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| 1 | Synthesis of rod-like metal-organic framework(MOF-5)nanomaterial for efficient removal of U(Ⅵ):batch experiments and spectroscopy study显示文摘With the widespread application of radionuclide235 U(Ⅵ), it is inevitable that part of U(Ⅵ) is released into the natural environment. The potential toxicity and irreversibility impact on the natural environment has become one of the most forefront pollution problems in nuclear energy utilization. In this work, rod-like metal-organic framework(MOF-5) nanomaterial was synthesized by a solvothermal method and applied to efficiently adsorb U(Ⅵ) from aqueous solutions. The batch experimental results showed that the sorption of U(Ⅵ) on MOF-5 was strongly dependent on p H and independent of ionic strength, indicating that the dominant interaction mechanism was inner-sphere surface complexation and electrostatic interaction. The maximum sorption capacity of U(Ⅵ) on MOF-5 was 237.0 mg/g at p H 5.0 and T = 298 K, and the sorption equilibrium reached within 5 min. The thermodynamic parameters indicated that the removal of U(Ⅵ) on MOF-5 was a spontaneous and endothermic process. Additionally, the FT-IR and XPS analyses implied that the high sorption capacity of U(Ⅵ) on MOF-5 was mainly attributed to the abundant oxygen-containing functional groups(i.e., CAO and C@O). Such a facile preparation method and efficient removal performance highlighted the application of MOF-5 as a candidate for rapid and efficient radionuclide contamination's elimination in practical applications. | Yihan Wu Hongwei Pang Wen Yao Xiangxue Wang Shujun Yu Zhimin Yu Xiangke Wang | 2018 | Science Bulletin2018，63，13： | 21 |
| 2 | A novel ionic liquids-based scrubbing process for efficient CO_(2) capture显示文摘A novel alkanolamine-based ionic liquid,N-methyl-diethanolammonium tetrafluoroborate ([MDEA][BF4]),was synthesized in our laboratory.The ionic liquid-based composite solution consisting of N-methyl-diethanolamine (MDEA),[MDEA][BF4],piperazine (PZ) and H2O was investigated for CO_(2) capture.The optimal performance for CO_(2) capture was found at 45°C,1.50 MPa,probably due to a synergistic action of the reaction and the transport.No apparent corrosion was found on stainless and carbon steel with the above composite solution.This finding is very significant to the promotion of its engineering application. | ZHANG SuoJiang ZHANG XiangPing ZHAO YanSong ZHAO GuoYing YAO XiaoQian YAO HongWei | 2010 | Science China Chemistry2010，53，7： | 16 |
| 3 | Burden of colorectal cancer in China, 1990-2017: Findings from the Global Burden of Disease Study 2017显示文摘Objective: Our goal is to analyze the trend of colorectal cancer(CRC) regarding the death, incidence and prevalence rates over time, and to provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes of CRC in 2017 to those data in 1990, which was extracted from the Global Burden of Disease(GBD).Methods: The time trend and changes of CRC burden from 1990 to 2017 were measured by using the methods and results from the Institute for Health Metrics and Evaluation(IHME) GBD 2017, based on the rates of death,incidence and prevalence.Results: The death rate of CRC is 13.24/100,000, accounting for 1.79% of total deaths in China in 2017. In1990, CRC ranked 21 st in all causes of death in China compared to its 11 th ranking in 2017. The death, incidence and prevalence rate of CRC were standardized by the age scale of the global population in 2010, the change of standardized death rate of CRC was not significant, from 9.33/100,000 in 1990 to 10.10/100,000 in 2017. The standardized incidence rate of CRC significantly increased from 12.18/100,000 in 1990 to 22.42/100,000 in 2017.The standardized prevalence rate of CRC significantly increased from 44.55/100,000 in 1990 to 118.40/100,000 in2017. The trend of the prevalence rate in both genders grow higher in 2017 compared to the 1990, resulting in141.6%, 209.8% and 189.0% for the studied three age groups(15-49, 50-69 and 70+ years old), respectively. The death rate increased in the age groups of 50-69 and 70+ years in both genders(8.6% and 31.0% respectively), in contrast to a decrease of death rate in the age group of 15-49 years old(-10.8%).Conclusions: China experienced a stunning increase in terms of incidence and prevalence rate of CRC from1990 to 2017. To decrease the burden of CRC, prevention and management of known risk factors should be promoted through national polices. | Jie Yin Zhigang Bai Jun Zhang Zhi Zheng Hongwei Yao Pengpeng Ye Jun Li Xin Gao Zhongtao Zhang | 2019 | Chinese Journal of Cancer Research2019，31，3： | 16 |
