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| 1 | GPS-constrained inversion of present-day slip rates along major faults of the Sichuan-Yunnan region, China显示文摘A linked-fault-element model is employed to invert for contemporary slip rates along major active faults in the Sichuan-Yunnan region (96°-108°E, 21°-35°N) using the least squares method. The model is based on known fault geometry, and constrained by a GPS-derived horizontal velocity field. Our results support a model attributing the eastward extrusion of the Tibetan Plateau driven mainly by the north-northeastward indentation of the Indian plate into Tibet and the gravitational collapse of the plateau. Resisted by a relatively stable south China block, materials of the Sichuan-Yunnan region rotate clockwise around the eastern Himalayan tectonic syntaxis. During the process the Garzê-Yushu, Xianshuihe, Anninghe, Zemuhe, Daliangshan, and Xiaojiang faults, the southwest extension of the Xiaojiang fault, and the Daluo-Jinghong and Mae Chan faults constitute the northeast and east boundaries of the eastward extrusion, with their left slip rates being 0.3-14.7, 8.9-17.1, 5.1 ± 2.5, 2.8 ± 2.3, 7.1 ± 2.1, 9.4 ± 1.2, 10.1 ± 2.0, 7.3 ± 2.6, and 4.9 ± 3.0 mm/a respectively. The southwestern boundary consists of a widely distributed dextral transpressional zone other than a single fault. Right slip rates of 4.2 ± 1.3, 4.3 ± 1.1, and 8.5 ± 1.7 mm/a are detected across the Nanhua-Chuxiong-Jianshui, Wuliangshan, and Longling-Lancang faults. Crustal deformation across the Longmenshan fault is weak, with short-ening rates of 1.4 ± 1.0 and 1.6 ± 1.3 mm/a across the Baoxing-Beichuan and Beichuan-Qingchuan segments. Northwest of the Longmenshan fault lies an active deformation zone (the Longriba fault) with 5.1±1.2 mm/a right slip across. Relatively large slip rates are detected across a few faults within the Sichuan-Yunnan block: 4.4±1.3 mm/a left slip and 2.7±1.1 mm/a shortening across the Litang fault, and 2.7±2.3 mm/a right-lateral shearing and 6.7±2.3 mm/a shortening across the Yunongxi fault and its surrounding regions. In conclusion, we find that the Sichuan-Yunnan region is divided into more than a dozen active micro-blocks by a large number of faults with relatively slow slip rates. The eastward extrusion of the Tibetan Plateau is absorbed and adjusted in the region mainly by these faults, other than a small number of large strike-slip faults with fast slip rates. | WANG YanZhao WANG EnNing SHEN ZhengKang WANG Min GAN WeiJun QIAO XueJun MENG GuoJie LI TieMing TAO Wei YANG YongLin CHENG Jia LI Peng | 2008 | Science China Earth Sciences2008，51，9： | 65 |
| 2 | Glacial distribution and mass balance in the Yarlung Zangbo River and its influence on lakes显示文摘Glaciers in the Yarlung Zangbo River witness severe glacial retreat nowadays,which gives important influence on lake processes in the region.We have studied glacial distribution,glacial mass balance and found large deficit in glacial mass and its impact in the region.Our study also integrated the variation in glacial-fed lakes of the Nam Co and Ranwu Lake,and presented an initial assessment of the impact of glacial mass balance on lakes.The study has shown a significant contribution of glacial melting to recent lake expansion and lake level rising. | YAO TanDong LI ZhiGuo YANG Wei GUO XueJun ZHU LiPing KANG ShiChang WU YanHong YU WuSheng | 2010 | Chinese Science Bulletin2010，55，20： | 34 |
| 3 | Tri-Co Robot: a Chinese robotic research initiative for enhanced robot interaction capabilities显示文摘Since the invention of the first industrial robot in 1959, the missions of robots have evolved from basic mechanical transfer or assistance to a diverse range of tasks through close interactions with environment, their human counterparts and robot peers. Through adaptation to uncertain and dynamic environments. | Han Ding Xuejun Yang Nanning Zheng Ming Li Yinan Lai Hao Wu | 2018 | National Science Review2018，5，6： | 24 |
