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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | A new solution for topology optimization problems with multiple loads:The guide-weight method显示文摘The guide-weight method is introduced to solve two kinds of topology optimization problems with multiple loads in this paper.The guide-weight method and its Lagrange multipliers' solution methods are presented first,and the Lagrange multipliers' soution method of problems with multiple constraints is improved by the dual method.Then the iterative formulas of the guide-weight method for topology optimization problems of minimum compliance and minimum weight are derived and coresponding numerical examples are calculated.The results of the examples exhibits that when the guide-weight method is used to solve topology optimization problems with multiple loads,it works very well with simple iterative formulas,and has fast convergence and good solution.After comparison with the results calculated by the SCP method in Ansys,one can conclude that the guide-weight method is an effective method and it provides a new way for solving topology optimization problems. | LIU XinJun LI ZhiDong CHEN Xiang | 2011 | Science China(Technological Sciences)2011，54，6： | 22 |
| 3 | Type Synthesis of 4-DOF Parallel Kinematic Mechanisms Based on Grassmann Line Geometry and Atlas Method显示文摘Many methods are proposed to deal with the type synthesis of parallel kinematic mechanisms(PKMs),but most of them are less intuitive to some extent.Thus,to propose a concise and intuitive type synthesis method for engineering application is a very challenging issue,which should be further studied in the field.Grassmann line geometry,which can investigate the dimensions of spatial line-clusters in a concise way,is taken as the mathematic foundation.Atlas method is introduced to visually describe the degrees of freedom(DOFs)and constraints of a mechanism,and the dual rule is brought in to realize the mutual conversion of the freedom-space and constraint-space.Consequently,a systematic method based on Grassmann line geometry and Atlas method is generated and the entire type synthesis process is presented.Three type 4-DOF PKMs,i.e.,1T3R,2T2R and 3T1R(T:translational DOF;R:rotational DOF),are classified according to the different combinations of the translational DOFs and rotational DOFs.The type synthesis of4-DOF PKMs is carried out and the possible configurations are thoroughly investigated.Some new PKMs with useful functions are generated during this procedure.The type synthesis method based on Grassmann line geometry and Atlas method is intuitive and concise,and can reduce the complexity of the PKMs’type synthesis.Moreover,this method can provide theoretical guidance for other PKMs’type synthesis and engineering application.A novel type synthesis method is proposed,which solves the existing methods’problems in terms of complicated,not intuitive and unsuitable for practical application. | XIE Fugui LI Tiemin LIU Xinjun | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 21 |
| 4 | Age and Growth of Chub Mackerel (Scomber japonicus) in the East China and Yellow Seas Using Sectioned Otolith Samples显示文摘Although chub mackerel (Scomber japonicus) is a primary pelagic fish species,we have only limited knowledge on its key life history processes. The present work studied the age and growth of chub mackerel in the East China and Yellow Seas. Age was determined by interpreting and counting growth rings on the sagitta otoliths of 252 adult fish caught by the Chinese commercial purse seine fleet during the period from November 2006 to January 2007 and 150 juveniles from bottom trawl surveys on the spawn-ing ground in May 2006. The difference between the assumed birth date of 1st April and date of capture was used to adjust the age determined from counting the number of complete translucent rings. The parameters of three commonly used growth models,the von Bertalanffy,Logistic and Gompertz models,were estimated using the maximum likelihood method. Based on the Akaike Information Criterion (AIC),the von Bertalanffy growth model was found to be the most appropriate model. The size-at-age and size-at-maturity values were also found to decrease greatly compared with the results achieved in the 1950s,which was caused by heavy exploitation over the last few decades. | LI Gang CHEN Xinjun FENG Bo | 2008 | Journal of Ocean University of China2008，7，4： | 12 |
