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| 1 | Fatty liver diseases,bile acids,and FXR显示文摘The prevalence of nonalcoholic fatty liver disease(NAFLD) worldwide has increased at an alarming rate,which will likely result in enormous medical and economic burden.NAFLD presents as a spectrum of liver diseases ranging from simple steatosis,nonalcoholic steatohepatitis(NASH),fibrosis,cirrhosis,and even to hepatocellular carcinoma(HCC).A comprehensive understanding of the mechanism(s) of NAFLD-to-NASH transition remains elusive with various genetic and environmental susceptibility factors possibly involved.An understanding of the mechanism may provide novel strategies in the prevention and treatment to NASH.Abnormal regulation of bile acid homeostasis emerges as an important mechanism to liver injury.The bile acid homeostasis is critically regulated by the farnesoid X receptor(FXR) that is activated by bile acids.FXR has been known to exert tissue-specific effects in regulating bile acid synthesis and transport.Current investigations demonstrate FXR also plays a principle role in regulating lipid metabolism and suppressing inflammation in the liver.Therefore,the future determination of the molecular mechanism by which FXR protects the liver from developing NAFLD may shed light to the prevention and treatment of NAFLD. | Yan Zhu Hongxia Liu Min Zhang Grace L.Guo | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 20 |
| 2 | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis显示文摘 | Yongting Luo Hongxia Duan Yining Qian Liqun Feng Zhenzhen Wu Fei Wang Jing Feng Dongling Yang Zhihai Qin Xiyun Yan | 2017 | Cell Research2017，27，3： | 18 |
| 3 | Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma显示文摘For successful therapy, hepatocellular carcinoma (HCC) must be detected at an early stage. Herein, we used a proteomic approach to analyze the secretory/releasing proteome of HCC tissues to identify plasma biomarkers. Serum-free conditioned media (CM) were collected from primary cultures of cancerous tissues and surrounding noncancerous tissues. Proteomic analysis of the CM proteins permitted the identification of 1365 proteins. The enriched molecular functions and biological processes of the CM proteins, such as hydrolase activity and catabolic processes, were consistent with the liver being the most important metabolic organ. Moreover, 19% of the proteins were characterized as extracellular or membrane-bound. For validation, secretory proteins involved in transforming growth factor-β signaling pathways were validated in plasma samples. Alphafetoprotein (AFP), metalloproteinase (MMP)1, osteopontin (OPN), and pregnancy-specific beta-1-glycoprotein (PSG)9 were significantly increased in HCC patients. The overall performance of MMP1 and OPN in the diagnosis of HCC remained greater than that of AFP. In addition, this study represents the first report of MMP1 as a biomarker with a higher sensitivity and specificity than AFP. Thus, this study provides a valuable resource of the HCC secretome with the potential to investigate serological biomarkers. MMP1 and OPN could be used as novel biomarkers for the early detection of HCC and to improve the sensitivity of biomarkers compared with AFP. | YANG Lei RONG WeiQi XIAO Ting ZHANG Ying XU Bin LIU Yu WANG LiMing WU Fan QI Jun ZHAO XiuYing WANG HongXia HAN NaiJun GUO SuPing WU JianXiong GAO YanNing CHENG ShuJun | 2013 | Science China(Life Sciences)2013，56，7： | 9 |
| 4 | Interaction of APT with BSA or HSA显示文摘In this work, N-n-amyl-N’-(sodium p- aminobenzenesulfonate) thiourea (APT) containing saturated fatty hydrocarbon group was synthesized. Fluorescence quenching methods in combination with UV absorption spectra and molecule modeling method were used to study the interaction between APT and bovine serum albumin (BSA) or human se-rum albumin (HSA). The binding constants of APT with BSA or HSA were determined at different tem-peratures under the optimum conditions based on the fluorescence quenching results. The binding characteristics of APT and BSA or HSA were reported and the binding sites were obtained. The binding mode was suggested to be mainly hydrophobic interaction, which was consistent with molecular modeling study. | CUI Fengling CUI Yanrui LUO Hongxia YAO Xiaojun FAN Jing LU Yan | 2006 | Chinese Science Bulletin2006，51，18： | 9 |
