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| 1 | Overcoming HBV immune tolerance to eliminate HBsAg-positive hepatocytes via pre-administration of GM-CSF as a novel adjuvant for a hepatitis B vaccine in HBV transgenic mice显示文摘尽管有矛盾的结果, Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 从动物和人的研究被知道是一个潜在的疫苗的助手。差异可能由于被使用的 GM-CSF 的不同剂量和政体,给那成熟或不成熟的树枝状的房间(DC ) 能在不同条件下面被导致。为了测试假设,那 GM-CSF 能为一个肝炎 B 病毒(HBV ) 被用作一个新奇助手治疗学的疫苗,我们与 recombinant HBV 疫苗(rHBVvac ) 在种痘以前每天管理了 GM-CSF 一次三天在老鼠。我们在作为与白天 1 每日的 GM-CSF 管理或白天 2 相比的白天 3 点在这些预先对待的动物观察了更大的 DC 成熟。这策略进一步为它打破在肝炎 B 表面建立的有免疫力的忍耐的能力被调查抗原转基因(HBsAg-Tg ) 动物。我们发现导致的 anti-HBsAg 抗体的层次在在第三免疫以后在 rHBV 种痘前跟随三天 GM-CSF 预告的处理的动物是显著地更高的。除了 anti-HBsAg 抗体层次的增加,调停房间的 anti-HBsAg 回答包括延期类型超敏性, T 房间增长, interferon-γ生产,和细胞毒素的 T 淋巴细胞,戏剧性地在三天的 GM-CSF 被提高预先对待的组。在从使免疫的动物的 CD8 + T 房间的采纳转移以后,抗原特定的 CD8 + T 房间在接受者 HBsAg-Tg 动物的肝被观察。而且,有在 rHBVvac 种痘以前的 GM-CSF 的三天的预告的处理能显著地消除 HBsAg 积极的 hepatocytes,建议有益的治疗学的效果。因此,与 rHBVvac 疫苗在联合作为一个助手利用 GM-CSF 的这个协议有潜力为长期的肝炎 B 病人成为新奇免疫疗法。 | Xianzheng Wang Aihua Dong Jingjing Xiao Xingjun Zhou Haili Mi Hanqian Xu Jiming Zhang Bin Wang | 2016 | Cellular & Molecular Immunology2016，13，6： | 11 |
| 2 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 3 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 4 | Seismic response analysis of continuous rigid frame bridge considering canyon topography effects under incident SV waves显示文摘To evaluate the importance of the canyon topography effects on large structures, based on a rigid frame bridge across a 137-m-deep and 600-m-wide canyon, the seismic response of the canyon site is analyzed using a two-dimensional finite element model under different seismic SV waves with the assumptions of vertical incidence and oblique incidence to obtain the ground motions, which are used as the excitation input on the pier foundations of the bridge with improved large mass method. The results indicate that canyon topography has significant influences on the ground motions in terms of incident angle. The peak ground acceleration values vary greatly from the bottom of the canyon to the upper corners. Under vertical incident SV waves, at the upper corners of canyon the peak ground accelerations greatly increase; whereas the peak ground accelerations diminish at the bottom corners of canyon. Under oblique incident SV waves, the shaking of the canyon slope perpendicular to the incidence direction is much more severe than that of the opposite side of canyon. And the ground surface has been characterized by larger deformations in the case of oblique incident waves. It is also concluded that the low piers and frame of the continuous rigid frame bridge are more sensitive to the multi-support seismic excitations than the flexible high piers. The canyon topography as well as the oblique incidence of the waves brings the continuous rigid frame bridge severe responses, which should be taken into account in bridge design. | Guoliang Zhou Xiaojun Li Xingjun Qi | 2010 | Earthquake Science2010，23，1： | 7 |
| 5 | A design method for high fabrication tolerance integrated optical mode multiplexer显示文摘The tapered asymmetric directional coupler has the potential to realize high fabrication tolerance and high transmission efficiency on-chip mode multiplexer.However,the geometry parameter selection of tapered structure remains empirical.In this paper,we propose a design method for the tapered structure based on genetic algorithm.Combined with the adjusted coupling equations and interpolation method,lowtime-cost optimization can be realized.Three mode multiplexers(TE0&TE1,TE0&TE2 and TE0&TE5)are designed by our method.According to simulation results,the insertion loss of the designed devices is lower than 1.8 dB and the crosstalk is lower than-15 dB when the fabrication error is within required range(±10 nm for TE0&TE2 and TE0&TE5,and±20 nm for TE0&TE1)in the bandwidth of 1.5–1.6μm.In addition,the entire optimization process takes only 2 h for each device,which is around the time cost of a single 3 D simulation. | Bitao SHEN Haowen SHU Linjie ZHOU Xingjun WANG | 2020 | Science China(Information Sciences)2020，63，6： | 3 |
