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| 1 | Variations of the spring precipitation day numbers reconstructed from tree rings in the Urumqi River drainage,Tianshan Mts.over the last 370 years显示文摘The tree-ring cores of Tianshan spruces collected from nine sites in the Urumqi River drainage of the middle Tianshan Mountains were used to establish three types of the tree-ring width chronologies over the last 370 years, using the international standard method of dendrochronology. Our study demonstrates that dendrochronology can be better used to reconstruct the number of the precipitation day than to reconstruct the precipitation amount in middle Tianshan Mountains. It is found that the residual chronology among the three tree-ring width chronologies has the best relationship with number of spring precipitation days from May 20 to June 8. The chronologies at Haxionggou B site and Zaierdegou site in the Urumiqi drainage have the highest correlation with the observed number of spring precipitation days at Daxigou meteorological station, and are used to reconstruct the spring precipitation days over the last 370 years in the drainage. The main significant decreasing trend of the number of the spring precipitation days occurred during 1665—1717, while the significant increasing trends happened during 1805—1841 and 1914—1943. The reconstructed series of the number of spring precipitation days has quasi-periodic variations of 3.3, 2.1, 2.5, 12.3 and 32.0 years with the dominated short periodical changes. The long cycle of 32 years is shown quite clearly in the 10-year smoothed sequence. The maximum spring precipitation days occurred mainly in the 1630s, 1840s and 1940s, while the lowest number of spring precipitation days for the 10-year average occurred in the 1710s. | YUANYujiang JINLiya SHAOXuemei HEQing LIZhizhong | 2003 | Chinese Science Bulletin2003，48，14： | 47 |
| 2 | Flavones Isolated from Codonopsis xundianensis显示文摘Genus Codonopsis comprises more than 40 species in China. The roots of these plants have been used as traditional Chinese medicines or folk love herbs. Codonopsis xundianensis Wang ZT et Xu GJ grows in Yunnan Province and its roots are often used as a tonic. In this paper, we report the isolation and structural elucidation of chrysoeriol (1), tricin (2), wogonin (3) and luteolin (4) from the roots of Codonopsis xundianensis. Compounds 1-3 were found in Codonopsis for the first time. | HEQing ZHUEn-yuan WANGZheng-tao XULuo-shan HUZhi-bi | 2004 | Journal of Chinese Pharmaceutical Sciences2004，13，3： | 24 |
| 3 | Fluvial diversity in relation to valley setting in the source region of the Yangtze and Yellow Rivers显示文摘山谷设定的空间分发(旁边地自由,部分限制,或限制) 并且在 Yangtze 和黄河的来源区域的河的形态学被对比并且分析。长江的来源区域被划分成 3 宽广的节(我, II 和 III )基于山谷设定和隧道坡度,与被描绘由的在上游、下游的节限制(一些活动范围部分限制)山谷,当中间的节被描绘与时宽、浅,旁边地自由的山谷。峡在节是突出的我和 III,当编织隧道模式统治节 II 时。由对比,黄河的来源区域基于山谷特征和隧道坡度被划分成 5 宽广的节(节 IV ) 。节我, II 和 IV 是冲积活动范围与主要旁边地自由(一些短活动范围部分限制) 山谷。节 III 和 V 主要被限制或部分限制。更大的词法差异在相对上面的长江的黄河的来源区域是明显的。这包括编织, anabranching,吻合,蜿蜒地流并且笔直地冲积的模式,与在限制活动范围的峡。这个区域的宏消除(举起,坡度,方面,山谷排列和监禁) ,直接连接了到 Qinghai 西藏高原的构造运动,系住到气候, hydrologic 和关於生命的考虑,是在在这个区域的河差异的模式之上的主要控制。 | YU Guo-an LIU Le LI Zhiwei LI Yanfu HUANG Heqing Gary BRIERLEY Brendon BLUE WANG Zhaoyin PAN Baozhu | 2013 | Journal of Geographical Sciences2013，23，5： | 14 |
| 4 | Glacier retreat and its effect on stream flow in the source region of the Yangtze River显示文摘在冰河上在气候变化的效果上正在种担心融化并且水文学。在这篇文章,我们在长江的来源区域使用了二自然的小规模的盆, Tuotuo 河和 Buqu 河,中国,到表演,冰河的影响融化在溪流流动上。在在 1970, 1992 和 2009 的冰河和冰体积的程度的变化用遥感图象被评估。在一样的时间间隔上的冰河表面区域的变化用 Landsat TM/ETM+ 形象通过冰河轮廓和位置的描述被估计。在 2009,冰河表面区域分别地在 Tuotuo 河和 Baqu 河盆由 1970 价值中的 20.83% 个和 34.81% 减少了。在每盆的全部的 meltwater 供应被估计是 2.56 ?? | WU Shanshan YAO Zhijun HUANG Heqing LIU Zhaofei CHEN Yuansheng | 2013 | Journal of Geographical Sciences2013，23，5： | 13 |
