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| 1 | Linear Strain-Gradient Effect on the Energy Bandgap in Bent CdS Nanowires显示文摘尽管在半导体的可能的非同类的紧张效果被调查了因为在一半上世纪和紧张坡度能每在灵活 nanostructures 的测微计是超过 1% ,我们仍然缺乏他们对精力乐队的影响的理解。这里,我们进行紧张坡度的系统的阴极射线发光光谱学研究在在低温度的有弹性地弄弯的 CdS nanowires 的导致的激子精力移动,并且发现在弄弯的 nanowires 的激子精力红移动与紧张坡度成正比,格子失真的一个索引。密度功能的计算在弄弯的 nanostructures 显示出乐队差距减小的一样的趋势并且揭示内在的机制。半导体的乐队差距上的重要线性紧张坡度效果应该在在 nanoelectronics 调节光电子的性质的方法上打开新灯。 | Qiang Fu Zi Yue Zhang Liangzhi KOU Peicai Wu Xiaobing Han Xinli Zhu Jingyun Gao Jun Xu Qing Zhao Wanlin Guo Dapeng Yu | 2011 | Nano Research2011，4，3： | 5 |
| 2 | Coupling of Hierarchical Al_(2)O_(3)/TiO_(2) Nanofibers into 3D Photothermal Aerogels Toward Simultaneous Water Evaporation and Purification显示文摘Serious freshwater shortage and environmental pollution boost the rapid development of solar-driven water production.Although improved evaporation rate has achieved in recent years,undesirable impurity(e.g.,pollutant components)can also be inevitably evaporated and collected as impurity in produced freshwater.This work reports new ultra-light three-dimensional(3D)aerogels assembled by hierarchical Al_(2)O_(3)/TiO_(2) nanofibers and reduced graphene oxide(RGO)for excit-ing synchronized solar-driven evaporation and water purification.Hydrophilic Al_(2)O_(3)/TiO_(2) fibrous channels linked up the graphene hot-spots and water body for sufficient water supply and bulk water insulation.Meanwhile,featured with thermal insulation effect,the Al_(2)O_(3)/TiO_(2) nanofibers effectively locked the converted heat with less energy loss from sunlight.The introducing of Al_(2)O_(3)/TiO_(2) nanofibers into RGO aerogel led to the effective interfacial evaporation for a more rapid water evaporation rate(2.19 kg·m−2·h−1,normalized to evaporation area including both top and side surface),which was 36%higher than that of pristine RGO aerogel.Moreover,simultaneous with the strong steam generation,Al_(2)O_(3)/TiO_(2) nanofibers in situ removed the pollutants within steam by photodegradation,achieving polluted wastewater purification with high con-taminant removal ratio of 91.3%.Our work on coupling Al_(2)O_(3)/TiO_(2) nanofibers into photothermal aerogel provides attractive solutions for the challenges of clean water scarcity and serious environmental pollution. | Xiangyu Meng Wanlin Xu Zhihui Li Jianhui Yang Jingwu Zhao Xixi Zou Yueming Sun Yunqian Dai | 2020 | Advanced Fiber Materials2020，2，2： | 4 |
| 3 | Sustained delivery of vascular endothelial growth factor mediated by bioactive methacrylic anhydride hydrogel accelerates peripheral nerve regeneration after crush injury显示文摘Neurotrophic factors,currently administered orally or by intravenous drip or intramuscular injection,are the main method for the treatment of peripheral nerve crush injury.However,the low effective drug concentration arriving at the injury site results in unsatisfactory outcomes.Therefore,there is an urgent need for a treatment method that can increase the effective drug concentration in the injured area.In this study,we first fabricated a gelatin modified by methacrylic anhydride hydrogel and loaded it with vascular endothelial growth factor that allowed the controlled release of the neurotrophic factor.This modified gelatin exhibited good physical and chemical properties,biocompatibility and supported the adhesion and proliferation of RSC96 cells and human umbilical vein endothelial cells.When injected into the epineurium of crushed nerves,the composite hydrogel in the rat sciatic nerve crush injury model promoted nerve regeneration,functional recovery and vascularization.The results showed that the modified gelatin gave sustained delivery of vascular endothelial growth factors and accelerated the repair of crushed peripheral nerves. | Wanlin Xu Yifan Wu Hao Lu Yun Zhu Jinhai Ye Wenjun Yang | 2022 | Neural Regeneration Research2022，17，9： | 2 |
| 4 | Analysis and seismic tests of composite shear walls with CFST columns and steel plate deep beams显示文摘A composite shear wall concept based on concrete filled steel tube(CFST)columns and steel plate(SP)deep beams is proposed and examined in this study.The new wall is composed of three different energy dissipation elements:CFST columns;SP deep beams;and reinforced concrete(RC)strips.The RC strips are intended to allow the core structural elements-the CFST columns and SP deep beams-to work as a single structure to consume energy.Six specimens of different configurations were tested under cyclic loading.The resulting data are analyzed herein.In addition,numerical simulations of the