| 4 | Research on the slope spectrum of the Loess Plateau显示文摘A new concept dealing with digital analysis of loess terrain,slope spectrum,is presented and discussed in this paper,by introducing its characteristic,represen-tation and extracting method from DEMs. Using 48 geomorphological units in dif-ferent parts of the loess as test areas and 5 m-resolution DEMs as original test data,the quantitative depiction and spatial distribution of slope spectrum in China's Loess Plateau have been studied on the basis of a series of carefully-designed experiments. In addition,initial experiment indicates a strong relationship between the slope spectrum and the loess landform types,displaying a potential importance of the slope spectrum in geomorphological studies. Based on the slope spectrums derived from the 25 m-resolution DEM data in whole loess terrain in northern part of Shaanxi,13 slope spectrum indices were extracted and integrated into a compre-hensive layer with image integration method. Based on that,a series of unsuper-vised classifications was applied in order to make a landform classification in northern Shaanxi Loess Plateau. Experimental results show that the slope spec-trum analysis is an effective method in revealing the macro landform features. A continuous change of slope spectrum from south to north in northern Shaanxi Loess Plateau shows an obvious spatial distribution of different loess landforms. This also proves the great significance of the slope spectrum method in describing the terrain roughness and landform evolution as well as a further understanding on landform genesis and spatial distribution rule of different landforms in the Loess Plateau. | TANG GuoAn,LI FaYuan,LIU XueJun,LONG Yi & YANG Xin Key Laboratory of Virtual Geographic Environment,Nanjing Normal University,Ministry of Education,Nanjing 210046,China | 2008 | Science China(Technological Sciences)2008，51，S1： | 22 |
| 5 | A precise velocity field of tectonic deformation in China as inferred from intensive GPS observations显示文摘Active tectonics, e.g., faulting, folding, and rifting are clearly manifested over the vast territory of China. The in-tensive crustal deformation with long-lived structures has given rise to numerous highly-elevated mountains in the western China with the Yangtze and Yellow rivers downstreaming to the east, | LI Qiang YOU XinZhao YANG ShaoMin DU RuiLin QIAO XueJun ZOU Rong WANG Qi | 2012 | Science China Earth Sciences2012，55，5： | 23 |
| 6 | Collision free 4D path planning for multiple UAVs based on spatial refined voting mechanism and PSO approach显示文摘In this paper, a four-dimensional coordinated path planning algorithm for multiple UAVs is proposed, in which time variable is taken into account for each UAV as well as collision free and obstacle avoidance. A Spatial Refined Voting Mechanism(SRVM) is designed for standard Particle Swarm Optimization(PSO) to overcome the defects of local optimal and slow convergence.For each generation candidate particle positions are recorded and an adaptive cube is formed with own adaptive side length to indicate occupied regions. Then space voting begins and is sorted based on voting results, whose centers with bigger voting counts are seen as sub-optimal positions. The average of all particles of corresponding dimensions are calculated as the refined solutions. A time coordination method is developed by generating specified candidate paths for every UAV, making them arrive the same destination with the same time consumption. A spatial-temporal collision avoidance technique is introduced to make collision free. Distance to destination is constructed to improve the searching accuracy and velocity of particles. In addition, the objective function is redesigned by considering the obstacle and threat avoidance, Estimated Time of Arrival(ETA), separation maintenance and UAV self-constraints. Experimental results prove the effectiveness and efficiency of the algorithm. | Yang LIU Xuejun ZHANG Yu ZHANG Xiangmin GUAN | 2019 | Chinese Journal of Aeronautics2019，32，6： | 20 |
| 7 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 8 | Antimony smelting process generating solid wastes and dust:Characterization and leaching behaviors显示文摘A large amount of solid waste has been produced by the antimony smelting process in the'World Capital of Antimony', Xikuangshan area in China. This study comprehensively investigated the physical and chemical characteristics of the various solid wastes, as well as the leaching behavior of the solid wastes, which included water-quenched slag,arsenic-alkali residue, desulfurized slag and blast furnace dust. These four types of waste were enriched in a variety of heavy metals and metalloids and more specifically with As and Sb levels up to 8.6 × 104 and 3.16 × 105mg/kg, respectively, in arsenic-alkali residue. For desulfurized slag and water-quenched slag, the leaching concentration of Sb significantly exceeded the acceptable limits during the leaching tests using the toxicity characteristic leaching procedure and the synthetic precipitation leaching procedure. In addition, As leaching in arsenic-alkali residue was extraordinarily hazardous, being three orders of magnitude higher than the regulatory level of As. According to the results of the extraction tests, all the tested wastes were classified as hazardous waste. | Xuejun Guo Kunpeng Wang Mengchang He Ziwei Liu Hailin Yang Sisi Li | 2014 | Journal of Environmental Sciences2014，26，7： | 13 |
