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| 1 | Early Warning of Acute Altitude Sickness by Physiological Variables and Noninvasive Cardiovascular Indicators显示文摘Objective To examine if the variations at sea level would be able to predict subsequent susceptibility to acute altitude sickness in subjects upon a rapid ascent to high altitude.Methods One hundred and six Han nationality male individuals were recruited to this research.Dynamic electrocardiogram,treadmill exercise test,echocardiography,routine blood examination and biochemical analysis were performed when subjects at sea level and entering the plateau respectively.Then multiple regression analysis was performed to construct a multiple linear regression equation using the Lake Louise Score as dependent variable to predict the risk factors at sea level related to acute mountain sickness(AMS).Results Approximately 49.05%of the individuals developed AMS.The tricuspid annular plane systolic excursion(22.0+2.66 vs.23.2+3.19 mm,t=l.998,P=0.048)was significantly lower in the AMS group at sea level,while count of eosinophil[(0.264+0.393)×109/L vs.(0.126+0.084)×109/L,t=-2.040,P—0.045],percentage of diflerences exceeding 50 ms between adjacent normal number of intervals(PNN50,9.66%±5.40%vs.6.98%±5.66%,t=-2.229,P=0.028)and heart rate variability triangle index(57.1+16.1 vs.50.6+12.7,t=-2.271,P=0.025)were significantly higher.After acute exposure to high altitude,C-reactive protein(0.098+0.103 vs.0.062+0.045 g/L,t=-2.132,P=0.037),aspartate aminotransferase(19.7+6.7275.17,3±3.95 U/L,t=-2.231,P=0.028)and creatinine(85.1±12.9 vs.77.7±11.2 mmol/L,t=3.162,P=0.002)were significantly higher in the AMS group,while alkaline phosphatase(71.7+18.2 vs.80.6+20.2 U/L,t=2.389,P=0.019),standard deviation of normal-to-normal RR intervals(126.5+35.9 vs.143.3+36.4 ms,t—2.320,P—0.022),ejection time(276.9+50.8 vs.313.8+48.9 ms,t—3.641,P—0.001)and heart rate variability triangle index(37.1+12.9 vs.41.9+11.1,t=2.O2O,P=0.047)were significantly lower.Using the Lake Louise Score as the dependent variable,prediction equation were established to estimate AMS:Lake Louise Score=3.783+0.281Xeosinophil-0.219Xalkaline phosphatase+O.O32XPNN50.Conclusions We elucidated the differences of pl^siological variables as well as noninvasive cardiovascular indicators for subjects after high altitude exposure compared with those at sea level.We also created an acute high altitude reaction early warning equation based on the physiological variables and noninvasive cardiovascular indicators at sea level. | Zongbin Li Chunwei Liu Jun Guo Yajun Shi Yang Li Jinli Wang Jing Wang Yundai Chen | 2020 | Chinese Medical Sciences Journal2020，35，1： | 8 |
| 2 | 宁夏年降水和季节降水的创新趋势分析显示文摘采用创新趋势分析(ITA)方法对1961年至2018年宁夏不同强度降水的时空变化进行研究。结果表明,区域年降水量增加主要是弱降水增加,而区域年降水量减少主要是强降水减少;极端降水的变化趋势明显。不同类型极端降水的贡献随季节变化。春季区域降水增加主要是强降水增加,区域降水减少主要是弱降水减少。夏季和秋季区域降水增加主要是弱降水增加,而区域降水减少是由强降水减少引起。该研究结果为水资源规划和应对干旱和洪涝灾害提供了支持。 | YANG Huiling XIAO Hui GUO Chunwei SUN Yue GAO Ruina | 2020 | Atmospheric and Oceanic Science Letters2020，13，4： | 4 |
| 3 | Recombinant Lactobacillus plantarum NC8 strain expressing porcine rotavirus VP7 induces specific antibodies in BALB/c mice显示文摘The major etiologic agent that causes acute gastroenteritis worldwide in young animals and children is Group A rotavirus.Currently,commercially available vaccines do not often prevent porcine rotavirus(PRV)infection.In this study,we evaluated the efficacy of oral recombinant Lactobacillus vaccine against PRV in a mouse model.Lactobacillus plantarum NC8 was used as the host strain,and bacterial vectors were constructed,because the NC8 isolated has shown the capability to survive gastric transit and to colonize the intestinal tract of humans and other mammals.To explore the immunological mechanisms,lactic acid bacterial vectors were used to express VP7 antigen from PRV.We constructed an L.plantarum strain with surface-displayed VP7,named NC8-pSIP409-pgsA-VP7-DCpep.The expressed recombinant protein had a molecular weight of~37 kDa.The strain was used to immunize BALB/c mice to evaluate their immunomodulatory characteristics.Mice were orally immunized with recombinant L.plantarum NC8-pSIP409-pgsA-VP7-DCpep at a dose of 2×10^(9) colony forming units/200μl.The results showed that NC8-pSIP409-pgsA-VP7-DCpep significantly stimulated the differentiation of dendritic cells(DCs)in Peyer’s patches(PPs)and increased the serum levels of IL-4 and IFN-γ,as measured by enzyme-linked immunosorbent assay in mice treated with NC8-pSIP409-pgsA-VP7-DCpep.Compared to the empty vector group,NC8-pSIP409-pgsA-VP7-DCpep significantly increased the production of B220^(+) B cells in mesenteric lymph nodes(MLNs)and PPs and also increased the titer levels of the VP7-specific antibodies,including IgG and sIgA.The administration of NC8-pSIP409-pgsA-VP7-DCpep mediated relatively broad cellular responses.This study reveals that clear alternatives exist for PRV control strategies and provides information on PRV infection. | Seria Masole Shonyela Chunwei Shi Wentao Yang Xin Cao Guilian Yang Chunfeng Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 2 |