| 5 | Multiple Cropping Intensity in China Derived from Agro-meteorological Observations and MODIS Data显示文摘Double-and triple-cropping in a year have played a very important role in meeting the rising need for food in China.However,the intensified agricultural practices have significantly altered biogeochemical cycles and soil quality.Understanding and mapping cropping intensity in China′s agricultural systems are therefore necessary to better estimate carbon,nitrogen and water fluxes within agro-ecosystems on the national scale.In this study,we investigated the spatial pattern of crop calendar and multiple cropping rotations in China using phenological records from 394 agro-meteorological stations(AMSs)across China.The results from the analysis of in situ field observations were used to develop a new algorithm that identifies the spatial distribution of multiple cropping in China from moderate resolution imaging spectroradiometer(MODIS)time series data with a 500 m spatial resolution and an 8-day temporal resolution.According to the MODIS-derived multiple cropping distribution in 2002,the proportion of cropland cultivated with multiple crops reached 34%in China.Double-cropping accounted for approximately 94.6%and triple-cropping for 5.4%.The results demonstrat that MODIS EVI(Enhanced Vegetation Index)time series data have the capability and potential to delineate the dynamics of double-and triple-cropping practices.The resultant multiple cropping map could be used to evaluate the impacts of agricultural intensification on biogeochemical cycles. | YAN Huimin XIAO Xiangming HUANG Heqing LIU Jiyuan CHEN Jingqing BAI Xuehong | 2014 | Chinese Geographical Science2014，24，2： | 11 |
| 6 | Efficient visible light photo-Fenton-like degradation of organic pollutants using in situ surface-modified BiFeO_3 as a catalyst显示文摘The visible light photo-Fenton-like catalytic performance of BiFeO3 nanoparticles was investigated using Methyl Violet(MV),Rhodamine B(RhB) and phenol as probes.Under optimum conditions,the pseudo first-order rate constant(k) was determined to be 2.21 × 102,5.56 × 102 and 2.01 × 102 min 1 for the degradation of MV(30 μmol/L),RhB(10 μmol/L) and phenol(3 mmol/L),respectively,in the BiFeO3-H2O2-visible light(Vis) system.The introduction of visible light irradiation increased the k values of MV,RhB and phenol degradation 3.47,1.95 and 2.07 times in comparison with those in dark.Generally,the k values in the BiFeO3H2O2-Vis system were accelerated by increasing BiFeO3 load and H2O2 concentration,but decreased with increasing initial pollutant concentration.To further enhance the degradation of pollutants at high concentrations,BiFeO3 was modified with the addition of surface modifiers.The addition of ethylenediamineteraacetic acid(EDTA,0.4 mmol/L) increased the k value of MV degradation(60 μmol/L) from 1.01 × 102 min-1 in the BiFeO 3-H2O2-Vis system to 1.30 min-1 in the EDTA-BiFeO3-H2O2-Vis system by a factor of 128.This suggests that in situ surface modification can enable BiFeO3 nano-particles to be a promising visible light photo-Fenton-like catalyst for the degradation of organic pollutants. | Junjian An Lihua Zhu Yingying Zhang Heqing Tang | 2013 | Journal of Environmental Sciences2013，25，6： | 10 |
| 7 | Shrinking and Drying up of Baiyangdian Lake Wetland:A Natural or Human Cause?显示文摘The shrinking and drying up of wetlands in arid and semiarid areas of China have been widely observed in the recent years,but there has been no consensus on whether the aggravation is caused by human activities or by global climate warming.For a better understanding of the cause,this study investigates the dynamic changes of Baiyangdian Lake wetland over the last 40 years.It is shown that since the 1980s,Baiyangdian Lake has suffered from an insufficient water input and shrunk considerably.By using SPSS11.0,this study undertakes a detailed analysis on the significance of the effects of the possible driving factors for the degradation.It is identified that the North China Plain has been warming up significantly in recent years,which causes a significant reduction in the precipitation and inflow to the lake.Although human disturbances such as the irrigation and storage of water in reservoirs do not play a decisive role,they accelerate the degradation and their effects should be minimized. | LIU Chunlan XIE Gaodi HUANG Heqing | 2006 | Chinese Geographical Science2006，16，4： | 9 |
