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| 1 | Tumor necrosis factor-a: a key contributor to intervertebral disc degeneration显示文摘Intervertebral 圆盘(IVD ) 退化(国际直拨长途电话) 是导致腰骶部疼痛(LBP ) 的最普通的原因,它是一高度流行,昂贵,并且削弱世界范围的状况。为国际直拨长途电话的当前的治疗被限制对待症状并且不指向 pathophysiology。肿瘤坏死因素 --(TNF-) 通过它的受体 TNFR1 和 TNFR2 是大多数有势力支持 inflammatory cytokines 和信号之一。TNF- 高度在退化 IVD 纸巾被表示,并且它深深地涉及圆盘退化的多重病理学的过程,包括矩阵破坏,煽动性的回答, apoptosis, autophagy,和房间增长。重要地, anti-TNF- 治疗为减轻圆盘退化并且减轻 LBP 显示出诺言。在这考察,跟随对 TNF- 信号 transduction 的简短描述,我们主要在国际直拨长途电话集中于表达式模式和 TNF- 的角色,并且总结关于它象磁盘退化和联系 LBP 的一条有希望的生物治疗学的途径的抑制的新兴的进步。更好的理解将帮助开发新奇 TNF -- 为退化圆盘疾病的集中的治疗学的干预。 | Cheng Wang Xiaohua Yu Yiguo Yan Wei Yang Shujun Zhang Yongxiao Xiang Jian Zhang Wenjun Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 26 |
| 2 | Synthesis of rod-like metal-organic framework(MOF-5)nanomaterial for efficient removal of U(Ⅵ):batch experiments and spectroscopy study显示文摘With the widespread application of radionuclide235 U(Ⅵ), it is inevitable that part of U(Ⅵ) is released into the natural environment. The potential toxicity and irreversibility impact on the natural environment has become one of the most forefront pollution problems in nuclear energy utilization. In this work, rod-like metal-organic framework(MOF-5) nanomaterial was synthesized by a solvothermal method and applied to efficiently adsorb U(Ⅵ) from aqueous solutions. The batch experimental results showed that the sorption of U(Ⅵ) on MOF-5 was strongly dependent on p H and independent of ionic strength, indicating that the dominant interaction mechanism was inner-sphere surface complexation and electrostatic interaction. The maximum sorption capacity of U(Ⅵ) on MOF-5 was 237.0 mg/g at p H 5.0 and T = 298 K, and the sorption equilibrium reached within 5 min. The thermodynamic parameters indicated that the removal of U(Ⅵ) on MOF-5 was a spontaneous and endothermic process. Additionally, the FT-IR and XPS analyses implied that the high sorption capacity of U(Ⅵ) on MOF-5 was mainly attributed to the abundant oxygen-containing functional groups(i.e., CAO and C@O). Such a facile preparation method and efficient removal performance highlighted the application of MOF-5 as a candidate for rapid and efficient radionuclide contamination's elimination in practical applications. | Yihan Wu Hongwei Pang Wen Yao Xiangxue Wang Shujun Yu Zhimin Yu Xiangke Wang | 2018 | Science Bulletin2018，63，13： | 21 |
| 3 | Synthesis of novel nanomaterials and their application in efficient removal of radionuclides显示文摘With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment. Nanomaterials have been considered as the potential candidates for the effective and selective removal of radionuclides from aqueous solutions under complicated conditions because of their high specific surface area, large amounts of binding sites, abundant functional groups, pore-size controllable and easily surface modification. This review mainly summarized the recent studies for the synthesis, fabrication and surface modification of novel nanomaterials and their applications in the efficient elimination and solidification of radionuclides,and discussed the interaction mechanisms from batch experiments, spectroscopy analysis and theoretical calculations. The sorption capacities with other materials, advantages and disadvantages of different nanomaterials are compared, and at last the perspective of the novel nanomaterials is summarized. | Xiangxue Wang Long Chen Lin Wang Qiaohui Fan Duoqiang Pan Jiaxing Li Fangting Chi Yi Xie Shujun Yu Chengliang Xiao Feng Luo Jun Wang Xiaolin Wang Changlun Chen Wangsuo Wu Weiqun Shi Shuao Wang Xiangke Wang | 2019 | Science China Chemistry2019，62，8： | 20 |
| 4 | Application of graphene oxides and graphene oxide-based nanomaterials in radionuclide removal from aqueous solutions显示文摘With the fast development of nanoscience and nanotechnology,the nanomaterials have attracted multidisciplinary interests.The high specific surface area and large numbers of oxygen-containing functional groups of graphene oxides(GOs) make them suitable in the preconcentration and solidification of radionuclides from wastewater.In this paper,mainly based on the recent work carried out in our laboratory,the efficient elimination of radionuclides using GOs and GO-based nanomaterials as adsorbents are summarized and the interaction mechanisms are discussed from the results of batch techniques,surface complexation modeling,spectroscopic analysis and theoretical calculations.This review is helpful for the understanding of the interactions of radionuclides with GOs and GO-based nanomaterials,which is also crucial for the application of GOs and GO-based nanomaterials in environmental radionuclide pollution management and also helpful in nuclear waste management. | Xiangxue Wang Shujun Yu Jie Jin Hongqing Wang Njud S. Alharbi Ahmed Alsaedi Tasawar Hayat Xiangke Wang | 2016 | Science Bulletin2016，61，20： | 17 |