| 4 | Mode selection and high-quality upconversion lasing from perovskite CsPb2Br5 microplates显示文摘In recent years,halide perovskite nanostructures have had great advances and have opened up a bright future for micro/nanolasers.However,upconversion lasing by two-photon excitation with mode selection and high quality factor in one device is still rarely reported.Herein,two lasing modes are demonstrated in the all-inorganic perovskite CsPb2Br5 microplates with subwavelength thickness and uniform square shape.The net optical gain is quickly established in less than 1 ps and persists more than 30 ps,revealed by ultrafast transient absorption spectroscopy.The temperature-dependent low-threshold amplified spontaneous emission confirms the net gain for stimulated emission with a high characteristic temperature of 403 K,far surpassing the all-inorganic CsPbBr3 semiconductor gain media.Remarkably,upconversion lasing based on two kinds of microcavity effects,Fabry–Pérot and whispering-gallery modes,from the microplates at room temperature is successfully achieved with a low threshold operating in multi-or single-mode,respectively.Surprisingly,the quality factor(~3551)is among the best values obtained from perovskite micro/nanoplate upconversion lasers without an external cavity.Moreover,the highly stable chromaticity with color drift only less than 0.1 nm also outbalances the all-inorganic CsPbBr3 ones.These superior performances of CsPb2Br5 microplate lasing with a facile solution synthesis procedure will offer a feasible structure to fabricate specific functionalities for high-performance frequency upconversion micro/nanoscale photonic integrated devices. | ZHENGZHENG LIU CHUNWEI WANG ZHIPING HU JUAN DU JIE YANG ZEYU ZHANG TONGCHAO SHI WEIMIN LIU XIAOSHENG TANG AND YUXIN LENG | 2020 | Photonics Research2020，8，9： | 2 |
| 5 | Experimental Study on the Hydrodynamic Characteristics of a Submersible Fish Cage at Various Depths in Waves显示文摘Submersible fish cages can be submerged under the water to mitigate the negative effects that arise from severe sea conditions and improve the growing environment for the farmed fish. Thus they are increasingly applied in offshore aquaculture. To ensure both safety and economic efficiency of submersible fish cages, it is important to determine the optimum submergence depth. In this study, a series of physical model experiments were conducted to investigate the hydrodynamic performance of a submersible fish cage at various submergence depths(1/6, 1/4, 1/3, and 1/2 of the water depth as well as the floating condition for reference) with a model scale of 1:20. The results of the physical model experiment for the different depths were compared to analyze the effects of submergence depths on the mooring line tension and the movement of the floating collar. The results showed that the mooring line tension and the floating collar movement significantly attenuated with increasing submergence depth. However, the attenuation tendency became stable when the fish cage reached a certain depth. According to the results, 1/3 of water depth was determined as the optimal submergence depth of the fish cages. Deeper submergence depths showed no significant advantage from a perspective of the hydrodynamic characteristics of the fish cage. The determination of the optimum submergence depth is beneficial for the structural design and operation safety of submersible net cages. | LIU Shengcong BI Chunwei YANG Hui HUANG Liuyi LIANG Zhenlin ZHAO Yunpeng | 2019 | Journal of Ocean University of China2019，18，3： | 2 |
| 6 | Preparation and characterization of carbon pillared clay material显示文摘Carbon pillared clay material was prepared from montmorillonite modified by C19H42BrN and C10H16ClN. SEM, FT-IR, XRD, N2 adsorption-desorption, thermal-gravimetric analysis and differential scanning calorimetry were employed to characterize the pore structure and test the effect of surfactant. The results show that organic modifier combines with montmorillonite particles by covalent bond and ion embedded. The microstructure of carbon pillared material looks like needle slice. The most probable pore size distribution is about 1.7 nm. The clay material slice mainly consists of two-dimensional aperture supported by a carbonization pillar. The high-temperature stability of carbon pillared clay is im- proved. | ZHANG ZengZhi YANG ChunWei NIU JunJie | 2009 | Science China(Technological Sciences)2009，52，1： | 2 |
