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| 1 | LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration显示文摘新兴的研究在少些在染色质水平,但是相对调整基因表示记录长非编码的 RNA (LncRNAs ) 的角色被知道他们怎么调整 DNA methylation。这里,我们识别 lncRNA, Dum (发展联系 pluripotency 2 (Dppa2 ) 在上游的有约束力的肌肉 lncRNA ) 在骨胳的 myoblast 房间。Dum 的表示动态地在 vitro 并且在 vivo 在 myogenesis 期间被调整。它被在 myoblast 区别之上有约束力的 MyoD transcriptionally 也导致。功能的分析证明它支持 myoblast 区别和导致损坏的肌肉新生。机械学地, Dum 被发现它的附近的基因到沉默, Dppa2,在通过招募的 cis Dnmt1, Dnmt3a 和 Dnmt3b。而且, intrachromosomal 在 Dum 地点和 Dppa2 倡导者之间循环为 Dum/Dppa2 相互作用是必要的。一起,我们识别了与 Dnmts 交往调整 myogenesis 的新奇 lncRNA。 | Lijun Wang Yu Zhao Xichen Bao Xihua Zhu Yvonne Ka-yin Kwok Kun Sun Xiaona Chen Yongheng Huang Ralf Jauch Miguel A Esteban Hao Sun Huating Wang | 2015 | Cell Research2015，25，3： | 34 |
| 2 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 3 | Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease显示文摘Accumulating evidence suggests that C-type lectin-like receptor-2(CLEC-2)plays an important role in atherothrombosis.In this case-control study,we investigated the association between CLEC-2 and incidence of coronary artery disease(CAD).A total of 216 patients,including 14 cases of stable angina pectoris(SAP,non-ACS)and 202 cases of acute coronary syndrome(ACS),and 89 non-CAD control subjects were enrolled.Plasma levels of soluble CLEC-2(sCLEC-2)were measured using the enzyme-linked immunosorbent assay(ELISA).Compared with the control group(65.69(55.36–143.22)pg/mL),the plasma levels of sCLEC-2 were significantly increased in patients with CAD(133.67(88.76–220.09)pg/mL)and ACS(134.16(88.88–225.81)pg/mL).The multivariate adjusted odds ratios(95%confidence interval)of CAD reached 2.01(1.52–2.66)(Ptrend<0.001)for each 1-quartile increase in sCLEC-2.Restricted cubic splines showed a positive dose-response association between sCLEC2 and CAD incidence(Plinearity<0.001).The addition of sCLEC-2 to conventional risk factors improved the C statistic(0.821 vs.0.761,P=0.004)and reclassification ability(net reclassification improvement:57.45%,P<0.001;integrated discrimination improvement:8.27%,P<0.001)for CAD.In conclusion,high plasma sCLEC-2 is independently associated with CAD risk,and the prognostic value of sCLEC-2 may be evaluated in future prospective studies. | Min Fei Li Xiang Xichen Chai Jingchun Jin Tao You Yiming Zhao Changgeng Ruan Yiwen Hao Li Zhu | 2020 | Frontiers of Medicine2020，14，1： | 5 |
| 4 | Profiles of muscular amino acids,fatty acids,and metabolites in Shaziling pigs of different ages and relation to meat quality显示文摘Pork meat is closely related to physicochemical alterations during growth and development,resulting in differences in nutritional value and meat flavor.This study aimed to evaluate the composition of amino acids,fatty acids,and metabolic profiles in the longissimus thoracis muscle(LM)of Shaziling pigs aged 30,90,150,210,and 300 days.The results showed that the predominant fatty acids identified in the LM of Shaziling pigs were C16:0,C16:1,C18:0,C18:1n9c,and C18:2n6c.An opposite correlation was observed for C18:2n6c and n6/n3 polyunsaturated fatty acids(P<0.05).Alanine,aspartate,glutamate,Dglutamine,and D-glutamate metabolism were the main metabolic pathways for the Shaziling pig meat flavor(P<0.05).Moreover,the correlation coefficients revealed that the contents of anserine,C16:0,C16:1,and C18:1n9c were positively correlated with intramuscular fat and/or p H24hand were negatively correlated with the values of L^(*)(lightness)and b^(*)(yellowness)(P<0.05).In conclusion,age greatly affected the meat quality of Shaziling pigs,and the contents of muscular anserine,C16:0,C16:1,and C18:1n9c might be promising indicators for better meat quality. | Yehui Duan Changbing Zheng Jie Zheng Lu Ma Xinran Ma Yinzhao Zhong Xichen Zhao Fengna Li Qiuping Guo Yulong Yin | 2023 | Science China(Life Sciences)2023，66，6： | 2 |