| 5 | FXYD6: a novel therapeutic target toward hepatocellular carcinoma显示文摘FXYD6, FXYD 领域包含离子运输管理者 6,被报导了影响 Na 的活动 < 啜 class= “ a-plus-plus ” >+/K+-ATPase 并且与心理疾病被联系。这里,我们证明 FXYD6 在 hepatocellular 癌(HCC ) 是起来调整的并且提高 HCC 房间的迁居和增长。FXYD6 的起来规定不仅断然随 Na 的增加相关 < 啜 class= “ a-plus-plus ” >+/K 有它发信号的下游的 Src 英皇家空军之阶级最低之兵的激活的 +-ATPase 而且坐标小径。更重要地,显著地由它的功能的抗体堵住 FXYD6 在老鼠禁止 xenografted HCC 肿瘤的生长潜力,显示 FXYD6 代表向 HCC 的一个潜在的治疗学的目标。总的来说,我们的结果在 HCC 前进建立 FXYD6 的一个关键角色并且建议指向 FXYD6 的治疗能向 HCC 病人有益于临床的治疗。 | Qian Gao Xiongfei Chen Hongxia Duan Zhaoqing Wang Jing Feng Dongling Yang Lina Song Ningxin Zhou Xiyun Yan | 2014 | Protein & Cell2014，5，7： | 7 |
| 6 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 7 | Modified Dachengqi Tang improves decreased gastrointestinal motility in postoperative esophageal cancer patients显示文摘OBJECTIVE:To investigate the clinical effects of modified Dachengqi Tang(DCQT) on promoting gastrointestinal motility in post-operative esophageal cancer patients.METHODS:Sixty postoperative esophageal cancer patients were enrolled and randomly assigned to the modified treatment group or the control group(30 patients in each group).Patients in the treatment group were given DCQT made from decocted herbs and administered via nasojejunal tube at a dosage of 150 mL.Gastrointestinal motility was assessed by recording time for recovery of bowel sounds,flatus,defecation,and the total amount of gastric drainage during the first three postoperative days.Plasma motilin(MTL) and vasoactive intestinal peptide(VIP) were measured one hour before and three days after surgery.RESULTS:Compared with the control group,the times to first bowel sound,flatus,and defecation were significantly shorter and there was less gastric drainage in the treatment group(P < 0.01,P < 0.01,P < 0.01,and P < 0.05,respectively).In the treatment group,postoperative plasma MTL was significantly higher(P < 0.01) and VIP was significantly lower than those in the control group(P < 0.05).There was no difference found in either MTL or VIP from before to after operation in the treatment group(P > 0.05).MTL was significantly lower and VIP was higher postoperatively in the control group,compared to before surgery(P < 0.01).CONCLUSION:Modified DCQT effectively improved decreased gastrointestinal motility in postoperative esophageal cancer patients by increasing MTL and reducing VIP. | Xu Zejun Xu Cuiping Ge Hongxia Li Yan Chu Liangliang Zhang Jie Cheng Kelin | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 5 |
| 8 | Mechanical, tribological and heat resistant properties of fluorinated multi-walled carbon nanotube/bismaleimide/cyanate resin nanocomposites显示文摘Bismaleimide containing cyanate resin(BMI/CE) pre-ploymer was used as resin matrix. Fluorinated multiwalled carbon nanotubes(F-MWCNTs) were used as fillers to prepare F-MWCNT/BMI/CE nanocomposites via a solution intercalation method. The influence of F-MWCNT content on the mechanical, tribological and heat resistant properties of the nanocomposites was investigated. The morphology of the fracture surface and the wear surface of nanocomposites were characterized by scanning electron microscopy.Results show that the addition of F-MWCNTs is beneficial to improving the mechanical and tribological properties of the nanocomposites. It's worth noting that when the content of F-MWNTs was 0.6 wt%, the performances of nanocomposite are optimized(i.e., highest impact strength, lowest frictional coefficient and wear rate). In addition, the nanocomposites exhibit good thermal stability in comparison with BMI/CE. | Pengbo Li Tiehu Li Hongxia Yan | 2017 | Journal of Materials Science & Technology2017，33，10： | 5 |
| 9 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 10 | 3D-printed controllable gradient pore superwetting structures for high temperature efficient oil-water separation显示文摘Superwetting surfaces have the potential to address oil pollution in water,through their ability to separate the two.However,it remains a great challenge to fabricate stable and efficient separation structures using conventional manufacturing techniques.Furthermore,the materials traditionally used for oil-water separation are not stable at high temperature.Therefore,there is a need to develop stable,customizable structures to improve the performance of oil-water separation devices.In recent years,3D printing technology has developed rapidly,and breakthroughs have been made in the fabrication of complicated ceramic structures using this technology.Here,a ceramic material with a gradient pore structure and superhydrophobic/superoleophilic properties was prepared using 3D printing for high-efficiency oil-water separation.The gradient pore structure developed here can support a flux of up to 25434 L/m^(2)h,which is nearly 40%higher than that an analogous structure with straight pores.At 200℃,the oil-water separation performance was maintained at 97.4%.Furthermore,samples of the material exhibited outstanding mechanical properties,and chemical stability in a variety of harsh environments.This study provides an efficient,simple,and reliable method for manufacturing oil-water separation materials using 3D printing,and may have broader implications for both fundamental research and industrial applications. | Zhipeng Jin Hui Mei Yuekai Yan Longkai Pan Hongxia Liu Shanshan Xiao Laifei Cheng | 2021 | Journal of Materiomics2021，7，1： | 4 |