| 9 | m^6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2显示文摘N6-methyladenosine (m6A),catalyzed by the methyltransferase complex consisting of Mettl3 and Mettl14,is the most abundant RNA modification in mRNAs and participates in diverse biological processes. However,the roles and precise mechanisms of m6A modification in regulating neuronal development and adult neurogenesis remain unclear. Here,we examined the function of Mettl3,the key component of the complex,in neuronal development and adult neurogenesis of mice. We found that the depletion of Mettl3 significantly reduced m6A levels in adult neural stem cells (aNSCs) and inhibited the proliferation of aNSCs. Mettl3 depletion not only inhibited neu-ronal development and skewed the differentiation of aNSCs more toward glial lineage,but also affected the morphological maturation of newborn neurons in the adult brain. m6A immunoprecip-itation combined with deep sequencing (MeRIP-seq) revealed that m6A was predominantly enriched in transcripts related to neurogenesis and neuronal development. Mechanistically,m6A was present on the transcripts of histone methyltransferase Ezh2,and its reduction upon Mettl3 knockdown decreased both Ezh2 protein expression and consequent H3K27me3 levels. The defects of neurogenesis and neuronal development induced by Mettl3 depletion could be rescued by Ezh2 overexpression. Collectively,our results uncover a crosstalk between RNA and histone modifica-tions and indicate that Mettl3-mediated m6A modification plays an important role in regulating neurogenesis and neuronal development through modulating Ezh2. | Junchen Chen Yi-Chang Zhang Chunmin Huang Hui Shen Baofa Sun Xuejun Cheng Yu-Jie Zhang Yun-Gui Yang Qiang Shu Ying Yang Xuekun Li | 2019 | Genomics, Proteomics & Bioinformatics2019，17，2： | 12 |
| 10 | Using the EMD Method to Determine Fault Criterion for Medium-low Pressure Gas Regulators显示文摘By extracting the outlet pressure data of gas regulators,this paper uses the EMD toolbox of the MATLAB software,which can perform data decomposition and the Hilbert-Huang Transform to find the rules with fault data.Eventually,the medium-low pressure gas regulator fault criterion can be established. | HAO Xuejun LIU Qiang YANG Guobin DU Yi | 2015 | Journal of Thermal Science2015，24，6： | 11 |
| 11 | Hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis:A multicenter propensity scorematched cohort study显示文摘Objective:Systemic chemotherapy has limited efficacy in the treatment of peritoneal metastasis(PM)in gastric cancer(GC).Hyperthermic intraperitoneal chemotherapy(HIPEC)combined with complete cytoreductive surgery(CRS)has shown promising outcomes but remains controversial.The present study aimed to evaluate the safety and efficacy of HIPEC without CRS in GC patients with PM.Methods:This retrospective propensity score-matched multicenter cohort study included GC patients with PM treated with either chemotherapy alone(Cx group)or with HIPEC combined with chemotherapy(HIPEC-Cx group)in four Chinese high-volume gastric medical centers between 2010 and 2017.The primary outcomes were median survival time(MST)and 3-year overall survival(OS).Propensity score matching was performed to compensate for controlling potential confounding effects and selection bias.Results:Of 663 eligible patients,498 were matched.The MST in the Cx and HIPEC-Cx groups was 10.8 and 15.9 months,respectively[hazard ratio(HR)=0.71,95%confidence interval(95%CI),0.58-0.88;P=0.002].The 3-year OS rate was 10.1%(95%CI,5.4%-14.8%)and 18.4%(95%CI,12.3%-24.5%)in the Cx and HIPEC-Cx groups,respectively(P=0.017).The complication rates were comparable.The time to first flatus and length of hospital stay for patients undergoing HIPEC combined with chemotherapy was longer than that of chemotherapy alone(4.6±2.4 d vs.2.7±1.8 d,P<0.001;14.2±5.8 d vs.11.4±7.7 d,P<0.001),respectively.The median follow-up period was 33.2 months.Conclusions:Compared with standard systemic chemotherapy,HIPEC combined with chemotherapy revealed a statistically significant survival benefit for GC patients with PM,without compromising patient safety. | Ziying Lei Jiahong Wang Zhi Li Baozhong Li Jiali Luo Xuejun Wang Jin Wang MingchenBa Hongsheng Tang Qingjun He Quanxing Liao Xiansheng Yang Tianpei Guan Han Liang Shuzhong Cui | 2020 | Chinese Journal of Cancer Research2020，32，6： | 11 |