| 5 | Starch supplementation improves the reproductive performance of sows in different glucose tolerance status显示文摘This study was to evaluate the effects of glucose tolerance status,maternal starch supplementation and soybean substitution in diets on the performance of dams and their offspring.Eighty-eight pregnant sows(Landrace x Large White)were selected from an initial total of 120 sows,based on blood glucose test values,and assigned to 4 experimental treatments in a 2×2 factorial design.The factors were glucose tolerance status(glucose intolerant[GIT]vs.normal glucose tolerant[NGT])or dietary treatments(corn starch diet[CS]vs.soybean substitution diet[SSI]).A higher area under the curve(AUC)for post-meal glucose was observed(P<0.05)in the GIT group than in the NGT group on d 109 of gestation.The CS group had a lower value of homeostasis model assessment-insulin resistance than the SS group(P<0.05)on d 109 of gestation.Corn starch supplementation for sows decreased the stillbirth rate(P<0.05),regardless of the sows’glucose tolerance status.The villus height of the jejunum and the villus height to crypt depth ratio of the ileum were greater in normal birth weight piglets from the CS group than from the SS group(P<0.01),and so was the activity of sucrase in the jejunum and ileum(P<0.01).Compared with the SS group,the CS group showed a reduction in pre-weaning mortality rate,an increase in the number of high-birth-weight piglets,and a decrease in the number of low-birth-weight piglets(P<0.05)under GIT status.In conclusion,sows fed CS decreased stillbirth rate and improved insulin resistance,as well as improving the intestinal morphology and digestive enzyme activities of their progeny,regardless of glucose tolerance status.Additionally,the CS group improved birth weight distribution and decreased pre-weaning mortality rate of piglets under GIT status. | Yunyu Yang Ming Deng Jianzhao Chen Xichen Zhao Kaili Xiao Wenliang He Xinggang Qiu Yanzhen Xu Yulong Yin Chengquan Tan | 2021 | Animal Nutrition2021，，4： | 2 |
| 6 | New development of laser cladding system on laser area for industrial application(Inveted paper)显示文摘 | Yang Xichen Zhao Xin Wang Yunshan | 1996 | SPIE Proceedings SPIE COEMA and COS1996，2888，67： | 1 |
| 7 | Optimization of static and linear beam pattern for laser surface modification显示文摘 | Yang Xichen Zhao Xin Wang Yunshan | 1999 | Industrial Lasers1999，3862，： | 1 |
| 8 | Laser repairing of parts in metallurgical industries显示文摘 | Yang Xichen Wang Yunshan Zhao Xin | 1999 | Industrial lasers1999，3862，： | 1 |
| 9 | New development oflasereladdingsystem on large area forinduslrial application (Invited Paper)显示文摘 | Yang Xichen Zhao Xin Wang Yunshan | 1996 | The Proceedings of SHE1996，2888，67： | 1 |
| 10 | SOLIDIFICATION PROCESS OF α(Al)-Mg_2Ge PSEUDOBINARY EUTECTIC ALLOYS显示文摘SOLIDIFICATIONPROCESSOFα(Al)Mg2GePSEUDOBINARYEUTECTICALLOYS①ZhaoShengxu,LiShunpu,ZhaoDeqian,PanMingxiangandChenXichenInstitu... | Zhao Shengxu, Li Shunpu, Zhao Deqian, Pan Mingxiang and Chen XichenInstitute of Physics, Chinese Academy of Sciences, Beijing 100080, P. R. China | 1998 | 中国有色金属学会会刊:英文版1998，8，1： | 0 |
| 11 | CORRECTION:Author Correction:Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘In the initial published version of this article,there were errors in the 5th and 6th affiliations.The correct 5th affiliation is“State Key Laboratory of Molecular Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Beijing,China”. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，6： | 0 |
| 12 | Progress of IMP Laser Ion Source显示文摘Progress of IMP Laser Ion SourceProgressofIMPLaserIonSource￥ZhaoZhizheng;YangYongfengandCaiXichenLotsOfprogressesofIMPlaserio... | Zhao Zhizheng Yang Yongfeng and Cai Xichen | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 13 | Stepwise Resonant Excitation and Photoionization of ^(169)Tm显示文摘StepwiseResonantExcitationandPhotoionizationof^(169)TmStepwiseResonantExcitationandPhotoionizationof^(169)Tm￥YangYOngfeng;Zhao... | Yang YOngfeng Zhao Zhizheng and Cai Xichen | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 14 | Design of a Stable AtomicSource and Ionizers显示文摘Design of a Stable Atomic Source and IonizersDesignofaStableAtomicSourceandIonizers￥CaiXichen,YangYongfengamdZhaoZhizhengForo... | Cai Xichen, Yang Yongfeng amd Zhao Zhizheng | 1995 | IMP & HIRFL Annual Report1995，，0： | 0 |