stress and damage processes for each specimen were carried out,and simulations were completed for a range of location and span-height ratio variations for the SP beams.The simulations show good agreement with the test results.The core structure exhibits a ductile yielding mechanism characteristic of strong column-weak beam structures,hysteretic curves are plump and the composite shear wall exhibits several seismic defense lines.The deformation of the shear wall specimens with encased CFST column and SP deep beam design appears to be closer to that of entire shear walls.Establishing optimal design parameters for the configuration of SP deep beams is pivotal to the best seismic behavior of the wall.The new composite shear wall is therefore suitable for use in the seismic design of building structures. | Dong Hongying Cao Wanlin Wu Haipeng Zhang Jianwei Xu Fangfang | 2013 | Earthquake Engineering and Engineering Vibration2013，12，4： | 1 |
| 5 | Determination of the Li/Nb Ratio in LiNbO3 Crystals Prepared by Vapor Transport Equilibration Method 显示文摘 | Chen Yunlin Zhang Wanlin Shu Yongchun Lou Cibo Kong Yongfa Huang Ziheng Xu Jingjun and Zhang Guangyin | 2003 | Optical Materials2003，23，12： | 1 |
| 6 | Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease显示文摘Background In Alzheimer’s Disease(AD),about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways.Among them,the Ras and Rab Interactor 3(RIN3)is a guanine nucleotide exchange factor(GEF)for the Rab5 small GTPase family and has been implicated to be a risk factor for both late onset AD(LOAD)and sporadic early onset AD(sEOAD).However,how RIN3 is linked to AD pathogenesis is currently undefined.Methods Quantitative PCR and immunoblotting were used to measure the RIN3 expression level in mouse brain tissues and cultured basal forebrain cholinergic neuron(BFCNs).Immunostaining was used to define subcellular localization of RIN3 and to visualize endosomal changes in cultured primary BFCNs and PC12 cells.Recombinant flag-tagged RIN3 protein was purified from HEK293T cells and was used to define RIN3-interactomes by mass spectrometry.RIN3-interacting partners were validated by co-immunoprecipitation,immunofluorescence and yeast two hybrid assays.Live imaging of primary neurons was used to examine axonal transport of amyloid precursor protein(APP)andβ-secretase 1(BACE1).Immunoblotting was used to detect protein expression,processing of APP and phosphorylated forms of Tau.Results We have shown that RIN3 mRNA level was significantly increased in the hippocampus and cortex of APP/PS1 mouse brain.Basal forebrain cholinergic neurons(BFCNs)cultured from E18 APP/PS1 mouse embryos also showed increased RIN3 expression accompanied by early endosome enlargement.In addition,via its proline rich domain,RIN3 recruited BIN1(bridging integrator 1)and CD2AP(CD2 associated protein),two other AD risk factors,to early endosomes.Interestingly,overexpression of RIN3 or CD2AP promoted APP cleavage to increase its carboxyl terminal fragments(CTFs)in PC12 cells.Upregulation of RIN3 or the neuronal isoform of BIN1 increased phosphorylated Tau level.Therefore,upregulation of RIN3 expression promoted accumulation of APP CTFs and increased phosphorylated Tau.These effects by RIN3 was rescued by the expression of a dominant negative Rab5(Rab5S34N)construct.Our study has thus pointed to that RIN3 acts through Rab5 to impact endosomal trafficking and signaling.Conclusion RIN3 is significantly upregulated and correlated with endosomal dysfunction in APP/PS1 mouse.Through interacting with BIN1 and CD2AP,increased RIN3 expression alters axonal trafficking and procession of APP.Together with our previous studies,our current work has thus provided important insights into the role of RIN3 in regulating endosomal signaling and trafficking. | Ruinan Shen Xiaobei Zhao Lu He Yongbo Ding Wei Xu Suzhen Lin Savannah Fang Wanlin Yang Kijung Sung Brian Spencer Robert A.Rissman Ming Lei Jianqing Ding Chengbiao Wu | 2020 | Translational Neurodegeneration2020，9，2： | 1 |