| 6 | 1-MCP对韭薹采后品质的影响显示文摘本文研究了在20℃贮藏条件下,1-MCP对韭薹贮藏品质及木质化的作用效果。结果表明,0.5μL·L-1的1-MCP可显著降低韭薹的失重率及开花率,保持较高的叶绿素及VC含量,抑制呼吸强度,降低苯丙氨酸解氨酶(PAL)、肉桂醇脱氢酶(CAD)及过氧化物酶(POD)的活性,延缓木质素和纤维素的积累。结果显示,1-MCP处理有利于韭薹采后品质的保持。 | Chuanwan Wu Xiaofeng Du Lianzhen Wang Weizhong Wang Qing Zhou Xingjun Tian | 2010 | 保鲜与加工2010，10，5： | 1 |
| 7 | Unsupervised machine learning for discovery of promising half-Heusler thermoelectric materials显示文摘hermoelectric materials can be potentially applied to waste heat recovery and solid-state cooling because they allow a direct energy conversion between heat and electricity and vice versa.The accelerated materials design based on machine learning has enabled the systematic discovery of promising materials.Herein we proposed a successful strategy to discover and design a series of promising half-Heusler thermoelectric materials through the iterative combination of unsupervised machine learning with the labeled known half-Heusler thermoelectric materials.Subsequently,optimized zT values of~0.5 at 925 K for p-type Sc_(0.7)Y_(0.3)NiSb_(0.97)Sn_(0.03)and~0.3 at 778 K for n-type Sc_(0.65)Y_(0.3)Ti_(0.05)NiSb were experimentally achieved on the same parent ScNiSb. | Xue Jia Yanshuai Deng Xin Bao Honghao Yao Shan Li Zhou Li Chen Chen Xinyu Wang Jun Mao Feng Cao Jiehe Sui Junwei Wu Cuiping Wang Qian Zhang Xingjun Liu | 2022 | npj Computational Materials2022，，1： | 1 |
| 8 | Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2显示文摘The combination of immune checkpoint blockade(ICB)with chemotherapy significantly improves clinical benefit of cancer treatment.Since chemotherapy is often associated with adverse events,concomitant treatment with drugs managing side effects of chemotherapy is frequently used in the combination therapy.However,whether these ancillary drugs could impede immunotherapy remains unknown.Here,we showed that∆9-tetrahydrocannabinol(THC),the key ingredient of drugs approved for the treatment of chemotherapy-caused nausea,reduced the therapeutic effect of PD-1 blockade.The endogenous cannabinoid anandamide(AEA)also impeded antitumor immunity,indicating an immunosuppressive role of the endogenous cannabinoid system(ECS). | Xinxin Xiong Siyu Chen Jianfei Shen Hua You Han Yang Chao Yan Ziqian Fang Jianeng Zhang Xiuyu Cai Xingjun Dong Tiebang Kang Wende Li Penghui Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 9 | Fast GF(p)modular inversion algorithm suitable for VLSI implementation显示文摘 | Zhou Tao Wu Xingjun Bai Guoqiang | 2002 | Electronics Letters2002，38，： | 1 |
| 10 | Microwave frequency upconversion employing a coupling-modulated ring resonator显示文摘We present a method to generate a frequency-doubled microwave signal by employing a coupling-modulated ring resonator. Critical coupling is achieved when the resonator intrinsic loss is perfectly balanced by the external coupling enabled by a Mach–Zehnder interferometer coupler. The high suppression of the carrier leads to a clean two-tone optical signal with the frequency interval two times larger than that of the input microwave frequency.The beating of the two-tone signal at a photodiode generates the frequency upconverted microwave signal.A theoretical model is established to analyze the modulation process and the microwave signal generation.Experimental results show that the electrical harmonic suppression ratio is around ~20 dB(29 dB) for an input microwave signal with 5 dBm(10 dBm) power. | YIMING ZHONG LINJIE ZHOU YANYANG ZHOU YUJIE XIA SIQI LIU LIANGJUN LU JIANPING CHEN XINGJUN WANG | 2017 | Photonics Research2017，5，6： | 1 |
