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| 1 | 白蛋白刺激肾小管上皮细胞表达基质金属蛋白酶2和9显示文摘目的探讨白蛋白对近端肾小管上皮细胞表达基质金属蛋白酶2(MMP-2)和MMP-9的影响。方法大鼠近端肾小管细胞株NRK52E培养至70%或100%融合时,分别给予不同浓度(0.1~1.0g/L)去脂和非去脂牛血清白蛋白(dBSA和BSA)刺激,于24、48、72h收集培养液,用明胶酶谱和Western印迹方法检测培养液MMP-2和MMP-9活性和蛋白水平。结果与空白对照组比较,1.0g/LBSA刺激未完全融合NRK52E72h后,MMP-2和MMP-9活性分别上调276%、176%(P〈0.05)。与刺激24h比较,1.0g/LBSA刺激72h,在未完全融合NRK52E的MMP-2和MMP-9活性分别上调536%、148%;在完全融合NRK52E分别上调212%、184%(P〈0.05)。与完全融合NRK52E比较,1.0g/LBSA刺激未完全融合NRK52E 72h,MMP-2活性上调增加了274%,MMP-9活性上调减少了45.1%(P〈0.05)。dBSA刺激结果与BSA类似。结论白蛋白刺激呈剂量和时间依赖性上调近端肾小管细胞表达MMP-2和MMP-9。细胞完全融合可抑制MMP-2表达,促进MMP-9表达。 | 孙良忠 Ibrini Juma Parker Emma 陈述枚 Johnson Timothy S. El Nahas A. Meguid | 2007 | 中华肾脏病杂志2007，23，8： | 9 |
| 2 | Accurate modelling of the crush behaviour of thin tubular columns using material point method显示文摘In this paper,we apply the material point method(MPM),also known as a meshfree method,to examine the crush behaviour of thin tubular columns.Unlike the finite element method,randomly-distributed-weak-particle triggers were used to account for the deformation behaviour of collapse modes.Both symmetric and asymmetric modes of deformation and their associated mean collapse loads are determined for an elasto-plastic constitutive law describing the tubular columns.Attention was devoted to the accuracy and the convergence of the MPM simulation,which is determined by the number of the particles and the size of the background cells used in our explicit solver.Furthermore,a novel contact approach was adopted to establish the crush behaviour of the tubular columns.Two aspects of the work were accordingly examined,including three different crush velocities(5,10 and 15 m/s) and varied geometrical features of the tube(t/d and l/d) based on the deformation history.The results of our model,which were compared with existing analytical predictions and experimental findings,identify the critical geometric features of the tubular columns that would dictate the deformation mode as being either progressive collapse or following Euler's buckling mode. | YANG PengFei MEGUID S.A. ZHANG Xiong | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 4 |
| 3 | 慢性肾脏病的负担 全球范围快速增长显示文摘 | Rizwan A Hamer A Meguid El Nahas 师素芳(译) 赵明辉(校) | 2006 | 英国医学杂志中文版2006，9，3： | 3 |
| 4 | Analysis of cracks perpendicular to bimaterial interfaces using a novel finite element显示文摘 | S. A. Meguid M. Tan Z. H. Zhu | 1985 | International Journal of Fracture1985，，1： | 2 |
| 5 | 外科实践中的营养支持(下)显示文摘对可能需要手术的高危病人入院后即给予肠内或肠外营养可减少术后并发症,降低死亡率。这组病人包括炎性肠道疾病,胃肠道瘘和胰腺炎。对器官衰竭的病人,适当的营养支持有助于病人在器官功能恢复前耐受疾病引起的代谢异常。消化系统疾病【短肠综合征】胃肠外营养的发明极大地提高短肠病人术后救治成功率,使残存肠管的结构与功能有时间发生适应性改变。 | Meguid MM 李宁 | 1991 | 国外医学(外科学分册)1991，18，1： | 2 |
| 6 | Aspects of amino acid and protein metabolism in cancer-bearing states显示文摘 | Landel AM Hammond WG Meguid MM | 1995 | Cancer1995，，： | 1 |
| 7 | Elasto-pastic Co-indentation A-nalysis of a Bounded Solid Using Finite Element Method显示文摘 | MEGUID S A KLAIR M S | 1985 | Int J Mech Sci1985，27，3： | 1 |
| 8 | Three-dimensional finite element analysis of cold expansion of adjacent holes显示文摘 | P Papanikos S.A Meguid | 1998 | International Journal of Mechanical Sciences1998，，： | 1 |
| 9 | Nutritional management of patients with gastrointestinal fistulas显示文摘 | Meguid MM Campos AC | 1996 | Surg Clin North Am1996，76，： | 1 |
| 10 | Finite element analysis of fir-tree region in turbine dises显示文摘 | Meguid S A Kanth P S Czekanski A | 2000 | Finite Elements in Analysis and Design2000，35，4： | 1 |
| 11 | On the Imple- mentation of Novel Generalized Nonlinear Con- straints in Explicit Finite Element Formulations 显示文摘 | HoRJ Sauv6 R G Meguid S A | 2004 | Computer Technology and Applications2004，482，： | 1 |
| 12 | Adenomyomatosis of the gallbladder显示文摘 | Meguid MM Aun F Bradford ML | 1984 | Am J Surg1984，147，2： | 1 |
| 13 | Evaluation of the effect of losartan and methotrexate combined therapy in adjuvant-induced arthritis in rats显示文摘 | Refaat R Salama M Abdel Meguid E | 2013 | Eur J Pharmacol2013，698，13： | 1 |
| 14 | FiniteElement Analysis of Fr-Tree Region in Turbine Discs显示文摘 | MEGUID SA KANTH PS CZEKANSKI A | 2000 | Finite Elem And Design2000，5，4： | 1 |
| 15 | FE Analysis of Geometry Effects of an Artificial Bird Striking an Aeroengine fan Blade 显示文摘 | Meguid S A Mao R H Ng T Y | 2008 | International Journal of Impact Engineering2008，，35： | 1 |
| 16 | Three dimensional nonlinear finite element analysis of dovetail joints in aeroengine dises显示文摘 | Papanikos P Meguid S A Stjepanovic Z | 1998 | Finite Elements in Analysis and Design1998，29，： | 1 |
| 17 | Nutrition,physical activity,and obesity显示文摘 | Das U N Meguid M M | 2002 | Lancet2002，360，9341： | 1 |
| 18 | Chronic kidney disease:the global challenge显示文摘 | Meguid EI Nahas A Bello AK | 2005 | Lancet2005，365，9456： | 1 |
| 19 | Finite Ele- ment Analysis of Fir-Tree Region in Turbine Discs 显示文摘 | Papanikos P Meguid S A Czekanski A | 2000 | Finite Element in Analysis and Design2000，35，： | 1 |
| 20 | Finite element modelling of shot-peening residual stresses 显示文摘 | Meguid S A Shagal G Stranart J C | 1999 | Journal of Materials Processing Technology1999，，： | 1 |
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