| 12 | CNN Feature Boosted SeqSLAM for Real-Time Loop Closure Detection显示文摘This paper proposes an efficient and robust Loop closure detection(LCD) method based on Convolutional neural network(CNN) feature. The primary method is called SeqCNNSLAM, in which both the outputs of the intermediate layer of a pre-trained CNN and the outputs of traditional sequence-based matching procedure are incorporated, making it possible to handle the viewpoint and condition variance properly. An acceleration algorithm for SeqCNNSLAM is developed to reduce the search range for the current image, resulting in a new LCD method called A-SeqCNNSLAM. To improve the applicability of A-SeqCNNSLAM to new environments, O-SeqCNNSLAM is proposed for online parameters adjustment in A-SeqCNNSLAM. In addition to the above work, we further put forward a promising idea to enhance Seq SLAM by integrating the both CNN features and VLAD's advantages called patch based Seq CNNSLAM(P-SeqCNNSLAM), and provide some preliminary experimental results to reveal its performance. | BAI Dongdong WANG Chaoqun ZHANG Bo YI Xiaodong YANG Xuejun | 2018 | Chinese Journal of Electronics2018，27，3： | 11 |
| 13 | Investigation on a vertical radial flow adsorber designed by a novel parallel connection method显示文摘Due to the increasing global demand for industrial gas, the development of large-scale cryogenic air separation systems has attracted considerable attention in recent years. Increasing the height of the adsorption bed in a vertical radial flow adsorber used in cryogenic air separation systems may efficiently increase the treatment capacity of the air in the adsorber. However, uniformity of the flow distribution of the air inside the adsorber would be deteriorated using the height-increasing method. In order to reduce the non-uniformity of the flow distribution caused by the excessive height of adsorption bed in a vertical radial flow adsorber, a novel parallel connection method is proposed in the present work. The experimental apparatus is designed and constructed; the Computational Fluid Dynamics(CFD) technique is used to develop a CFD-based model, which is used to analyze the flow distribution, the static pressure drop and the radial velocity in the newly designed adsorber. In addition, the geometric parameters of annular flow channels and the adsorption bed thickness of the upper unit in the parallelconnected vertical radial flow adsorber are optimized, so that the upper and lower adsorption units could be penetrated by air simultaneously. Comparisons are made between the height-increasing method and the parallel connection method with the same adsorber height. It is shown that using the parallel connection method could reduce the difference between the maximum and minimum radial static pressure drop by 86.2% and improve the uniformity by 80% compared with those of using the height-increasing method. The optimal thickness ratio of the upper and lower adsorption units is obtained as 0.966, in which case the upper and lower adsorption units could be penetrated by air simultaneously, so that the adsorbents in adsorption space could be used more efficiently. | Zhengshu Dai Meng Yu Daozhe Rui Xuejun Zhang Yang Zhao | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 9 |