| 7 | Recommendations for control and prevention of infections for pediatric orthopedics during the epidemic period of COVID-19显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged and spread rapidly throughout the world.As of February 29,2020,79389 cases of COVID-19 have been reported,and the outbreak is linked to 2838 deaths.The population is generally susceptible to the disease,and differences in incubation periods after infection exist among individuals.These two aspects of COVID-19 pose significant challenges to pediatric orthopedic diagnosis and treatment.As a dedicated center for managing pediatric cases of SARS-CoV-2 in Shanghai,our hospital has mobilized all branches and departments to undertake joint actions for scientific prevention and control,precise countermeasure and comprehensive anti-epidemic efforts.Combined with our experience,we have consulted the relevant national regulations and the latest research advances and have formulated the prevention and control measures of SARS-CoV-2 infection,including outpatient,emergency,inpatient and surgical cares,for clinical practices of pediatric orthopedics according to the physicochemical properties of SARS-CoV-2.It may serve as practical references and recommendations for managing SARS-CoV-2 infection in other pediatric specialties and in other hospitals. | Chunxing Wu Zhiqiang Zhang Yueqiang Mo Dahui Wang Bo Ning Ping Xu Jun Song Xinhong Pei Xiaoyan Ni Yiming Zheng Tian Xia Yanhui Jing Wanlin Sun Junrong Meng Chuang Qian | 2020 | World Journal of Pediatric Surgery2020，3，1： | 0 |
| 8 | High Temperature-preventing Cultivation Technology of Single-season Middle Rice for High Yield and High Quality in Jianghuai Area显示文摘In recent years,with the global climate change,the frequency and duration of high temperature in summer and autumn have increased,causing high temperature heat damage to summer crops such as rice and maize.From the end of July to early August is the main period of high temperature occurrence,during which the daily average temperature above 30℃is a high probability event,and even the highest temperature is above 38℃,while this period coincides with the booting-blooming-filling stage of the single-season middle rice in Jianghuai,especially the middle-season indica rice,so it often leads to the degradation of rice spikelets,pollen abortion,difficulty in pollen dispersion,and even difficulty in heading,resulting in a serious decline in the seed setting rate and poor filling of grains,which finally affect the yield and quality.Based on the goal of high-yielding high-quality rice cultivation,this paper proposed targeted technical measures for single-season middle rice from the aspects of planting time sequence optimization,selection of high-temperature-resistant varieties,population construction,fertilizer and water management technology,and how to compensate for the occurrence of unexpected disasters to promote plant growth.This study provides technical support for high-yielding high-quality stress-resistant and disaster-reducing rice cultivation technology. | Dewen ZHANG Wei ZHANG Youzun XU Wanlin WANG Dewei TAI Xiaozhong ZHANG Xueyuan SUN | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
| 9 | Peripheral CD4^(+)CD8^(+) double positive T cells:A potential marker to evaluate renal impairment susceptibility during systemic lupus erythematosus显示文摘Lupus nephritis(LN) has a high incidence in systemic lupus erythematosus(SLE) patients, but there is a lack of sensitive predictive markers. The purpose of the study was to investigate the association between the CD4^(+)CD8^(+)double positive T(DPT) lymphocytes and LN. The study included patients with SLE without renal impairment(SLE-NRI), LN, nephritic syndrome(NS), or nephritis. Peripheral blood lymphocyte subsets were analyzed by flow cytometry. Biochemical measurements were performed with peripheral blood in accordance with the recommendations proposed by the National Center for Clinical Laboratories. The proportions of DPT cells in the LN group were significantly higher than that in the SLE-NRI group(t=4.012, P<0.001), NS group(t=3.240,P=0.001), and nephritis group(t=2.57, P=0.011). In the LN group, the risk of renal impairment increased significantly in a DPT cells proportion-dependent manner. The risk of LN was 5.136 times(95% confidence interval, 2.115–12.473) higher in cases with a high proportion of DPT cells than those whose proportion of DPT cells within the normal range. These findings indicated that the proportion of DPT cells could be a potential marker to evaluate LN susceptibility, and the interference of NS and nephritis could be effectively excluded when assessing the risk of renal impairment during SLE with DPT cell proportion. | Kai Chang Wanlin Na Chenxia Liu Hongxuan Xu Yuan Liu Yanyan Wang Zhongyong Jiang | 2023 | The Journal of Biomedical Research2023，37，1： | 0 |
