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| 1 | Localization of HCV RNA and capsid protein in human hepatocellular carcinoma显示文摘INTRODUCTIONThe relation of HCV to hepatocytic carcinoma(HCC) has been emphasized recently in low HBVinfection countries and regions.The distributionpatterns of HCV in liver tissues are not wellunderstood although studies on HCV infection inblood and hepatocytes have been conducted byPCR.In this study,42 liver cancers | Dai YM Shou ZP Ni CR Wang NJ Zhang SP | 2000 | World Journal of Gastroenterology2000，6，1： | 15 |
| 2 | Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment显示文摘Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ between individual patients and even among individual tumor regions.In recent years,large-scale genomic studies and new next-generation sequencing technologies have uncovered more scientifc details about tumor heterogeneity,with significant implications for the choice of specific molecular biomarkers and clinical decision making Genomic heterogeneity signifcantly contributes to the generation of a diverse cell population during tumor development and progression,representing a determining factor for variation in tumor treatment response.It has been considered a prominent contributor to therapeutic failure,and increases the likelihood of resistance to future therapies in most common cancers.The understanding of molecular heterogeneity in cancer is a fundamental component of precision oncology,enabling the identification of genomic alteration of key genes and pathways that can be targeted therapeutically.Here,we review the emerging knowledge of tumor genomics and heterogeneity,as well as potential implications for precision medicine in cancer treatment and new therapeutic discoveries.An analysis and interpretation of the TCGA database was included. | Jialing Zhang Stephan Stanislaw Späth Sadie L.Marjani Wengeng Zhang Xinghua Pan | 2018 | Precision Clinical Medicine2018，1，1： | 5 |
| 3 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 4 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 5 | Clinical observation on YiSuiShengXueGranule on treating 156 patients with thalassemia major and the molecular mechanism study显示文摘 | Wu ZK Zhang XH | 2007 | Biol Pharm Bull2007，30，11： | 1 |
| 6 | Plant oil-based biofoam composites with balanced performance 显示文摘 | Wu SP Qiu JF Rong MZ Zhang MQ Zhang LY | 2009 | Polymer International2009，58，： | 1 |
| 7 | Human T ceils that are able to produce IL-17 express the chemokine receptor CCR6 显示文摘 | Singh SP Zhang HH Foley JF | 2008 | J Immunol2008，180，1： | 1 |
| 8 | Discussion of the CO2 Corrosion Mechanism between Low Partial Pressure and Supercritical Condition显示文摘 | Zhang YC Pang XL Qu SP | 2012 | Corrosion Science2012，59，： | 1 |
| 9 | Neuroprotective effect of the endogenous neural peptide Apelin in cultured mouse cortical neurons 显示文摘 | Zeng XJ Yu SP Zhang L | 2010 | Exp Cell Res2010，316，11： | 1 |
| 10 | Human T cells that are able to produce IL-17 express the chemokine re-ceptor CCR5 显示文摘 | Singh SP Zhang HH Foley JF Hedrick MN Farber JM | 2008 | J Immunol2008，180，1： | 1 |
| 11 | Loss of expression of SDHA predicts SDHA mutations in gastrointestinal stromal tumors 显示文摘 | Wagner A J Remillard SP Zhang YX | 2013 | Mod Pathol2013，26，2： | 1 |
| 12 | Study of operational performance and electrical response on mediator-less microbial fuel cells fed with carbonand protein-rich substrates显示文摘 | Liu ZD Liu J Zhang SP | 2009 | Bioche Eng J2009，45，3： | 1 |
| 13 | Neuropmtective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons 显示文摘 | Zeng XJ Yu SP Zhang L | 2010 | Exp Cell Res2010，316，11： | 1 |
| 14 | The use of flow cytometry to detect expression of subunits encoded by 11 Salmonella enterica serotype Typhimurium fimbrial operons 显示文摘 | Humphries AD Raffatellu M Winter S Weening EA Droleskey R Zhang SP Figueiredo J Khare S Nunes J Adams LG Tsolis RM Baumler AJ | 2003 | Mol Microbiol2003，48，5： | 1 |
| 15 | Effects of hydroxyapatite ultrafine powder or colony formation and cytoskeletones of MGC80-3 cell显示文摘 | Li SP Zhang SC Chen WJ | 1998 | Bioceramics1998，9，2： | 1 |
| 16 | Concurrent chemoradiotherapy with paclitax- el and nedaplatin followed by consolidation chemotherapy in locally ad- vanced squamons cell carcinoma of the uterine cervix: preliminary results of a phase lI study 显示文摘 | Zhang MQ Liu SP Wang XE | 2010 | Int J Radiat Oncol Biol Phys2010，78，3： | 1 |
| 17 | A new method to measure effective soil solution concentration predicts copper availability to plants显示文摘 | Zhang H Zhao F J Sun B Davison W McGrath SP | 2001 | Environmental Science and Technology2001，35，12： | 1 |
| 18 | New gene for bacterial blight resistance in rice located on chromosome 12 identified from Minghui63 an elite restorer line 显示文摘 | Chen HL Wang SP Zhang QF | 2002 | Phytopathology2002，92，7： | 1 |
| 19 | D-ring-opened phragmalin type limonoid orthoesters from the twigs of Swieteniamacrophylla显示文摘 | Lin BD Zhang CR Yang SP | 2009 | J Nat Prod2009，72，7： | 1 |
| 20 | Hypoglycemic activity of polysaccharide with antioxidation isolated from cultured Cordyceps mycelia 显示文摘 | Li SP Zhang GH Zeng Q | 2006 | Phytomedicine2006，13，6： | 1 |
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