| 14 | Spatiotemporal Variations of Meteorological Droughts in China During 1961–2014: An Investigation Based on Multi-Threshold Identification显示文摘As a major agricultural country, China suffers from severe meteorological drought almost every year.Previous studies have applied a single threshold to identify the onset of drought events, which may cause problems to adequately characterize long-term patterns of droughts.This study analyzes meteorological droughts in China based on a set of daily gridded(0.5° 9 0.5°) precipitation data from 1961 to 2014. By using a multi-threshold run theory approach to evaluate the monthly percentage of precipitation anomalies index(Pa), a drought events sequence was identified at each grid cell. The spatiotemporal variations of drought in China were further investigated based on statistics of the frequency, duration,severity, and intensity of all drought events. Analysis of the results show that China has five distinct meteorological drought-prone regions: the Huang-Huai-Hai Plain, Northeast China, Southwest China, South China coastal region,and Northwest China. Seasonal analysis further indicates that there are evident spatial variations in the seasonal contribution to regional drought. But overall, most contribution to annual drought events in China come from the winter. Decadal variation analysis suggests that most of China's water resource regions have undergone an increase in drought frequency, especially in the Liaohe, Haihe, and Yellow River basins, although drought duration and severity clearly have decreased after the 1960 s. | Jun He Xiaohua Yang Zhe Li Xuejun Zhang Qiuhong Tang | 2016 | International Journal of Disaster Risk Science2016，7，1： | 7 |
| 15 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 6 |
| 16 | A benchmark test of boson sampling on Tianhe-2 supercomputer显示文摘Boson sampling, thought to be intractable classically, can be solved by a quantum machine composed of merely generation, linear evolution and detection of single photons. Such an analog quantum computer for this specific problem provides a shortcut to boost the absolute computing power of quantum computers to beat classical ones. However, the capacity bound of classical computers for simulating boson sampling has not yet been identified. Here we simulate boson sampling on the Tianhe-2 supercomputer, which occupied the first place in the world ranking six times from 2013 to 2016. We computed the permanent of the largest matrix using up to 312 000 CPU cores of Tianhe-2, and inferred from the current most efficient permanent-computing algorithms that an upper bound on the performance of Tianhe-2 is one 50-photon sample per ~100 min. In addition, we found a precision issue with one of two permanent-computing algorithms. | Junjie Wu Yong Liu Baida Zhang Xianmin Jin Yang Wang Huiquan Wang Xuejun Yang | 2018 | National Science Review2018，5，5： | 6 |
| 17 | Effect of Astragali and Angelica particle on proteinuria in Chinese patients with primary glomerulonephritis显示文摘OBJECTIVE: To investigate the effect of the traditional Chinese herbs Astragali and Angelicae Sinensis(A & As) particle [contains Huangqi(Radix Astragali Mongolica), Danggui(Radix Angelicae Sinensis),Huzhanggeng(Rhizoma Polygoni Cuspidati) and Danshen(Radix Salviae Miltiorrhizae)] on proteinuria in glomerulonephritis patients with stage 2 chronic kidney disease.METHODS: A prospective, multi-center, and randomized controlled clinical trial was performed for 24 weeks. From March 2011 to April 2012, 158 patients from nine hospitals in China participated.They were randomized into the A&As group(79 cases, A&As particle 15.2 g/day) and losartan group(79 cases, losartan 50 mg/day). At each follow-up visit, clinical data including blood pressure, urinalysis, 24-h-urinary protein excretion, serum albumin and serum creatinine were collected.RESULTS: All 158 patients completed the follow-up. Proteinuria in the losartan group exhibited a biphasic time-dependent decline with a significant steady reduction from baseline to week 12(P = 0.0014), and a platform level during the remaining 12-week follow-up(P > 0.05). In contrast, there was a continual significant decrease of proteinuria in the A & As group(P < 0.001). When compared with the losartan results, proteinuria in the A & As group from week 16 to week 24 was significantly reduced(P < 0.001). Stable e GFRs and blood pressure were also observed in both groups. Medication side effects were minimal and non-fatal.CONCLUSION: For Chinese glomerulonephritis patients with stage 2 chronic kidney disease, therapy with A & As particles may provide effective anti-proteinuria treatment. | Shen Peicheng Yang Xuejun He Liqun | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 6 |
