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| 1 | Functional Electrospun Nanocomposites for Efficient Oxygen Reduction Reaction显示文摘Electrospinning with a simple and controllable process has extremely received considerable concerns by virtue of the fabrication and development of nanofibers.Moreover,nanofibers are playing an increasing impact on energy conversion and storage devices,especially for fuel cells based on oxygen reduction reaction(ORR),in view of the rich porosity,large surface area,excellent mass transportation and simply tunable composition,as well as good mechanical strength.In this review,we mainly introduce the primary principle of electrospinning technique,electrochemical reaction mechanism of ORR and synthetic strategies,and summarize the recent advances of unique non-noble-metal nanofibers on the basis of metal-organic framework(MOF)derivatives,single-atom catalysts(SACs)and transition metal oxides.More importantly,we emphasize on the influences of the components,morphology and architecture of advanced electrospun catalysts on their corresponding electrochemical performances towards ORR.Finally,the remaining puzzles and perspectives for further development of the electrospinning nanofibers involving electrocatalysis are presented.It is envisioned that this review would offer an important direction in designing novel electrocatalysts based on electrospinning nanofibrous structures and developing their potential. | ZHANG Xiuling GUO Shiquan QIN Yue LI Congju | 2021 | Chemical Research in Chinese Universities2021，37，3： | 1 |
| 2 | Ancient water wells reveal a prolonged drought in the lower Yellow River area about 2800 years ago显示文摘Proxy records from the North Atlantic realm reveal that large and rapid cooling known as the Bond events continued into the Holocene [1],repeatedly punctuating what is conventionally thought to have been a relatively stable climate.Given that the Holocene is the most recent interglacial period that has spurred the development of modern societies,scrutinizing climate variabil- ity during this period is important not only for predicting the trend of future climate changes,but also for better understanding the driving forces behind the rise and fall of ancient civilizations. | Shiyong Yu Xuexiang Chen Xiuling Liu Zhen Fang Junfeng Guo Senyang Zhan Hui Fang Fahu Chen | 2018 | Science Bulletin2018，63，20： | 1 |
| 3 | Enhanced Multi-phosphopeptide Enrichment and Nano LC-ESI-qTOF-MS Detection Strategy Using Click OEG-CD Matrix显示文摘 | ZHAO Yanyan WANG Liheng GUO Zhimou CHI Xiaofei MA Xiaochi QI Yan FANG Shinong LI Xiuling LIANG Xinmiao | 2015 | Chemical Research in Chinese Universities2015，31，1： | 1 |
| 4 | Generation of neutralizing monoclonal antibodies against Enterovirus 71 using synthetic peptides显示文摘 | Xiuling Li Chunming Mao Shujun Ma Xiaoqing Wang Zhe Sun Yao Yi Minzhuo Guo Xinliang Shen Le Sun Shengli Bi | 2009 | Biochemical and Biophysical Research Communications2009，，4： | 1 |
| 5 | Concurrent silencing of TBCE and drug delivery to overcome platinum-based resistance in liver cancer显示文摘Platinum-based chemotherapy resistance is a key factor of poor prognosis and recurrence in hepatocellular carcinoma(HCC).Herein,RNAseq analysis revealed that elevated tubulin folding cofactor E(TBCE)expression is associated with platinum-based chemotherapy resistance.High expression of TBCE contributes to worse prognoses and earlier recurrence among liver cancer patients.Mechanistically,TBCE silencing significantly affects cytoskeleton rearrangement,which in turn increases cisplatin-induced cycle arrest and apoptosis.To develop these findings into potential therapeutic drugs,endosomal pH-responsive nanoparticles(NPs)were developed to simultaneously encapsulate TBCE siRNA and cisplatin(DDP)to reverse this phenomena.NPs(siTBCE+DDP)concurrently silenced TBCE expression,increased cell sensitivity to platinum treatment,and subsequently resulted in superior anti-tumor effects both in vitro and in vivo in orthotopic and patient-derived xenograft(PDX)models.Taken together,NP-mediated delivery and the co-treatment of siTBCE+DDP proved to be effective in reversing chemotherapy resistance of DDP in multiple tumor models. | Senlin Li Siyu Chen Zhihui Dong Xingdong Song Xiuling Li Ziqi Huang Huiru Li Linzhuo Huang Ganyuan Zhuang Ran Lan Mingyan Guo Wende Li Phei Er Saw Lei Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 6 | Optimization of the Ethanol Extraction Method of Monoester Alkaloids from Radix Aconiti Preparata Based on HPLC-MS and Orthogonal Test显示文摘[Objectives] This study was conducted to optimize the ethanol extraction technology of monoester alkaloids from Radix Aconiti Preparata. [Methods]On the basis of defined extraction times,ethanol concentration,ethanol times and extraction time were investigated by HPLC-MS combined with orthogonal test to optimize extraction process using the content of monoester alkaloids( the sum of benzoyl neoaconitine,benzoyl hypoaconitine and benzoyl aconitine) as an index.