| 11 | A real-time tunable arbitrary power ratios graphene based power divider显示文摘Recently, photonics integrated circuits have at-tracted extensive consideration for its rcalizationof latrge-scalc integration of vatrious devices and functionatlitics on a single chip . | Haowen SHU Yuansheng TAO Ming JIN Xingjun WANG Zhiping ZHOU | 2018 | Science China(Information Sciences)2018，61，8： | 0 |
| 12 | Water-soluble brown carbon in atmospheric aerosols from the resource-dependent cities:Optical properties,chemical compositions and sources显示文摘As a vital type of light-absorbing aerosol,brown carbon(BrC)presents inherent associations with atmospheric photochemistry and climate change.However,the understanding of the chemical and optical properties of BrC is limited,especially in some resource-dependent cities with long heating periods in northwest China.This study showed that the annual average abundances of Water-soluble BrC(WS-BrC)were 9.33±7.42 and 8.69±6.29μg/m^(3)in Baotou and Wuhai and the concentrations,absorption coefficient(Abs_(365)),and mass absorption efficiency(MAE365)of WS-BrC presented significant seasonal patterns,with high values in the heating season and low values in the non-heating season;while showing opposite seasonal trends for the Absorption Angstr?m exponent(AAE_(300-400)).Comparatively,the levels of WS-BrC in developing regions(such as cities in Asia)were higher than those in developed regions(such as cities in Europe and Australia),indicating the significant differences in energy consumption in these regions.By combining fluorescence excitation-emission matrix(EEM)spectra with the parallel factor(PARAFAC)model,humic-like(C1 and C2)and proteinlike(C3)substances were identified,and accounted for 61.40%±4.66%and 38.6%±3.78%at Baotou,and 60.33%±6.29%and 39.67%±4.17%at Wuhai,respectively.The results of source apportionment suggested that the potential source regions of WS-BrC varied in heating vs.non-heating seasons and that the properties of WS-BrC significantly depended on primary emissions(e.g.,combustion emissions)and secondary formation. | Haoji Wang Yue Su Yangzheng Liu Fei Xie Xingjun Zhou Ruihong Yu Changwei Lü Jiang He | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 13 | Revealing the Defect-Dominated Electron Scattering in Mg_(3)Sb_(2)-Based Thermoelectric Materials显示文摘The thermoelectric parameters are essentially governed by electron and phonon transport.Since the carrier scattering mechanism plays a decisive role in electron transport,it is of great significance for the electrical properties of thermoelectric materials.As a typical example,the defect-dominated carrier scattering mechanism can significantly impact the room-temperature electron mobility of n-type Mg_(3)Sb_(2)-based materials.However,the origin of such a defect scattering mechanism is still controversial.Herein,the existence of the Mg vacancies and Mg interstitials has been identified by synchrotron powder X-ray diffraction.The relationship among the point defects,chemical compositions,and synthesis conditions in Mg_(3)Sb_(2)-based materials has been revealed.By further introducing the point defects without affecting the grain size via neutron irradiation,the thermally activated electrical conductivity can be reproduced.Our results demonstrate that the point defects scattering of electrons is important in the n-type Mg_(3)Sb_(2)-based materials. | Jucai Jia Yan Zhou Xiaoxi Chen Wenhua Xue Hulei Yu Jing Li Shizhen Zhi Chen Chen Jian Wang Shuaihang Hou Xingjun Liu Yumei Wang Feng Cao Yue Chen Jun Mao Qian Zhang | 2023 | Research2023，，1： | 0 |
