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| 1 | Validation of the Rockall scoring system for outcomes from non-variceal upper gastrointestinal bleeding in a Canadian setting显示文摘AIM: To validate the Rockall scoring system for predicting outcomes of rebleeding, and the need for a surgical procedure and death. METHODS: We used data extracted from the Registry of Upper Gastrointestinal Bleeding and Endoscopy including information of 1869 patients with non-variceal upper gastrointestinal bleeding treated in Canadian hospitals. Risk scores were calculated and used to classify patients based on outcomes. For each outcome, we used χ2 goodness-of-fit tests to assess the degree of calibration, and built receiver operating characteristic curves and calculated the area under the curve (AUC) to evaluate the discriminative ability of the scoring system. RESULTS: For rebleeding, the χ2 goodness-of-fit test indicated an acceptable fit for the model [χ2 (8) = 12.83, P = 0.12]. For surgical procedures [χ2 (8) = 5.3, P = 0.73] and death [χ2 (8) = 3.78, P = 0.88], the tests showed solid correspondence between observed proportions and predicted probabilities. The AUC was 0.59 (95% CI: 0.55-0.62) for the outcome of rebleeding and 0.60 (95% CI: 0.54-0.67) for surgical procedures, representing apoor discriminative ability of the scoring system. For the outcome of death, the AUC was 0.73 (95% CI: 0.69-0.78), indicating an acceptable discriminative ability. CONCLUSION: The Rockall scoring system provides an acceptable tool to predict death, but performs poorly for endpoints of rebleeding and surgical procedures. | Robert A Enns Yves M Gagnon Alan N Barkun David Armstrong Jamie C Gregor Richard N Fedorak RUGBE Investigators Group | 2006 | World Journal of Gastroenterology2006，12，48： | 14 |
| 2 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 3 | Multiband emission from single β-NaYF_(4)(Yb,Er) nanoparticles at high excitation power densities and comparison to ensemble studies显示文摘Ensemble and single particle studies of the excitation power density (P)-dependent upconversion luminescence (UCL) of core and core-shell β-NaYF_(4):Yb,Er upconversion nanoparticles (UCNPs) doped with 20% Yb^(3+) and 1% or 3% Er^(^(3+)) performed over a P regime of 6 orders of magnitude reveal an increasing contribution of the emission from high energy Er^(3+) levels at P > 1 kW/cm^(2). This changes the overall emission color from initially green over yellow to white. While initially the green and with increasing P the red emission dominate in ensemble measurements at P < 1 kW/cm^(2), the increasing population of higher Er^(^(3+)) energy levels by multiphotonic processes at higher P in single particle studies results in a multitude of emission bands in the ultraviolet/visible/near infrared (UV/vis/NIR) accompanied by a decreased contribution of the red luminescence. Based upon a thorough analysis of the P-dependence of UCL, the emission bands activated at high P were grouped and assigned to 2–3, 3–4, and 4 photonic processes involving energy transfer (ET), excited-state absorption (ESA), cross-relaxation (CR), back energy transfer (BET), and non-radiative relaxation processes (nRP). This underlines the P-tunability of UCNP brightness and color and highlights the potential of P-dependent measurements for mechanistic studies required to manifest the population pathways of the different Er^(3+) levels. | Florian Frenzel Christian Würth Oleksii Dukhno Frédéric Przybilla Lisa MWiesholler Verena Muhr Thomas Hirsch Yves Mély Ute Resch-Genger | 2021 | Nano Research2021，14，11： | 3 |
| 4 | Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection显示文摘 | Yves Panis David M McMullan Jean C Emond | 1997 | Surgery1997，，2： | 2 |
| 5 | Cervical artery dissection: Trauma and other potential mechanical trigger events显示文摘 | Stefan T. Engelter Caspar Grond-Ginsbach Tiina M. Metso Antti J. Metso Manja Kloss Stephanie Debette Didier Leys Armin Grau Jean Dallongeville Marie Bodenant Yves Samson Valeria Caso Alessandro Pezzini Leo H. Bonati Vincent Thijs Henrik Gensicke Juan J. M | 2013 | Neurology2013，，21： | 2 |
