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| 1 | Efficacy and safety of external application of Traditional Chinese Medicine for the treatment of acute gouty arthritis: a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the clinical efficacy and safety of external application of Traditional Chinese Medicine (EATCM) on acute gouty arthritis (AGA).METHODS:Six electronic data bases were retrieved from their inception to march 2017.15 randomized controlled clinical trials (RCTs) were included.The quality of the literatures was assessed according to Cochrane review criteria by using RevMan5.3 software;and related data was counted using Stata14.0 software.RESULTS:There was no significant difference in C-reactiveprotein (CRP) between experimental intervention group and control group [(WMD =1.093,95% C/(-2.514,4.701);P =0.553)].In terms of overall efficacy,the EATCM's treatment group was significantly superior to control group [(OR =3.692;95% CI (2.408,5.661);P <0.001)].The EATCM was better than western medicine treatments or other interventions in reducing the adverse reactions [(OR =0.135;95% CI (0.067,0.274);P < 0.001)].All these funnel plots showed unlikelihood of publishing bias.But due to excessive heterogeneity,the statistical results of serum uric acid and visual analogue scale and CRP between the two groups became uncertain.CONCLUSION:The results indicate that EATCM may have greater overall efficacy with fewer adverse drug reactions,although the evidence is weak owing to the low methodological quality and the small number of the included trials. | Huang Xinxing Zhu Zonghua Wu Guang-hui Min Peng Fei Peng Zhu Tao Wang Xuezong Xiao Lianbo | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 12 |
| 2 | Metabolic regulation of T cell development by Sinl-mTORC2 is mediated by pyruvate kinase M2显示文摘Glucose metabolism plays a key role in thymocyte development. The mammalian target of rapamycin complex 2 (mT0RC2) is a critical regulator of cell growth and metabolism, but its role in early thymocyte development and metabolism has not been fully studied. We show here that genetic ablation of Sinl, an essential component of mTORC2, in T lineage cells results in severely impaired thymocyte development at the CD4^- CD8^- double negative (DN) stages but not at the CD4^+ CD8^+ double positive (DP) or later stages. Notably, Sinl-deficient DN thymocytes show markedly reduced proliferation and glycolysis.Importantly, we discover that the M2 isoform of pyruvate kinase (PKM2) is a novel and crucial Sinl effector in promoting DN thymocyte development and metabolism. At the molecular level, we show that Sinl-mTORC2 controls PKM2 expression through an AKT-dependent PPAR-y nuclear translocation. Together, our study unravels a novel mTORC2-PPAR-γ-PKM2 pathway in immune-metabolic regulation of early thymocyte development. | Xinxing Ouyang Yuheng Han Guojun Qu Man Li Ningbo Wu Hongzhi Liu Omotooke Arojo Hongxiang Sun Xiaobo Liu Dou Liu Lei Chen Qiang Zou Bing Su | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 3 | MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis显示文摘T cell-mediated immunity in the intestine is stringently controlled to ensure proper immunity against pathogenic microbes and to prevent autoimmunity,a known cause of inflammatory bowel disease.However,precisely how T cells regulate intestine immunity remains to be fully understood.In this study,we found that mitogen-activated protein kinase kinase kinase 2(MAP3K2)is required for the CD4^(+)T cell-mediated inflammation in the intestine.Using a T cell transfer colitis model,we found that MAP3K2-deficient naïve CD4^(+)T cells had a dramatically reduced ability to induce colitis compared to wild type T cells.In addition,significantly fewer IFN-γ-but more IL-17A-producing CD4^(+)T cells in the intestines of mice receiving MAP3K2-deficient T cells than in those from mice receiving wild type T cells was observed.Interestingly,under well-defined in vitro differentiation conditions,MAP3K2-deficient naïve T cells were not impaired in their