroxyl radicals(·OH) via Fenton reaction, subsequently catalyzing nontoxic APAP into toxic NAPQI. Meanwhile, NAPQI depletes intracellular glutathione(GSH) rapidly, leading to alleviating the antioxidant ability of cancer cells and amplifying Fenton activity. The intracellular oxidative stress and the toxic metabolite of APAP can provide a synergistic effect on antitumor activity. | Fanwen Sun Yayun Peng Yanping Li Menghan Xu Ting Cai | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
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