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| 1 | Discovery of mitochondrial chimeric-gene associated with cytoplasmic male sterility of HL-rice显示文摘The mitochondrial genome libraries of HL-type sterile line(A) and maintainer line(B) have been constructed. Mitochondrial gene, atp6, was used to screen libraries, due to the different Southern and Northern blot results between sterile and maintainer line. Sequencing analysis of positive clones proved that there were two copies of atp6 gene in sterile line and only one in maintainer line. One copy of atpt6 in sterile line was same to that in maintainer line; the other showed different flanking sequence from the 49th nucleotide downstream of the termination codon of atp6 gene. A new chimeric gene, orfH79, was found in the region. OrfH79 had homology to mitochondrial gene cox Ⅱ and orf107, and was special to HL-sterile cytoplasm. | Yl Ping WANG Li SUN Qingping ZHU Yingguo | 2002 | Chinese Science Bulletin2002，47，9： | 36 |
| 2 | Submarine Landslides on the North Continental Slope of the South China Sea显示文摘Recent and paleo-submarine landslides are widely distributed within strata in deep-water areas along continental slopes, uplifts, and carbonate platforms on the north continental margin of the South China Sea(SCS). In this paper, high-resolution 3D seismic data and multibeam data based on seismic sedimentology and geomorphology are employed to assist in identifying submarine landslides. In addition, deposition models are proposed that are based on specific geological structures and features, and which illustrate the local stress field over entire submarine landslides in deep-water areas of the SCS. The SCS is one of the largest fluvial sediment sinks in enclosed or semi-enclosed marginal seas worldwide. It therefore provides a set of preconditions for the formation of submarine landslides, including rapid sediment accumulation, formation of gas hydrates, and fluid overpressure. A new concept involving temporal and spatial analyses is tested to construct a relationship between submarine landslides and different time scale trigger mechanisms, and three mechanisms are discussed in the context of spatial scale and temporal frequency: evolution of slope gradient and overpressure, global environmental changes, and tectonic events. Submarine landslides that are triggered by tectonic events are the largest but occur less frequently, while submarine landslides triggered by the combination of slope gradient and overpressure evolution are the smallest but most frequently occurring events. In summary, analysis shows that the formation of submarine landslides is a complex process involving the operation of different factors on various time scales. | WANG Weiwei WANG Dawei WU Shiguo VOKER David ZENG Hongliu CAI Guanqiang LI Qingping | 2018 | Journal of Ocean University of China2018，17，1： | 11 |
| 3 | Effects of grain size on phase transition behavior of nanocrystalline shape memory alloys显示文摘We report recent advances in the experimental and theoretical study of grain size(GS)effects on the thermal and mechanical properties of nanostructured NiTi polycrystalline shape memory alloy(SMA).It is shown that when GS<60 nm,the superelastic stress-strain hysteresis loop area(H)of the polycrystal decreases rapidly with GS and tends to vanish as GS approaches 10 nanometers.At the same time,the temperature dependence of the transition stress also decreases with GS and eventually approaches zero,leading to a wide superelastic temperature window and breakdown of the Clausius-Claperyon relationship.Rate dependence of the stress-strain responses is significantly reduced and the cyclic stability of the material is improved by the nanocrystallization.It is proposed that the emergence of such significant changes in the behavior of the material with GS reduction originate from the large increase in the area-to-volume ratios of the nanometer-thick interfaces(grain boundary and Austenite-Martensite(A-M)interface)in the polycrystal.In particular,with GS reduction,interfacial energy terms will gradually become dominant over the bulk energy of the crystallite,eventually bring fundamental changes in the phase transition responses of the material.Modelling strategy leading to the establishment of quantitative relationships among GS,grain boundary,A-M interfaces and the macroscopic responses of the material are outlined. | SUN QingPing ASLAN Ahadi LI MingPeng CHEN MingXiang | 2014 | Science China(Technological Sciences)2014，57，4： | 9 |