| 11 | An aqueous zinc-ion hybrid super-capacitor for achieving ultrahigh-volumetric energy density显示文摘Zinc-ion hybrid super-capacitors are regarded as promising safe energy storage systems,However,the relatively low volumetric energy density has become the main bottlenecks in practical applications of portable electronic devices,In this work,the zinc-ion hybrid super-capacitor with high volumetric energy density and superb cycle stability had been constructed which employing the high-density threedimensional graphene hydrogel as cathode and Zn foil used as anode in 1 mol/L ZnSO4 electrolyte.Benefiting from the abundant ion transport paths and the abundant active sites for graphene hydrogel with high density and porous structure,the zinc-ion hybrid super-capacitor exhibited an extremely high volumetric energy density of 118.42 Wh/L and a superb power density of 24.00 kW/L,as well as an excellent long cycle life(80% retention after 30,000 cycles at 10 A/g),which was superior to the volumetric energy density of the reported zinc-ion hybrid super-capacitors.This device,based on the fast ion adsorption/deso rption on the capacitor-type graphene cathode and reversible Zn^(2+) plating/stripping on the battery-type Zn anode,which will inspire the development of zinc-ion hybrid super-capacitor in miniaturized devices. | Li Zhang Dandan Wu Gaowei Wang Yongtai Xu Hongxia Li Xingbin Yan | 2021 | Chinese Chemical Letters2021，32，2： | 4 |
| 12 | Experimental study of low-damage drilling fluid to minimize waterblocking of low-permeability gas reservoirs显示文摘This paper discusses the systematic design and development of low-damage drilling fluid to protect the low-permeability gas reservoir of the Sulige block in the Ordos Basin,Inner Mongolia Autonomous Region,China.Based on investigation of the geological characteristics and the potential formation damage of the Permian formation of the reservoir,waterblocking due to invasion of drilling or completion fluids was identified one of the most severe causes of damage to gas well deliverability.By adopting the phase trap prevention method,ideal packing theory,and film-forming technology,a low- damage drilling fluid,sodium formate brine containing efficient waterblocking preventing surfactants, optimized temporary bridging agents(TBAs),and film-forming agents has been developed.The performance of the new drilling fluid was evaluated by using a variety of techniques.The results show that the fluid has good rheological properties,good strong shale-swelling inhibition,good temporary plugging effect,ultra-low filtration,and good lubricity.It can efficiently minimize waterblocking and can be used to drill horizontal wells with minimal intervention of the reservoir in the Sulige Gas Field. | Zhang Hongxia Yan Jienian Lu Yu Shu Yong Zhao Shengying | 2009 | Petroleum Science2009，6，3： | 4 |
| 13 | CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases显示文摘Blood vessel dysfunction causes several retinal diseases,including diabetic retinopathy,familial exudative vitreoretinopathy,macular degeneration and choroidal neovascularization in pathological myopia.Vascular endothelial growth factor(VEGF)-neutralizing proteins provide benefits in most of those diseases,yet unsolved haemorrhage and frequent intraocular injections still bothered patients.Here,we identified endothelial CD146 as a new target for retinal diseases.CD146 expression was activated in two ocular pathological angiogenesis models,a laser-induced choroid neovascularization model and an oxygeninduced retinopathy model.The absence of CD146 impaired hypoxia-induced cell migration and angiogenesis both in cell lines and animal model.Preventive or therapeutic treatment with anti-CD146 antibody AA98 significantly inhibited hypoxia-induced aberrant retinal angiogenesis in two retinal disease models.Mechanistically,under hypoxia condition,CD146 was involved in the activation of NFκB,Erk and Akt signalling pathways,which are partially independent of VEGF.Consistently,anti-CD146therapy combined with anti-VEGF therapy showed enhanced impairment effect of hypoxia-induced angiogenesis in vitro and in vivo.Given the critical role of abnormal angiogenesis in retinal and choroidal diseases,our results provide novel insights into combinatorial therapy for neovascular fundus diseases. | Bai Xue Ping Wang Wenzhen Yu Jing Feng Jie Li Rulian Zhao Zhenglin Yang Xiyun Yan Hongxia Duan | 2022 | Science China(Life Sciences)2022，65，6： | 3 |
