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| 1 | Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia显示文摘Microglia 玩在由降级的 A 的清理的一个枢轴的角色他们在 lysosomes,在 Alzheimers 疾病(广告) 阻止淀粉的匾致病。最近的证据建议那个 lysosomal 机能障碍导致有毒的蛋白质总数的不够的消除。我们测试了是否与抄写因素 EB (TFEB ) 提高 lysosomal 功能,必要管理者 modulating lysosomal 小径,将在 microglia 支持一个清理。这里,我们证明 TFEB 的那 microglial 表情便于降级和还原剂扔了的纤丝状的 A (fA ) 淀粉的匾,它被 TFEB 的 deacetylation 进一步提高。用集体 spectrometry 分析,我们第一证实了是的 acetylation 一以前 TFEB 的 unreported 修正并且发现那 SIRT1 直接交往了与并且在离氨酸残余 116 点的 deacetylated TFEB。随后,当 TFEB 被击倒时, SIRT1 overexpression 由 TFEB 下游的目标的 upregulating transcriptional 层次提高了 lysosomal 功能和 fA 降级,它能被禁止。而且,在在 microglia 变异的 K116R 的 deacetylated TFEB 的 overexpression 由刺激 lysosomal 生物的续生说加速了细胞内部的 fA 降级并且极大地在 APP/PS1 转基因的老鼠的大脑片减少了扔的淀粉的匾。我们的调查结果表明 TFEB 的 deacetylation 能调整 lysosomal 生物的续生说和 fA 降级,为 attenuating 使 TFEB 的 microglial 激活成为可能的策略在广告的淀粉的匾免职。 | Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji | 2016 | Protein & Cell2016，7，6： | 10 |
| 2 | Synergistic effect of MXene on the flame retardancy and thermal degradation of intumescent flame retardant biodegradable poly(lactic acid)composites显示文摘The effect of Ti3C2 MXene nanosheets on the intumescent flame retardant(IFR)poly(lactic acid)(PLA)composites was investigated among a series of PLA/IFR/MXene,which were prepared by melt blending 0-2.0 wt%MXene,10.0 wt%-12.0 wt%IFR and PLA together.The results of limiting oxygen index(LOI)and vertical burning(UL-94)discover that the combination of 0.5 wt%MXene and 11.5 wt%IFR synergistically improves the fire safety of PLA to reach UL-94 V-0 rating with LOI value of 33.0%.The PLA/IFR/MXene composites perform an obvious reduction in peak of heat release rate(HRR)in cone calorimeter tests(CCTs).Furthermore,the carbon residues after CCTs were characterized by scanning electron microscope(SEM),laser Raman spectroscopy(LRS),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS).It is demonstrated that both the titanium composition of the MXene structure and the characteristics of the two-dimensional material enhance the PLA/IFR/MXene composite materials’ability to produce a dense barrier layer to resist burnout during thermal degradation. | Haowei Huang Dexuan Dong Weijie Li Xinya Zhang Li Zhang Ying Chen Xinxin Sheng Xiang Lu | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 7 |
| 3 | Nano-selenium controlled cadmium accumulation and improved photosynthesis in indica rice cultivated in lead and cadmium combined paddy soils显示文摘Selenium nanoparticles(Se NPs) are less toxic and more biocompatible than selenite or selenate. However, studies involving spraying with Se NPs for reducing accumulation of cadmium(Cd) and lead(Pb) in rice grains have been rarely reported as yet. Herein, indica rice seedlings cultivated in Cd + Pb-spiked paddy soils(denoted as positive control) were sprayed with Se NPs sols for four times from tillering to booting stage. Compared to positive control, 50–100 μmol/L Se NPs downregulated Cd transporters-related genes such as Os LCT 1, OsH MA 2 and Os CCX2 in leaves and OsLCT1, Os PCR1 and Os CCX2 genes in node I at filling stage. Meanwhile, Se-binding protein 1 was distinctly elevated, involving the repression of Cd and Pb transportation to rice grains. Se NPs also differentially improved RuBP carboxylase and chlorophylls especially some key genes and proteins involving photosynthetic system. Besides, 25–50 μmol/L Se NPs diminished reactive oxygen species overproduction from NADPH oxidases whereas boosted glutathione peroxidase, reducing protein carbonylation in rice seedlings. However, the antioxidant isozymes and oxidatively modified proteins were slightly rebounded at 100 μmol/L. Se contents were noticeably elevated and confirmed to exist as selenomethionine in the rice grains following all the treatments by Se NPs. Thus, the optimal dosage of Se NPs for foliar application is 50 μmol/L, which significantly decreased Cd accumulation, improved photosynthesis and Se enrichment whereas caused no distinct reduction of Pb in the grains. Thus, an appropriate dosage of Se NPs can be conducted to decrease Cd accumulation, improve photosynthesis, and organic Se contents in rice grains. | Chengrun Wang Tingting Cheng Haitao Liu Fangyun Zhou JifengZhang Min Zhang Xinya Liu Wenjun Shi Tong Cao | 2021 | Journal of Environmental Sciences2021，33，5： | 5 |