| 5 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 6 | Standardization of CPUE for Chilean Jack Mackerel (Trachurus murphyi) from Chinese Trawl Fleets in the High Seas of the Southeast Pacific Ocean显示文摘The generalized linear model(GLM) and generalized additive model(GAM) were applied to the standardization of catch per unit effort(CPUE) for Chilean jack mackerel from Chinese factory trawl fishing fleets in the Southeast Pacific Ocean from 2001 to 2010 by removing the operational,environmental,spatial and temporal impacts.A total of 9 factors were selected to build the GLM and GAM,i.e.,Year,Month,Vessel,La Ni a and El Ni o events(ELE),Latitude,Longitude,Sea surface temperature(SST),SST anomaly(SSTA),Nino3.4 index and an interaction term between Longitude and Latitude.The first 5 factors were significant components in the GLM,which in combination explained 27.34% of the total variance in nominal CPUE.In the stepwise GAM,all factors explained 30.78% of the total variance,with Month,Year and Vessel as the main factors influencing CPUE.The higher CPUE occurred during the period April to July at a SST range of 12-15℃ and a SSTA range of 0.2-1.0℃.The CPUE was significantly higher in normal years compared with that in La Ni a and El Ni o years.The abundance of Chilean jack mackerel declined during 2001 and 2010,with an increase in 2007.This work provided the relative abundance index of Chilean jack mackerel for stock assessment by standardizing catch and effort data of Chinese trawl fisheries and examined the influence of temporal,spatial,environmental and fisheries operational factors on Chilean jack mackerel CPUE. | LI Gang ZOU Xiaorong CHEN Xinjun ZHOU Yinqi ZHANG Min | 2013 | Journal of Ocean University of China2013，12，3： | 9 |
| 7 | Step kinematic calibration of a 3-DOF planar parallel kinematic machine tool显示文摘This paper presents a novel step kinematic calibration method for a 3 degree-of-freedom(DOF) planar parallel kinematic machine tool,based on the minimal linear combinations(MLCs) of error parameters.The method using mapping of linear combinations of parameters in error transfer multi-parameters coupling system changes the modeling,identification and error compensation of geometric parameters in the general kinematic calibration into those of linear combinations of parameters.By using the four theorems of the MLCs,the sets of the MLCs that are respectively related to the relative precision and absolute precision are determined.All simple and feasible measurement methods in practice are given,and identification analysis of the set of the MLCs for each measurement is carried out.According to the identification analysis results,a step calibration including step measurement,step identification and step error compensation is determined by taking into account both measurement costs and observability.The experiment shows that the proposed method has the following merits:(1) the parameter errors that cannot influence precision are completely avoided;(2) it reflects the mapping of linear combinations of parameters more accurately and enhances the precision of identification;and(3) the method is robust,efficient and effective,so that the errors in position and orientation are kept at the same order of the measurement noise.Due to these merits,the present method is attractive for the 3-DOF planar parallel kinematic machine tool and can be also applied to other parallel kinematic machine tools with weakly nonlinear kinematics. | CHANG Peng,WANG JinSong,LI TieMin,LIU XinJun & GUAN LiWen Department of Precision Instruments and Mechanology,Tsinghua University,Beijing 100084,China | 2008 | Science China(Technological Sciences)2008，51，12： | 9 |
| 8 | 声波激励的超小型纳机电系统磁电天线显示文摘当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。 | Tianxiang Nan Hwaider Lin Yuan Gao Alexei Matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun Wei Zhiguang Wang Menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui Matteo Rinaldi Michael E.McConney BrANDon M.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) | 2017 | 通信对抗2017，36，4： | 8 |