| 8 | Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism显示文摘The obstruction of post-insulin receptor signaling is the main mechanism of insulin-resistant diabetes.Progestin and adipoQ receptor 3(PAQR3),a key regulator of inflammation and metabolism,can negatively regulate the PI3 K/AKT signaling pathway.Here,we report that gentiopicroside(GPS),the main bioactive secoiridoid glycoside of Gentiana manshurica Kitagawa,decreased lipid synthesis and increased glucose utilization in palmitic acid(PA) treated HepG2 cells.Additionally,GPS improved glycolipid metabolism in streptozotocin(STZ) treated high-fat diet(HFD)-induced diabetic mice.Our findings revealed that GPS promoted the activation of the PI3 K/AKT axis by facilitating DNA-binding protein 2(DDB2)-mediated PAQR3 ubiquitinated degradation.Moreover,results of surface plasmon resonance(SPR),microscale thermophoresis(MST) and thermal shift assay(TSA) indicated that GPS directly binds to PAQR3.Results of molecular docking and cellular thermal shift assay(CETSA) revealed that GPS directly bound to the amino acids of the PAQR3 NH2-terminus including Leu40,Asp42,Glu69,Tyr125 and Ser129,and spatially inhibited the interaction between PAQR3 and the PI3 K catalytic subunit(P110α) to restore the PI3 K/AKT signaling pathway.In summary,our study identified GPS,which inhibits PAQR3 expression and directly targets PAQR3 to restore insulin signaling pathway,as a potential drug candidate for the treatment of diabetes. | Haiming Xiao Xiaohong Sun Zeyuan Lin Yan Yang Meng Zhang Zhanchi Xu Peiqing Liu Zhongqiu Liu Heqing Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 7 |
| 9 | EXPERIMENTAL STUDY ON THE RELATION OF BED MORPHOLOGY WITH SURFACE FLOW IN MEANDER CHANNELS显示文摘Alternate bars have the property that they migrate downstream whenever floods occur. However, in meander channels whose bend angles are larger than a critical value, the migration of bars can be suppressed, and the positions of bank erosion and flood attack also will be steady. In this study, the bed morphology in flume channels with bends of various lengths and angles is investigated at various flow discharges, and the relation of bed morphology to surface flow is investigated in detail using fluid measuring software. An effort is made to obtain guidelines for the plane shape design of meander channels. Based on the experimental results of bed topography and measurement of surface flow direction and velocity distribution, from the viewpoint of bank erosion and the concentration and dispersion of flood flow the most suitable plane shape for meandering channels is suggested through which the migration of alternate bars is suppressed. | Heqing DU Hajime MIWA | 2006 | International Journal of Sediment Research2006，21，1： | 6 |
| 10 | Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy显示文摘 | Deng Yanhui Lan Tian Huang Juan Huang Heqing | 2014 | Chinese Medical Journal2014，，16： | 6 |
| 11 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 12 | Controlled growth and photoluminescence of highly oriented arrays of ZnO nanocones with different diameters显示文摘Large-scale oriented ZnO nanocone arrays were directly grown on zinc substrate through a hydro-thermal reaction of Zn foil with aqueous butylamine solution(3 mol/L) at 100-180 ℃ for 12 h.The syn-thesized products were characterized with X-ray diffraction,Raman spectrum,scanning electron mi-croscopy and transmission electron microscopy.The results showed that the ZnO nanocones were single crystalline with the wurtzite structure and grown along the [0001] direction.The diameter of nanocones is decreased with increasing the reaction temperature.A possible growth mechanism was also proposed to account for the formation of the ZnO nanocone arrays.The photoluminescence spectra of the ZnO nanocone arrays were studied at room temperature,two UV emission bands at 377 and 396 nm assigned to free exciton emission and exciton-exciton collision,respectively,and phonon replicas associated with 2-E2 phonon were observed in the PL spectra. | MA JunHu YANG HeQing SONG YuZhe LI Li XIE XiaoLi LIU RuiNi WANG LinFang | 2009 | Science China(Technological Sciences)2009，52，5： | 4 |