| 10 | CONSTRAINTS ON THE CRACK TIP PLASTIC FIELDS UNDER LARGE SCALE YIELD显示文摘Plane strain elastic-plastic finite element analyses are used to study the stress, strain fields aound a straight crack in power hardening plastic material. Center crack panel (CCP), single edge crack panel (SECP) and double edge crack panel (DECP) tension specimens are analyzed with various crack lengths. Two local constraint parameters, i.e. in-plane stress ratio T and out-of-plane constraint Tz are analyzed, which are defined as tangential stress dividing normal (open) stress and out-of-plane stress dividing the sum of tangential stress and normal stress respectively. Numerical analyses indicate that the two local constraint parameters are nearly independent of the specimen geometry and the loading level in the plastic zone. Methods of estimating two constraint parameters and ways to define the boundary of the blunt zone are given. By using these parameters, the stress distributions in the plastic zone, especially in the blunt zone can be accurately predicted. | Xu Fei~1 Guo Wanlin~(1,2) (1 State Key Laboratory of Mechanical Structure Strength and Vibration, Xi’an Jiaotong University, Xi’an 710049, China) (2 School of Aeronautics and Astronautics,Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China) | 2001 | Acta Mechanica Solida Sinica2001，14，2： | 0 |
| 11 | YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths显示文摘N6-methyladenosine(m^(6)A)is a critical regulator in the fate of RNA,but whether and how m^(6)A executes its functions in different tissues remains largely obscure.Here we report downregulation of a crucial m^(6)A reader,YTHDF2,leading to tissue-specific programmed cell deaths(PCDs)upon fluorene-9-bisphenol(BHPF)exposure.Currently,Bisphenol A(BPA)substitutes are widely used in plastic manufacturing.Interrogating eight common BPA substitutes,we detected BHPF in 14%serum samples of pregnant participants.In a zebrafish model,BHPF caused tissue-specific PCDs triggering cardiac and vascular defects.Mechanistically,BHPF-mediated downregulation of YTHDF2 reduced YTHDF2-facilitated translation of m^(6)A-gch1 for cardiomyocyte ferroptosis,and decreased YTHDF2-mediated m^(6)A-sting1 decay for caudal vein plexus(CVP)apoptosis.The two distinct YTHDF2-mediated m^(6)A regulations and context-dependent co-expression patterns of gch1/ythdf2 and tnfrsf1a/ythdf2 contributed to YTHDF2-mediated tissue-specific PCDs,uncovering a new layer of PCD regulation.Since BHPF/YTHDF2-medaited PCD defects were also observed in mammals,BHPF exposure represents a potential health threat. | Jiebo Lin Guankai Zhan Jinfeng Liu Yasen Maimaitiyiming Zhiping Deng Baohua Li Kunhui Su Jiafeng Chen Siqi Sun Wanlin Zheng Xianghui Yu Feng He Xiaodong Cheng Lingfang Wang Bin Shen Ziqin Yao Xinquan Yang Jian Zhang Wentao He Hengyu Wu Hua Naranmandura Kao-Jung Chang Junxia Min Jun Ma Mikael Björklund Peng-Fei Xu Fudi Wang Chih-Hung Hsu | 2023 | National Science Review2023，10，12： | 0 |
| 12 | Discovery and inspiration of large-and medium-sized glutenite-rich oil and gas fields in the eastern South China Sea:An example from Paleogene Enping Formation in Huizhou 26 subsag,Pearl River Mouth Basin显示文摘Based on the practice of oil and gas exploration in the Huizhou Sag of the Pearl River Mouth Basin,the geochemical indexes of source rocks were measured,the reservoir development morphology was restored,the rocks and minerals were characterized microscopically,the measured trap sealing indexes were compared,the biomarker compounds of crude oil were extracted,the genesis of condensate gas was identified,and the reservoir-forming conditions were examined.On this basis,the Paleogene Enping Formation in the Huizhou 26 subsag was systematically analyzed for the potential of oil and gas resources,the development characteristics of large-scale high-quality conglomerate reservoirs,the trapping effectiveness of faults,the hydrocarbon migration and accumulation model,and the formation conditions and exploration targets of large-and medium-sized glutenite-rich oil and gas fields.The research results were obtained in four aspects.First,the Paleogene Wenchang Formation in the Huizhou 26 subsag develops extensive and thick high-quality source rocks of semi-deep to deep lacustrine subfacies,which have typical hydrocarbon expulsion characteristics of'great oil generation in the early stage and huge gas expulsion in the late stage',providing a sufficient material basis for hydrocarbon accumulation in the Enping Formation.Second,under the joint control of the steep slope zone and transition zone of the fault within the sag,the large-scale near-source glutenite reservoirs are highly heterogeneous,with the development scale dominated hierarchically by three factors(favorable facies zone,particle component,and microfracture).The(subaqueous)distributary