| 4 | The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice显示文摘Hepatic ischemia/reperfusion injury(HIRI) is a serious complication that occurs following shock and/or liver surgery. Gut microbiota and their metabolites are key upstream modulators of development of liver injury. Herein, we investigated the potential contribution of gut microbes to HIRI.Ischemia/reperfusion surgery was performed to establish a murine model of HIRI. 16 S r RNA gene sequencing and metabolomics were used for microbial analysis. Transcriptomics and proteomics analysis were employed to study the host cell responses. Our results establish HIRI was significantly increased when surgery occurred in the evening(ZT12, 20:00) when compared with the morning(ZT0, 08:00);however, antibiotic pretreatment reduced this diurnal variation. The abundance of a microbial metabolite3,4-dihydroxyphenylpropionic acid was significantly higher in ZT0 when compared with ZT12 in the gut and this compound significantly protected mice against HIRI. Furthermore, 3,4-dihydroxyphenylpropionic acid suppressed the macrophage pro-inflammatory response in vivo and in vitro. This metabolite inhibits histone deacetylase activity by reducing its phosphorylation. Histone deacetylase inhibition suppressed macrophage pro-inflammatory activation and diminished the diurnal variation of HIRI. Our findings revealed a novel protective microbial metabolite against HIRI in mice. The potential underlying mechanism was at least in part, via 3,4-dihydroxyphenylpropionic acid-dependent immune regulation and histone deacetylase(HDAC) inhibition in macrophages. | Rui Li Li Xie Lei Li Xiaojiao Chen Tong Yao Yuanxin Tian Qingping Li Kai Wang Chenyang Huang Cui Li Yifan Li Hongwei Zhou Neil Kaplowitz Yong Jiang Peng Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 5 | Kinetic hydrate inhibitor performance of new copolymer poly(N-vinyl-2-pyrrolidone-co-2-vinyl pyridine)s with TBAB显示文摘In oil and gas field, the application of kinetic hydrate inhibitors (KHIs) independently has remained problematic in high subcooling and high water-cut situation. One feasible method to resolve this problem is the combined use of KHIs and some synergists, which would enhance KHIs’ inhibitory effect on both hydrate nucleation and hydrate crystal growth. In this study, a novel kind of KHI copolymer poly(N-vinyl-2-pyrrolidone-co-2-vinyl pyridine)s (HGs) is used in conjunction with TBAB to show its high performance on hydrate inhibition. The performance of HGs with different monomer ratios in structure II tetrahydrofuran (THF) hydrate is investigated using kinetic hydrate inhibitor evaluation apparatus by step-cooling method and isothermal cooling method. With the combined gas hydrate inhibitor at the concentration of 1.0 wt%, the induction time of 19 wt% THF solution could be prolonged to 8.5 h at a high subcooling of 6℃. Finally, the mechanism of HGs inhibiting the formation of gas hydrate is proposed. | Jun Hu Sijia Li Yanhong Wang Xuemei Lang Qingping Li Shuanshi Fan | 2012 | Journal of Natural Gas Chemistry2012，21，2： | 8 |
| 6 | Study of a Horizontal Shear Line over the Qinghai–Tibetan Plateau and the Impact of Diabatic Heating on Its Evolution显示文摘Based on the 4 times daily 0.75°× 0.75° ERA-Interim data, the structural evolution of a Qinghai–Tibetan Plateau horizontal(east–west-oriented) shear line(TSL) during 15–19 August 2015 and the effect of diabatic heating on its evolution were analyzed. The results show that the TSL possessed a vertical thickness of up to 1.5 km(approximately 600–450 h Pa), and was baroclinic in nature. Weak ascending motions occurred near the TSL, accompanied with more significant gradients in dew point temperature than in temperature. The TSL was characterized by diurnal variations in its appearance and structure. It was relatively full in shape(broken) and was the lowest(highest) in vertical extent at 0000(1800) UTC, and veered clockwise(anticlockwise) during 0000–0600(1200–1800) UTC. When the