| 13 | Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models显示文摘In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy wereinvestigated as new temporary implants for urinary applications. The corrosion mechanism in artificialurine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarizationtests. The corrosion potential of pure magnesium and ZK60 alloy were -1820 and -1561 mV, respectively,and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm^-2, respectively. Thein vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0.382 and 1.023 mm/y,respectively, determined from immersion tests. The ZK60 alloy degraded faster than the pure Mg in bothartificial urine and in rat bladders (the implants of both samples are ø 3 mm × 5 mm). Histocompatibilityevaluations showed good histocompatibility for the pure Mg and ZK60 alloy during the 3 weeks postimplantationin rat bladders, and no harm was observed in the bladder, liver and kidney tissues. Theresults provide key information on the degradation properties and corrosion mechanism of pure Mg andZK60 alloy in the urinary system. | Shiying Zhang Yanze Bi Jianye Li Zhenguo Wang Jingmin Yan Jiawang Song Haibo Sheng Heqing Guo Yan Li | 2017 | Bioactive Materials2017，2，2： | 4 |
| 14 | A Novel Design of Hybrid Energy Storage System for Electric Vehicles显示文摘In order to provide long distance endurance and ensure the minimization of a cost function for electric vehicles,a new hybrid energy storage system for electric vehicle is designed in this paper.For the hybrid energy storage system,the paper proposes an optimal control algorithm designed using a Li-ion battery power dynamic limitation rule-based control based on the SOC of the super-capacitor.At the same time,the magnetic integration technology adding a second-order Bessel low-pass filter is introduced to DC-DC converters of electric vehicles.As a result,the size of battery is reduced,and the power quality of the hybrid energy storage system is optimized.Finally,the effectiveness of the proposed method is validated by simulation and experiment. | Xiangyang Xia Xinxin Zhao Heqing Zeng Xiaoyong Zeng | 2018 | Chinese Journal of Electrical Engineering2018，4，1： | 4 |
| 15 | Influence of Initiator on Synthesis and Properties of Polyurethane-acrylate Hybrid Emulsion显示文摘The prepolymer polyurethanes(PUs)based on isophorone diisocyanate(IPDI),poly(propylene glycol)(PPG),1,4-butanediol(BDO)and dimethylopropionic acid(DMPA)were synthesized at 75-80℃for 7-8 hours,using dibutyltin dilauate(DBTDL)as catalyzer,and polyurethane-acrylate hybrid emulsion was prepared after methyl methacrylate(MMA)was polymerized,using potassium persulfate and azobisisobutyronitrile (AIBN)as initiator,respectively.The influences of these factors such as the kind of initiator,the feed method of initiator and the addition of initiator on properties of polyurethane-acrylate were studied.The FTIR and GPC of aqueous polyurethane were analyzed.The FTIR spectra show that the degree of mierophase-separate between the soft segments and rigid segments is high.The analysis of molecular weights stated that molecular weights increased most significantly after amine was added.The experimental results reveal that the appearance of emulsion is excellent,the film is harder and the water absorption radio of the film is less when oil-solubility AIBN is used as initiator.The semi-continuous can increase the molecular weight of polymer and the optimum amount of the initiator was 3% for MMA. | 胡国文 SHEN Huifang FU Heqing CHEN Huanqin | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，1： | 3 |
