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| 1 | Therapeutic imaging window of cerebral infarction revealed by multisequence magnetic resonance imaging An animal and clinical study显示文摘In this study, we established a Wistar rat model of right middle cerebral artery occlusion and observed pathological imaging changes (T2-weighted imaging [T2WI], T2FLAIR, and diffusion-weighted imaging [DWI]) following cerebral infarction. The pathological changes were divided into three phases: early cerebral infarction, middle cerebral infarction, and late cerebral infarction. In the early cerebral infarction phase (less than 2 hours post-infarction), there was evidence of intracellular edema, which improved after reperfusion. This improvement was defined as the ischemic penumbra. In this phase, a high DWI signal and a low apparent diffusion coefficient were observed in the right basal ganglia region. By contrast, there were no abnormal T2WI and T2FLAIR signals. For the middle cerebral infarction phase (2-4 hours post-infarction), a mixed edema was observed. After reperfusion, there was a mild improvement in cell edema, while the angioedema became more serious. A high DWI signal and a low apparent diffusion coefficient signal were observed, and some rats showed high T2WI and T2FLAIR signals. For the late cerebral infarction phase (4-6 hours post-infarction), significant angioedema was visible in the infarction site. After reperfusion, there was a significant increase in angioedema, while there was evidence of hemorrhage and necrosis. A mixed signal was observed on DWI, while a high apparent diffusion coefficient signal, a high T2WI signal, and a high T2FLAIR signal were also observed. All 86 cerebral infarction patients were subjected to T2WI, T2FLAIR, and DWI. MRI results of clinic data similar to the early infarction phase of animal experiments were found in 51 patients, for which 10 patients (10/51) had an onset time greater than 6 hours. A total of 35 patients had MRI results similar to the middle and late infarction phase of animal experiments, of which eight patients (8/35) had an onset time less than 6 hours. These data suggest that defining the 'therapeutic time window' as the time 6 hours after infarction may not be suitable for all patients. Integrated application of MRI sequences including T2WI, T2FLAIR, DW-MRI, and apparent diffusion coefficient mapping should be used to examine the ischemic penumbra, which may provide valuable information for identifying the 'therapeutic time window'. | Hong Lu Hui Hu Zhanping He Xiangjun Han Jing Chen Rong Tu | 2012 | Neural Regeneration Research2012，7，31： | 16 |
| 2 | Gene interference regulates aquaporin-4 expression in swollen tissue of rats with cerebral ischemic edema Correlation with variation in apparent diffusion coefficient显示文摘To investigate the effects of mRNA interference on aquaporin-4 expression in swollen tissue of rats with ischemic cerebral edema, and diagnose the significance of diffusion-weighted MRI, we injected 5 μL shRNA- aquaporin-4 (control group) or siRNA- aquaporin-4 solution (1:800) (RNA interference group) into the rat right basal ganglia immediately before occlusion of the middle cerebral artery. At 0.25 hours after occlusion of the middle cerebral artery, diffusion-weighted MRI displayed a high signal; within 2 hours, the relative apparent diffusion coefficient decreased markedly, aquaporin-4 expression increased rapidly, and intracellular edema was obviously aggravated; at 4 and 6 hours, the relative apparent diffusion coefficient slowly returned to control levels, aquaporin-4 expression slightly increased, and angioedema was observed. In the RNA interference group, during 0.25- 6 hours after injection of siRNA- aquaporin-4 solution, the relative apparent diffusion coefficient slightly fluctuated and aquaporin-4 expression was upregulated; during 0.5-4 hours, the relative apparent diffusion coefficient was significantly higher, while aquaporin-4 expression was significantly lower when compared with the control group, and intracellular edema was markedly reduced; at 0.25 and 6 hours, the relative apparent diffusion coefficient and aquaporin-4 expression were similar when compared with the control group; obvious angioedema remained at 6 hours. Pearson's correlation test results showed that aquaporin-4 expression was negatively correlated with the apparent diffusion coefficient (r = -0.806, P < 0.01). These findings suggest that upregulated aquaporin-4 expression is likely to be the main molecular mechanism of intracellular edema and may be the molecular basis for decreased relative apparent diffusion coefficient. Aquaporin-4 gene interference can effectively inhibit the upregulation of aquaporin-4 expression during the stage of intracellular edema with time-effectiveness. Moreover, diffusion-weighted MRI can accurately detect intracellular edema. | Hui Hu Hong Lu Zhanping He Xiangjun Han Jing Chen Rong Tu | 2012 | Neural Regeneration Research2012，7，21： | 14 |