north–south span of the TSL increased, it was prone to fracturing; and it disappeared when the dew point temperature gradients to its either side decreased. When the TSL moved northward(southward), its western(eastern) section broke up, while the eastern(western) section inclined to regenerate or merge. The TSL tended to move towards the positive vorticity areas with significant increases in vorticity. When the positive vorticity center moved down, the height of TSL decreased. Further analysis shows that the plateau surface heating dominated the vorticity attribute of the TSL and its movement, with different contributions from local variation, horizontal advection, and vertical advection of the diabatic heating to the TSL at different heights. | Qin GUAN Xiuping YAO Qingping LI Yuancang MA Honghua ZHANG | 2018 | Journal of Meteorological Research2018，32，4： | 7 |
| 7 | Carbon-based derivatives from metal-organic frameworks as cathode hosts for Li–S batteries显示文摘Lithium-sulfur batteries(Li–S batteries) are promising candidates for the next generation high-energy rechargeable Li batteries due to their high theoretical specific capacity(1672 m Ahg-1) and energy density(2500 Wh kg-1). The commercialization of Li–S batteries is impeded by several key challenges at cathode side, e.g. the insulating nature of sulfur and discharged products(Li2S 2 and Li2S), the solubility of long-chain polysulfides and volume variation of sulfur cathode upon cycling. Recently, the carbonbased derivatives from metal-organic frameworks(MOFs) has emerged talent in their utilization as cathode hosts for Li–S batteries. They are not only highly conductive and porous to enable the acceleration of Li +/e-transfer and accommodation of volumetric expansion of sulfur cathode during cycling, but also enriched by controllable chemical active sites to enable the adsorption of polysulfides and promotion of their conversion reaction kinetics. In this review, based on the types of MOFs(e.g. ZIF-8, ZIF-67, Prussian blue, Al-MOF, MOF-5, Cu-MOF, Ni-MOF), the synthetic methods, formation process and morphology, structural superiority of MOFs-derived carbon frameworks along with their electrochemical performance as cathode host in Li–S batteries are summarized and discussed. | Qingping Wu Xuejun Zhou Jun Xu Fahai Cao Chilin Li | 2019 | Journal of Energy Chemistry2019，28，11： | 7 |
| 8 | Transcriptomic analyses identify albino-associated genes of a novel albino tea germplasm ‘Huabai 1’显示文摘Albinism in shoots of tea plants is a common phenotypic expression which gives the tea infusion a pleasant umami taste.A novel natural albino mutant tea germplasm containing high amino acids content was found and named as‘Huabai 1’.‘Huabai 1’has white jade tender shoots under low temperature and turns green with increased temperature.In order to understand the molecular mechanism of color change in leaf of‘Huabai 1’,transcriptome analysis was performed to identify albino-associated differentially expressed genes(DEGs).A total of 483 DEGs were identified from white shoots of‘Huabai 1’compared to its green shoots.There were 15 DEGs identified to be involved in phenylpropanoid biosynthesis,which account for the majority of characterized DEGs.The metabolites related to phenylpropanoid biosynthesis revealed similar expression pattern of DEGs.Furthermore,metabolic pathways such as ubiquonone,tyrosine,and flavonoid biosynthesis associated with phenylpropanoid biosynthesis could also contribute to the color change in‘Huabai 1’tender shoots.Protein–protein interaction analysis revealed a hub protein NEDD8(CSA009575)which interacted with many regulated genes in spliceosome,nitrogen metabolism,phenylpropanoid biosynthesis,and other pathways.In conclusion,the findings in this study indicate that the color change of‘Huabai 1’tender shoots is a combined effect of phenylpropanoid biosynthesis pathway and other metabolic pathways including flavonoid biosynthesis in tea plants.Chlorophyll biosynthesis-related genes LHCII and SGR may also play some roles in color change of‘Huabai 1’. | Qingping Ma Huan Li Zhongwei Zou Emmanuel Arkorful Qianru Lv Qiongqiong Zhou Xuan Chen Kang Sun Xinghui Li | 2018 | Horticulture Research2018，5，1： | 7 |