| 16 | Landscape relations to eco-environmental dynamics of the Sanjiangyuan Journal of Geographical Sciences Editorial显示文摘The Sanjiangyuan is a very special place.Its distinctive geography,ecology and history imbue a suite of unique,irreplaceable values,in biophysical,socio-cultural and economic terms.Because of its high species richness and abundance of endemic species,this area,along with Southeast China and the Himalayan biodiversity hotspot,is considered to be one of the 34 most important centres of biodiversity in the world (Myers et al.,2000).The challenging environmental setting,it terms of its altitude,tectonic setting and climate,alongside significant development pressures,present major challenges for sustainability and conservation planning.In this special issue we draw together a series of papers that outline how geomorphic (landscape) considerations present an integrative biophysical template with which to develop and enact scientifically informed environmental management activities in this region.The fundamental premise here is a simple one:geodiversity underpins biodiversity and land use potential,thereby fashioning ecosystem values and socio-cultural and economic opportunities. | Gary BRIERLEY HUANG Heqing | 2013 | Journal of Geographical Sciences2013，23，5： | 3 |
| 17 | Electro-Fenton treatment of concentrates generated in nanofiltration of biologically pretreated landfill leachate显示文摘 | Yujue Wang Xinyang Li Limin Zhen Heqing Zhang Ying Zhang Chengwen Wang | 2012 | Journal of Hazardous Materials2012，，： | 3 |
| 18 | Sono-assisted preparation of highly-efficient peroxidase-like Fe 3 O 4 magnetic nanoparticles for catalytic removal of organic pollutants with H 2 O 2显示文摘 | Nan Wang Lihua Zhu Dali Wang Mingqiong Wang Zhifen Lin Heqing Tang | 2009 | Ultrasonics - Sonochemistry2009，，3： | 2 |
| 19 | Water quality and light absorption attributes of glacial lakes in Mount Qomolangma region显示文摘因为他们是冰河运动的产品,冰川的湖的水身体作文和水质量属性与内陆湖相比有不同特征。尽管卫星遥感提供一条有效途径监视水质量,缺乏在原处,包围冰川的湖的地位和环境上的测量数据在联系卫星数据浇优秀指示物介绍主要限制。这研究在山 Qomolangma 区域介绍初步的调查的调查结果进 3 个冰川的湖的水质量属性。推迟的微粒物质(SPM ) ,浮游植物的轻吸收属性, nonalgal 粒子(小睡) ,和有颜色的溶解有机物(CDOM ) 被测量。推迟的物质集中从 0320 mg/L 显著地变化。这被认为反映湖开发的不同舞台。叶绿素集中比作出对内陆湖有利的裁决的低得多,作为包围这些高高度湖的风景几乎不有植被生长。浮游植物和 CDOM 集中取决于湖斜坡的长期的稳定性。在 Qomolangma 区域给外长、内长的输入的缺乏,在冰川的湖的 CDOM 比在内陆湖显著地低。这些初步的调查结果能支持努力用遥远地察觉到的图象估价水质量参数的估计。 | YAN Huimin YAO Zhijun HUANG Heqing JIANG Dong DONG Xiaohui DUAN Rui ZHANG Yili | 2013 | Journal of Geographical Sciences2013，23，5： | 2 |
| 20 | Environmental chemical stressors as epigenome modifiers:a new horizon in assessment of toxicological effects显示文摘In eukaryotic cells, chromatin transformation from euchromatin into heterochromatin as a means of controlling gene expression and replication has been known as the ‘‘accessibility hypothesis' '. The interplay of epigenetic changes including histone modifications, DNA methylation, RNA interference(RNAi) and other func- tional epigenetic components are intricate. It is believed that these changes are well-programmed, inherited and can be modified by environmental contaminant stressors. Environmentally-driven epigenetic alterations during development, e.g. embryonic, foetal or neonatal stage, may influence disease susceptibility in adulthood. Therefore, understanding how epigenome modifications develop in response to environmental chemicals and, how epigenetic-xenobiotic interactions influence human health will shed new insights into gene-environment interactions in the epidemiology of several diseases including cancer. In this review, we consider studies of chemical modifiers including nutritional and xenobiotic effects on epigenetic components in vitro or in vivo. By examining the most-studied epigenome modifications and how their respective roles are interlinked, we highlight the central role of xenbiotic- modified epigenetic mechanisms. A major requirement will be to study and understand effects following environmentally-relevant exposures. We suggest that the study of epigenetic toxicology will open up new opportunities to devise strategies for the prevention or treatment of at-risk populations. | Heqing Shen F.L.Martin Yanhua Su | 2014 | Chinese Science Bulletin2014，59，4： | 2 |
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