| 14 | Exploring and exploiting genetics and genomicsfor sweetpotato improvement: Status andperspectives显示文摘Sweetpotato(Ipomoea batatas(L.)Lam.)is one of the most important root crops cultivated worldwide.Because of its adaptability,high yield potential,and nutritional value,sweetpotato has become an important food crop,particularly in developing countries.To ensure adequate crop yields to meet increasing demand,it is essential to enhance the tolerance of sweetpotato to environmental stresses and other yield-limiting factors.The highly heterozygous hexaploid genome of I.batatas complicates genetic studies and limits improvement of sweetpotato through traditional breeding.However,application of next-generation sequencing and high-throughput genotyping and phenotyping technologies to sweetpotato genetics and genomics research has provided new tools and resources for crop improvement.In this review,we discuss the genomics resources that are available for sweetpotato,including the current reference genome,databases,and available bioinformatics tools.We systematically review the current state of knowledge on the polyploid genetics of sweetpotato,including studies of its origin and germplasm diversity and the associated mapping of important agricultural traits.We then outline the conventional and molecular breeding approaches that have been applied to sweetpotato.Finally,we discuss future goals for genetic studies of sweetpotato and crop improvement via breeding in combination with state-of-the-art multi-omics approaches such as genomic selection and gene editing.These approaches will advance and accelerate genetic improvement of this important root crop and facilitate its sustainable global production. | Mengxiao Yan Haozhen Nie Yunze Wang Xinyi Wang Robert Jarret Jiamin Zhao Hongxia Wang Jun Yang | 2022 | Plant Communications2022，3，5： | 2 |
| 15 | β-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma显示文摘 | Shuang Yan Cuiqi Zhou Wei Zhang Guo Zhang Xuejian Zhao Shangbin Yang Yihua Wang Ning Lu Hongxia Zhu Ningzhi Xu | 2008 | Cancer Letters2008，，1： | 2 |
| 16 | Heavy ion micro-beam study of single-event transient(SET) in Si Ge heterjunction bipolar transistor显示文摘Silicon-germainum heterojunction bipolar transistor(Si Ge HBT)has been demonstrated to be suitable in extreme environment because of its superior temperature characteristics which can operate from 43 K to 400 K[1].In addition,outstanding hardness to both total ionizing dose(TID)radiation and displacement damage make Si Ge HBT technology particularly attractive for | Jinxin ZHANG Hongxia GUO Fengqi ZHANG Chaohui HE Pei LI Yunyi YAN Hui WANG Linxia ZHANG | 2017 | Science China(Information Sciences)2017，60，12： | 2 |
| 17 | Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis显示文摘The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis. | Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong Wenmei Wang Yuan Fan Qing Liu Xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin Shen Yingfang Wu Lijie Fan Zhi Wang Yuan He Hongxia Dan Jiantang Yang Hui Wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen | 2022 | International Journal of Oral Science2022，14，2： | 2 |
| 18 | Observed features of temperature, salinity and current in central Chukchi Sea during the summer of 2012显示文摘During the summer of 2012, the fifth CHINARE Arctic Expedition was carried out, and a submersible mooring system was deployed in M5 station located at(69°30.155'N,169°00.654'W) and recovered 50 d later. A set of temperature, salinity and current profile records was acquired. The characteristics of these observations are analyzed in this paper. Some main results are achieved as below.(1) Temperature generally decreases while salinity generally increases with increasing depth. The average values of all records are 2.98°C and 32.21 psu.