| 5 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 6 | One-pot synthesis of graphene oxide and Ni-Al layered double hydroxides nanocomposites for the efficient removal of U(VI) from wastewater显示文摘Graphene oxide and Ni-Al layered double hydroxides(GO@LDH) nanocomposites were synthesized via a one-pot hydrothermal process,and characterized by X-ray diffraction(XRD),Fourier transformed infrared spectroscopy(FTIR),scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS) and Raman spectroscopy in detail.The exploration of U(VI) sorption on GO@LDH surface was performed as a function of ionic strength,solution pH,contact time,U(VI) initial concentrations and temperature.Results of Langmuir isotherms showed that the sorption capacity of GO@LDH(160 mg/g) was much higher than those of LDH(69 mg/g) and GO(92 mg/g).The formed surface complexes between surface oxygen-containing functional groups of GO@LDH and U(VI) turned out to be the interaction mechanism of U(VI) with GO@LDH.According to the thermodynamic studies results,the sorption interaction was actually a spontaneous and endothermic chemical process.The sorption isotherms were better fitted with the Langmuir model compared with other models,which suggested the interaction was mainly dominated by mono layer coverage.The GO@LDH nanocomposites provide potential applications as adsorbents in the enrichment of radionuclides from wastewater in nuclear waste management and environmental remediation. | Shujun Yu Jian Wang Shuang Song Kunyu Sun Jun Li Xiangxue Wang Zhongshan Chen Xiangke Wang | 2017 | Science China Chemistry2017，60，3： | 12 |
| 7 | Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma显示文摘For successful therapy, hepatocellular carcinoma (HCC) must be detected at an early stage. Herein, we used a proteomic approach to analyze the secretory/releasing proteome of HCC tissues to identify plasma biomarkers. Serum-free conditioned media (CM) were collected from primary cultures of cancerous tissues and surrounding noncancerous tissues. Proteomic analysis of the CM proteins permitted the identification of 1365 proteins. The enriched molecular functions and biological processes of the CM proteins, such as hydrolase activity and catabolic processes, were consistent with the liver being the most important metabolic organ. Moreover, 19% of the proteins were characterized as extracellular or membrane-bound. For validation, secretory proteins involved in transforming growth factor-β signaling pathways were validated in plasma samples. Alphafetoprotein (AFP), metalloproteinase (MMP)1, osteopontin (OPN), and pregnancy-specific beta-1-glycoprotein (PSG)9 were significantly increased in HCC patients. The overall performance of MMP1 and OPN in the diagnosis of HCC remained greater than that of AFP. In addition, this study represents the first report of MMP1 as a biomarker with a higher sensitivity and specificity than AFP. Thus, this study provides a valuable resource of the HCC secretome with the potential to investigate serological biomarkers. MMP1 and OPN could be used as novel biomarkers for the early detection of HCC and to improve the sensitivity of biomarkers compared with AFP. | YANG Lei RONG WeiQi XIAO Ting ZHANG Ying XU Bin LIU Yu WANG LiMing WU Fan QI Jun ZHAO XiuYing WANG HongXia HAN NaiJun GUO SuPing WU JianXiong GAO YanNing CHENG ShuJun | 2013 | Science China(Life Sciences)2013，56，7： | 9 |