ability to differentiate into Th1,Th17 and Treg.Furthermore,the MAP3K2-regulated colitis severity was mediated by Th1 but not Th17 cells in the intestine.At the molecular level,we showed that MAP3K2-mediated Th1 cell differentiation in the intestine was regulated by IL-18 and required specific JNK activation.Together,our study reveals a novel regulatory role of MAP3K2 in intestinal T cell immunity via the IL-18-MAP3K2-JNK axis and may provide a novel target for intervention in T cell-mediated colitis. | Ningbo Wu Dongping Chen Hongxiang Sun Jianmei Tan Yao Zhang Tianyu Zhang Yuheng Han Hongzhi Liu Xinxing Ouyang Xiao-Dong Yang Xiaoyin Niu Jie Zhong Zhengting Wang Bing Su | 2021 | Science China(Life Sciences)2021，64，3： | 3 |
| 4 | Enhanced stretch formability and mechanical properties of a magnesium alloy processed by cold forging and subsequent annealing显示文摘 | Xinxing Wu Xuyue Yang Jijun Ma Qinghuan Huo Jun Wang Huan Sun | 2013 | Materials and Design2013，，： | 2 |
| 5 | HPV16E7-HSP70 Hybrid DNA Vaccine Induces E7-Specific Cytotoxic T Cells and Antitumor Immunity显示文摘Using human papillomavirus type 16 (HPV16) E7 as an antigen and Heat Shock Protein 70 as adjuvant, we constructed a DNA vaccine by linking HSP70 gene to E7~ C91G gene. Mice, after being immunized with E7~ C91G -HSP70, E7~ C91G /HSP70, E7~ C91G , and wild E7 DNA vaccines respectively, produced E7 specific CD8^+ T-cell precursor frequencies of 280.33±2.52, 144.34±4.04, 164.34±5.13 and 82.33±3.51 respectively within every 1×10~5 mouse splenocytes. This proves that E7~ C91G -HSP70 fusion vaccine can significantly enhance the E7 specific cellular immunity within the mice body(p<0.01). After being immunized with E7~ C91G -HSP70 fusion vaccine, tumor-bearing mice of the group being treated have significantly longer latency and survival periods, comparing with other three categories of E7 vaccines. Experiment shows that this vaccine has a significant effect on enhancing E7 positive tumor-treatment within mice body. After being immunized with E7~ C91G -HSP70 vaccine, there were no pathological changes found in livers, kidneys and spleens of the mice, which proves that the vaccine is quite safe. After all, E7~ C91G -HSP70 fusion vaccine has a much stronger tumor- treatment effect than that of wild type E7 DNA vaccine. | ZHU Liqin LI Hui XIONG Jinhu WANG Tongxiang OU Xuan WEI Yun WU Xinxing | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 2 |
| 6 | Distributed cache replacement method for geospatial data using spatiotemporal localitybased sequence显示文摘Specific features of tile access patterns can be applied in a cache replacement strategy to a limited distributed high-speed cache for the cloud-based networked geographic information services(NGISs),aiming to adapt to changes in the access distribution of hotspots.By taking advantage of the spatiotemporal locality,the sequential features in tile access patterns,and the cache reading performance in the burst mode,this article proposes a tile sequence replacement method,which involves structuring a Least Recently Used(LRU)stack into three portions for the different functions in cache replacement and deriving an expression for the temporal locality and popularity of the relevant tile to facilitate the replacement process.Based on the spatial characteristics of both the tiles and the cache burst mode with regard to reading data,the proposed method generates multiple tile sequences to reflect spatiotemporal locality in tile access patterns.Then,we measure the caching value by a technique based on a weighted-based method.This technique draws on the recent access popularity and low caching costs of tile sequences,with the aim of balancing the temporal and spatial localities in tile access.It ranks tile sequences in a replacement queue to adapt to the changes in accessed hotspots while reducing the replacement frequency.Experimental results show that the proposed method effectively improves the hit rate and utilization rate for a limited distributed cache while achieving satisfactory response performance and high throughput for users in an NGIS.Therefore,it can be adapted to handle numerous data access requests in NGISs in a cloud-based environment. | Rui LI Jiapei FAN Xinxing WANG Zhen ZHOU Huayi WU | 2015 | Geo-Spatial Information Science2015，18，4： | 1 |