| 4 | The impact of the new cooperative medical scheme on financial burden of tuberculosis patients: evidence from six counties in China显示文摘Background:Tuberculosis(TB)patients in China encounter heavy financial burdens throughout the course of their treatment and it is unclear how China’s health insurance systems affect the alleviation of this burden under the integrated approach.This study aimed to measure reimbursement for TB services under the New Cooperative Medical Scheme(NCMS)in rural China and to evaluate changes in catastrophic health expenditure(CHE)caused by the reimbursement policies.Methods:Reimbursement data were obtained from routine data systems for the NCMS in Yichang(YC)and Hanzhong(HZ).1884 TB inpatients reimbursed by NCMS from 2010 to 2012 were included.Household surveys were conducted.A total of 494 TB patients under the NCMS were selected in this paper.12 Focus Group Discussions(FGDs)were held.We measured the impact of the NCMS by counterfactual analysis,which analyzed the financial burden alleviation.Equity was assessed by Concentration Index(CI),and disaggregated by project sites.Results:TB inpatients were reimbursed with an effective reimbursement rate of 57.3%.Average out-of-pocket(OOP)payments for outpatient and inpatient services after diagnosis were 1413 yuan and 430 yuan,and 3572 yuan and 3013 yuan in YC and HZ,respectively.The reimbursement level for TB outpatient care after diagnosis was very low due to a limited outpatient quota.TB patients in HZ incurred higher effective reimbursement rates,but the incidence of CHE remained higher.The reduction of CHE incidence after the NCMS showed no difference statistically(P>0.05).The severity of CHE was alleviated slightly.CIs after reimbursement were all below zero and their absolute values were higher than those before reimbursement.Conclusions:Low reimbursement for TB patients could lead to heavy financial burden.Poor TB patients incurred high rates of CHE.The NCMS was found to be a protective factor for CHE,but the impact was modest and the equity of CHE did not improve.The NCMS reimbursement policies should be improved in the future to include a more comprehensive coverage of care.Supplemental programs may be necessary to expand coverage for TB care. | Li Xiang Yao Pan Shuangyi Hou Hongwei Zhang Kaori DSato Qiang Li Jing Wang Shenglan Tang | 2016 | Infectious Diseases of Poverty2016，5，1： | 9 |
| 5 | Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions显示文摘Genotyping and phenotyping large natural populations provide opportunities for population genomic analysis and genome-wide association studies(GWAS). Several rice populations have been re-sequenced in the past decade;however, many major Chinese rice cultivars were not included in these studies. Here, we report large-scale genomic and phenotypic datasets for a collection mainly comprised of 1,275 rice accessions of widely planted cultivars and parental hybrid rice lines from China. The population was divided into three indica/Xian and three japonica/Geng phylogenetic subgroups that correlate strongly with their geographic or breeding origins. We acquired a total of 146 phenotypic datasets for 29 agronomic traits under multi-environments for different subpopulations. With GWAS, we identified a total of 143 significant association loci, including three newly identified candidate genes or alleles that control heading date or amylose content. Our genotypic analysis of agronomically important genes in the population revealed that many favorable alleles are underused in elite accessions, suggesting they may be used to provide improvements in future breeding efforts. Our study provides useful resources for rice genetics research and breeding. | Xiuxiu Li Zhuo Chen Guomin Zhang Hongwei Lu Peng Qin Ming Qi Ying Yu Bingke Jiao Xianfeng Zhao Qiang Gao Hao Wang Yunyu Wu Juntao Ma Liyan Zhang Yongli Wang Lingwei Deng Shanguo Yao Zhukuang Cheng Diqiu Yu Lihuang Zhu Yongbiao Xue Chengcai Chu Aihong Li Shigui Li Chengzhi Liang | 2020 | Science China(Life Sciences)2020，63，11： | 8 |