| 14 | Development of the high-strength ductile ferritic alloys via regulating the intragranular and grain boundary precipitation of G-phase显示文摘A typical G-phase strengthened ferritic model alloy(1Ti:Fe-20Cr-3Ni-1Ti-3Si,wt.%)has been carefully studied using both advanced experimental(EBSD,TEM and APT)and theoretical(DFT)techniques.During the classic“solid solution and aging”process,the superfine(Fe,Ni)_(2)TiSi-L2_(1)particles densely precipitate within the ferritic grain and subsequently transform into the(Ni,Fe)_(16)Ti_(6)Si_(7)-G phase.In the meanwhile,the elemental segregation at grain boundaries and the resulting precipitation of a large amount of the(Ni,Fe)_(16)Ti_(6)Si_(7)-G phase are also observed.These nanoscale microstructural evolutions result in a remarkable increase in hardness(100-300 HV)and severe embrittlement.When the“cold rolling and aging”process is used,the brittle fracture is effectively suppressed without loss of nano-precipitation strengthening ef-fect.Superhigh yield strength of 1700 MPa with 4%elongation at break is achieved.This key improvement in mechanical properties is mainly attributed to the pre-cold rolling process which effectively avoids the dense precipitation of the G-phase at the grain boundary.These findings could shed light on the further exploration of the precipitation site via optimal processing strategies. | Mujin Yang Chao Huang Jiajia Han Haichen Wu Yilu Zhao Tao Yang Shenbao Jin Chenglei Wang Zhou Li Ruiying Shu Cuiping Wang Huanming Lu Gang Sha Xingjun Liu | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
| 15 | Versatile photonic molecule switch in multimode microresonators显示文摘Harnessing optical supermode interaction to construct artificial photonic molecules has uncovered a series of fundamental optical phenomena analogous to atomic physics.Previously,the distinct energy levels and interactions in such two-level systems were provided by coupled microresonators.The reconfigurability is limited,as they often require delicate external field stimuli or mechanically altering the geometric factors.These highly specific approaches also limit potential applications.Here,we propose a versatile on-chip photonic molecule in a multimode microring,utilizing a flexible regulation methodology to dynamically control the existence and interaction strength of spatial modes.The transition between single/multi-mode states enables the“switched-off/on”functionality of the photonic molecule,supporting wider generalized applications scenarios.In particular,“switched-on”state shows flexible and multidimensional mode splitting control in aspects of both coupling strength and phase difference,equivalent to the a.c.and d.c.Stark effect.“Switched-off”state allows for perfect low-loss single-mode transition(Qi~10 million)under an ultra-compact bend size(FSR~115 GHz)in a foundry-based silicon microring.It breaks the stereotyped image of the FSR-Q factor trade-off,enabling ultra-wideband and high-resolution millimeter-wave photonic operations.Our demonstration provides a flexible and portable solution for the integrated photonic molecule system,extending its research scope from fundamental physics to real-world applications such as nonlinear optical signal processing and sixth-generation wireless communication. | Zihan Tao Bitao Shen Wencan Li Luwen Xing Haoyu Wang Yichen Wu Yuansheng Tao Yan Zhou Yandong He Chao Peng Haowen Shu Xingjun Wang | 2024 | Light(Science & Applications)2024，13，3： | 0 |