| 9 | Artemisinin mimics calorie restriction to extend yeast lifespan via a dual-phase mode: a conclusion drawn from global transcriptome profiling显示文摘Calorie restriction(CR) promotes longevity among distinct organisms from yeast to mammals. Although CR-prolonged lifespan is believed to associate with enhanced respiratory activity, it is apparently controversial for accelerated energy consumption regardless of insufficient nutrient intake. In reconciling the contradiction of less food supply versus much metabolite dispense, we revealed a CR-based mode of dual-phase responses that encompass a phase of mitochondrial enhancement(ME) and a phase of post-mitochondrial enhancement(PME), which can be distinguished by the expression patterns and activity dynamics of mitochondrial signatures. ME is characterized by global antioxidative activation, and PME is denoted by systemic metabolic modulation. CR-mediated aging-delaying effects are replicated by artesunate, a semi-synthetic derivative of the antimalarial artemisinin that can alkylate heme-containing proteins, suggesting artesunate-heme conjugation functionally resembles nitric oxide-heme interaction. A correlation of artesunate-heme conjugation with cytochrome c oxidase activation has been established from adduct formation and activity alteration. Exogenous hydrogen peroxide also mimics CR to trigger antioxidant responses, affect signaling cascades, and alter respiratory rhythms, implying hydrogen peroxide is engaged in lifespan extension. Conclusively, artesunate mimics CR-triggered nitric oxide and hydrogen peroxide to induce antioxidative networks for scavenging reactive oxygen species and mitigating oxidative stress, thereby directing metabolic conversion from anabolism to catabolism, maintaining essential metabolic functionality, and extending life expectancy in yeast. | WANG DaTing WU Ming LI SiMing GAO Qian ZENG QingPing | 2015 | Science China(Life Sciences)2015，58，5： | 6 |
| 10 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 11 | Synthesis and application of a novel combined kinetic hydrate inhibitor显示文摘In oil and gas exploration and transportation,low dosage hydrate inhibitors(LDHIs) are more favorably utilized to inhibit the formation of hydrates than thermodynamic inhibitors(THs) as a trend. However,there are no industrial products of LDHIs available domestically,and the corresponding application experience is in urgent need. In this paper,a combined hydrate inhibitor(HY-1) was synthesized after a series of reaction condition optimization,and its performance on THF hydrate inhibition was investigated using kinetic hydrate inhibitor evaluation apparatus with 6 cells bathing in air. The results show that when the reaction temperature is 60°C,the reaction time is 6 h,and the monomer:solvent ratio is 1:2,the product has the best kinetic hydrate inhibitor performance on THF hydrate. On these bases,the scale-up production of this combined hydrate inhibitor was carried out. Although the scale-up product(HY-10) performs less effectively on the THF hydrate inhibition than HY-1,it functions better than a commercial product(Inhibex501) during in-house tests. HY-10 was successfully applied to the gas production process. Field trials in northern Shaanxi PetroChina Changqing Oilfield Company(PCOC) show that 2 wt% of HY-10 is effective on natural gas hydrate inhibition. It is found through economic analysis that the use of HY-10 has obvious economical advantage over methanol and Inhibex501. | HU Jun WANG YanHong LANG XueMei DU Juan LI QingPing FAN ShuanShi | 2011 | Science China(Technological Sciences)2011，54，12： | 6 |
| 12 | The simulation of nature gas production from ocean gas hydrate reservoir by depressurization显示文摘The vast amount of hydrocarbon gas encaged in gas hydrates is regarded as a kind of future potential energy supply due to its wide deposition and cleanness. How to exploit gas hydrate with safe, effective and economical methods is being pursued. In this paper, a mathematical model is developed to simulate the hydrate dissocia- tion by depressurization in hydrate-bearing porous medium. The model can be used to analyze the effects of the flow of multiphase fluids, the intrinsic kinetic process of hydrate dissociation, the endothermic process of hydrate dissociation, ice-water