| 6 | The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice显示文摘Hepatic ischemia/reperfusion injury(HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein, we investigated the potential contribution of gut microbes to HIRI.Ischemia/reperfusion surgery was performed to establish a murine model of HIRI. 16 S r RNA gene sequencing and metabolomics were used for microbial analysis. Transcriptomics and proteomics analysis were employed to study the host cell responses. Our results establish HIRI was significantly increased when surgery occurred in the evening(ZT12, 20:00) when compared with the morning(ZT0, 08:00);however, antibiotic pretreatment reduced this diurnal variation. The abundance of a microbial metabolite3,4-dihydroxyphenylpropionic acid was significantly higher in ZT0 when compared with ZT12 in the gut and this compound significantly protected mice against HIRI. Furthermore, 3,4-dihydroxyphenylpropionic acid suppressed the macrophage pro-inflammatory response in vivo and in vitro. This metabolite inhibits histone deacetylase activity by reducing its phosphorylation. Histone deacetylase inhibition suppressed macrophage pro-inflammatory activation and diminished the diurnal variation of HIRI. Our findings revealed a novel protective microbial metabolite against HIRI in mice. The potential underlying mechanism was at least in part, via 3,4-dihydroxyphenylpropionic acid-dependent immune regulation and histone deacetylase(HDAC) inhibition in macrophages. | Rui Li Li Xie Lei Li Xiaojiao Chen Tong Yao Yuanxin Tian Qingping Li Kai Wang Chenyang Huang Cui Li Yifan Li Hongwei Zhou Neil Kaplowitz Yong Jiang Peng Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 7 | Advanced hydrogels for the repair of cartilage defects and regeneration显示文摘Cartilage defects are one of the most common symptoms of osteoarthritis(OA),a degenerative disease that affects millions of people world-wide and places a significant socio-economic burden on society.Hydrogels,which are a class of biomaterials that are elastic,and display smooth surfaces while exhibiting high water content,are promising candidates for cartilage regeneration.In recent years,various kinds of hydrogels have been developed and applied for the repair of cartilage defects in vitro or in vivo,some of which are hopeful to enter clinical trials.In this review,recent research findings and developments of hydrogels for cartilage defects repair are summarized.We discuss the principle of cartilage regeneration,and outline the requirements that have to be fulfilled for the deployment of hydrogels for medical applications.We also highlight the development of advanced hydrogels with tailored properties for different kinds of cartilage defects to meet the requirements of cartilage tissue engineering and precision medicine. | Wei Wei Yuanzhu Ma Xudong Yao Wenyan Zhou Xiaozhao Wang Chenglin Li Junxin Lin Qiulin He Sebastian Leptihn Hongwei Ouyang | 2021 | Bioactive Materials2021，6，4： | 8 |
| 8 | Mechanisms of Qi-blood circulation and Qi deficiency syndrome in view of blood and interstitial fluid circulation显示文摘OBJECTIVE: Based on comparison between fundamental theories of Traditional Chinese Medicine (TCM) and Western Medicine (WM) and modern scientific research on meridians, we find that 'Qi' in TCM is closely related to tissue fluid. In this study, the essence of Qi is explored in the view of circulation of blood and interstitial fluid. METHODS: Because the concept of Qi is complicated, Qi deficiency syndrome (QDS) is chosen to probe the relationship between of Qi deficiency and Qi-blood circulation (QBC). We analyze Qi-blood theory in terms of WM, set up a hemodynamic model to describe QBC, and review clinical research on QDS in the view of blood-interstitial fluid circulation. RESULTS: QDS is caused by imbalances of substance exchanges between blood and interstitial fluid, leading to an increase in the interstitial liquid volume or a decrease in nutrients and retention ofmetabolic wastes in interstitial fluid. CONCLUSION: This study describes the essence of Qi, providing support for further research on theories of Qiand Qi-blood circulation inTCM. | Wei Yao Hongwei Yang Guanghong Ding | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 8 |
| 9 | In-situ reduction synthesis of manganese dioxide@polypyrrole core/shell nanomaterial for highly efficient enrichment of U(Ⅵ) and Eu(Ⅲ)显示文摘Radionuclides with long half-life are toxic,and thereby result in serious threat to human beings and ecological balance.Herein,a simple two-step synthesis method was used to prepare manganese dioxide@polypyrrole(Mn O_2@PPy)core/shell structures for efficient removal of U(Ⅵ)and Eu(Ⅲ)from aqueous solutions.The adsorption of U(Ⅵ)and Eu(Ⅲ)were investigated under different kinds of experimental conditions.The experimental results suggested that the adsorption of U(Ⅵ)and Eu(Ⅲ)on Mn O_2@PPy were greatly affected by p H.U(Ⅵ)adsorption on Mn O_2@PPy was independent of ionic strength at p H<6.0,and dependent