| 8 | (Bi_(0.51)Na_(0.47))TiO_(3) based lead free ceramics with high energy density and efficiency显示文摘Dielectric ceramics with high energy storage density and energy efficiency play an important role in high power energy storage applications.In this work,lead free relaxor ferroelectric ceramics in (1-x) Bi_(0.51)Na_(0.47)TiO_(3-x)Ba(Zr_(0.3)Ti_(0.7))O_(3)(BNT-BZT100x:x=0.20,0.30,0.40 and 0.50)system are fabricated by conventional solid-state sintering method.The BNT-BZT100x ceramics are sintered dense with minimal pores,exhibiting pseudocubic symmetry and strong relaxor characteristic.A high energy storage density of 3.1 J/cm^(3) and high energy efficiency of 91% are simultaneously achieved in BNT-BZT40 ceramic with 0.1mm in thickness,at the applied electric field of 280 kV/cm.The temperature stability of the energy density is studied over temperature range of 20-160℃ ,showing minimal variation below 1.5%,together with the excellent cycling reliability(the variations of both energy density and efficiency are below 3% up to 106 cycles),making BNT-BZT40 ceramic promising candidate for high-temperature dielectric and energy storage applications. | Yu Huang Fei Li Hua Hao Fangquan Xia Hanxing Liu Shujun Zhang | 2019 | Journal of Materiomics2019，5，3： | 7 |
| 9 | In-situ reduction synthesis of manganese dioxide@polypyrrole core/shell nanomaterial for highly efficient enrichment of U(Ⅵ) and Eu(Ⅲ)显示文摘Radionuclides with long half-life are toxic,and thereby result in serious threat to human beings and ecological balance.Herein,a simple two-step synthesis method was used to prepare manganese dioxide@polypyrrole(Mn O_2@PPy)core/shell structures for efficient removal of U(Ⅵ)and Eu(Ⅲ)from aqueous solutions.The adsorption of U(Ⅵ)and Eu(Ⅲ)were investigated under different kinds of experimental conditions.The experimental results suggested that the adsorption of U(Ⅵ)and Eu(Ⅲ)on Mn O_2@PPy were greatly affected by p H.U(Ⅵ)adsorption on Mn O_2@PPy was independent of ionic strength at p H<6.0,and dependent on ionic strength at p H>6.0.However,Eu(Ⅲ)adsorption on Mn O_2@PPy was independent of ionic strength at the whole p H range of experimental conditions.The maximum adsorption capacities(q_(max))of U(Ⅵ)and Eu(Ⅲ)were 63.04 and54.74 mg g^(-1)at T=298 K,respectively.The BET,XRD,FTIR and XPS analysis evidenced that high adsorption capacities of U(Ⅵ)and Eu(Ⅲ)on Mn O_2@PPy were mainly due to high surface area and rich metal oxygen-containing group(i.e.,Mn–OH and Mn–O),and the interaction was mainly attributed to strong surface complexation and electrostatic interaction.This study highlighted the excellent adsorption performance of U(Ⅵ)and Eu(Ⅲ)on Mn O_2@PPy and could provide the reference for the elimination of radionuclides in real wastewater management. | Wen Yao Yihan Wu Hongwei Pang Xiangxue Wang Shujun Yu Xiangke Wang | 2018 | Science China Chemistry2018，61，7： | 7 |
| 10 | Pose Planning for the End-effector of Robot in the Welding of Intersecting Pipes显示文摘All-position robots are widely applied in the welding of complicated parts.Welding of intersecting pipes is one of the most typical tasks.The welding seam is a complicated saddle-like space curve,which puts a great challenge to the pose planning of end-effector.The special robots designed specifically for this kind of tasks are rare in China and lack sufficient theoretical research.In this paper,a systematic research on the pose planning for the end-effectors of robot in the welding of intersecting pipes is conducted. First,the intersecting curve of pipes is mathematically analyzed.The mathematical model of the most general intersecting curve of pipes is derived,and several special forms of this model in degraded situations are also discussed.A new pose planning approach of bisecting angle in main normal plane(BAMNP) for the welding-gun is proposed by using differential geometry and the comparison with the traditional bisecting angle in axial rotation plane(BAARP) method is also analytically conducted.The optimal pose of the welding-gun is to make the orientation posed at the center of the small space formed by the two cylinders and the intersecting curve to help the welding-pool run smoothly.The BAMNP method can make sure the pose vertical to the curve and center between the two cylinders at the same time,therefore its performance in welding-technique is superior to the BAARP method.By using the traditional BAARP method,the robot structure can become simpler and easier to be controlled,because one degree of freedom(DOF) of the robot can be reduced.For the special case of perpendicular intersecting,an index is constructed to evaluate the quality of welding technique in the process of welding.The effect of different combination of pipe size on this index is also discussed.On the basis of practical consideration,selection principle for BAARP and BAMNP is described.The simulations of those two methods for a serial joint-type robot are made in MATLAB,and the simulation results are consistent to the analysis.The mathematical model and the proposed new pose-planning method will lay a solid foundation for future researches on the control and design of all-position welding robots. | LIU Yu ZHAO Jing LU Zhenyang CHEN Shujun | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 7 |