[Results]The optimum ethanol extraction technology was as follows: 75% ethanol,ethanol amount 25 times of the medicinal material,and each extraction for 1. 5 h.[Conclusions] The optimal extraction technology is simple,feasible,stable and reliable. It can provide reference for the industrial production and quality control of monoester alkaloids from Radix Aconiti Preparata. | Changkai ZHOU Rui ZHANG Xiuling SHANG Lihua ZHOU Zukang ZHANG Jing GAO Hongxia YU Hongyan JI Xiaomin XING Qie GUO Donghua LIU Fangang MENG Jingchun YAO Na ZHANG Yongjun LIU Fanbo JING | 2020 | Agricultural Biotechnology2020，9，3： | 0 |
| 7 | Nanoparticle(NP)-mediated APOC1 silencing to inhibit MAPK/ERK and NF-κB pathway and suppress breast cancer growth and metastasis显示文摘Breast cancer is one of the most common malignant tumors with high mortality and poor prognosis in women.There is an urgent need to discover new therapeutic targets for breast cancer metastasis.Herein,we identified that Apolipoprotein C1(APOC1)was up-regulated in primary tumor of breast cancer patient that recurrence and metastasis by immunohistochemistry(IHC).Kaplan-Meier Plotter database showed that high levels of APOC1 in breast cancer patients were strongly associated with worse overall survival(OS)and relapse-free survival(RFS).Mechanistically,APOC1 silencing significantly inhibits MAPK/ERK kinase pathway and restrains the NF-κB to decrease the transcription of target genes related to growth and metastasis in vitro.Based on this regulatory mechanism,we developed these findings into potential therapeutic drugs,glutathione(GSH)responsive nanoparticles(NPs)were used for systemic APOC1 siRNA delivery,NPs(siAPOC1)silenced APOC1 expression,and subsequently resulted in positive anti-tumor effects in orthotopic and liver metastasis models in vivo.Taken together,GSH responsive NPmediated siAPOC1 delivery was proved to be effective in regulating growth and metastasis in multiple tumor models.These findings show that APOC1 could be a potential biomarker to predict the prognosis of breast cancer patients and NP-mediated APOC1 silencing could be new strategies for exploration of new treatments for breast cancer metastasis. | Shaomin Liu Fengqian Zhang Yixia Liang Guo Wu Rong Liu Xiuling Li Phei Er Saw Zhonghan Yang | 2023 | Science China(Life Sciences)2023，66，11： | 0 |
| 8 | 血压变化和空气污染微粒的化学成分显示文摘[背景]血压升高与颗粒物(PM)空气污染相关,但是与PM化学成分的关联尚不明确。[目的]通过对一组39名大学生进行460次反复访查,探讨血压与不同化学成分的细颗粒物(PM2.5)之间的关联。 | Shaowei Wu Furong Deng Jing Huang Hongyi Wang Masayuki Shima Xin Wang Yu Qin Chanjuan Zheng Hongying Wei Yu Hao Haibo Lv Xiuling Lu Xinbiao Guo | 2013 | 环境与职业医学2013，30，4： | 0 |
| 9 | Electronic interaction and oxygen vacancy engineering of g-C_(3)N_(4)/α-Bi_(2)O_(3) Zscheme heterojunction for enhanced photocatalytic aerobic oxidative homo-/hetero-coupling of amines to imines in aqueous phase显示文摘Photocatalytic oxidation coupling of amines represents a green and cost-effective method for the synthesis of highly value-added imines under visible light irradiation.However,the catalytic efficiency was severely limited by poor visible light response and easy recombination of photogenerated charge carriers.Herein,we report a g-CgN_(4)/α-Bi_(2)O_(3)Z-scheme heterojunction via electrostatic self-assembly of g-C_(3)N_(4)nanosheets and oxygen-va-cancy-rich aα-Bi_(2)O_(3)microsphere for visible-light driven oxidative coupling of amines to imines in H_(2)0 as green solvent at room temperature.Amines with diverse functional groups were efficiently converted into the corre-sponding imines in good to excellent yields.Impressively,this photocatalytic protocol is applicable for the challenging hetero-coupling of two structurally different amines to construct complicated asymmetric imines,which is the first report of photocatalytic hetero-coupling of amines to imines to our knowledge.Furthermore,the Z-scheme heterojunction also demonstrated high stability and could be readily separated and reused without obvious decay in activity and selectivity.Comprehensive characterizations and control experiments reveal the construction of Z-scheme heterojunction with intimate interface between g-CgN4 and a-Bi_(2)O_(3)greatly boosts the transfer and separation of photogenerated charge carries and enhances the redox capability.Meanwhile,the surface oxygen vacancies in a-Biz_(2)O_(3)also benefits the separation of photogenerated charge carriers and acti-vation of reactants.These jointly contributed to an enhanced photocatalytic performance for oxidative coupling of amines to imines. | Yanhua Gao Tao Song Xiuling Guo Yan Zhang Yong Yang | 2023 | Green Carbon2023，1，2： | 0 |
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