| 7 | Thermal reversible gelation during phase separation of poly(N-isopropyl acrylamide)/water solution显示文摘 | Fang Zeng Xinxing Liu Zhen Tong Yanyin Yang Shuizhu Wu | 2000 | Science in China Series B: Chemistry2000，，4： | 1 |
| 8 | Constructing of the risk classification model of cervical cancer by artificial neural network 显示文摘 | Xiaoping Qiu Ning Tao Yun Tan Xinxing Wu | 2007 | Expert Systems with Applications2007，32，4： | 1 |
| 9 | Constructing of the risk classification model of cervical cancer by artificial neural network显示文摘 | Xiaoping Qiu Ning Tao Yun Tan Xinxing Wu | 2007 | Expert Systems with Applications Volume 32 Issue 4 May 20072007，，： | 1 |
| 10 | Supplier selection in agile supply chains: an information-processing model and illustration 显示文摘 | Luo Xinxing Wu Chong Rosenberg D | 2009 | Journal of Purchasing & Supply Management2009，15，： | 1 |
| 11 | Bladder cancer-associated protein is suppressed in human cervical tumors显示文摘 | Min Peng Tingbo Xie Juan Yu Bin Xu Qibin Song Xinxing Wu | 2012 | Experimental and Therapeutic Medicine2012，，2： | 1 |
| 12 | Macular and Retinal Nerve Fiber Layer Thickness Measurements in Normal Eyes With the Stratus OCT, the Cirrus HD-OCT, and the Topcon 3D OCT-1000显示文摘 | Jingjing Huang Xing Liu Ziqiang Wu Xinxing Guo Hongzhi Xu Laurie Dustin Srinivas Sadda | 2011 | Journal of Glaucoma2011，，2： | 1 |
| 13 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 14 | Analysis on Radar Characteristics of a Short-time Heavy Rainfall Event in Wuchuan County显示文摘Using minute rainfall data of automatic ground station and a variety of products from new generation Doppler weather radar in Wuchuan, the characteristics of a short-time heavy precipitation process on April 23, 2022 were analyzed. The results showed that the appearance of differential reflectivity(ZDR) column and big-value zone of high-elevation ZDR had better indication on short-term heavy rainfall process in Shichao station. Ice phase process played a very important role in particle growth. The storm tracking information product can predict the path of the storm 15 min in advance. The storm stayed and moved less or even turned back to more than two to three scanning volumes in one place, indicating the occurrence of short-term heavy rainfall. One-hour accumulated precipitation(OHP) had a good effect on the estimation of continuous precipitation in a large area where the hourly rainfall exceeded 50 mm for more than two stations. It had the ability to estimate short-term heavy precipitation in areas lacking automatic stations. | Jianfei GAO Xia LI Xinxing WU Yu LI Zirui HUANG | 2022 | Meteorological and Environmental Research2022，13，6： | 0 |
| 15 | Author Correction:Regulation of CD8^(+)T memory and exhaustion by the mTOR signals显示文摘Correction to:Cellular&Molecular Immunology http://gffzzd3cc09b8251d45dfswpxvx0kv96cw6wq0.ffgz.tsg.suse.edu.cn/10.1038/s41423-023-01064-3,published online 15 August 2023 In this article the author name Yuheng Han was incorrectly written as Yuhen Han.The original article has been corrected. | Yao Chen Ziyang Xu Hongxiang Sun Xinxing Ouyang Yuheng Han Haihui Yu Ningbo Wu Yiting Xie Bing Su | 2023 | Cellular & Molecular Immunology2023，20，11： | 0 |
| 16 | HLA-B*6701 as a Subtype Performing Post-Selected Marking Gene for Cervical Cancer显示文摘A method of sequence-based typing(SBT) has been adopted to assort types of exons 2 and 3,which have the most polymorphism,of HLA-B locus of the Tujia nation group in Hubei province.The correlation among the HLA-B alleles,human papillomavirus(HPV) infection and cervical cancer risk has also been investigated.Under the condition of resident location and age,race unified,100 specimens of cancer patients were sampled as a case group,of which 86 were HPV positive and were screened for HLA-B alleles;while 187 specimens were taken from healthy people,of which 92 were HPV negative as a control group.The result shows that by comparing the above mentioned 86 HPV positive cervical cancer group and 92 HPV negative normal group,it was concluded that HLA-B*6701 was only found in the cervical cancer group(p<0.034),which shows that HLA-B*6701 can be used as an important candidate biological marking gene for generation of cervical cancer in Wufeng county of Hubei province. | QIU Xiaoping TAO Ning TAN Yun WU Xinxing | 2010 | Wuhan University Journal of Natural Sciences2010，15，6： | 0 |