| 7 | A time-efficient pattern reduction algorithm for K-means clustering显示文摘 | CHIANG Mingchao TSAI Chunwei YANG Chusing | | 0，，04： | 1 |
| 8 | Thwarting intercept-and-resend attack on Zhang’s quantum secret sharing using collective rotation noises显示文摘 | Yang Chunwei Tsai Chia-wei Hwang Tzonelih | 2012 | Quantum Information Processing2012，11，1： | 1 |
| 9 | Dynamic quantum secret sharing protocol based on GHZ state显示文摘 | Liao Cihong Yang Chunwei Hwang T | 2014 | Quantum Information Processing2014，13，8： | 1 |
| 10 | Comparison of Aerosol Effects on Simulated Spring and Summer Hailstorm Clouds显示文摘Numerical simulations are carried out to investigate the effect of cloud condensation nuclei(CCN) concentrations on microphysical processes and precipitation characteristics of hailstorms. Two hailstorm cases are simulated, a spring case and a summer case, in a semiarid region of northern China, with the Regional Atmospheric Modeling System. The results are used to investigate the differences and similarities of the CCN effects between spring and summer hailstorms. The similarities are:(1) The total hydrometeor mixing ratio decreases, while the total ice-phase mixing ratio enhances, with increasing CCN concentration;(2) Enhancement of the CCN concentration results in the production of a greater amount of small-sized hydrometeor particles, but a lessening of large-sized hydrometeor particles;(3) As the CCN concentration increases, the supercooled cloud water and rainwater make a lesser contribution to hail, while the ice-phase hydrometeors take on active roles in the growth of hail;(4) When the CCN concentration increases, the amount of total precipitation lessens,while the role played by liquid-phase rainfall in the amount of total precipitation reduces, relatively, compared to that of icephase precipitation. The differences between the two storms include:(1) An increase in the CCN concentration tends to reduce pristine ice mixing ratios in the spring case but enhance them in the summer case;(2) Ice-phase hydrometeor particles contribute more to hail growth in the spring case, while liquid water contributes more in the summer case;(3) An increase in the CCN concentration has different effects on surface hail precipitation in different seasons. | Huiling YANG Hui XIAO Chunwei GUO Guang WEN Qi TANG Yue SUN | 2017 | Advances in Atmospheric Sciences2017，34，7： | 1 |
| 11 | A hierarchical AHP/DEA methodology for the facilities layout design problem显示文摘 | Taho Yang Chunwei Kuo | 2002 | European Journal of Operational Research2002，，1： | 1 |
| 12 | African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-βpathway activation by degrading TBK1显示文摘African swine fever virus(ASFV)is an important pathogen causing acute infectious disease in domestic pigs and wild boars that seriously endangers the global swine industry.As ASFV is structurally complex and encodes a large number of functional proteins,no effective vaccine has been developed to date.Thus,dissecting the mechanisms of immune escape induced by ASFV proteins is crucial.A previous study showed that the ASFV-encoded protein is an important factor in host immunity.In this study,we identified a negative regulator,MGF505-3R,that significantly downregulated cGAS/STING-and poly(dG:dC)-mediated IFN-βand interferon stimulation response element(ISRE)reporter activity and suppressed IFNB1 and IFIT2 mRNA levels.In addition,TBK1,IRF3 and IκBαphosphorylation levels were also inhibited.Mechanistically,MGF505-3R interacted with cGAS/TBK1/IRF3 and targeted TBK1 for degradation,thereby disrupting the cGAS-STING-mediated IFN-βsignaling pathway,which appears to be highly correlated with autophagy.Knockdown MGF505-3R expression enhanced IFN-βand IL-1βproduction.Taken together,our study revealed a negative regulatory mechanism involving the MGF505-3R-cGAS-STING axis and provided insights into an evasion strategy employed by ASFV that involves autophagy and innate signaling pathways. | Mingyang Cheng Jiawei Luo Yuetong Duan Yu Yang Chunwei Shi Yu Sun Yiyuan Lu Junhong Wang Xiaoxu Li Jianzhong Wang Nan Wang Wentao Yang Yanlong Jiang Guilian Yang Yan Zeng Chunfeng Wang Xin Cao | 2022 | Animal Diseases2022，2，3： | 1 |
| 13 | hierarchical AHP/DEA methodology for the facilities layout design problem显示文摘 | YANG T H CHUNWEI A | 2003 | Eur J Operat Res2003，147，： | 1 |
| 14 | Small target detection in infrared video sequence using robust dictionary learning显示文摘 | Yang Chunwei Liu Huaping Liao Shouyi | 2015 | Infrared Physics & Technology2015，68，： | 1 |
