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| 1 | Human amniotic epithelial cell feeder layers maintain mouse embryonic stem cell pluripotency via epigenetic regulation of the c-Myc promoter显示文摘老鼠胚胎的干细胞(转换字符) 在老鼠的 feeder 层上典型地是有教养的胚胎的成纤维细胞(MEF ) ,与白血病,禁止的因素(LIF ) 增加了处于一个无差别的状态维持他们。我们以前证明了人的羊膜的上皮的房间(hAECs ) 能被用作 feeder 房间维持老鼠转换字符 pluripotency,但是为这的机制是未知的。在现在的学习,我们发现那 CpG 5 c-Myc 基因仍然是的岛在在 hAECs 上有教养的老鼠转换字符的 hypomethylated。另外,在 c-Myc 基因倡导者 histone H3 的 acetylation 和 histone H3K4 的 trimethylation 铺平比在在 MEF 上有教养的 ES 房间的那些在在 hAECs 上有教养的 ES 房间是更高的。这些数据建议 hAECs 能经由 c-Myc 的 epigenetic 修正改变鼠标转换字符基因表示,提供为处于一个无差别的状态的转换字符的导致 hAEC 的维护的可能的机制。 | Te Liu Weiwei Cheng Tianjin Liu Lihe Guo Qin Huang Lizhen Jiang Xiling Du Fuhui Xu Zhixue Liu Dongmei Lai | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 6 |
| 2 | Severe human infection with a novel avian-origin influenza A(H7N4) virus显示文摘Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient.We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets(LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry(chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR. | Xiang Huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi Huang Feifei Hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu | 2018 | Science Bulletin2018，63，16： | 4 |
| 3 | Design, Synthesis and Activities of Aziridine Derivatives of N^5-Methyltetrahydrofolate Against Methionine Synthase显示文摘 | DENG Xiling GUO Ying TIAN Chao LIU Junyi WANG Xiaowei ZHANG Zhili | 2015 | Chemical Research in Chinese Universities2015，31，5： | 2 |
| 4 | Biological Permeability Enhancement Technology for Coal Reservoir显示文摘Objective Despite the adoption of various permeability enhancement technologies,the low permeability of coal reservoir has not been fundamentally improved for the development of coalbed methane(CBM)on the ground or the control of gas underground.New | GUO Hongyu LIU Xile XIA Daping BAI Yang FU Chaoyong | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 1 |
| 5 | Growth of Cadmium Mercury Thiocyanate Dimethyl-sulphoxide Single Crystal for Laser Frequency Doubling显示文摘 | Guo Shiyi Yuan Duorong Xu Dong Zhang Guanghui Sun Suoying Meng Fanqing Wang Xinqiang Jiang Xuening Jiang Minhua Sun Daliang Yu Xiling | 2000 | Progress in Crystal Growth and Characterization of Materials2000，，： | 1 |
| 6 | The Design and De-velopment of Microwave Holdup Meter and Application in Pro-duction Logging Interpretation of Multiphase Flows显示文摘 | Guo Haimin Wu Xiling Jin Zhenwu | | 0，，： | 1 |
| 7 | The short isoform of the long‐type PML ‐ RARA fusion gene in acute promyelocytic leukaemia lacks sensitivity to all‐trans‐retinoic acid显示文摘 | Yanhong Tan Sicheng Bian Zhifang Xu Xiuhua Chen Xiling Qi Fanggang Ren Li Li Haixiu Guo Aining Xu Linlin Zhang Hongwei Wang | 2013 | Br J Haematol2013，，1： | 1 |
| 8 | The de-sign and development of microwave holdup meter andapplication in production logging,interpretation of mul-tiphase flows 显示文摘 | Guo Haimin Wu Xiling Jin Zhenwu | 1993 | SPE Annual Technical Conference andExhibition1993，10，： | 1 |
| 9 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 10 | Operando monitoring of dendrite formation in lithium metal batteries via ultrasensitive tilted fiber Bragg grating sensors显示文摘Lithium(Li)dendrite growth significantly deteriorates the performance and shortens the operation life of lithium metal batteries.Capturing the intricate dynamics of surface localized and rapid mass transport at the electrolyte–electrode interface of lithium metal is essential for the understanding of the dendrite growth process,and the evaluation of the solutions mitigating the dendrite growth issue.Here we demonstrate an approach based on an ultrasensitive tilted fiber Bragg grating(TFBG)sensor which is inserted close to the electrode surface in a working lithium metal battery,without disturbing its operation.Thanks to the superfine optical