| 17 | Fabrication of cellulose based superhydrophobic microspheres for the production of magnetically actuatable smart liquid marbles显示文摘Cellulose microspheres were fabricated on the basis of sol-gel transition using NaOH/urea/H_(2)O as the solvent system.These microspheres had an average diameter of about 30μm.Upon modification with Fe_(3)O_(4) and poly(DOPAm-co-PFOEA),superhydrophobic magnetic cellulose microspheres were generated,which were analyzed by FTIR,TG,XRD,XPS and water contact angle tests.Magnetic cellulose microspheres contained approximately 15 wt%of Fe_(3)O_(4).Poly(DOPAm-co-PFOEA)/Fe_(3)O_(4)/cellulose microspheres and had a low surface energy and a high water-repellency.These superhydrophobic microspheres were also converted into liquid marbles via an easily scalable process. | Xinxing Lin Wei Ma Hui Wu Liulian Huang Lihui Chen Atsushi Takahara | 2017 | Journal of Bioresources and Bioproducts2017，2，3： | 0 |
| 18 | On the thermo-mechanical properties of unsaturated soils显示文摘The establishment of energy balance equation is necessary to study the thermo-mechanical properties of unsaturated soils.To solve this equation,the determination of two fundamental parameters as volumetric specific parameter and thermal conductivity coefficient is essential.In this paper,the effective thermal conductivity coefficient of dry soil grain is analyzed for soils with different compositions,and the thermo-mechanical properties of porous media with water and gas are studied by considering the soil water retention curve(SWRC).Different methods,i.e.volumetric average method,self-consistent method,Hashin-Strikman method,are employed to calculate thermal conductivity coefficients,and a new method is proposed to determine the thermo-mechanical parameters.Comparison of the results obtained by different methods shows that the proposed method is in a good agreement with the experimental results and is suitable for describing the main properties of the thermo-mechanical behaviors of soils.The relationship between the SWRC and the seepage curve is further studied by the natural proportional rule.The characteristics of the SWRC,its differential coefficient and the seepage curve,are investigated by considering the physico-mechanical mechanism;the limit scopes of the indices of the SWRC and the seepage curve are also given. | Yingfa Lu Xinxing Wu Yujun Cui | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，2： | 0 |
| 19 | LINEAR CHAOS IN THE QUANTUM HARMONIC OSCILLATOR显示文摘In this note,it is proved that for the annihilation operator B of the unforced quantum harmonic oscillator,B^n is mixing and generically 5-chaotic with any 0 < δ < 2 for each positive integer n.Besides,by using the result in[Wu X and Zhu P,J.Phys.A:Math.Theor.,2011,44:505101],the authors obtain that the principal measure of B^n is equal to 1 for each positive integer n. | WU Xinxing ZHU Peiyong | 2014 | Journal of Systems Science & Complexity2014，27，4： | 0 |
| 20 | Distribution-dependent concentration inequalities for tighter generalization bounds显示文摘Concentration inequalities play a crucial role in statistical learning theory because they are useful for deriving the generalization capacity of learning models.Generally,they can be used to estimate the deviations between empirical risk and expectation risk[1].Some important learning the- | Xinxing WU Junping ZHANG | 2018 | Science China(Information Sciences)2018，61，4： | 0 |
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