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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability显示文摘 | Yamamoto H Itoh F Fukushima H | 1999 | Int Cancer1999，84，4： | 1 |
| 4 | Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability显示文摘 | Yamamoto H Itoh F Fukushima H | 1999 | Int J Cancer1999，8，： | 1 |
| 5 | Mean velocity and turbulence characteristics of water flow in the bubble dispersion region induced by plunging water jet 显示文摘 | Iguchi M Okita K Yamamoto F | 1998 | International Journal of Multiphase Flow1998，24，4： | 1 |
| 6 | Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals显示文摘 | Takeuchi F Yamamoto K Katsuya T | 2011 | Diabetologia2011，54，6： | 1 |
| 7 | Supplemental effect of bile salts to soybean meal-based diet on growth and feed utilization of rainbow trout(Oncorhynchus mykiss)显示文摘 | Yamamoto T Suzuki N Furuita F | 2007 | Fisheries Science2007，73，1： | 1 |
| 8 | Expression of MMP-7 mRNA in human colorectal cancers显示文摘 | Yoshimoto M Itoh F Yamamoto H | 1993 | Int J Cancer1993，54，4： | 1 |
| 9 | Hybrid treatment systems for dye wastewater显示文摘 | Hai F I Yamamoto K Fukushi K | 2007 | Critical Reviews in Environmental Science and Technology2007，37，4： | 1 |
| 10 | Expression of MMP- 7(PUMP-1) mRNA in human colorectal cancers 显示文摘 | Yoshimoto M Itoh F Yamamoto H | 1993 | Int J Cancer1993，54，4： | 1 |
| 11 | PIV measurement of particle motion in spiral gas-solid twophase flow显示文摘 | MIYAZAKI K CHEN G YAMAMOTO F | 1999 | Experimental Thermal and Fluid Science1999，19，： | 1 |
| 12 | Japanese regulation on GMP/GQP and its challenges显示文摘 | NAKAI K NAGAI H YAMAMOTO F | 2009 | J Pharmaceutical Innovation2009，4，4： | 1 |
| 13 | Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomycesfradiae NBRC 12773显示文摘 | Kudo F Yamamoto Y K Eguchi T | 2005 | JAntibiot2005，58，： | 1 |
| 14 | Preischemic and postischemic treatment with a new Na+/H+-exchange inhibitor,FR183998,shows cardioprotective effects n rats with cardiacischemiaand reperfusion显示文摘 | Sugimoto T Yamamoto N | 1999 | JCardiovascPharmacol1999，34，6： | 1 |
| 15 | Difficulty of peripheral blood stem cell collection after multiple consolidation therapy in acute myeloid leukaemia显示文摘 | Narimatsu H Yamamoto F Kurahashi S etal | 2008 | J Clin Exp Hematol2008，48，： | 1 |
| 16 | Molecular genetic analysis of the ABO blood group显示文摘 | Yamamoto F McMeil PD Yamamoto M | 1990 | Nature1990，345，6272： | 1 |
| 17 | Hydrogen storage properties of new ternary system alloys: La2MgNi9, La5Mg2Ni23, La3MgNi14 显示文摘 | KOHNO T YOSHIDA H KAWASHIMA F INABA T SAKAI I YAMAMOTO M KANDA M | 2000 | Journal of Alloys and Compounds2000，311，： | 1 |
| 18 | Involvement of two distinct N-acetylglucosaminyltransferases and a dual- function deacetylase in neomycin biosynthesis显示文摘 | Yokoyama K Yamamoto Y Kudo F | 2008 | Chem Bio Chem2008，9，6： | 1 |
| 19 | The effects of Na movement on surgical myocardial protection : the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury 显示文摘 | Liu KX Yamamoto F Yamamoto H | 2007 | Ann Thorac Cardiovasc Surg2007，13，5： | 1 |
| 20 | Expression of matrix metalloproteinase and tissue inhibitors of metalloproteinase in human pancreatic adenocarcinoma as clinicopathologic and prognostic significance of matrilysin expression显示文摘 | Yamamoto H Itoh F Jku S | 2000 | J Clin Oncol2000，19，： | 1 |
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