| 11 | Simulation of regional land subsidence in the southern Yangtze Delta显示文摘Investigation of the deformation characteristics of individual hydrostratigraphic units is the key to construct a regional land subsidence model. All of 12 hydrostratigraphic units in the study area were discussed throughout. On the basis of the measured data of groundwater level, five kinds of changing patterns of groundwater level were deduced and the relationship between the deformation characteris-tics of aquifer units and the corresponding changing patterns of groundwater level was discussed. The study area is 1.7×104 km2, where the geological condition is complex. The changing patterns of groundwater level the hydrostratigraphic units have experienced vary from site to site and from time to time. Consequently, the deformation characteristics of units are sophisticated. An identical hydros-tratigraphic unit may exhibit different deformation characteristics, such as elasticity, elasto-plasticity, visco-elasticity, and visco-elasto-plasticity, at different sites or during different periods, not to mention the different units. The existing models are difficult to describe the complex visco-elasto-plastic con-stitutive law under the condition of land subsidence. So the Merchant’s model was modified to depict the visco-elasto-plastic behavior of units. Then a three-dimensional flow model with variable parame-ters and a vertical one-dimensional subsidence model were constructed and coupled. The coupled model was applied in simulating land subsidence in the southern Yangtze Delta and a satisfactory re-sult was obtained. The simulation results show that the new coupled model can depict the complex geological conditions and describe the developing process of land subsidence very well in the south-ern Yangtze Delta. The new model can surely be used to predict land subsidence in the future, which is very helpful to taking measurements to control land subsidence. | XUE YuQun WU JiChun ZHANG Yun YE ShuJun SHI XiaoQing WEI ZiXin LI QinFen YU Jun | 2008 | Science China Earth Sciences2008，51，6： | 6 |
| 12 | Identification of causative compounds and microorganisms for musty odor occurrence in the Huangpu River,China显示文摘There are regular problems of musty odor in the Huangpu River,a major source of drinking water for Shanghai,China.In this study,the musty odor and its main causative compounds in the Huangpu River source water were confirmed through a yearly investigation using flavor profile analysis combined with HSPME-GC-MS analysis.The investigation showed that 2-methylisoborneol (2-MIB) with a concentration level between 28.6 and 71.0 ng/L was responsible for the musty odor in summer from July to September.Microscopic observation confirmed with the cloning results showed that Phormidium spp.,which accounted for 80%-95% of the algal cell density,was the microorganisms responsible for the production of 2-MIB and the estimated 2-MIB yield was 0.022 pg/cell.Results from a wide-area sampling campaign in the Huangpu River watershed showed that,other than the large tributaries receiving water from Tai Lake,several small creeks close to the intake may have contributed most of the 2-MIB and the Phormidium spp.to the Huangpu River source water.This study provides methodology for the investigation of odor causing compounds and microorganisms in river-type source water,and the result will be useful for water quality control in both source water and drinking water. | Daolin Sun Jianwei Yu Wei An Min Yang Guoguang Chen Shujun Zhang | 2013 | Journal of Environmental Sciences2013，25，3： | 6 |
| 13 | Two Confirmed Patients of Anthrax—Binzhou City,Shandong Province,China,August 2021显示文摘As of August 15,2021,2 confirmed cases of anthrax were reported to Shandong CDC,one of which was a 14-year-old student(Patient A)and the other was a 35-year-old man(Patient B)engaging in the slaughter of cattle.Patient A died on August 6,and Patient B has been transferred to an infectious disease hospital for isolation and treatment.The Shandong CDC formed a joint investigation team to determine the source of infection and prevent any further spread. | Xiaolin Yu Lifang Zhang Ming Fang Hao Liang Qi Zhang Xiusheng Yin Zengqiang Kou Wenwu Yin Zhong Li Enmin Zhang Shujun Ding | 2021 | China CDC weekly2021，3，38： | 4 |