phase equilibrium, the variation of permeability, the convection and conduction on the hydrate dissociation and gas and water production. The nu- merical results agreed well with the 1-D and 2-D experiments. The numerical results for 3-D hydrate reservoir show that in the first stage of depressurization gas can be produced effectively from hydrate reservoir. With the depletion of reservoir energy because of endothermic process of hydrate dissociation the gas rate decreases rapidly. Then, methods such as thermal stimulation and inhibitor injection should be considered to replace | BAI YuHu LI QingPing LI XiangFang DU Yan | 2008 | Science China(Technological Sciences)2008，51，8： | 6 |
| 13 | Evaluation of seed production in a first-generation seed orchard of Chinese pine (Pinus tabuliformis)显示文摘We evaluated seed production in a first-generation orchard of Chinese pine(Pinus tabuliformis) during the crucial transition period from first generation to advanced generations.Clones varied significantly in all traits related to seed production.Repeatability of these traits ranged from 0 to 0.96.Seed production per ramet(SPPR),seed producing index(SPI),the number of relative female strobili(RFS),the number of scales,and the number of ineffective scales had comparatively high repeatability at 0.86,0.87,0.89,0.96,and 0.91,respectively.Correlation analysis showed that SPPR was greatly influenced by RFS and by the number of full seeds per cone.Finally,we showed that SPI was the best predictor of the seed-producing ability of clones.Our findings will assist seed orchard managers in effectively predicting and improving seed production of Chinese pine seed orchards. | Huwei Yuan Shihui Niu Xianqing Zhou Qingping Du Yue Li Wei Li | 2016 | Journal of Forestry Research2016，27，5： | 4 |
| 14 | Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults:Results from a Population-Based Study—Beijing,China,2017–2018显示文摘Summary What is already known about this topic?Metabolic syndrome(MetS)is one of the most easily available health indicative markers for cardiovascular diseases,and it has become a major public health problem worldwide due to increasing urbanization and aging populations.The prevalence of MetS increased dramatically in China,however,there are no records of MetS defined by the 2017 Chinese Diabetes Society for Beijing by far.What is added by this report?In this study,the data of 24,412 participants aged 18–74 years from a large population-based study in Beijing was collected.The overall prevalence of MetS among Beijing residents was 24.5%.The prevalence was 35.2%in males and 15.4%in females.What are the implications for public health practice?Effective public health strategies should target males,people with older age,lower education,higher body mass index,smokers,those who drink alcohol,those who are unemployed or retired,and those who live in rural areas on MetS prevention and control. | Jufen Liu Qingping Liu Zhiwen Li Jing Du Chao Wang Yanlin Gao Zaihua Wei Jing Wang Yunping Shi Jianting Su Yang Liu Ping Wang Chunyan Xie Gang Li Bing Shao Le Zhang | 2022 | China CDC weekly2022，4，29： | 4 |
| 15 | Visible and Infrared Video Fusion Using Uniform Discrete Curvelet Transform and Spatial-Temporal Information显示文摘Multiple visual sensor fusion provides an effective way to improve the robustness and accuracy of video surveillance system. Traditional video fusion methods fuse the source videos using static image fusion methods frame-by-frame without considering the information in temporal dimension. The temporal information can't be fully utilized in fusion procedure. Aiming at this problem, a visible and infrared video fusion method based on Uniform discrete curvelet transform(UDCT) and spatial-temporal information is proposed. The source videos are decomposed by using UDCT, and a set of local spatial-temporal energy based fusion rules are designed for decomposition coefficients. In these rules, we consider the current frame's coefficients and the coefficients on temporal dimension which are the coefficients of adjacent frames. Experimental results demonstrated that the proposed method works well and outperforms comparison methods in terms of temporal stability and consistency as well as spatial-temporal information extraction. | LI Qingping DU Junping XU Liang | 2015 | Chinese Journal of Electronics2015，24，4： | 4 |
