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| 1 | Modulating autophagy:a strategy for cancer therapy显示文摘Autophagy is a process in which long-lived proteins,damaged cell organelles,and other cellular particles are sequestered and degraded.This process is important for maintaining the cellular microenvironment when the cell is under stress.Many studies have shown that autophagy plays a complex role in human diseases,especially in cancer,where it is known to have paradoxical effects.Namely,autophagy provides the energy for metabolism and tumor growth and leads to cell death that promotes tumor suppression.The link between autophagy and cancer is also evident in that some of the genes that regulate carcinogenesis,oncogenes and tumor suppressor genes,participate in or impact the autophagy process.Therefore,modulating autophagy will be a valuable topic for cancer therapy.Many studies have shown that autophagy can inhibit the tumor growth when autophagy modulators are combined with radiotherapy and/or chemotherapy.These findings suggest that autophagy may be a potent target for cancer therapy. | Jun-Lin Li1,Shao-Liang Han2 and Xia Fan3 1Department of General Surgery,The Central Hospital of Yongzhou City,Yongzhou,Hunan 425000,P.R.China 2Department of General Surgery,First Affiliated Hospital of Wenzhou Medical College,Wenzhou,Zhejiang 325000,P.R.China 3State Key Laboratory of Trauma,Burns,and Combined Injury Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,P.R.China. | 2011 | Chinese Journal of Cancer2011，30，10： | 3 |
| 2 | Biological Permeability Enhancement Technology for Coal Reservoir显示文摘Objective Despite the adoption of various permeability enhancement technologies,the low permeability of coal reservoir has not been fundamentally improved for the development of coalbed methane(CBM)on the ground or the control of gas underground.New | GUO Hongyu LIU Xile XIA Daping BAI Yang FU Chaoyong | 2017 | Acta Geologica Sinica(English Edition)2017，91，5： | 1 |
| 3 | Evidence for GAL3ST4 mutation as the potential cause of Dectus excavatum显示文摘 | Song Wu Xiaojuan Sun Weimin Zhu Yi Huang Lisha Mou Mingming Liu Xia Li Feiyang Li Xianxin Li Yong Zhang Zheng Wang Wencui Li Zesong Li Aifa Tang Yaoting Gui Rongfu Wang Weiping Li Zhiming Cai Daping Wang | 2012 | Cell Research2012，22，12： | 0 |
| 4 | An Outbreak of Dengue Virus Type 1--Jiangxi Province,China,2019显示文摘What is known about this topic?Dengue fever is an acute febrile illness caused by four types of dengue virus(DENV 1–4),and is a mosquitoborne infectious disease.The incidence of dengue has increased dramatically around the world in recent decades.An estimated of 3.9 billion people in 128 countries are at risk of infection with dengue viruses,70%of whom are in Asia.In 2017,the first local infections of dengue virus(DENV-2)in Jiangxi Province was reported in Zhanggong District,Ganzhou City.What is added by this report?From August to September 2019,the first dengue outbreak happened in Xin’gan County,where 81 local dengue fever cases were reported,35 were laboratoryconfirmed cases,and 46 were clinically-diagnosed cases;all cases were dengue virus type 1.The DENV-virus strains isolated from the cases of Xin’gan County were close to the strains isolated in Singapore(MF033254|25657|Singapore|2016)and Henan(MK905537|He nan201903|China:Henan Province|2019).What are the implications for public health practice?The outbreak might have been caused by imported cases or covert infections.The outbreak in Xin’gan County indicated that more proactive countermeasures should be taken during the dengue epidemic period such as intensifying surveillance for dengue cases,virus serotype,and Aedes vector density and strengthening cooperation with customs and tourism departments.Moreover,the outbreak should prompt training in medical institutions and improved ability for doctor’s to diagnose dengue fever,which is very important for early detection of dengue cases and taking preventive measures. | Fuqiang Yang Guanghui Xia Zhili Zeng Zhongjian Li Huijian Cheng Daping Che Jun Zong Jianxiong Li Tian Gong Guihua Liu Weidong Zhou Bihai Wei Xiaobo Liu Jiandong Li Sheng Ding | 2020 | China CDC weekly2020，2，35： | 0 |
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