| 6 | ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-experienced Patients with HCV Genotype 1b Infection显示文摘 | Pietro Andreone Massimo G. Colombo Jeffrey V. Enejosa Iftihar Koksal Peter Ferenci Andreas Maieron Beat Müllhaupt Yves Horsmans Ola Weiland Henk W. Reesink Lino Rodrigues Yiran B. Hu Thomas Podsadecki Barry Bernstein | 2014 | Gastroenterology2014，，： | 2 |
| 7 | Quantitative element mapping of Mg alloys by laser ablation ICP-MS and EPMA显示文摘 | Christopher L Yves M Patrik S | 2005 | Applied Surface Science2005，252，1： | 1 |
| 8 | Early postnatal food intake alters myofiber maturation in pig skeletal muscle1显示文摘 | LOUIS L PATRICK E YVES M B | 2003 | The Journal of Nutrition2003，133，1： | 1 |
| 9 | The impli-cations of spatial variability in surface seal hydraulic resistance for infiltration in a mound and depression microtopography显示文摘 | Dennis M F Yves Le Bissonnais Philippe Quetin | 1998 | Catena1998，32，： | 1 |
| 10 | ENSO signals in global upper-ocean temperature显示文摘 | YVES M WARREN B W | 1995 | J Phys Oceanogr1995，25，： | 1 |
| 11 | Class switch recombination junctions are not affected by the absence of the immunoglobulin heavy chain E_(μ) enhancer显示文摘After encountering antigen,B-cells undergo class switch recombination(CSR)that substitutes the constant(C)μgene with Cγ,Cε,or Cα,thereby generating IgG,IgE,and IgA antibodies with new effector functions but the same antigenic specificity.1 The DNA-editing enzyme activation-induced deaminase(AID)is required for CSR by targeting specific DNA switch(S)regions preceding the C region,except Cδ.2 Sμis the donor region,while Sγ,ε,αare the acceptor regions.CSR is controlled in cis by the immunoglobulin heavy chain(IgH)3’regulatory region(3’RR).3 The 3’RR is essential to poise AID on the S acceptor region.During CSR IgH,intrachromosomal interactions(schematized in Fig.1a)are found between the 3’RR and the intronic Eμenhancer.1,4 Looping allows transcriptional binding activators to enhancers to facilitate CSR.However,CSR is only modestly influenced by Eμdeletion.5–7 During CSR,two different DNA repair pathways take place:the classical nonhomologous end joining(c-NHEJ)and the alternative end joining(A-EJ)pathways. | Hussein Issaoui Nour Ghazzaui Mélissa Ferrad François Boyer Yves Denizot | 2019 | Cellular & Molecular Immunology2019，16，7： | 1 |
| 12 | Soil solution chemistry of a Brazilian oxisol irrigated with treated sewage effluent显示文摘 | Thomas V Gloaguen M -Gristina Forti Yves Lucas | 2007 | Agricultural Water Management2007，88，： | 1 |
| 13 | Steroid saponins from fenugreek seeds:extraction,purification,and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R P Yves D S Dominique M H | 1995 | Steroids1995，60，10： | 1 |
| 14 | Steroid saponins from fenugreek seeds:extraction,purification and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R Yves D Dominique M | 1995 | Steroids1995，60，： | 1 |
| 15 | Wide-area measurement based stabilizing control of large power systems-A decentralized/hierarchical approach显示文摘 | KAMWA I ROBERT M YVES H | | 0，，16： | 1 |
| 16 | Investigation of high-pressure selective adsorption/desorption behavior of CO2and CH4on coals:An experimental study显示文摘 | Andress B Yves G Bemhard M | 2006 | International Journal of Coal Geology2006，66，： | 1 |
| 17 | Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids显示文摘 | Yves M Dupertuis Michael M Meguid Claude Pichard | 2007 | Current Opinion in Clinical Nutrition and Metabolic Care2007，，4： | 1 |
| 18 | Comparison and study of different progressive collapse simulation tech- niques for RC structures 显示文摘 | KFIR M THIERRY J M YVES R | 2009 | Journal of Structural Engi- neering2009，135，6： | 1 |
| 19 | Bcl-2 protects against hyperoxia-induced apoptosis through inhibition of the mitochondria-dependent pathway显示文摘 | Isabelle Métrailler-Ruchonnet Alessandra Pagano Stephanie Carnesecchi Christiane Ody Yves Donati Constance Barazzone Argiroffo | 2007 | Free Radical Biology and Medicine2007，，： | 1 |
| 20 | Amination of Arenes with Electron-Deficient zodicarboxylates显示文摘 | Helen M Yves L | 1994 | J Org Chem1994，59，3： | 1 |
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