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| 1 | TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells显示文摘免疫疗法和化疗的联合为癌症的某些类型的治疗被认为是一条有希望的途径。然而,内在的机制需要充分被调查为癌症 chemoimmunotherapy 指导更有效的协议的设计。联系危险的分子的模式(阻尼) 能激活有免疫力的房间,是众所周知的,包括树枝状的房间(DC ) ,经由像使用费的受体(TLR ) ;然而,在有免疫力的反应的激活免除化学对待药的肿瘤房间的阻尼的角色需要进一步被阐明。这里,我们发现那 colorectal 与 oxaliplatin (OXA ) 对待的癌症(CRC ) 房间或 5 氟尿嘧啶(5-Fu ) 释放了高活动性的组盒子 1 的高水平(HMGB1 ) 和热吃惊蛋白质 70 (HSP70 ) 。在 OXA/5-Fu 治疗以后,也展出的 CRC 病人的 sera 增加了 HMGB1 和 HSP70 的层次,哪个是著名阻尼。与 OXA/5-Fu 对待的垂死的 CRC 房间的上层清液支持了老鼠和人的 DC 成熟,与 HLA 医生, CD80 和 CD86 表示和 IL-1β 的改进的 upregulation;, TNF-α, MIP-1α, MIP-1β, RANTES 和 IP-10 生产。由 DC 组成的疫苗与导致的化学上强调的 CRC 房间的上层清液搏动了更重要的 IFN-γ在 vitro 并且在 vivo 生产 Th1 反应。然而,化学上强调的 CRC 房间的上层清液没能在 TLR4 缺乏的 DC 导致 phenotypic 成熟和 cytokine 生产,显示在导致阻尼的 DC 成熟和激活的 TLR4 的一个必要角色。而且,有化学上强调的 CRC 房间的上层清液的 pulsing 高效地没导致 IFN-γ在 TLR4 缺乏的 DC 生产 Th1 反应。一起,这些结果证明免除化学上强调的癌症房间的阻尼能经由 TLR4 激活 DC 并且提高反肿瘤 T 房间有免疫力的回答的正式就职,描出一条临床上相关的免疫助手小径由阻尼被触发。 | Hongliang Fang Bing Ang Xinyun Xu Xiaohui Huang Yanfeng Wu Yanping Sun Wenying Wang Nan Li Xuetao Cao Tao Wan | 2014 | Cellular & Molecular Immunology2014，11，2： | 11 |
| 2 | Effect of Banxia Xiexin decoction on Helicobacter pylori-related peptic ulcers and its possible mechanism via the TGF-β/Smad signaling pathway显示文摘OBJECTIVE: To investigate the effect of Banxia Xiexin decoction(BXD) on Helicobacter pylori(Hp)-related peptic ulcers(PUs) and the possible mecha-nism underlying BXD actions via the transforming growth factor-β/small mothers against decapentaplegic(TGF-β/Smad) signaling pathway.METHODS: PU patients with cold-heat complex syndrome were randomly assigned to groups that received Chinese or Western medicines with 20 patients in each group. Serum was collected after 7 d of treatment. The healthy group included 20 individuals. Gastric mucosal epithelial cell line GES-1 was cultured in vitro and randomly divided into the following seven groups: control, model, healthy,Western Medicine, prior treatment, low dosage,and high dosage. After 72 h of treatment with the corresponding serum, the m RNA and protein expression levels of TGF-β1, Smad3, and Smad7 were measured by reverse transcription quantitative polymerase chain reaction and western blotting, respectively.RESULTS: The m RNA expression levels of TGF-β1 and Smad3 in GES-1 cells were increased after Hp introduction, and these increased levels were reduced by the BXD-containing serum. The protein levels of p-Smad3, but not TGF-β1 or Smad3, were significantly increased in Hp-treated GES-1 cells,and treatment with the BXD-containing serum markedly decreased the protein levels. Smad7 expression was significantly enhanced following treatment with the BXD-containing serum at transcriptional and protein levels in a dose-dependent manner.CONCLUSION: BXD regulates the TGF-β/Smad signaling pathway by inhibiting the expression of TGF-β1 and Smad3, and increasing the expression of Smad7. | Chen Shaofang Liang Huiqing Chen Shaodong Huang Yanping Wan Shichuan Huang Yanxia | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 7 |
| 3 | Groundwater contributions in water-salt balances of the lakes in the Badain Jaran Desert,China显示文摘Groundwater-fed lakes are essential for the ecology in arid and semiarid regions.As a typical arid region,the Badain Jaran Desert (BJD) is famous in the world for the presence of a large number of groundwater-fed saline lakes among the mega dunes.Based on the up to date geological surveys and observations,this study analyzed the groundwater contributions in water-salt balances of the lakes in the desert.We found different types of springs,including the sublacustrine springs that indicate an upward flow of groundwater under the lakebed.A simplified water balance model was developed to analyze the seasonal variations of water level in the Sumu Barun Jaran Lake,which revealed an