resonances of the TFBG,in situ and rapid monitoring of mass transport kinetics and lithium dendrite growth at the nanoscale interface of lithium anodes have been achieved.Reliable correlations between the performance of different natural/artificial solid electrolyte interphases(SEIs)and the time-resolved optical responses have been observed and quantified,enabling us to link the nanoscale ion and SEI behavior with the macroscopic battery performance.This new operando tool will provide additional capabilities for parametrization of the batteries’electrochemistry and help identify the optimal interphases of lithium metal batteries to enhance battery performance and its safety. | Xile Han Hai Zhong Kaiwei Li Xiaobin Xue Wen Wu Nan Hu Xihong Lu Jiaqiang Huang Gaozhi Xiao Yaohua Mai Tuan Guo | 2024 | Light(Science & Applications)2024，13，1： | 0 |
| 11 | Genome transfer for the prevention of female infertility caused by maternal gene mutation显示文摘Poor oocyte quality is associated with early embryo developmental arrest and infertility.Maternal gene plays crucial roles in the regulation of oocyte maturation,and its mutation is a common cause of female infertility.However,how to improve oocyte quality and develop effective therapy for maternal gene mutation remains elusive.Here,we use Zar1 as an example to assess the feasibility of genome transfer to cure maternal gene mutationecaused female infertility.We first discover that cytoplasmic deficiency primarily leads to Zar1-null embryo developmental arrest by disturbing maternal transcript degradation and minor zygotic genome activation(ZGA)during the maternal-zygotic transition.We next perform genome transfer at the oocyte(spindle transfer or polar body transfer)and zygote(early pronuclear transfer or late pronuclear transfer)stages to validate the feasibility of preventing Zar1 mutationecaused infertility.We finally demonstrate that genome transfer either at the oocyte or at the early pronuclear stage can support normal preimplantation embryo development and produce live offspring.Moreover,those pups grow to adulthood and show normal fertility.Therefore,our findings provide an effective basis of therapies for the treatment of female infertility caused by maternal gene mutation. | Dandan Bai Jin Sun Yanping Jia Jiqing Yin Yalin Zhang Yanhe Li Rui Gao Xiling Du Kunming Li Jiaming Lin Zhifen Tu Yu Wang Jiaping Pan Shanshan Liang Yi Guo Jingling Ruan Xiaochen Kou Yanhong Zhao Hong Wang Cizhong Jiang Fengchao Wang Xiaoming Teng Wenqiang Liu Shaorong Gao | 2020 | Journal of Genetics and Genomics2020，47，6： | 0 |
| 12 | Genetic polymorphisms of 21 STR loci of Goldeneye^(TM) DNA ID 22NC kit in five ethnic groups of China显示文摘Dear Editor,Short tandem repeats(STRs),polymorphic DNA regions with a variable number of repeated units(2–6 base pairs),are attractive to forensic applications such as human identification and parentage testing[1].Nowadays,most of the commercial STR kits are designed based on STRs from the combined DNA index system(CODIS),European Standard Set(ESS),expanded CODIS,and extended ESS[2].In this study,we evaluated 21 STRs from GoldeneyeTM DNA ID 22NC kit(PeopleSpot Inc.,Beijing,China),which including 20 polymorphic non-CODIS STR loci(i.e.D1S1656,D2S441,D3S1744,D3S3045,D4S2366,D5S2500,D6S477,D7S1517,D7S3048,D8S1132,D10S1248,D10S1435,D11S2368,D13S325,D14S608,D15S659,D17S1290,D18S535,D19S253,D22GATA198B05)and a CODIS STR locus(D3S1358),in five ethnic groups(i.e.Eastern Han,Ningxia Hui,Xinjiang Uygur,Xizang Tibetan,and Inner Mongolia Mongolian)of China.The forensic genetic investigation of above loci may provide more genetic information in complex kinship testing and population studies[3,4]. | Jiashuo Zhang Yun Bao Ruiyang Tao Fei Guo Xiang Sheng Yingnan Bian Xiling Liu Suhua Zhang Chengtao Li | 2019 | Forensic Sciences Research2019，4，4： | 0 |
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