| 15 | Effect of Li and Ti Additions on Lα(Al)+Mg_2Si Pseudobinary Eutectic Reaction显示文摘Effect of Li and Ti additions on Lα(AI)+Mg2Si pseudobinary eutectic reaction in ternary Al-Mg-Si system has been investigated by thermoanalysis, directional solidification and metallographic techniques in this study. It has been found that Li addition causes decreasing of the volume fraction of Mg2Si, while a little amount of Ti causes to increasing, which is of a great importance to the adjustment of phase constitution and alloy properties. Doping components have little influence on the eutectic temperature. | Shengxu ZHAO Shunpu LI Deqian ZHAO Mingxiang PAN and Xichen CHEN(Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China) | 1997 | Journal of Materials Science & Technology1997，13，6： | 0 |
| 16 | Optical Detector Used for Measuring CVL Beam Pulse Properties 显示文摘Optical Detector Used for Measuring CVL Beam Pulse Properties￥ZhuShaofei;ZhaoZhizheng;YangYongfengandCaiXichenBecauselaserion... | Zhu Shaofei Zhao Zhizheng Yang Yongfeng and Cai Xichen | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 17 | Status of Studying Laser Ion Source显示文摘Status of Studying Laser Ion Source￥ZhaoZhizheng;YangYongfeng;ZhuShaofei;CaiXichen;ShangRenchengandXuSida(PhysicsDepartment,T... | Zhao Zhizheng Yang Yongfeng Zhu Shaofei Cai Xichen Shang Rencheng and Xu Sida(Physics Department,Tsinghua University.) | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
| 18 | Piglet growth performance improved by dietary supplementation of porous or nano particles of zinc oxide may be related to the gut microbiota显示文摘Previous studies on porous or nano particles zinc oxide(ZnO)in the piglets have mainly focused on growth performance and intestinal inflammation,but have scarcely explored the efficacy on gut microbiota.In addition,the efficacy of nano particles ZnO,which is related to its product quality,remains undefined.This study aimed to determine the efficacy of dietary 500 mg/kg porous or nano particles ZnO on the growth performance and gut microbiota of the weaned piglets.A total of 128 weaned piglets were randomly assigned to the dietary groups:NC(basal diet),PC(basal diet+3,000 mg/kg conventional ZnO),500HiZ(basal diet+500 mg/kg porous particles ZnO),and 500ZNP(basal diet+500 mg/kg nano particles ZnO).Compared with the NC diet group,both 500HiZ and 500ZNP increased(P<0.05)average daily feed intake(1 to 28 d)and average daily gain(1 to 28 d),and the 500ZNP tended to decrease feed to gain ratio(F:G ratio,1 to 28 d)(P=0.09).Both 500HiZ and 500ZNP decreased crypt depth of the ileum and increased claudin-2 in the duodenum and zonula occludens-1 in the ileum(P<0.05).Moreover,both 500HiZ and 500ZNP decreased IL-1βand tumor necrosis factor-a(TNF-a)in the jejunum and decreased TNF-a and IL-6 in the ileum(P<0.05).Both 500HiZ and 500ZNP increased microbialβ-diversity index in the ileum and microbial a-diversity indices in the colon of piglets(P<0.05).The probiotic genera Coprococcus(500ZNP)and Blautia(500HiZ)were positively correlated with the F:G ratio(1to 28 d)in colon of piglets(P<0.05).In addition,500HiZ promoted mitochondrial fusion protein 1(MFN1)and zinc transporter-1(ZnT-1)in the jejunum(P<0.05),whilst 500ZNP decreased MFN1 in the jejunum and ZnT-1 in the ileum(P<0.05).In summary,both 500HiZ and 500ZNP improved the growth performance of piglets,which is likely via the genera Blautia and Coprococcus,respectively.Both 500HiZ and 500ZNP improved barrier function and inflammation of the intestine,and 500HiZ achieved better efficacy than 500ZNP on intestine mitochondrial functions. | Lina Long Xichen Zhao Jie Chen Zixi Wang Yanfang Tang Jian Huang Yulong Yin | 2023 | Animal Nutrition2023，，4： | 0 |
| 19 | Trichomonas vaginalis induces extracellular trap release in mouse neutrophils in vitro显示文摘Trichomonas vaginalis,a zoonotic anaerobic parasite first discovered in the secretions of vaginitis patients in 1836,is mainly transmitted through sexual activities.In addition,T.vaginalis can also be transmitted through indirect contact in public swimming pools,toilets,bathtubs,etc.Infected females suffer from diseases such as vaginitis,urethritis,miscarriage,and premature birth,while infected males are mostly asymptomatic carriers or with chronic urethral inflammation and prostate inflammation,which can cause infertility in severe cases.Infection with T.vaginalis increases the risk of human immunodeficiency virus infection[1]. | Yuhang Gao Xin Li Nan Zhang Panpan Zhao Shan Li Lixin Tai Xinyu Li Ling Li Jianhua Li Xichen Zhang Min Sun Lili Cao Pengtao Gong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 0 |
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