| 9 | Y-chromosome evidence for no independent origin of modern human in China显示文摘East Asia is one of the few regions in the world where a large number of human fossils have been unearthed. The continuity of hominid fossils in East Asia, particularly in China has been presented as strong evidence supporting an independent origin of modern humans in this area. To search for such evidence of a possible independent origin of modern humans in China, a total of 9988 male individuals were sampled across China. Three Y-chromosome biallelic markers (M89, M130 and YAP), which were located at the non-re-combinant region of Y-chromosome, were typed among the samples. Our result showed that all the individuals carry a mutation at one of the three loci. The three mutations (M89T, M130T, YAP+) coalesce to another mutation (M168T), which was originally derived from Africa about 31000 to 79000 years ago. In other words, all Y-chromosome samples from China, with no exception, were originally derived from a lineage of African origin. Hence, we conclude that even a very minor contribution of in situ hominid origin in China cannot be supported by the Y-chromosome evidence. | KE Yuehai SU Bing LI Hongyu CHEN Lifeng QI Chunjian GUO Xinjun HUANG Wei JIN Jianzhong LU Daru JIN Li | 2001 | Chinese Science Bulletin2001，46，11： | 7 |
| 10 | Third generation high strength low alloy steels with improved toughness显示文摘On-line thermo mechanical controlled processing(TMCP) was conducted to develop the third generation high strength low alloy(HSLA) steel with high toughness economically.The ultra-low carbon content ensured a high level of upper shelf energy while ultrafine lath martensitic structure transformed from super-thin pancaked austenite during controlled rolling and cooling.The reduction of martensite block size decreased ductile-to-brittle transition temperature(DBTT) and compensated the strength loss due to carbon reduction.Consequently,the excellent balance of strength and toughness values was obtained as 950-1060 MPa for yield strength,180 J for Charpy V-notch impact absorbed energy at 30℃,which is much superior to that of traditional martensitic steel.Two mechanisms for the refinement of lath martensite block were proposed:One is the austenite grain refinement in the direction of thickness,and the other is the reduction in the fraction of sub-block boundaries with small misorientation and the increase in the fraction of block boundaries with large misorientation,possibly due to austenite hardening. | SUN XinJun LI ZhaoDong YONG QiLong YANG ZhiGang DONG Han WENG YuQing | 2012 | Science China(Technological Sciences)2012，55，7： | 7 |
| 11 | Novel algorithm for constructing support vector machine regression ensemble显示文摘A novel algorithm for constructing support vector machine regression ensemble is proposed. As to regression prediction, support vector machine regression (SVMR) ensemble is proposed by resampling from given training data sets repeatedly and aggregating several independent SVMRs, each of which is trained to use a replicated training set. After training, several independently trained SVMRs need to be aggregated in an appropriate combination manner. Generally, the linear weighting is usually used like expert weighting score in Boosting Regression and it is without optimization capacity. Three combination techniques are proposed, including simple arithmetic mean,linear least square error weighting and nonlinear hierarchical combining that uses another upper-layer SVMR to combine several lower-layer SVMRs. Finally, simulation experiments demonstrate the accuracy and validity of the presented algorithm. | Li Bo Li Xinjun Zhao Zhiyan | 2006 | Journal of Systems Engineering and Electronics2006，17，3： | 6 |
| 12 | Seasonal Variation of Biochemical Components in Clam (Saxidomuspurpuratus Sowerby 1852) in Relation to Its Reproductive Cycle and the Environmental Condition of Sanggou Bay, China显示文摘Seasonal variation of biochemical components in clam(Saxidomus purpuratus Sowerby 1852) was investigated from March 2012 to February 2013 in relation to environmental condition of Sanggou Bay and the reproductive cycle of clam.According to the histological analysis,the reproductive cycle of S.purpuratus includes two distinctive phases:a total spent and inactive stage from November to January,and a gametogenesis stage,including ripeness and spawning,during the rest of the year.Gametes were generated at a low temperature(2.1℃) in February.Spawning took place once a year from June to October.The massive spawning occurred in August when the highest water temperature and chlorophyll a level could be observed.The key biochemical components(glycogen,protein and lipid) in five tissues(gonad,foot,mantle,siphon and adductor muscle) were analyzed.The glycogen content was high before gametogenesis,and decreased significantly