| 4 | Superior anti-corrosion and self-healing bi-functional polymer composite coatings with polydopamine modified mesoporous silica/graphene oxide显示文摘In this article,graphene oxide(GO)and benzotriazole-loaded mesoporous silica nanoparticles(BTA/MSNs)are combined on micro scale through the in situ polymerization of polydopamine(PDA),preparing a selfhealing bi-functional GO(fGO)used as nano-fillers for anti-corrosion enhancement of waterborne epoxy(WEP)coatings.Scanning electronic microscopy(SEM)images show that the BTA/MSNs are uniformly distributed on the surface of high aspect ratio GO nanosheets to endow GO nanocontainer characteristics.UV-vis profiles demonstrate that fGO has p H-controlled release function.Modulus at lowest frequency is generally used for comparing the corrosion resistance of organic coatings.Modulus at lowest frequency(1.42×10^(5)Ωcm^(2))after 30 days immersion in 3.5 wt.%Na Cl solution revealed 2 orders of magnitude higher that of blank WEP(1.17×10^(7)Ωcm^(2)).With artificial cracks on its coatings,fGO/WEP had no obvious rust compared with blank WEP after 240 h of immersion.We anticipate that self-healing and physical barrier bi-functional nanocontainers improve the traditional anticorrosion coating efficiency with better,longer-lasting performance for shipping,oil drilling or bridge maintenance. | Yanqi Ma Haowei Huang Hongda Zhou Michael Graham James Smith Xinxin Sheng Ying Chen Li Zhang Xinya Zhang Elena Shchukina Dmitry Shchukin | 2021 | Journal of Materials Science & Technology2021，，36： | 4 |
| 5 | Integration of filter membrane and Ca_(2)Nb_(3)O_(10) nanosheets for high performance flexible UV photodetectors显示文摘We report that the integration of filter membrane and Ca_(2)Nb_(3)O_(10)nanosheets(FM@CNO) UV photodetector(UV PD) shows high performance and excellent flexibility. The Ca_(2)Nb_(3)O_(10)nanosheets were prepared by a facile solid-state reaction and liquid exfoliation process. The Ca_(2)Nb_(3)O_(10)nanosheets can be integrated into the pores of a filter membrane via a simple vacuum filtration method. The FM@CNO UV PD shows high performance under 300 nm light illumination at 5 V bias, including high responsivity(0.08 AW^(-1)), high detectivity(1.1 × 10^(12)Jones), high UV/visible rejection ratio(3.86 × 10^(3)) and fast speed(0.12/1.24 ms). Furthermore, the FM@CNO device exhibits excellent flexibility after many bending cycles.In addition, the FM@CNO array device was used as a pixel array detector for UV imaging. This work provides a novel approach to achieve high performance flexible PDs based on filter membrane and two dimensional materials. | Yong Zhang Fa Cao Siyuan Li Xinya Liu Lixing Kang Limin Wu Xiaosheng Fang | 2022 | Journal of Materials Science & Technology2022，，34： | 1 |
| 6 | Kinetics for chlorination of maleic anhydride grafted polypropylene显示文摘 | Fu Heqing Huang Hong Zhang Xinya | 2007 | Journal of Appied Polymer Science2007，106，1： | 1 |
| 7 | A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers显示文摘Mutations of the RAS oncogene are found in around 30%of all human cancers yet direct targeting of RAS is still considered clinically impractical except for the KRAS^(G12C)mutant.Here we report that RAS-ON(RASON),a novel protein encoded by the long intergenic non-protein coding RNA 00673(LINC00673),is a positive regulator of oncogenic RAS signaling.RASON is aberrantly overexpressed in pancreatic ductal adenocarcinoma(PDAC)patients,and it promotes proliferation of human PDAC cell lines in vitro and tumor growth in vivo.CRISPR/Cas9-mediated knockout of Rason in mouse embryonic fibroblasts inhibits KRAS-mediated tumor transformation.Genetic deletion of Rason abolishes oncogenic KRAS-driven pancreatic and lung cancer tumorigenesis in LSL Kras^(G12D);Trp53R172H/+mice.Mechanistically,RASON directly binds to KRAS^(G12D)/V and inhibits both intrinsic and GTPase activating protein(GAP)-mediated GTP hydrolysis,thus sustaining KRAS^(G12D/V)in the GTP-bound hyperactive state.Therapeutically,deprivation of RASON sensitizes KRAS mutant pancreatic cancer cells and patient-derived organoids to EGFR inhibitors.Our findings identify RASON as a critical regulator of oncogenic KRAS signaling and a promising therapeutic target for KRAS mutant cancers. | Rongjie Cheng Fanying Li Maolei Zhang Xin Xia Jianzhuang Wu Xinya Gao Huangkai Zhou Zhi Zhang Nunu Huang Xuesong Yang Yaliang Zhang Shunli Shen Tiebang Kang Zexian Liu Feizhe Xiao Hongwei Yao Jianbo Xu Chao Yan Nu Zhang | 2023 | Cell Research2023，33，1： | 1 |