channels near the fault system,with equal grains,a low mud content(<5%),and a high content of feldspar composition,are conducive to the development of sweet spot reservoirs.Third,the strike-slip pressurization trap covered by stable lake flooding mudstone is a necessary condition for oil and gas preservation,and the NE and nearly EW faults obliquely to the principal stress have the best control on traps.Fourth,the spatiotemporal configuration of high-quality source rocks,fault transport/sealing,and glutenite reservoirs controls the degree of hydrocarbon enrichment.From top to bottom,three hydrocarbon accumulation units,i.e.low-fill zone,transition zone,and high-fill zone,are recognized.The main area of the channel in the nearly pressurized source-connecting fault zone is favorable for large-scale hydrocarbon enrichment.The research results suggest a new direction for the exploration of large-scale glutenite-rich reservoirs in the Enping Formation of the Pearl River Mouth Basin,and present a major breakthrough in oil and gas exploration. | XU Changgui GAO Yangdong LIU Jun PENG Guangrong LIU Pei XIONG Wanlin SONG Penglin | 2024 | Petroleum Exploration and Development2024，51，1： | 0 |
| 13 | Oxide Nanofibers as Catalysts Toward Energy Conversion and Environmental Protection显示文摘Ultrathin oxide nanofibers are widely used in an array of catalytic applications toward energy conversion and environmental protection.Remarkable progress has been made with regard to the development of engineering oxide nanofibers into unique structures to suit or enable various functions.We aim to provide a comprehensive overview of oxide nanofibers,including the structure engineering,derivates,assemblies and their applications.We begin with a brief introduction to the production of nanofibers with diversified compositions,structures and properties,followed by discussions of the wet-chemistry derivates.Afterward,we discuss the applications of catalytic oxide nanofibers,including electrocatalysis,photocatalysis and thermal-catalysis.Then we highlight the most significant role of oxide nanofibers as catalyst support for the immobilization of metal nanoparticles.Moreover,we showcase the advanced assemblies based on oxide nanofibers,including their use as multi-functional membranes and foams.In the end,we offer perspectives on the challenges,opportunities and new directions for future development. | WANG Jun FU Wanlin XU Wanlin WU Min SUN Yueming DAI Yunqian | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 14 | Li-Mg-Si bioceramics provide a dynamic immuno-modulatory and repair-supportive microenvironment for peripheral nerve regeneration显示文摘Biomaterials can modulate the local immune and repair-supportive microenvironments to promote peripheral nerve regeneration. Inorganic bioceramics have been widely used for regulating tissue regeneration and local immune response. However, little is known on whether inorganic bioceramics can have potential for enhancing peripheral nerve regeneration and what are the mechanisms underlying their actions. Here, the inorganic lithium-magnesium-silicon (Li-Mg-Si, LMS) bioceramics containing scaffolds are fabricated and characterized. The LMS-containing scaffolds had no cytotoxicity against rat Schwann cells (SCs), but promoted their migration and differentiation towards a remyelination state by up-regulating the expression of neurotrophic factors in a β-catenin-dependent manner. Furthermore, using single cell-sequencing, we showed that LMS-containing scaffolds promoted macrophage polarization towards the pro-regenerative M2-like cells, which subsequently facilitated the migration and differentiation of SCs. Moreover, implantation with the LMS-containing nerve guidance conduits (NGCs) increased the frequency of M2-like macrophage infiltration and enhanced nerve regeneration and motor functional recovery in a rat model of sciatic nerve injury. Collectively, these findings indicated that the inorganic LMS bioceramics offered a potential strategy for enhancing peripheral nerve regeneration by modulating the immune microenvironment and promoting SCs remyelination. | Yiting Sun Hongjian Zhang Yu Zhang Zheqi Liu Dongming He Wanlin Xu Siyi Li Chenping Zhang Zhen Zhang | 2023 | Bioactive Materials2023，，10： | 0 |