during the gonad development in the gonad,mantle and foot of both females and males,suggesting that glycogen was an important energy source for gonad development.The protein and lipid contents increased in the ovary during the gonad development,demonstrating that they are the major organic components of oocytes.The lipid and protein contents decreased in the testis,implying that they can provide energy and material for spermatogenesis.The results also showed that protein stored in the mantle and foot could support the reproduction after the glycogen was depleted. | BI Jinhong LI Qi ZHANG Xinjun ZHANG Zhixin TIAN Jinling XU Yushan LIU Wenguang | 2016 | Journal of Ocean University of China2016，15，2： | 6 |
| 13 | Trophic Ecology of Sharks in the Mid-East Pacific Ocean Inferred from Stable Isotopes显示文摘As apex predators, sharks are of ecological and conservation importance in marine ecosystems. In this study, trophic positions of sharks were estimated using stable isotope ratios of carbon and nitrogen for five representative species caught by the Chinese longline fleet in the mid-east Pacific, i.e., the blue shark(Prionace glauca), the bigeye thresher shark(Alopias superciliosus), the silky shark(Carcharhinus falciformis), the scalloped hammerhead(Sphyrna lewini), and the oceanic whitetip shark(Carcharhinus longimanus). Of these species, oceanic whitetip shark has the lowest trophic level and mean δ15N value(3.9 and 14.93‰± 0.84‰), whereas bigeye thresher shark has the highest level/values(4.5 and 17.02‰± 1.21‰, respectively). The bigeye thresher shark has significantly higher δ15N value than other shark species, indicating its higher trophic position. The blue shark and oceanic whitetip shark has significantly higher δ13C values than bigeye thresher shark, silky shark and scalloped hammerhead, possibly due to different diets and/or living habitats. The stable isotope data and stomach content data are highly consistent, suggesting that stable isotope analysis supplements traditional feeding ecology study of sharks, and thus contributes to understanding their trophic linkage. | LI Yunkai GONG Yi CHEN Xinjun DAI Xiaojie ZHU Jiangfeng | 2014 | Journal of Ocean University of China2014，13，2： | 6 |
| 14 | A New model to forecast fishing ground of Scomber japonicus in the Yellow Sea and East China Sea显示文摘The pelagic species is closely related to the marine environmental factors, and establishment of forecasting model of fishing ground with high accuracy is an important content for pelagic fishery. The chub mackerel(Scomber japonicus) in the Yellow Sea and East China Sea is an important fishing target for Chinese lighting purse seine fishery. Based on the fishery data from China's mainland large-type lighting purse seine fishery for chub mackerel during the period of 2003 to 2010 and the environmental data including sea surface temperature(SST), gradient of the sea surface temperature(GSST), sea surface height(SSH) and geostrophic velocity(GV), we attempt to establish one new forecasting model of fishing ground based on boosted regression trees. In this study, the fishing areas with fishing effort is considered as one fishing ground, and the areas with no fishing ground are randomly selected from a background field, in which the fishing areas have no records in the logbooks. The performance of the forecasting model of fishing ground is evaluated with the testing data from the actual fishing data in 2011. The results show that the forecasting model of fishing ground has a high prediction performance, and the area under receiver operating curve(AUC) attains 0.897. The predicted fishing grounds are coincided with the actual fishing locations in 2011, and the movement route is also the same as the shift of fishing vessels, which indicates that this forecasting model based on the boosted regression trees can be used to effectively forecast the fishing ground of chub mackerel in the Yellow Sea and East China Sea. | GAO Feng CHEN Xinjun GUAN Wenjiang LI Gang | 2016 | Acta Oceanologica Sinica2016，35，4： | 5 |
