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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Development of a new tool material to ensure high performance in hot steel rolling显示文摘 | Tsubouchi K Akiyama M Yamamoto E | 1999 | Journal of tribology1999，121，4： | 2 |
| 3 | Antioxidative properties of Jaffa sweeties and grapefruit and their influence on lipid metabolism and plasma antioxidative potential in rats显示文摘 | Gorinstein S Yamamoto K Katrich E | 2003 | Biosci Biotechnol Biochem2003，67，： | 1 |
| 4 | Very low-den- sity lipoprotein receptor in fetal intestine and gastric adenocarcinoma cells显示文摘 | Nakamura Y Yamamoto M Kumamaru E | 2000 | Arch Pathol Lab Med2000，124，1： | 1 |
| 5 | Tektin5, a new Tektin family member, is a component of the middle piece of flagella in rat spermatozoa 显示文摘 | Murayama E Yamamoto E Kaneko T | 2008 | Mol Reprod Dev2008，75，4： | 1 |
| 6 | Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis-a five-year prospective cohort study显示文摘 | Sasaki E Tsuda E Yamamoto Y | 2015 | Arthritis Res Ther2015，17，3： | 1 |
| 7 | Expression of lactate dehydrogenase-A and -B messenger ribonucleic acids in chick glycogen body 显示文摘 | Imagawa T Yamamoto E Sawada M | 2006 | Pouh Sci2006，85，： | 1 |
| 8 | Lignin:occurrence,biogenesis and biodegradation显示文摘 | LEWIS N G YAMAMOTO E | 1990 | Annu Rev Plant Physiol and Plant Mol Biol1990，41，： | 1 |
| 9 | Identification of renal podocytes in multiple species:higher vertebrates are vimentin positive/lower vertebrates are desmin positive显示文摘 | Aoita E Franke WW Yamamoto T | 1999 | Histochem Cell Biol1999，111，2： | 1 |
| 10 | Appearance pattern of TDP43 in Japanese frontotemporal lobar degeneration with ubiquitin-posirive inclusions显示文摘 | Higashi S Iseki E Yamamoto R | 2007 | Neurosci Lett2007，419，3： | 1 |
| 11 | Comparative study of modification and degradation of neurofilament proteins in rats subchronically treated with allyl chloride, acrylamide, or 2,5-hexanedione显示文摘 | Nagano M Yamamoto H Harada E Miyamoto E Futatsuka M | 1993 | Environ Res1993，63，2： | 1 |
| 12 | Expression of MMP-9 in mesangial cells and its changes in anti-GBM glomerulonephritis in WKY rats显示文摘 | Kuroda T Yoshida Y Kamiie J Kovalenko P Nameta M Fujinaka H Yaoita E Endo T Ishizuka S Nakabayashi K Yamada A Nagasawa T Yamamoto T | 2004 | Clin Exp Nephrol2004，8，： | 1 |
| 13 | Effectiveness of preoperative concurrent chemoradiation therapy(CCRT)for locally advanced adenocarcinoma of cervix显示文摘 | Shibata K Kajiyama H Yamamoto E | 2009 | Eur J Surg Oncol2009，35，7： | 1 |
| 14 | Canonical correlation analysis for multivariate regression and its application to metabolic fingerprinting显示文摘 | Yamamoto H Yamaji H Fukusaki E | 2008 | Biochemical Engineering J2008，40，2： | 1 |
| 15 | 显示文摘 | Do L Han E Yamamoto N | 1996 | Mol Cryst Liq Cryst1996，280，： | 1 |
| 16 | Initial accumulation of paraquat in the heart leading to acute death显示文摘 | Noguchi N Tanaka E Yamamoto H | 1990 | Nippon Hoigaku Zasshi1990，44，1： | 1 |
| 17 | Modifications of neurofilament protein by possible metabolites of allyl chloride in vitro显示文摘 | He Y Nagano M Yamamoto H Miyamoto E Futatsuka M | 1995 | Drug Chem Toxicol1995，18，4： | 1 |
| 18 | Suppression of growth of hepatocellular carcinoma by sodium butyrate in vitro and in vivo显示文摘 | Yamamoto H Fujimoto J Okamoto E | 1998 | Int J Cancer1998，76，6： | 1 |
| 19 | Determination of Halofuginone and Amprolium in Chicken Muscle and Egg by Liquid Chromatography显示文摘 | Yamamoto Y Kondo E | 2001 | J AOAC Int2001，84，1： | 1 |
| 20 | Differential inhibition by staurosporine, a potent protein kinase C inhibitor of 12 - O - tetradecanoylphorbol - 13 - acetate - caused skin tumor promotion, epidermal omithine decarboxylase induction, hyperplasia and inflammation显示文摘 | Yamamoto S Kiyoto I Aizu E | 1989 | Carcinogenesis(Lond)1989，10，： | 1 |
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