| 15 | A waterproof and breathable Cotton/rGO/CNT composite for constructing a layer-by-layer structured multifunctional flexible sensor显示文摘Developing a cotton fabric sensing layer with good waterproofness and breathability via a low-cost and eco-friendly method is increasingly important for the construction of comfortable and wearable electronic devices.Herein,a waterproof and breathable cotton fabric composite decorated by reduced graphene oxide(rGO)and carbon nanotube(CNT),Cotton/rGO/CNT,is reported by a facile solution infiltration method,and we adopt such Cotton/rGO/CNT composite to develop a layer-by-layer structured multifunctional flexible sensor,enabling the high-sensitivity detection of pressure and temperature stimulus.Particularly,the multifunctional flexible sensor exhibits a high response toward tiny pressure,demonstrating salient superiority in the continuous and reliable monitoring of human physiological information.Concerning temperature sensing,a good linear response for the temperatures ranging from 28 to 40℃ is achieved by the multifunctional flexible sensor and gives rise to be successfully applied to the non-contact real-time monitoring of human respiration signal.Finally,an array consisting of multifunctional flexible sensors further demonstrates its feasibility in perceiving and mapping the pressure and temperature information of contact objects.This work provides a feasible strategy for designing cotton-based sensing layers that can effectively resist liquid water penetration and allow water vapor transmission,and offers reasonable insight for constructing comfort and multifunctional wearable electronics. | Feifei Yin Yunjian Guo Hao Li Wenjing Yue Chunwei Zhang Duo Chen Wei Geng Yang Li Song Gao Guozhen Shen | 2022 | Nano Research2022，15，10： | 1 |
| 16 | Determination of oxytetracycline, tetracycline and chloramphenicol antibiotics in animal feeds using subcritical water extraction and high performance liquid chromatography 显示文摘 | WANG Linling YANG Hai ZHANG Chunwei | 2008 | Analytica Chimca Acta2008，619，1： | 1 |
| 17 | Determination of oxytetracycline, tetracycline and chlorampheni- col antibiotics in animal feeds using subcritical water extraction and high performance liquid chromatography 显示文摘 | WANG Linling YANG Hai ZHANG Chunwei | 2008 | Anal Chim Acta2008，619，1： | 1 |
| 18 | Miniaturiza- tion of WEDM using electrostatic induction feeding meth- od 显示文摘 | Yang Xiaodong Xu Chunwei Kunieda M | 2010 | Precision Engineering2010，34，2： | 1 |
| 19 | Obesity paradox: Clinical benefits not observed in obese patients with ST-segment elevation myocardial infarction: A multicenter, prospective, cohort study of the northern region of China显示文摘 | Yuze Li Chunwei Wu Yujiao Sun Daming Jiang Bo Zhang Lina Ren Yuan Gao Haijie Yu Guang Yang Qigang Guan Wen Tian Haishan Zhang Liang Guo Guoxian Qi | 2013 | International Journal of Cardiology2013，，： | 1 |
| 20 | Intratumoural microbiota:a new frontier in cancer development and therapy显示文摘Human microorganisms,including bacteria,fungi,and viruses,play key roles in several physiological and pathological processes.Some studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms,which have been confirmed to be closely related to oncogenesis.The concept of intratumoural microbiota was subsequently proposed.Microbiota could colonise tumour tissues through mucosal destruction,adjacent tissue migration,and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour microenvironment.Mechanistic studies have demonstrated that intratumoural microbiota potentially promote the initiation and progression of tumours by inducing genomic instability and mutations,affecting epigenetic modifications,promoting inflammation response,avoiding immune destruction,regulating metabolism,and activating invasion and metastasis.Since more comprehensive and profound insights about intratumoral microbiota are continuously emerging,new methods for the early diagnosis and prognostic assessment of cancer patients have been under examination.In addition,interventions based on intratumoural microbiota show great potential to open a new chapter in antitumour therapy,especially immunotherapy,although there are some inevitable challenges.Here,we aim to provide an extensive review of the concept,development history,potential sources,heterogeneity,and carcinogenic mechanisms of intratumoural microorganisms,explore the potential role of microorganisms in tumour prognosis,and discuss current antitumour treatment regimens that target intratumoural microorganisms and the research prospects and limitations in this field. | Yaqi Cao Hui Xia Xueyun Tan Chunwei Shi Yanling Ma Daquan Meng Mengmeng Zhou Zhilei Lv Sufei Wang Yang Jin | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
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