| 15 | A β-glucosidase-producing M-2 strain: Isolation from cow dung and fermentation parameter optimization for flaxseed cake显示文摘Flaxseed cake contains cyanogenic glucosides, which can be metabolized into hydrocyanic acid in an animal's body, leading to asphyxia poisoning in cells. Beta-glucosidase is highly efficient in degrading cyanogenic glucosides. The Cattle may have b-glucosidase-producing strains in the intestinal tract after eating small amounts of flaxseed cake for a long time. This study aimed to isolate of a strain from cow dung that produces b-glucosidase with high activity and can significantly reduce the amount of cyanogenic glucosides. We used cow dung as the microflora source and an esculin agar as the selective medium. After screening with 0.05% esculin and 0.01% ferric citrate, we isolated 5 strains producing high amounts of b-glucosidase. In vitro flaxseed cake fermentation was fermented by these 5 strains, in which the strain M-2 exerted the best effect(P < 0.05). The strain M-2 was identified as Lichtheimia ramosa and used as the fermentation strain to optimize the fermentation parameters by a single factor analysis and orthogonal experimental design. The optimum condition was as follows: inoculum size3%, water content 60%, time 144 h, and temperature 32℃. Under this condition, the removal rate of cyanogenic glucosides reached 89%, and crude protein increment reached 44%. These results provided a theoretical basis for the removal of cyanogenic glucosides in flaxseed and the comprehensive utilization of flaxseed cake. | Chenhui Li Junshu Wei Yaping Jing Baoxia Teng Pingrong Yang Xinjun Chen Haiying Huang Tang Zhao Tuanjie Che Chunjiang Zhang | 2019 | Animal Nutrition2019，，1： | 5 |
| 16 | A comprehensive review of bio-oil, bio-binder and bio-asphalt materials: Their source, composition, preparation and performance显示文摘To promote the application of bio-materials and provide a direction for their further researches,this paper comprehensively summarizes the research progress of biomaterials in recent years.The review results show that bio-oil is a mixture obtained from different biomasses through pyrolysis,alcoholysis,acidolysis,high liquefaction,etc.,and those biomasses mainly include wood fiber type,waste oil type and animal manure type.Biobinder refers to the product of bio-oil processed by distillation,extraction oxidation and polymer modification,and it can be served as a modifier,diluent or substitute material of asphalt;the main chemical components of bio-oil include ethers,esters,aldehydes,ketones,phenols,organic acids,alcohols and sugars.Bio-asphalt is obtained by adding biobinder into the petroleum asphalt for modification or blending,and the shear temperature and shear rate of bio-asphalt derived from wood fiber type and waste oil type are usually higher than that of bio-asphalt derived from swine manure.Compared with petroleum asphalt,bio-asphalt binder usually shows lower high-temperature performance as well as higher low-temperature performance and aging resistance.Also,bio-asphalt mixture generally exhibits lower high-temperature stability,higher low-temperature crack resistance and water stability than petroleum asphalt mixture.Future studies should be conducted combining with the source,composition,preparation,properties and oil production rate of bio-oil.First,how to raise the bio-binder content in bio-asphalt as much as possible while ensuring the sufficient performance becomes the focus of future researches.Second,the micro reaction mechanism between bio-binder and petroleum asphalt should be illustrated in depth.Moreover,developing a complete and unifying technical standard and application specification of bio-asphalt technology is necessary for future researches.Furthermore,determining the optimum bio-binder potentially used as the substitute of petroleum asphalt is also an interesting topic. | Zhengqi Zhang Ying Fang Jianhua Yang Xinjun Li | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，2： | 5 |
| 17 | Gladius growth pattern and increment of jumbo squid(Dosidicus gigas)in the tropical Pacific Ocean显示文摘Gladius is an accepted hard tissue for determining the age,size-specific growth,and trophic dynamics of pelagic squid.However,little is known about the inter-and intra-stock variability of gladius growth pattern and increment deposition.In this study,the gladius growth patterns with somatic growth and gonad development were evaluated for two geographic stocks of the jumbo squid(Dosidicus gigas)in the tropical Pacific Ocean.The microstructure and periodicity of the gladius growth increments were also investigated.Results showed varied correlations between four gladius morphometric characteristics with dorsal mantle length,while growth in body weight almost followed a power model.Sexual gladius growth patterns occurred with gonad development,possibly due to different