| 3 | Knockdown of Oct4 and Nanog expression inhibits the stemness of pancreatic cancer cells显示文摘 | Yuhua Lu Hui Zhu Haiyan Shan Junjie Lu Xu Chang Xiaohong Li Jingjing Lu Xiangjun Fan Shajun Zhu Yao Wang Qingsong Guo Lei Wang Yan Huang Mingyan Zhu Zhiwei Wang | 2013 | Cancer Letters2013，，： | 3 |
| 4 | LiFePO_4/C via fluoride doping显示文摘Non-stoichiometric compound fluoride-doped LiFePO4/C cathode materials were synthesized via solid-state reaction using MgF2 and AlF3 as dopant. The fluoride-doped LiFePO4/C samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and electrochemical testing. The results show that the materials are well crystallized and fluoride doping cannot change the space structure of LiFePO4. Slight amounts of Fe2O3 with no fluoride impurity were detected. Charge-discharge curves show that fluoride-doped samples have higher capacity at low rates compared with undoped LiFePO4/C. AlF3-doped samples have highest capacity at high discharge current. Both doped samples have larger polarization voltage than undoped samples. All samples exhibit good cycle stability. | Gu Yuan Zhang Xiangjun Lu Shigang Zhao Ting Jiang Danping Yang Rong Wu Aide | 2012 | Rare Metals2012，31，6： | 2 |
| 5 | Tin oxide-graphite composite for lithium storage material in lithium-ion batteries显示文摘A SnO-graphite composite material, which can deliver high capacities and good cycling stability compared with unsupported SnO, was described. This material prepared via chemical co-precipitation reaction in the presence of graphite consists of high dispersion of SnO with a size of about several hundred nanometers in the graphite. The phase structure was analyzed by X-ray diffraction (XRD). The morphology and the element distribution were examined by scanning electron microscopy (SEM) equipped with energy spectrum. The results show that the SnO-graphite composites produced by slowly hydrolysis have higher rechargeable capacities than pure graphite and better cycling performance than SnO. | ZHANG Xiangjun, HUANG Songtao, WU Guoliang, LU Shigang, and CAI ZhenpingGeneral Research Institute for Non-ferrous Metals, Beijing 100088, China | 2003 | Rare Metals2003，22，3： | 2 |
| 6 | Impacts of Multigrid NLS-4DVar-based Doppler Radar Observation Assimilation on Numerical Simulations of Landfalling Typhoon Haikui (2012)显示文摘We applied the multigrid nonlinear least-squares four-dimensional variational assimilation(MG-NLS4DVar)method in data assimilation and prediction experiments for Typhoon Haikui(2012)using the Weather Research and Forecasting(WRF)model.Observation data included radial velocity(Vr)and reflectivity(Z)data from a single Doppler radar,quality controlled prior to assimilation.Typhoon prediction results were evaluated and compared between the NLS-4DVar and MG-NLS4DVar methods.Compared with a forecast that began with NCEP analysis data,our radar data assimilation results were clearly improved in terms of structure,intensity,track,and precipitation prediction for Typhoon Haikui(2012).The results showed that the assimilation accuracy of the NLS-4DVar method was similar to that of the MG-NLS4DVar method,but that the latter was more efficient.The assimilation of Vr alone and Z alone each improved predictions of typhoon intensity,track,and precipitation;however,the impacts of Vr data were significantly greater that those of Z data.Assimilation window-length sensitivity experiments showed that a 6-h assimilation window with 30-min assimilation intervals produced slightly better results than either a 3-h assimilation window with 15-min assimilation intervals or a 1-h assimilation window with 6-min assimilation intervals. | Lu ZHANG Xiangjun TIAN Hongqin ZHANG Feng CHEN | 2020 | Advances in Atmospheric Sciences2020，37，8： | 1 |
| 7 | Outer synchronization of uncertain general complex delayed networks with adaptive coupling显示文摘 | WU Xiangjun and LU Hongtao | 2012 | Neurocomputing2012，82，： | 1 |
| 8 | Virtual manipulator-based binocular stereo vision positioning system and errors modelling显示文摘 | Xiangjun Zou Haixin Zou Jun Lu | 2012 | Machine Vision and Applications2012，，1： | 1 |
| 9 | Exponential synchronization ofweighted general delay coupled and non-delay coupled dy-namical networks 显示文摘 | Wu Xiangjun Lu Hongtao | 2010 | Computer & Mathematics with Ap-plication2010，60，8： | 1 |