approximately steady groundwater discharge in the lake and explained why the amplitude of seasonal changes in lake level is less than 0.5 m.In addition,a salt balance model was developed to evaluate the salt accumulations in the groundwater-fed lakes.The relative salt accumulation time is 800–7,000 years in typical saline lakes,which were estimated from the concentration of Cl-,indicating a long history evolution for the lakes in the BJD.Further researches are recommended to provide comprehensive investigations on the interactions between the lakes and groundwater in the BJD. | GONG Yanping WANG Xusheng HU B Xiao ZHOU Yangxiao HAO Chunbo WAN Li | 2016 | Journal of Arid Land2016，8，5： | 7 |
| 4 | Phenotypic identification of peanut germplasm for resistance to southern stem rot显示文摘Southern stem rot,caused by Sclerotium rolfsii Sacc.,is a destructive soil fungal disease of peanut in China and other countries.To evaluate resistant germplasm,a total of 256 peanut accessions were investigated on their resistance to southern stem rot in 3 environments by artificial inoculation.Variance analysis indicated that disease index was significantly influenced by environment,genotype and genotypeenvironment interactions.Peanut accessions of var.vulgaris type exhibited higher resistance to southern stem rot.Disease index was significantly negatively correlated with linoleic acid content,while positively correlated with oleic acid content.Six resistant accessions were identified,including Hua 28,Shandongzai,ICG 6326,Quanhua 7,Quanhua 9 and Guihua 836,with their disease indexes under 40 and mortality were less than 30%in the three environments.The identified resistant accessions showed the great potential to be applied in resistant peanut breeding,and would be good genetic resources for enhancing the resistance to southern stem rot. | Pengmin Fan Wanduo Song Yanping Kang Liyun Wan Yong Lei Dongxin Huai Yuning Chen Xin Wang Huifang Jiang Liying Yan Boshou Liao | 2020 | Oil Crop Science2020，5，4： | 3 |
| 5 | Genetic diversity of atoxigenic Aspergillus flavus isolates from peanut kernels in China显示文摘Aflatoxin contamination in peanuts is a major threat to public health, especially in tropical and subtropical regions of the world. Recently, the use of atoxigenic Aspergillus flavus strains as biological control agents prove to be effective in reducing aflatoxin contamination in crops. A total of 208 atoxigenic A. flavus isolates, collected from peanut kernels, were grouped into 7 deletion patterns by quadruplex PCR products of nor-1, ver-1, aflR and omtA genes. 49 SNPs, found in 1254 bp fragment of omtA gene, showed genetic variation of omtA among different A. flavus isolates. These isolates were assigned to either MAT1-1 type or MAT1-2 type with primers for each MAT locus. Thus, rich genetic diversity was found in the atoxigenic A. flavus isolates of peanut in China. The results indicated that quadruplex PCR would be an effective method for rapid screening of atoxigenic isolates with gene deletion in aflatoxin biosynthetic cluster. | Liying Yan Yanping Kang Yong Lei Liyun Wan Dongxin Huai Huifang Jiang Xiaoping Ren Boshou Liao | 2018 | Oil Crop Science2018，3，1： | 2 |
| 6 | Biocontrol potential of reducing aflatoxin contamination by an atoxigenic strain of Aspergillus flavus. isolated from peanut显示文摘 | Liying YAN Yanping KANG Yong LEI Liyun WAN Dongxin HUAI Huifang JIANG Xiaoping REN Boshou LIAO | 2016 | Oil Crop Science2016，1，1： | 2 |
| 7 | Discovery of Late Jurassic Sporopollen Assemblage from the Tamulangou Formation in the Hongqi Sag of the Hailar Basin,Inner Mongolia,China显示文摘Objective The Hailar Basin is situated in the northwestern margin of the Jiamusi-Mongolia Block.It was a continent marginal basin to the south of the Mongolia-Okhotsk Ocean during the Jurassic and Cretaceous.The basement of the basin is a late Paleozoic marine deposit.The filling of the basin is characterized by terrestrial volcanic rocks。 | WAN Chuanbiao XUE Yunfei SUN Yuewu HOU Yanping JIN Yudong ZHANG Xin LI Ti | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 1 |