biological functions of these gladius parts and sex-specific energetic allocations.Gladius increments were observed formation in the stem and lateral plate and could be consistently enumerated.The daily periodicity of increment deposition,at least over 144 days old,was validated by comparing gladius increments with the ages obtained from the statoliths.The different oceanographic conditions between two areas likely influence the gladius growth and increment deposition and promote higher increment counts in squid from equatorial waters.Above all,these results provided new information on gladius microstructures and growth increment in different stocks of D.gigas and confirmed the use of this tissue for size-specific growth and age determination. | Yi Gong Yunkai Li Xinjun Chen Xiaodi Gao Ling Chen | 2018 | Aquaculture and Fisheries2018，3，4： | 4 |
| 18 | Fishery Biology of Jumbo Flying Squid Dosidicus gigas off Costa Rica Dome显示文摘The jumbo flying squid(Dosidicus gigas) population was surveyed with the help of Chinese squid jigging vessels off the Costa Rica Dome(4°–11°N, 90°–100°W) in 2009 and 2010. The daily catch of D. gigas in the two survey cruises ranged from 0 to 5.5 t and was mostly obtained from the areas bounded by 6°–9°N and 91°–94°W and by 6°30′–7°30′N and 96°–97°W. The sea surface temperature in the areas yielding the most catch ranged from 27.5 to 29℃. The sex ratio of the total catch was 3.75:1(female: male). The mantle length of the squid ranged from 211 to 355 mm(male) and from 204 to 429 mm(female) with an average of 297.9 and 306.7 mm, respectively. In the relationship of the mantle length(mm) and body weight(g) of the squid, there was no significant difference between sexes. The female and male were at a similar maturity, and most individuals are maturing or have matured with a few females being spent. The size(mantle length) and age at the first sexual maturity were 297 mm and 195 d in females, and less than 211 mm and 130 d in males, respectively. Most of the sampled stomachs(70.6%) had no food remains. The major preys of the squids were fish, cephalopods and crustaceans, with the most abundant Myctophum orientale and D. gigas. The preys in more than 65% of the non-empty sampled stomachs evidenced the cannibalism of D. gigas. The results improved current understanding of the fishery biology of D. gigas off the Costa Rica Dome, which may facilitate the assessment and management of relative fishery resources. | CHEN Xinjun LI Jianghua LIU Bilin LI Gang LU Huajie | 2014 | Journal of Ocean University of China2014，13，3： | 4 |
| 19 | Identification of Three Common Loliginidae Squid Species in the South China Sea by Analyzing Hard Tissues with Geometric Outline Method显示文摘The hard tissues of squid can provide important information for species identification. In this study, we used statolith and beak to identify three squid species including Uroteuthis duvaucelii, Loliolus beka, and U. edulis in the South China Sea. Because of the highly overlapping habitat and similar body morphology of the three squid species, we explored four different ways to identify them, by using statolith, upper beak, lower beak and a combination of statolith and beak. An outline geometric morphometric method and stepwise discriminant analysis were used to evaluate the most suitable method for the identification. We found that the combination of statolith and beak had the highest cross validation rate that was 75.0%, 87.5% and 88.7% for U. duvaucelii, L. beka and U. edulis, respectively. Using two beaks had similar results and the lowest cross validation rate was 60.0%, 50.0%, and 73.7% for the upper beak, 46.9%, 58.5% and 75.3% for the lower beak of U. duvaucelii, L. beka and U. edulis, respectively. Analyzing with the statolith had moderate cross validation which was 72.2%, 80.0%, and 87.7% for U. duvaucelii, L. beka and U. edulis, respectively. From the results it is suggested when the entire body of a squid is available, a combination of statolith and beak should be used for the identification. When only one hard tissue is available, species identification can be subjected to large errors. | JIN Yue LIU Bilin LI Jianhua CHEN Xinjun | 2017 | Journal of Ocean University of China2017，16，5： | 4 |
| 20 | Long-term follow-up for Shang Ring male circumcision显示文摘 | Cheng Yue Wu Kerong Yan Zejun Yang Shuwei Li Fang Su Xinjun | 2014 | Chinese Medical Journal2014，，10： | 4 |
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