| 10 | Luminescence Chronology and Radiocarbon Reservoir Age Determination of Lacustrine Sediments from the Heihai Lake,NE Qinghai-Tibetan Plateau and Its Paleoclimate Implications显示文摘The accurately determining the lake ^(14)C reservoir age has a crucial significance for climatic reconstruction. In this study, the optically stimulated luminescence(OSL) dating method is employed to date samples from highstand lacustrine sediments, palaeoshoreline, fluvial terrace, and the alluvial fan of the Heihai Lake catchment. Accelerator mass spectrometry(AMS) ^(14)C dating was also used to date fossil plants from highstand lacustrine sediments. Based on the calculations of linear regression with OSL against radiocarbon ages for same layers of two sections, the quantitative ^(14)C reservoir ages were estimated to lie between 3 353 and 3 464 yr during the 1.8 to 2.4 ka, which showed temporal variation. The sources of old carbon are the dissolution of carbonate bedrocks distributed along the Kunlun Mountain. The OSL ages of the different members of the hydatogen sedimentary system at Heihai Lake catchment indicate that a stronger hydrologic condition occurred from 3.0±0.2 to 1.8±0.2 ka, with a maximum lake level of 9 m higher than present. This humid stage was widely recorded in different sediments on the QTP and Chinese Loess Plateau(CLP), indicating its broad synchronicity across the Asian Summer Monsoon region. The enhanced East Asian Summer Monsoon(EASM) and the Indian Summer Monsoon(ISM) resulted in the increase of moisture availability for the Heihai Lake area during this stage. | Fuyuan An Zhongping Lai Xiangjun Liu Yixuan Wang Qiufang Chang Baoliang Lu Xiaoyun Yang | 2018 | Journal of Earth Science2018，29，3： | 1 |
| 11 | Generalized projective syn-chronization between two different general complex dy-namical networks with delayed coupling显示文摘 | Wu Xiangjun Lu Hongtao | 2010 | PhysicsLetters A2010，374，： | 1 |
| 12 | Hybrid Synchronization of the General Delayed and Non-delayed Complex Dynamical Networks via Pinning Control显示文摘 | Wu Xiangjun Lu Hongtao | 2012 | Neurocomputing2012，89，： | 1 |
| 13 | Projective Lag Synchronization of the General Complex Dynamical Networks with Distinct Nodes显示文摘 | Wu Xiangjun Lu Hongtao | 2012 | Communications in Nonlinear Science and Numerical Simulation2012，17，11： | 1 |
| 14 | Virtual manipulator- based binocular stereo vision positioning system and errors modeling显示文摘 | Zou Xiangjun Zou Haixin Lu Jun | 2012 | Machine Vision and Applications2012，23，1： | 1 |
| 15 | Virtual manipulator-based binocular stereo vision positioning system and errors modelling显示文摘 | Zou Xiangjun Zou Haixin Lu Jun | 2012 | Machine Vision and Applications2012，23，1： | 1 |
| 16 | Polypy- rrole/carbon nanotube nanocomposite enhanced the electro- chemical capacitance of flexible graphene film for superca- pacitors显示文摘 | Lu Xiangjun Dou Hui Yuan Changzhou | 2012 | J Power Sources2012，197，： | 1 |
| 17 | Virtual manipulator-based binocular stereo vision positioning system and errors modelling显示文摘 | Xiangjun Zou Haixin Zou Jun Lu | 2012 | Machine Vision and Applications2012，，1： | 1 |
| 18 | Winter wheat leaf area index inversion by the genetic algorithms neural network model based on SAR data显示文摘The leaf area index(LAI)is an important agroecological physiological parameter affecting vegetation growth.To apply the genetic algorithms neural network model(GANNM)to the remote sensing inversion of winter wheat LAI throughout the growth cycle and based on GaoFen-3 Synthetic aperture radar(GF-3 SAR)images and GaoFen-1 Wide Field of View(GF-1 WFV)images,the Xiangfu District in the east of Kaifeng City,Henan Province,was selected as the testing region.Winter wheat LAI data from five growth stages were combined,and optical and microwave polarization decomposition vegetation index models were used.The backscattering coefficient was extracted by modified water cloud model(MWCM),and the LAI was obtained by MWCM inversion as input factors to construct GANNM to invert LAI.The root mean square error(RMSE)and determination coefficient(R2)were used as evaluation indicators of the model.The fitting accuracy of winter wheat LAI in five growth stages by GANNM inversion was better than that of the BP neural network model;the R2 was higher than 0.8,and RMSE was lower than 0.3,indicating that the model could accurately invert the growth status of winter wheat in five growth stages. | Xiaoping Lu Xiaoxuan Wang Xiangjun Zhang Jun Wang Zenan Yang | 2022 | International Journal of Digital Earth2022，15，1： | 1 |
| 19 | Generalized projective synchronization of?the?fractional-order Chen hyperchaotic system显示文摘 | Xiangjun Wu Yang Lu | 2009 | Nonlinear Dynamics (-)2009，，1： | 1 |
| 20 | Outer Synchronization of Uncertain General Complex Delayed Networks with Adaptive Coupling显示文摘 | WU Xiangjun LU Hongtao | 2012 | Neurocomputing2012，82，： | 1 |
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