| 16 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 17 | Free-volume evolution of glassy Zr_(65)Al_(7.5)Ni_(10)Cu_(17.5) during inhomogeneous deformation显示文摘Free-volume evolutions of the as-cast and pre-annealed Zr65Al7.5Ni10Cu17.5 metallic glasses during cold-rolling were investigated using differential scanning calorimetry. As deformation degree increases, free volume in the glasses always increases first and then saturates above a critical strain, while the structure remains completely amorphous. The glass with less initial free volume possesses a higher increase rate of free-volume content during deformation, and as a result the free-volume contents of all the glasses approach each other at higher strains. Coalescence of free volume in shear bands into nanovoids is proposed to be responsible for the saturation of free-volume content at high strains. | LIU HuiBin LI JinFut CAO QingPing ZHOU YaoHe | 2007 | Chinese Science Bulletin2007，52，24： | 4 |
| 18 | Numerical simulation on gas production from a hydrate reservoir underlain by a free gas zone显示文摘Physical and mathematical models of gas production by depressurization from a hydrate reservoir underlain by a free gas zone are established. The mathematical model can interpret the effects of the flow of multiphase fluids, the process of hydrate dissociation, ice-water phase transition, the variation of permeability, the convection and conduction on hydrate dissociation and gas and water production. The evolutions of temperature, pressure, and saturations in the hydrate and free gas zones are eluci-dated during gas production. The variation of some parameters, such as gas and water rates, with time is presented. The results show that the overlying hydrate zone can supply a certain amount of gas to improve the output of a production well and evidently prolong the lifespan of a gas reservoir. | BAI YuHu LI QingPing LI XiangFang DU Yan | 2009 | Chinese Science Bulletin2009，54，5： | 4 |
| 19 | Toxicity assessment and histopathological analysis of nano-ZnO against marine fish(Mugilogobius chulae) embryos显示文摘The toxicity of nano-materials has received increasing attention in recent years.Nevertheless,relatively few studies have focused on their oceanic distributions and toxicities.In this study,we assessed nano-ZnO toxicity in marine organisms using the yellowstriped goby(Mugilogobius chulae).The relative differences in nano-ZnO dissolution and dispersal in seawater and fresh water were also investigated.The effects of nano-ZnO on embryonic development,deformity,hatching,mortality,and histopathology were analyzed.In addition,the effects of the Zn^(2+) concentration on M.chulae hatching and mortality were compared.The results showed that nano-ZnO had higher solubility in seawater than in fresh water.Nano-ZnO significantly inhibited hatching.By the fifth day of exposure,the LC_(50) of nano-ZnO was 45.40 mg/L,and the mortality rate spiked.Hatching inhibition and lethality were dose-dependent over a range of1–25 mg/L nano-ZnO.Zn^(2+) inhibited hatching and increased lethality,but its effects were weaker than those of nano-ZnO at the same concentrations.Nano-ZnO also induced spinal bending,oedema,hypoplasia,and other deformities in M.chulae embryos and larvae.Histopathology revealed vacuolar degeneration,hepatocyte and enterocyte enlargement,and morphological abnormalities of the vertebrae.Therefore,nano-ZnO caused malformations in M.chulae by affecting embryonic growth and development.We conclude that nano-ZnO toxicity in seawater was significantly positively correlated with the associated Zn^(2+) concentration and sedimentary behaviour.The toxicity of nano-ZnO was cumulative and showed a critical point,beyond which embryonic and developmental toxicity in marine fish was observed. | Jianjun Li Zhanming Chen Ren Huang Zongyu Miao Lei Cai Qingping Du | 2018 | Journal of Environmental Sciences2018，30，11： | 4 |
| 20 | Weight Distributions of Two Classes of Linear Codes from Perfect Nonlinear Functions显示文摘 | DAI Qingping LI Chao | 2009 | Chinese Journal of Electronics2009，18，3： | 4 |
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