| 18 | Reactive oxygen species may play an essential role in driving biological evolution: The Cambrian Explosion as an example显示文摘The Cambrian Explosion is one of the most significant events in the history of life;essentially all easily fossilizable animal body plans first evolved during this event. Although many theories have been proposed to explain this event, its cause remains unresolved.Here, we propose that the elevated level of oxygen, in combination with the increased mobility and food intake of metazoans, led to increased cellular levels of reactive oxygen species(ROS), which drove evolution by enhancing mutation rates and providing new regulatory mechanisms. Our hypothesis may provide a unified explanation for the Cambrian Explosion as it incorporates both environmental and developmental factors and is also consistent with ecological explanations for animal radiation. Future studies should focus on testing this hypothesis, and may lead to important insights into evolution. | Dong Yang Xuejun Guo Tian Xie Xiaoyan Luo | 2018 | Journal of Environmental Sciences2018，30，1： | 5 |
| 19 | Phase Ⅱ open-label study of recombinant circularly permuted TRAIL as a single-agent treatment for relapsed or refractory multiple myeloma显示文摘Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In an earlier phase I study, a novel form of recombinant human Apo2L/tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) that is currently in clinical development for the treatment of hematologic malignancies, i.e., circularly permuted TRAIL(CPT), was well tolerated at a dose of 2.5 mg/kg per day and showed promising preliminary activity in patients with RRMM. This phase II, open-label, multicenter study further investigated the eicacy and safety of 2.5-mg/kg per day CPT as single-agent therapy for patients with RRMM.Methods: Patients with RRMM were treated once daily with CPT(2.5 mg/kg, intravenously) for 14 consecutive days for each 21-day cycle. Clinical response and toxicity were assessed after each treatment cycle.Results: Twenty-seven patients received CPT. Using the European Group for Blood and Marrow Transplantation criteria, we calculated the overall response rate of 33.3% with 1 near-complete response(n CR) and 8 partial responses(PRs). The clinical beneit rate(48.1%) included 1 nCR, 8 PRs, and 4 minimal responses. The most common treatmentrelated adverse events(TRAEs) were fever, aspartate aminotransferase elevation, alanine aminotransferase elevation, leucopenia, rash, neutropenia, and thrombocytopenia. We graded toxicity using the Common Toxicity Criteria for Adverse Events, version 3.0, and determined that 37.0% of patients had at least 1 grade 3–4 TRAE.Conclusions: CPT as a single agent can elicit a response in patients with RRMM and is well tolerated. Further clinical investigation is warranted. | Yun Leng Lugui Qiu Jian Hou Yaozhong Zhao Xuejun Zhang Shifang Yang Hao Xi Zhongxia Huang Ling Pan Wenming Chen | 2016 | Chinese Journal of Cancer2016，35，12： | 4 |
| 20 | Laminin-coated multifilament entubulation, combined with Schwann cells and glial cell line-derived neurotrophic factor, promotes unidirectional axonal regeneration in a rat model of thoracic spinal cord hemisection显示文摘Biomaterial bridging provides physical substrates to guide axonal growth across the lesion.To achieve efficient directional guidance,combinatory strategies using permissive matrix,cells and trophic factors are necessary.In the present study,we evaluated permissive effect of poly(acrylonitrile-co-vinyl chloride)guidance channels filled by different densities of laminin-precoated unidirectional polypropylene filaments combined with Schwann cells,and glial cell line-derived neurotrophic factor for axonal regeneration through a T10 hemisected spinal cord gap in adult rats.We found that channels with filaments significantly reduced the lesion cavity,astrocytic gliosis,and inflammatory responses at the graft-host boundaries.The laminin coated low density filament provided the most favorable directional guidance for axonal regeneration which was enhanced by co-grafting of Schwann cells and glial cell line-derived neurotrophic factor.These results demonstrate that the combinatorial strategy of filament-filled guiding scaffold,adhesive molecular laminin,Schwann cells,and glial cell line-derived neurotrophic factor,provides optimal topographical cues in stimulating directional axonal regeneration following spinal cord injury.This study was approved by Indiana University Institutional Animal Care and Use Committees(IACUC#:11011)on October 29,2015. | Ling-Xiao Deng Nai-Kui Liu Ryan Ning Wen Shuang-Ni Yang Xuejun Wen Xiao-Ming Xu | 2021 | Neural Regeneration Research2021，16，1： | 4 |
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