| 15 | Variation of Out-of-Plane Constraint and Its Effects on Fracture显示文摘The limitations of using one-parameter to describe the crack-tip fields have prompted investigators to consider better descriptions of the crack tip fields. The two-parameter descriptions, such as J-Q theory, have been an important development in this field. But under the consideration of plane strain and three-dimensional problem, the effects of the out-of-plane stress can not be neglected In this paper, effects of the in-plane constraint as well as the out-of-plane constraint are studied by aid of the finite element method on the plane strain condition. It is obvious that both the in-plane constraint (Q factor) and the out-of-plane constraint (Tz = σzz/(σxx + σyy) ) affect the crack tip fields.Several important features of the out-of-plane constraint are described out based on the simulation results. At the end of this paper, a three-parameter formulation is proposed, in which both the in-plane constraint and the out-of-plane constraint are considered. Comparing with the results of the FEM numerical simulation, the three-parameter description can provide a better prediction near the crack tip. | Fei Xu Yulong Li Wanlin Guo | 2004 | 上海交通大学学报2004，38，z2： | 0 |
| 16 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy显示文摘Microphthalmia transcription factor(MITF)regulates melanocyte development and is the“lineage-specific survival”oncogene of melanoma.MITF is essential for melanoma initiation,progression,and relapse and has been considered an important therapeutic target;however,direct inhibition of MITF through small molecules is considered impossible,due to the absence of a ligand-binding pocket for drug design.Here,our structural analyses show that the structure of MITF is hyperdynamic because of its out-of-register leucine zipper with a 3-residue insertion.The dynamic MITF is highly vulnerable to dimer-disrupting mutations,as we observed that MITF loss-of-function mutations in human Waardenburg syndrome type 2 A are frequently located on the dimer interface and disrupt the dimer forming ability accordingly.These observations suggest a unique opportunity to inhibit MITF with small molecules capable of disrupting the MITF dimer.From a high throughput screening against 654,650 compounds,we discovered compound TT-012,which specifically binds to dynamic MITF and destroys the latter’s dimer formation and DNA-binding ability.Using chromatin immunoprecipitation assay and RNA sequencing,we showed that TT-012 inhibits the transcriptional activity of MITF in B16F10 melanoma cells.In addition,TT-012 inhibits the growth of high-MITF melanoma cells,and inhibits the tumor growth and metastasis with tolerable toxicity to liver and immune cells in animal models.Together,this study demonstrates a unique hyperdynamic dimer interface in melanoma oncoprotein MITF,and reveals a novel approach to therapeutically suppress MITF activity. | Zaizhou Liu Kaige Chen Jun Dai Peng Xu Wei Sun Wanlin Liu Zhixin Zhao Steven P.Bennett Peifeng Li Tiancheng Ma Yuqi Lin Akinori Kawakami Jing Yu Fei Wang Chunxi Wang Miao Li Peter Chase Peter Hodder Timothy P.Spicer Louis Scampavia Chunyang Cao Lifeng Pan Jiajia Dong Yong Chen Biao Yu Min Guo Pengfei Fang David E.Fisher Jing Wang | 2023 | Cell Research2023，33，1： | 0 |
| 17 | A comparative genomics analysis of lung adenocarcinoma for Chinese population by using panel of recurrent mutations显示文摘Previous studies have demonstrated that Chinese lung adenocarcinoma(LUAD)patients have unique genetic characteristics,however,the specific genomic features relating to the development and treatment of LUAD in the Chinese population are not fully understood.Here,we applied the ultra-deep targeted sequencing to 66 Chinese LUAD samples,accompanied by comparative analysis with 162 Caucasian LUAD in The Cancer Genome Atlas.We focused on the 68 recurrently mutated genes and results revealed that the panel-based tumor mutational burden(pTMB)is significantly higher in the Chinese LUAD(P=0.0017).Additionally,the percentage of smoking-associated C>A transversion is significantly lower in Chinese LUAD(15.5%vs.39.7%,P=5.69×10^(-27)),while C>T transition is more frequent in Chinese LUAD(35.8%vs.25.7%,P=2.67×10^(-5)),which indicated the ethnic difference in mutation types.Notably,novel driver genes(GNAS and JAK1)that are peculiar to Chinese LUAD were identified,and a more convergent distribution of mutations was observed in the Chinese cohort(P=0.012)compared with scattered mutations in Caucasian LUAD.Our results present a distinct genomic profile of Chinese LUAD compared to Caucasians LUAD and elucidate the ethnic difference in mutation distribution besides the type and rate. | Wanlin Li Min Wu Qianqian Wang Kun Xu Fan Lin Qianghu Wang Renhua Guo | 2021 | The Journal of Biomedical Research2021，35，1： | 0 |
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