on ionic strength at p H>6.0.However,Eu(Ⅲ)adsorption on Mn O_2@PPy was independent of ionic strength at the whole p H range of experimental conditions.The maximum adsorption capacities(q_(max))of U(Ⅵ)and Eu(Ⅲ)were 63.04 and54.74 mg g^(-1)at T=298 K,respectively.The BET,XRD,FTIR and XPS analysis evidenced that high adsorption capacities of U(Ⅵ)and Eu(Ⅲ)on Mn O_2@PPy were mainly due to high surface area and rich metal oxygen-containing group(i.e.,Mn–OH and Mn–O),and the interaction was mainly attributed to strong surface complexation and electrostatic interaction.This study highlighted the excellent adsorption performance of U(Ⅵ)and Eu(Ⅲ)on Mn O_2@PPy and could provide the reference for the elimination of radionuclides in real wastewater management. | Wen Yao Yihan Wu Hongwei Pang Xiangxue Wang Shujun Yu Xiangke Wang | 2018 | Science China Chemistry2018，61，7： | 7 |
| 10 | Mathematical Model and Experiment Validation of Fluid Torque by Shear Stress under Influence of Fluid Temperature in Hydro-viscous Clutch显示文摘The current design of hydro-viscous clutch(HVC)in tracked vehicle fan transmission mainly focuses on high-speed and high power.However,the fluid torque under the influence of fluid temperature can not be predicted accurately by conventional mathematical model or experimental research.In order to validate the fluid torque of HVC by taking the viscosity-temperature characteristic of fluid into account,the test rig is designed.The outlet oil temperature is measured and fitted with different rotation speed,oil film thickness,oil flow rate,and inlet oil temperature.Meanwhile,the film torque can be obtained.Based on Navier-Stokes equations and the continuity equation,the mathematical model of fluid torque is proposed in cylindrical coordinate.Iterative method is employed to solve the equations.The radial and tangential speed distribution,radial pressure distribution and theoretical flow rate are determined and analyzed.The models of equivalent radius and fluid torque of friction pairs are introduced.The experimental and theoretical results indicate that tangential speed distribution is mainly determined by the relative rotating speed between the friction plate and the separator disc.However,the radial speed distribution and pressure distribution are dominated by pressure difference at the lower rotating speed.The oil film fills the clearance and the film torque increases with increasing rotating speed.However,when the speed reaches a certain value,the centrifugal force will play an important role on the fluid distribution.The pressure is negative at the outer radius when inlet flow rate is less than theoretical flow,so the film starts to shrink which decreases the film torque sharply.The theoretical fluid torque has good agreement with the experimental data.This research proposes a new fluid torque mathematical model which may predict the film torque under the influence of temperature more accurately. | CUI Hongwei YAO Shouwen YAN Qingdong FENG Shanshan LIU Qian | 2014 | Chinese Journal of Mechanical Engineering2014，27，1： | 6 |
| 11 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 12 | Seismic stability evaluation of embankment slope based on catastrophe theory显示文摘An evaluation method for the seismic stability of embankment slope was presented based on catastrophe theory. Seven control factors, including internal frictional angle, cohesion force, slope height, slope angle, surface gradients, peak acceleration, and distance to fault were selected for analysis of multi-level objective decomposition. According to the normalization formula and the fuzzy subject function produced by combination of catastrophe theory and fuzzy math, a recursive calculation was carried out to obtain a catastrophic affiliated functional value, which can be used to evaluate the seismic stability of embankment slope. Fifteen samples were used to verify the effectiveness of this method. The results show that compared with the traditional quantitative method, the catastrophe progression owns higher accuracy and good application potential in predicting the seismic stability of embankment slope. | Hongwei Zhu Lingkan Yao Yuan Luo | 2013 | Journal of Modern Transportation2013，21，2： | 5 |