| 16 | Effect of dipole location on profile properties of symmetric surface plasmon polariton mode in Au/Al2O3/Au waveguide显示文摘这研究使用在 Al2O3 层嵌入使对称的表面电浆子电磁声子(SPP ) 激动的偶极子在 Au/Al2O3/Au 波导到的模式由使用有限差别的时间域(FDTD ) 调查它的侧面性质方法。激动的偶极子腐烂由于 100 nm 的薄 Al2O3 层的放射地直接的近地的联合到 SPP 模式。效果电并且磁场紧张侧面和腐烂长度被考虑了并且描绘。偶极子地点是一个重要因素在 Au/Al2O3/Au 波导影响对称的 SPP 模式的水平、垂直的侧面性质,这被发现。振幅电并且磁场紧张和 metal-insulatormetal (MIM ) 的波长 SPP 回声模式能被变化调节偶极子地点。水平、垂直的腐烂长度分别地是 19 和 24 nm。Au/Al2O3/Au 波导结构为设计 SPP 来源的实际应用是很有用的,这被期望。 | Gongli XIAO Xiang JI Linfei GAO Xingjun WANG Zhiping ZHOU | 2012 | Frontiers of Optoelectronics2012，5，1： | 0 |
| 17 | A low-fabrication-temperature,high-gain chip-scale waveguide amplifier显示文摘The increasing prevalence of integrated on-chip optoelectronic devices has identified serious issues regarding inter-device transmission and coupling losses,highlighting an urgent need for on-chip waveguide amplifiers to compensate for these losses.Compared with other Er-based optical materials,erbium silicate is ideally suited to high-efficiency on-chip amplifiers and lasers because of its extremely high Er^(3+) concentration(10^(22)cm^(-3)).Nevertheless,erbium silicate must be annealed above 1000℃ to crystallize and activate the Er^(3+),which damages other on-chip optoelectronic components and is not conducive to device integration.Here,we report a low-fabrication-temperature,high-luminescence-efficiency gain material by adding Bi_(2)O_(3)to an erbium-ytterbium silicate mixed film.Our experiments demonstrate that the proposed film crystallizes at 600℃ while the activation of Er^(3+) is also achieved,which is the lowest activation temperature of on-chip waveguide amplifier to our knowledge.This material forms the basis for a new chip-scale waveguide amplifier design,with a theoretical multi-energy-level model of Bi-Er-Yb in the mixed thin films used to analyze its signal enhancement properties.We achieve a peak on-chip gain of 23 dB in a 3.3-mm-long waveguide under the pump and signal powers of 300 mW and 1μW,respectively.These results highlight the potential of the proposed material for realizing on-chip amplifiers and lasers for large-scale nanophotonic integrated circuits. | Bo WANG Peiqi ZHOU Xingjun WANG Yandong HE | 2022 | Science China(Information Sciences)2022，65，6： | 0 |
| 18 | Spontaneous emission rate and optical amplification of Er3+ in double slot waveguide显示文摘The spontaneous emission(SE) of Er3+ embedded in a double slot dielectric structure was studied by a quantum-electrodynamical formalism. The study shows that the slot width and the position of Er3+ in slot structure have a significant effect on the SE. The double slot waveguides were fabricated by embedding two low-index Er/Yb silicate material layers into high-index silicon. The radiative efficiency of Er3+ in the double slot waveguides is found to be higher than that of the single slot waveguide, which is consistent with the theory simulation. The 0.67 d B signal enhancement at 1.53 ?m in a 4.6-mm-long slot waveguide was observed pumped by 1476 nm laser. These results show the relevance of our model to study the SE processes in multilayer structures and are important for future realization of silicon-compatible active optical devices. | WANG XingJun JIANG LingJun GUO RuiMin YE Rui ZHOU ZhiPing | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 0 |
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