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| 1 | The “1-3-7” Approach to Malaria Surveillance and Response--Henan Province, China, 2012−2018显示文摘What is already known about this topic?The“1-3-7”approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization(WHO)as an international guideline for malaria surveillance and response in 2018.What is added by this report?The“1-3-7”approach was well implemented in Henan Province from 2012−2018.Over this study period,a total of 1,294 malaria cases were detected and reported,and all cases were diagnosed and reported within 1 day with 99.23%(1,284/1,294)of cases were investigated within 3 days.In addition,93.7%(1,212/1,294)of foci were investigated and vector control was implemented within 7 days at all residual non-active foci to prevent further spread.What are the implications for public health practice?The“1-3-7”controlling pattern would be an effective and approachable method for implementation especially in malaria-eliminating countries and regions,but the interval from symptom onset to diagnosis cannot be ignored.Thus,the roles and responsibilities that all actors involved in the health sector must be specified too. | Qunqun Zhang Ying Liu Yabo Hu Yuling Zhao Chengyun Yang Dan Qian Ruimin Zhou Suhua Li Zhou Guan Deling Lu Hongwei Zhang Wanshen Guo | 2020 | China CDC weekly2020，2，17： | 3 |
| 2 | Self-immolative micellar drug delivery:The linker matters显示文摘Redox-responsive polymer-drug conjugate micelles are excellent nanoscale vehicles for self-immolative intracellular drug delivery.To covalently connect the polymer and drug,disulfide-bearing linkers,such as 3,3'-dithiodipropionic acid (DDPA) and 4,4'-dithiodibutyric add (DDBA),are used.In this paper,we report the influence of linker length on the therapeutic outcome of redox-sensitive conjugate micelles.Curcumin was selected as the model drug and it was conjugated to a multivalent methoxy poly(ethylene glycol)-polylysine copolymer with DDPA or DDBA as the linker.The obtained two polymer-curcumin conjugates were amphiphilic and could self-assemble into micelles that have a hydrodynamic diameter less than 100 nm.The loading of curcumin in both micelles was above 20% (w/w).Irrespective of the linker type,micelle disassembly was observed due to the collapse of the disulfide bond in a reducing environment.However,the rate of curcumin release was much faster with the DDBA linker than with the DDPA linker as the side product was a 5-membered ring with a low ring strain.The linker length-induced variation of curcumin release kinetics caused a significant difference in the intracellular drug concentration and a higher cytotoxicity was witnessed in three model cell lines (HeLa,PC3,and 4T1) for the micelles with a DDBA linker compared to those containing a DDPA linker.As expected,this phenomenon was also observed in HeLa tumor-bearing nude mice in vivo.The current work highlights the significance of linker length in engineering redox-responsive on-demand delivery systems. | Xuan Meng Min Gao Jian Deng Di Lu Aiping Fan Dan Ding Deling Kong Zheng Wang Yanjun Zhao | 2018 | Nano Research2018，11，12： | 2 |
| 3 | Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression显示文摘 | Chi Han Li Feiyue Xu Sheungching Chow Lu Feng Deling Yin Tzi Bun Ng Yangchao Chen | 2014 | European Journal of Cancer2014，，15： | 2 |
| 4 | Targeting Phosphatidylcholine-Specific Phospholipase C for Atherogenesis Therapy显示文摘 | HaiYing Li Lu Zhang DeLing Yin Yun Zhang JunYing Miao | 2010 | Trends in Cardiovascular Medicine2010，，5： | 1 |
| 5 | A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients with Advanced Non-small Cell Lung Cancer显示文摘 | Andrew Weickhardt Robert Doebele Ana Oton Janice Lettieri DeLee Maxson Michele Reynolds Amy Brown Mary K. Jackson Grace Dy Araba Adjei Gerald Fetterly Xian Lu Wilbur Franklin Marileila Varella-Garcia Fred R. Hirsch Murry W. Wynes Hagop Youssoufian Alex Ad | 2012 | Journal of Thoracic Oncology2012，，2： | 1 |
| 6 | Valsartan Blocked Alcohol‐Induced, Toll‐Like Receptor 2 Signaling‐Mediated Inflammation in Human Vascular Endothelial Cells显示文摘 | Yushu Wang Yi Li Qingyu Shen Xiangpen Li Juan Lu Xiangping Li Deling Yin Ying Peng | 2014 | Alcohol Clin Exp Res2014，，10： | 1 |
| 7 | Extended pancreatoduodenectomy with portal vein and inferior vena cava resection and reconstruction combined with sorafenib for hepatoid carcinoma of the pancreas:a strategy of superextended surgery combined with targeted therapy显示文摘Hepatoid carcinoma of the pancreas(HCP)is an extremely rare pancreatic cancer resembling hepatocellular carcinoma,a type of liver cancer(1).Most reports have shown that it has an aggressive behavior and is associated with early metastasis.There is no standardized treatment for HCP due to its rarity,and the limited number of cases reported in the literature(2,3).However,treatment options for this type of rare cancer include surgery,chemotherapy,and radiation therapy,depending on the stage of the cancer.Nevertheless,the prognosis of HCP is poor. | Deling Wei Banghao Xu Hai Zhu Jilong Wang Zongrui Jin Weitao Chen Jianyong Zhang Zhujing Lan Keyu Huang Ling Zhang Tingting Lu Ni Fang Ya Guo Tao Peng Minhao Peng Zhang Wen | 2023 | Hepatobiliary Surgery and Nutrition2023，12，4： | 0 |
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