| 13 | Activity of cold vortex in northeastern China and its connection with the characteristics of precipitation and circulation during 1960-2012显示文摘Based on the daily reanalysis data released by NCEP/NCAR and the daily precipitation of 753 Chinese stations from May to August during the period of 1960 to 2012, the statistical characteristics of the cold vortex in northeastern China were analyzed. In addition, the strength index, which described the characteristics of the vortex consistently and frequently, and the geographical distribution were given by continuous anomalies of circulation. Based on this index, the activity routines of the cold vortex, characteristics of atmospheric circulation, and their effects on precipitation in northeastern China were analyzed. The results show that: the activities of the cold vortex exhibit remarkable features of annual and interdecadal oscillation, and the vortex high frequency and its characteristics of atmospheric circulation are described more accurately by the strength index of the cold vortex, which shows a high correspondence with the vortex precipitation during early summer and midsummer in the northeast. In strong(weak) vortex years, the general circulation in the middle and high latitudes of Eurasia is to the advantage(disadvantage) of the formation, development and maintenance of the cold vortex, thus it is easy(difficult) to form the circulation which is beneficial to transmit vapor from south to north during the period of July to August. Blocking over the Ural Mountains prevails(does not prevail) in early summer, and blocking over the Sea of Okhotsk prevails(does not prevail) in midsummer. Areas where the subtropical high is too small(large) and moves toward the north too late(early) are better(worse) for the maintenance of the cold vortex in northeastern China. | LIU Gang FENG Guolin QIN Yulin CAO Ling YAO Hongwei LIU Ziqi | 2015 | Journal of Geographical Sciences2015，25，12： | 5 |
| 14 | Numerical analysis on water exchange and its response to the coastal engineering in the Yueqing Bay in China显示文摘On the basis of a numerical model of tidal current using Delft3D, the distribution of the semi - exchange time of water was simula- ted in the Yueqing Bay here. The result showed that the semi - exchange time was about more than 6 d in the bay end, and about 1~2 d in the bay mouth. Besides, based on the calculation of the semi - exchange time before and after the Xuanmen Dam pro- ject, a comparison between them was further carried out. And the same work was also done with the recent reclamation projects in the Yueqing Bay as well. The results showed that the change in semi - exchange time caused by the Xuanmen Dam project was a- bout 6 d increase near the dam and 4.5 d increase at the bay end. And it was about 5 d increase at the bay end and 1 d increase at the mouth of the bay caused by the recent reclamation projects. | LI Jia YAO Yanming LI Xiaoyan ZHANG Hongwei | 2008 | Acta Oceanologica Sinica2008，27，z1： | 5 |
| 15 | Fine relocation, mechanism, and tectonic indications of middle-small earthquakes in the Central Tibetan Plateau显示文摘The medium-small earthquakes that occurred in the middle part of Tibetan Plateau(32°N–36°N, 90°E–93°E) from August 2016 to June 2017 were relocated using the absolute earthquake location method Hypo2000. Compared to the reports of Chinese Seismological Networks, our relocation results are more clustered on the whole, the horizontal location differences exceed 10 km, and the focal depths are concentrated in 0–8 km, which indicates that the upper crust inside the Tibetan Plateau is tectonically active. In June2017 altogether eight earthquakes above magnitude 3.0 took place; their relocated epicenters are concentrated around Gêladaindong.The relocation results of M<3.0 small earthquakes also showed obvious differences. Therefore, we used the CAP method to invert for the focal mechanisms of the M ≥3.0 earthquakes; results generally tally with the surface geological structures, indicating that the Tibetan Plateau is still under the strong compressional force from the India Plate. Among them the eight earthquakes that occurred near Gêladaindong in June 2017 are all of normal fault type or with some strike-slip at the same time; based on previous research results we conjecture that these events are intense shallow crust responses to deep crust-mantle activities. | YuLan Li BaoShan Wang RiZheng He HongWei Zheng JiangYong Yan Yao Li | 2018 | Earth and Planetary Physics2018，2，5： | 4 |