| 8 | Influence of carboxyl groups on the particle size and rheological properties of polyacrylate latices显示文摘 | Xinya Zhang Heqing Fu Hong Huang Huanqin Chen | 2010 | Journal of Wuhan University of Technology - Mater Sci Ed2010，，3： | 1 |
| 9 | Effect of reflection and 2 K gratings on self-pumped phase-conjugate mirrors: theoretical and experimental studies 显示文摘 | DOU S X CHI Mingjun ZHANG Xinya | 1999 | J Opt Soc Am (B)1999，16，3： | 1 |
| 10 | Improved in situ sequencing for high-resolution targeted spatial transcriptomic analysis in tissue sections显示文摘Spatial transcriptomics enables the study of localization-indexed gene expression activity in tissues,providing the transcriptional landscape that in turn indicates the potential regulatory networks of gene expression.In situ sequencing(ISS)is a targeted spatial transcriptomic technique,based on padlock probe and rolling circle amplification combined with next-generation sequencing chemistry,for highly multiplexed in situ gene expression profiling.Here,we present improved in situ sequencing(IISS)that exploits a new probing and barcoding approach,combined with advanced image analysis pipelines for high-resolution targeted spatial gene expression profiling.We develop an improved combinatorial probe anchor ligation chemistry using a 2-base encoding strategy for barcode interrogation.The new encoding strategy results in higher signal intensity as well as improved specificity for in situ sequencing,while maintaining a streamlined analysis pipeline for targeted spatial transcriptomics.We show that IISS can be applied to both fresh frozen tissue and formalin-fixed paraffin-embedded tissue sections for single-cell level spatial gene expression analysis,based on which the developmental trajectory and cell-cell communication networks can also be constructed. | Xinbin Tang Jiayu Chen Xinya Zhang Xuzhu Liu Zhaoxiang Xie Kaipeng Wei Jianlong Qiu Weiyan Ma Chen Lin Rongqin Ke | 2023 | Journal of Genetics and Genomics2023，50，9： | 1 |
| 11 | Co-adsorption behaviors of asphaltenes and different flow improvers and their impacts on the interfacial viscoelasticity显示文摘Commonly used flow improvers in oilfields,such as ethylene–vinyl acetate copolymer(EVA),poly(octadecyl acrylate)(POA),and polymethylsilsesquioxane(PMSQ)are proven to be effective to enhance the flowability of crude oil.However,the addition of these flow improvers may change the stability of the emulsion and make the crude oil treatment process challenging.In this research,the impacts of different flow improvers on the interfacial properties of the emulsions containing asphaltenes are systematically investigated.The co-adsorption behaviors of the flow improvers and asphaltenes are analyzed through dynamic interfacial tension(DIFT).The rheological properties of the interfacial layer after the adsorption are explored via dilational viscoelasticity.Significant difference is observed in the structural properties of the interface adsorbed by different flow improvers,which is attributed to different interactions between the flow improvers and asphaltenes.To investigate these interactions,conductivity,asphaltenes precipitation,dynamic light scattering(DLS),and contact angle experiments are conducted systematically.Results show that EVA and POA can alter the interfacial properties by changing the asphaltene dispersion state.The interaction between EVA and asphaltenes is stronger than that between POA and asphaltenes due to the difference in molecular structures.Unlike EVA and POA,the change of interfacial property with the addition of PMSQ is attributed to the partial adsorption of asphaltenes on PMSQ. | Hao Zhang Daiwei Liu Jiangbo Wen Guangyu Sun Chuanxian Li Xinya Chen Huihui Zhang Ze Duan | 2022 | Chinese Journal of Chemical Engineering2022，35，8： | 1 |