| 8 | HPV16 E6蛋白与hDaxx的相互作用及其对HeLa细胞凋亡的影响(英文)显示文摘Objective: To study the interaction of human papillomavirus type 16 (HPV16 E6) protein and human death domain associated protein (hDaxx) and its effect on apoptosis of HeLa cells to provide the experimental basis for exploring the oncogenic mechanism of HPV16 E6 protein. Methods: Recombinant vector of pGADT7/E6 or pGBKT7/hDaxx was con- structed. The interaction of E6 protein and hDaxx was detected by yeast two-hybrid system. Their expression in yeast was detected by Western blotting. The eukaryotic plasmids of E6 and hDaxx were co-transfected into HeLa cells. Apoptosis was induced by 5-FU. The apoptotic rate was measured by flow cytometry (FCM). Results: E6 protein had intracellular interaction with hDaxx. The apoptotic rate was rising with the increase in the transfection quantity of pcDNA3.1 (-) / hDaxx in pcDNA3.1 (-) /E6 and pcDNA3.1 (-) / hDaxx co-transfected cells. The difference was significant ( P < 0. 01). Conclusion: There is intracellular interaction between HPV16 E6 protein and hDaxx. The over-expression of hDaxx can increase the sensitivity of E6 protein positive HeLa cells to 5-FU. The effect was in a dose dependent manner. HPV16 E6 protein inhibited the apoptosis of HeLa cells by interacting with hDaxx. | Aitao He Xin Wang Cuiming Zhu Hengling Cai Yanping Wan | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，12： | 1 |
| 9 | Control of profiles and transport by ion Bernstein waves in the Hefei Tokamak-7显示文摘 | Wan Baonian Zhao Yanping Li Jiangang | 2003 | Phys Plasmas2003，10，： | 1 |
| 10 | Recent advances in the diversification of chromones and flavones by direct C-H bond activation or functionalization显示文摘Chromone and flavone are both central backbones of natural products and clinical medicines.Synthesis of diversely functionalized chromones and flavones constitutes significant research contents of the modern synthetic science because abundant molecular libraries of such types are crucial in providing candidate compounds for the discovery of new pharmaceuticals and functional materials.The direct C—H bond activation or functionalization on these heterocyclic backbones provides highly powerful tools for the rapid accesses to densely functionalized chromone and flavone derivatives.Considering the importance of the functionalized chromone and flavone compounds as well as the notable advances in the synthesis of such products by direct C—H activation or functionalization,we review herein the research advances in the C—H bond activation and functionalization reactions of chro mone and flavones,in hope of showing the current states and promise of the research domain. | Shanghui Tian Tian Luo Yanping Zhu Jie-Ping Wan | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
| 11 | Effects of drip irrigation and cropping on soil salinity,ionic composition and waxy corn production in a severely saline and calcareous and gypsiferous soil显示文摘Drip technologies have been suggested as practical for irrigation under conditions of high salinity and for reclamation of saline soils.Drip irrigation triggered by soil water potential thresholds was applied to both reclaim a severely saline calcareous gypsiferous soil and irrigate a waxy corn crop(Zea mays L.sinesis Kulesh).However,there is a lack of knowledge on the sustainability of reclamation of saline soils with drip irrigation and the changes in soil salinity and salt ion composition during the amelioration process.Therefore,effects on soil salinity,its ionic composition,and on crop growth and yields were evaluated in an experiment conducted in the Yinchuan Plain,northwest