| 14 | Fibrinolytic Evaluation of Compounds Isolated from a Marine Fungus Stachybotrys Iongispora FG216显示文摘 | Ruihua Guo Yiting Zhang Dong Duan Qiang Fu Xiangyu Zhang Xiaowei Yu Shujun Wang Bin Bao Wenhui Wu | 2016 | Chinese Journal of Chemistry2016，34，11： | 4 |
| 15 | Interaction of radionuclides with natural and manmade materials using XAFS technique显示文摘The X-ray absorption fine structure(XAFS)technology has exhibited a very unique application in the study of sorption mechanism,chemical species and microstructures of radionuclides at the natural solid-water interfaces.In this review,the interaction mechanism of radionuclides with clay minerals and nanomaterials under different environmental conditions are summarized from the XAFS spectroscopy analysis.The coordination number and the bond distances of radionuclides,the oxidation-reduction reactions,the influence of humic substances and microorganisms on the species and structures of radionuclides at molecule level are reviewed and compared.This review is helpful to understand the interactions of radionuclides with oxides,natural clay minerals and nanomaterials,which is also crucial to evaluate the physicochemical behaviors of radionuclides in the natural environment. | Shujun Yu Xiangxue Wang Shitong Yang Guodong Sheng Ahmed Alsaedi Tasawar Hayat Xiangke Wang | 2017 | Science China Chemistry2017，60，2： | 3 |
| 16 | Polycrystalline diamond MESFETs by Au-mask technology for RF applications显示文摘Metal-semiconductor field effect transistors (MESFETs) were fabricated on H-terminated polycrystalline diamond.The DC characteristics of the p-channel MESFET showed a maximum drain current density of 204 mA/mm at a gate-source voltage of 6 V,and a maximum transconductance of 20 mS/mm at a gate-source voltage of 1.5 V.The small signal S-parameters of MESFET with 2 100 m gate width and 2 m gate length were measured.An extrinsic cut-off frequency (fT) of 1.7 GHz and the maximum oscillation frequency (fmax) of 2.5 GHz were obtained,which was the first report on diamond MESFETs with RF characteristics in China. | FENG ZhiHong WANG JingJing HE ZeZhao DUN ShaoBo YU Cui LIU JinLong ZHANG PingWei GUO Hui LI ChengMing CAI ShuJun | 2013 | Science China(Technological Sciences)2013，56，4： | 2 |
| 17 | Crucial control measures to contain China's first Delta variant outbreak显示文摘The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,China.Transmission characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 days.The basic reproduction number(R_0) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing result.Facing the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 pre-symptomatic.The dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 days.By breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained. | Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao Shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong Deng Zhicong Yang Nanshan Zhong | 2022 | National Science Review2022，9，4： | 2 |
| 18 | Biochar for the removal of contaminants from soil and water:a review显示文摘Biochar shows significant potential to serve as a globally applicable material to remediate water and soil owing to the extensive availability of feedstocks and conducive physio-chemical surface characteristics.This review aims to highlight biochar production technologies,characteristics of biochar,and the latest advancements in immobilizing and eliminating heavy metal ions and organic pollutants in soil and water.Pyrolysis temperature,heat transfer rate,residence time,and type of feedstock are critical influential parameters.Biochar’s efficacy in managing contaminants relies on the pore size distribution,surface groups,and ion-exchange capacity.The molecular composition and physical architecture of biochar may be crucial when practically applied to water and soil.In general,biochar produced at relatively high pyrolysis temperatures can effectively manage organic pollutants via increasing surface area,hydrophobicity and microporosity.Biochar generated at lower temperatures is deemed to be more suitable for removing polar organic and inorganic pollutants through oxygen-containing functional groups,precipitation and electrostatic attraction.This review also presents the existing obstacles and future research direction related to biochar-based materials in immobilizing organic contaminants and heavy metal ions in effluents and soil. | Muqing Qiu Lijie Liu Qian Ling Yawen Cai Shujun Yu Shuqin Wang Dong Fu Baowei Hu Xiangke Wang | 2022 | Biochar2022，4，1： | 2 |