| 16 | Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas显示文摘The limited molecular classifications and disease signatures of osteoarthritis(OA)impede the development of prediagnosis and targeted therapeutics for OA patients.To classify and understand the subtypes of OA,we collected three types of tissue including cartilage,subchondral bone,and synovium from multiple clinical centers and constructed an extensive transcriptome atlas of OA patients.By applying unsupervised clustering analysis to the cartilage transcriptome,OA patients were classified into four subtypes with distinct molecular signatures:a glycosaminoglycan metabolic disorder subtype(C1),a collagen metabolic disorder subtype(C2),an activated sensory neuron subtype(C3),and an inflammation subtype(C4).Through ligand-receptor crosstalk analysis of the three knee tissue types,we linked molecular functions with the clinical symptoms of different OA subtypes.For example,the Gene Ontology functional term of vasculature development was enriched in the subchondral bone-cartilage crosstalk of C2 and the cartilage-subchondral bone crosstalk of C4,which might lead to severe osteophytes in C2 patients and apparent joint space narrowing in C4 patients.Based on the marker genes of the four OA subtypes identified in this study,we modeled OA subtypes with two independent published RNA-seq datasets through random forest classification.The findings of this work contradicted traditional OA diagnosis by medical imaging and revealed distinct molecular subtypes in knee OA patients,which may allow for precise diagnosis and treatment of OA. | Chunhui Yuan Zongyou Pan Kun Zhao Jun Li Zixuan Sheng Xudong Yao Hua Liu Xiaolei Zhang Yang Yang Dongsheng Yu Yu Zhang Yuzi Xu Zhi-Yong Zhang Tianlong Huang Wanlu Liu Hongwei Ouyang | 2020 | Bone Research2020，8，4： | 4 |
| 17 | Pristine mesoporous carbon hollow spheres as safe adjuvants induce excellent Th2-biased immune response显示文摘放大有免疫力的反应到抗原的一个安全、有效的助手的发展为疫苗的交货是重要的。在这研究,我们开发了太古的 mesoporous 碳是的空范围为增加有免疫力的反应的高能力的疫苗的蛋白质 nanocarriers 和安全助手。单音分散入鞘空碳范围(IMHCS ) 有的 mesostructured 200 nm, 15 nm 的大毛孔尺寸,和为 SRCA 的 2.85 厘米 3 的高毛孔体积的一种平均粒子尺寸。以便证实这试金的特性,包括属于不同 Shigella 种类和 23 个 non-Shigella 细菌的 11 个种类的 34 个种类与纯文化被检测。由 SRCA 的 Shigella flexneri 的敏感用 agarose 胶化电气泳动被评估,它是 7.3 ?> 并且 CH 4( 大约 13 ? ktonnd FE-SEM 证明 grafting 是成功的。我们然后证明 grafted 膜用吸附对牛的浆液白朊而且葡聚糖显示出优秀低犯规的性质不仅吗?? | Manasi Jambhrunkar Meihua Yu Hongwei Zhang Prasanna Abbaraju Anand Kumar Meka Antonino Cavallaro Yao Lu Neena Mitter Chengzhong Yu | 2018 | Nano Research2018，11，1： | 4 |
| 18 | Pseudo-noise preamble based joint frame and frequency synchronization algorithm in OFDM communication systems显示文摘Frame and frequency synchronization are essential for orthogonal frequency division multiplexing(OFDM) systems. The frame offset owing to incorrect start point position of the fast Fourier transform(FFT) window, and the carrier frequency offset(CFO) due to Doppler frequency shift or the frequency mismatch between the transmitter and receiver oscillators, can bring severe intersymbol interference(ISI) and intercarrier interference(ICI) for the OFDM system. Relying on the relatively good correlation characteristic of the pseudonoise(PN) sequence, a joint frame offset and normalized CFO estimation algorithm based on PN preamble in time domain is developed to realize the frame and frequency synchronization in the OFDM system. By comparison, the performances of the traditional algorithm and the improved algorithm are simulated under different conditions. The results indicate that the PN preamble based algorithm both in frame offset estimation and CFO estimation is more accurate, resourcesaving and robust even under poor channel condition, such as low signaltonoise ratio(SNR) and large normalized CFO. | Qingfeng Jing Ming Cheng Yuping Lu Weizhi Zhong Hongwei Yao | 2014 | Journal of Systems Engineering and Electronics2014，25，1： | 4 |
| 19 | ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI显示文摘Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P? | Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han | 2019 | Science Bulletin2019，64，14： | 3 |
| 20 | A cynomolgus monkey with naturally occurring Parkinson’s disease显示文摘Evidence for the existence of monkeys with spontaneous Parkinson’s disease(PD)has been lacking.Here,we screened macaque colonies at the Kunming Primate Research Center(Association for Assessment and Accreditation of Laboratory Animal Care(AAALAC)accredited),Kunming Institute of Zoology,Chinese Academy of Sciences,which has a large population of monkeys(>2400),to identify naturally occurring PD monkeys. | Hao Li Ling-Yan Su Lixin Yang Min Li Qianjin Liu Zhenhui Li Yan Hu Hongwei Li Shihao Wu Wenchao Wang Yingzhou Hu Zhengbo Wang Joshua DRizak Baihui Huang Min Xu Jing Wu Long-Bao Lv Christoph W.Turck Yong Yin Yong-Gang Yao Bing Su Xintian Hu | 2021 | National Science Review2021，8，3： | 3 |
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