China.Treatments included fields in their first to fourth years of the drip irrigation reclamation-cropping scheme and adjacent native,non-cropped or irrigated salinesodic land as control.Yield of waxy corn increased and days of growth to maturity decreased as a function of time and reclamation management.The improvement in crop performance could be largely credited to the reduction of soil salinity and changes in salt composition under the drip-irrigated reclamation protocols.The drip irrigation regime created a region of low salinity proximal to the emitters conducive to germination and plant growth.Deleterious ions for crop growth such as Na+and Cl^(-)were reduced while Ca2+and Mg2+concentration increased,especially in the upper 40 cm of soil.After only a single season of drip-irrigated waxy corn production,both Cl-SO_(4)^(2-)ratios and sodium adsorption ratio(SAR)decreased dramatically.The results suggested that drip irrigation is an effective technology for reclamation of severely saline-affected soils,such as those widely distributed over the Ningxia Plain in China and that this or similar reclamation strategy could be appropriate for reclamation of other hard to manage calcareous and gypsiferous soils. | Junli Tan Yaohu Kang Yanping Jiao Shuqin Wan Xina Wang Juncang Tian Ran Erel Alon Ben-Gal | 2023 | International Journal of Agricultural and Biological Engineering2023，16，5： | 0 |
| 12 | Seismic response of a mid-story isolated structure considering SSI in mountainous areas under long-period earthquakes显示文摘At present,there is not much research on mid-story isolated structures in mountainous areas.In this study,a model of a mid-story isolated structure considering soil-structure interaction(SSI)in mountainous areas is established along with a model that does not consider SSI.Eight long-period earthquake waves and two ordinary earthquake waves are selected as inputs for the dynamic time history analysis of the structure.The results show that the seismic response of a mid-story isolated structure considering SSI in mountainous areas can be amplified when compared with a structure that does not consider SSI.The structure response under long-period earthquakes is larger than that of ordinary earthquakes.The structure response under far-field harmonic-like earthquakes is larger than that of near-fault pulse-type earthquakes.The structure response under near-fault pulse-type earthquakes is larger than that of far-field non-harmonic earthquakes.When subjected to long-period earthquakes,the displacement of the isolated bearings exceeded the limit value,which led to instability and overturning of the structure.The structure with dampers in the isolated story could adequately control the nonlinear response of the structure,effectively reduce the displacement of the isolated bearings,and provide a convenient,efficient and economic method not only for new construction but also to retrofit existing structures. | Wan Feng Qin Shengwu Liu Dewen Zhao Tiange Zheng Yanping Shan Hang Li Zhiang Peng Fusong Xu Jingran Lei Min | 2024 | Earthquake Engineering and Engineering Vibration2024，23，1： | 0 |
| 13 | Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling显示文摘Drug-associated reward memories are conducive to intense craving and often trigger relapse.Simvastatin has been shown to regulate lipids that are involved in memory formation but its influence on other cognitive processes is elusive.Here,we used a mass spectrometry-based lipidomic method to evaluate the impact of simvastatin on the mouse brain in a cocaine-induced reinstatement paradigm.We found that simvastatin blocked the reinstatement of cocaine-induced conditioned place preference(CPP)without affecting CPP acquisition.Specifically,only simvastatin administered during extinction prevented cocaine-primed reinstatement.Global lipidome analysis showed that