(2)Salinity and temperature are well negatively correlated, and the correlation coefficient between them is –0.84.However, they did not always vary synchronously. Their co-variation featured different characters during different significant periods.(3) The average velocity for the whole water column is 141 mm/s with directional angle of347.1°. The statistical distribution curve of velocity record number gets narrower with increasing depth. More than85% of the recorded velocities are northward, and the mean magnitudes of dominated northward velocities are100–150 mm/s.(4) Rotary spectrum analysis shows that motions with low frequency take a majority of energy in all layers. The most significant energy peaks for all layers are around 0.012 cph(about 3.5 d period), while the tidal motion in mooring area is nonsignificant.(5) Velocities in all layers feature similar and synchronous temporal variations, except for the slight decrease in magnitude and leftward twist from top to bottom. The directions of velocity correspond well to those of surface wind. The average northward volume transport per square meter is0.1–0.2 m3/s under southerly wind, but about –0.2 m3/s during northerly wind burst. | HE Yan LIU Na CHEN Hongxia TENG Fei LIN Lina WANG Huiwu | 2015 | Acta Oceanologica Sinica2015，34，5： | 2 |
| 19 | Synthesis of Ag@Al_2O_3 Core-shell Structure Nanoparticles and Their Enhancement Effect on Dielectric Properties for Ag@Al_2O_3/Polyimide Nanocomposites显示文摘A novel core-shell structure Ag@Al2O3 nano-particles were synthesized and doped into polyimide as conductive fillers to prepare the composite films with high dielectric properties and low dielectric loss. The morphology and structures of the Ag@Al2O3 nano-particles were characterized by transmission electron microscopy(TEM), X-ray diffraction(XRD), and UV-visible spectroscopy. All the results proved that the Ag@Al2O3 nano-particles had a typical core-shell structure, for the Ag particles were coated by Al2O3 shell and the average sizes of Ag@Al2O3 particles were between 30 to 150 nm. The as-prepared Ag@Al2O3 nanoparticles were doped into the polyimide with different mass fractions to fabricate the Ag@Al2O3/PI composite films via in-situ polymerization process. SEM analysis of composite films showed that the Ag@Al2O3 nanoparticles homogeneously dispersed in polyimide matrix with nanoscale. As dielectric materials for electronic packaging systems, the Ag@Al2O3/PI composites exhibited appropriate mechanical properties and enhanced dielectric properties, including greatly enhanced dielectric constant and just a slight increase in dielectric loss. These improvements were attributed to the core-shell structure of fillers and their fine dispersion in the PI matrix. | 翁凌 YAN Liwen LI Hongxia XIA Qianshan LIU Lizhu | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，1： | 2 |
| 20 | Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria显示文摘Cerebral malaria(CM)is a life-threatening diffuse encephalopathy caused by Plasmodium falciparum,in which the destruction of the blood–brain barrier(BBB)is the main cause of death.However,increasing evidence has shown that antimalarial drugs,the current treatment for CM,do little to protect against CM-induced BBB damage.Therefore,a means to alleviate BBB dysfunction would be a promising adjuvant therapy for CM.The adhesion molecule CD146 has been reported to be expressed in both endothelial cells and proinflammatory immune cells and mediates neuroinflammation.Here,we demonstrate that CD146 expressed on BBB endothelial cells but not immune cells is a novel therapeutic target in a mouse model of experimental cerebral malaria(eCM).Endothelial CD146 is upregulated during eCM development and facilitates the sequestration of infected red blood cells(RBCs)and/or proinflammatory lymphocytes in CNS blood vessels,thereby promoting the disruption of BBB integrity.Mechanistic studies showed that the interaction of CD146 and Galectin-9 contributes to the aggregation of infected RBCs and lymphocytes.Deletion of endothelial CD146 or treatment with the anti-CD146 antibody AA98 prevents severe signs of eCM,such as limb paralysis,brain vascular leakage,and death.In addition,AA98 combined with the antiparasitic drug artemether improved the cognition and memory of mice with eCM.Taken together,our findings suggest that endothelial CD146 is a novel and promising target in combination with antiparasitic drugs for future CM therapies. | Hongxia Duan Shuai Zhao Jianquan Xiang Chenhui Ju Xuehui Chen Irene Gramaglia Xiyun Yan | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
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