| 12 | 上海天文馆显示文摘上海天文馆坐落于滴水湖畔,总面积约3.8万m^(2)作为上海科技馆分馆,是全球规模最大的天文学主题博物馆。其致力于营造沉浸式体验,让游客可以与各种天文现象直接互动,并通过对比例、形态以及光线的细致处理,提升人们对于太阳和地球轨道运动之间的基本关系的认知。 | 无 V.Guy Maxwell Grace Chen Wei Wei Kuang Charles Wolf Anthony Guaraldo Jorge Arias Margarita Calero Michael Caton Christina Ciardullo Eugene Colberg Regina Jiang Jörg Kiesow Aidan Kim Stefan Knust Xinya Li Francelle Lim Xiaoyun Mao David Monnar Nikita Payusov James Rhee Yong Kyun Roh Miya Ruan Na Sun Eric Tsui Stephanie Tung Charles Wong David Yu Fred Zhang | 2022 | 建筑实践2022，，5： | 1 |
| 13 | Advances in the research of nitrogen containing stainless steels显示文摘The current status of nitrogen containing stainless steels at home and aboard has been introduced. The function and existing forms of nitrogen in the stainless steels, influence of nitrogen on mechanical properties and anti-corrosion properties as well as the application of nitrogen containing cast stainless steels were discussed in this paper. It is clear that nitrogen will be a potential and important alloying element in stainless steels. And Argon Oxygen Decarbonization (AOD) refining can provide an advanced manufacture process for nitrogen containing stainless steels with ultra-low- carbon and high cleanliness. | Zhongqiu ZHANG Xinya LI Yanchun LOU Xili LIU Zhi Wang | 2004 | China Foundry2004，1，1： | 1 |
| 14 | Effect of reflection and 2K gratings on self-pumped phase-conjugate mirrors: theoretical and experimental studies显示文摘 | S X Dou Mingjun Chi Xinya Zhang Yong Zhu Peixian Ye | 1999 | J Opt Soc Am B1999，16，3： | 1 |
| 15 | Orange-red, green, and blue fiuorescence carbon dots for white light emitting diodes显示文摘Fluorescent carbon dots(CDs) are admirable nanomaterials due to their superior optical properties and low cost.However,regulation of the emission colors in CDs for lighting device still remains a challenge.In this work,we developed a green hydrothermal method to obtain three emission colors of CDs using L-tyrosine(for blue CDs),o-phenylendiamine(for green CDs) and L-tyrosine/o-phenylendiamine mixture(for orange-red CDs).These CDs possess good water dispersibility,strong emission with high quantum yields,and excellent photostability.Furthermore,the resulting CDs were dispersed in polyvinyl alcohol(PVA) matrix to yield solid state films,where the self-quenching effect in solid state was effectively avoided.A full-color light-emitting diode was fabricated by packing the CDs-PVA composites on the top of a UV-chip,which have superior potential applications in CDs-based solid-state lighting system. | Ling Jin Li Zhang Lei Yang Xingrong Wu Cheng Zhang Kang Wei Lifang He Xinya Han Hongbin Qiao Abdullah MAsiri Khalid AAlamry Kui Zhang | 2020 | Journal of Materials Science & Technology2020，47，15： | 1 |
| 16 | Preparation of water-borne polyurethane dispersion modified by epoxy resin显示文摘 | Zhu Yan'an Zhang Xinya Yan Hong | 2008 | Journal of Jiangsu University:Natural Science Edition2008，29，2： | 1 |
| 17 | Evidence of surface acoustic wave band gaps in the phononic crystals created on thin plates显示文摘 | Zhang Xinya Jackson T Lafond E | | 0，，04： | 1 |
| 18 | Characterization and properties of gradient polyacrylate latex particles by gradient emulsion polymerization显示文摘 | Xinya Zhang Xia Wei Wenxing Yang Yongjin Li Huanqin Chen | 2012 | Journal of Coatings Technology and Research2012，，6： | 1 |
| 19 | Influence of carboxyl groups on the particle size and rheological properties of polyacrylate latices显示文摘 | Xinya Zhang Heqing Fu Hong Huang Huanqin Chen | 2010 | Journal of Wuhan University of Technology - Mater Sci Ed2010，，3： | 1 |
| 20 | Effect of Reflection and 2K Gratings on Self-pumped Phase-cojugate Minors: Theoretical and Experimental Studies 显示文摘 | Dou S X Mingjun Chi Xinya Zhang Yong Zhu Peixian Ye | 1999 | J Opt Soc Am B1999，16，3： | 1 |
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