the nucleus accumbens was the region with the greatest degree of change caused by simvastatin.The metabolism of fatty-acids,phospholipids,and triacylglycerol was profoundly affected.Simvastatin reversed most of the effects on phospholipids induced by cocaine.The correlation matrix showed that cocaine and simvastatin significantly reshaped the lipid metabolic pathways in specific brain regions.Furthermore,simvastatin almost reversed all changes in the fatty acyl profile and unsaturation caused by cocaine.In summary,pre-extinction treatment with simvastatin facilitates cocaine extinction and prevents cocaine relapse with brain lipidome remodeling. | Wei Xu Yuman He Jiamei Zhang Hongchun Li Xuemei Wan Menglu Li Yonghai Wang Rui Xu Haoluo Zhang Yanping Dai Haxiaoyu Liu Linhong Jiang Ying Zhao Xiaobo Cen | 2021 | Neuroscience Bulletin2021，37，12： | 0 |
| 14 | Direct synthesis of high-quality perovskite nanocrystals on a flexible substrate and deterministic transfer显示文摘Solid-state perovskite nanocrystals are promising coherent light sources, as there is optical feedback within the crystal structure. In order to utilize the high performance of perovskites for on-chip applications, or observe new physical phenomena, these crystals must be integrated with pre-fabricated electronic or photonic structures. However, the material's fragility has made the deterministic transfer a great challenge thus far. Here, we report the first deterministic transfer of perovskite nanocrystals with sub-micron accuracy. Cesium lead halide(CsPbI_3) nanocrystals were directly synthesized on flexible polydimethylsiloxane(PDMS) stamps via chemical vapor deposition(CVD) and subsequently transferred onto arbitrary substrates/structures. We demonstrated the transfer of a CsPbI_3 crystalline nanoplate(NP)onto an 8 mm fiber core and achieved single-mode whispering gallery mode lasing. Our method can be extended to a variety of other arbitrary substrates(e.g., electrodes, photonic structures, micromechanical systems), laying the foundations for previously unattainable opportunities in perovskites-based devices. | Yilun Wang Xing Cheng Kai Yuan Yi Wan Pan Li Yuhao Deng Haoran Yu Xiaolong Xu Yi Zeng Wanjin Xu Yanping Li Renmin Ma Kenji Watanabe Takashi Taniguchi Yu Ye Lun Dai | 2018 | Science Bulletin2018，63，23： | 0 |
| 15 | Edge localized modes suppression via edge E × B velocity shear induced by RF sheath of ion cyclotron resonance heating in EAST显示文摘The control of large edge localized modes(ELMs) is a critical issue for the successful operation of future burning plasma devices,such as the international thermonuclear experimental reactor(ITER) and China fusion engineering test reactor(CFETR). In this paper, we present a new active and effective means of ELM suppression using ion cyclotron resonant heating(ICRH) on the experimental advanced superconducting tokamak(EAST). We obtained the key role of the external E × B velocity shear near the pedestal top and the scrape-off-layer(SOL) induced by the RF sheath potential of ICRH in ELM suppression. The experimental results showed a positive correlation between the RF sheath and the E × B shear rate in SOL. BOUT++ simulations indicate that increased E × B velocity shear rates in the pedestal and SOL regions promote ELM suppression;thereby, supporting the experimental observations on EAST. These findings suggest a new simple approach to access the ELM suppressed regimes in plasma with low torque input as ITER baseline discharges. | XinJun Zhang Chu Zhou XiaoLan Zou TianYang Xia YanLong Li ChengMing Qin XianZu Gong Qing Zang MingHui Li Tao Zhang ShouXin Wang HaiQing Liu Guillaume Urbanczyk Adi Liu YanMing Duan YanPing Zhao JinPing Qian Robert Isaac Pinsker MinYou Ye BaoNian Wan | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，3： | 0 |
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