| 19 | One-pot synthesis of arginine modified hydroxyapatite carbon microsphere composites for efficient removal of U(Ⅵ) from aqueous solutions显示文摘Uranium was not only the main source of nuclear energy but also one of the long-lived radionuclide.Herein, a novel arginine modified hydroxyapatite carbon microsphere composites(defined as C@HAp/Arg) obtained promptly via a one-step mild hydrothermal method, was applied to remove U(Ⅵ) from aqueous solutions. Based on the characterization of transmission electron microscopy(TEM), scanning electron microscopy(SEM), Fourier transformed infrared spectroscopy(FT-IR), X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS), the synthesized C@HAp/Arg presented globular morphology and abundant functional groups(e.g., —COO^-), which were beneficial to its combination with U(Ⅵ). The interaction mechanism and removal capability of U(Ⅵ) on C@HAp/Arg were studied by batch adsorption technique and spectroscopy analysis. The results implied that U(Ⅵ) can form strong surface complexes on C@HAp/Arg. The kinetics adsorption of U(Ⅵ) followed pseudo-second-order kinetic model with high removal efficiency($95% within 5h at pH 5.0). The adsorption isotherms were well fitted by Langmuir model, implying that U(Ⅵ) uptake on C@HAp/Arg was monolayer coverage. It was found that the maximum adsorption capacities of CSs, C@HAp and C@HAp/Arg toward U(Ⅵ) were calculated to be 23.16,72.09 and 569.66 mg/g, respectively, at 298.15 K and pH 5.0, and thermodynamic parameters revealed that the adsorption processes of U(Ⅵ) were spontaneous and endothermic. In addition, effect of co-existed ions and CO_3^(2-)concentrations demonstrated that U(Ⅵ) adsorption on C@HAp/Arg was weakly interfered by foreign ions and carbonate concentrations. More importantly, the adsorption performance of U(Ⅵ) on C@HAp/Arg was still over $87% after five cycles. Therefore, it was noted that the versatile C@HAp/Arg could be potentially used as a powerful building block for the enrichment and disposal of U(Ⅵ) from aqueous solutions, which could efficiently reduce the potential toxicity of U(Ⅵ) in the U(Ⅵ)-contaminated water. | Dongxu Yang Xiangxue Wang Gang Song Guixia Zhao Zhe Chen Shujun Yu Pengcheng Gu Hongqing Wang Xiangke Wang | 2017 | Science Bulletin2017，62，23： | 2 |
| 20 | Succinylated whey protein isolate as a sustained-release excipient of puerarin derivative oral tablets:Preparation,optimization and pharmacokinetics显示文摘This work was done to investigate succinylated commercial whey protein isolate(S-WPI)as an oral sustained-release delivery carrier for puerarin 5(PR-5). The succinylation condi-tions were established for S-WPIs by optimization of single factor study and Box–Beehnkendesign. The effect of succinylation degree on S-WPIs solubility was evaluated. Physicochem-ical properties of S-WPIs dried by different three methods on their flow ability, particle size,morphology and in vitro release behavior were studied. After preparing PR-5 sustained re-lease protein tablets with S-WPIs as the carrier by direct powder compression method, thedrug release were studied in vitro and the oral pharmacokinetics and bioavailability wasevaluated using in vivo dog model. It was observed that concentration of substrate has asignificant effect on succinylation. Release behavior in vitro showed spry dried S-WPIs with100% succinylation rate and 30% drug loading would be applied to the preparation of PR-5 sustained-release protein tablets based on the swelling mechanism(protein loss). Comparedwith PR-5 conventional tablet with oral administration, T max value of PR-5 sustained-releaseprotein tablets was approximately 1.58 fold greater than those of the conventional tablets asfurther evidenced by the significantly prolonged MRT and T 1/2. The findings demonstratedthat spray-dried S-WPIs has potential as a promising functional excipient for the design of PR-5 oral sustained-release tablets which can fully improve sustained-release effect and oral bioavailability. | Rui Zhang Yu Zhang Yue Wu Jun Liu Tiantian Ye Shujun Wang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，4： | 2 |
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