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| 1 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | The study on influence factors of the mechanical smoke evacuation system in atrium buildings显示文摘 | XU Junbin ZHANG Cheng ZHAO Junfei | 2013 | Procedia Engineering2013，52，： | 1 |
| 3 | Mode analysis of lattice main boom for crawler crane based on ANSYS_WORKBENCH显示文摘 | Xu Gening Yang Junbin Liu Jinshuai | 2013 | Advanced Materials Research2013，7127，： | 1 |
| 4 | Ustilaginoidea virens modulates lysine 2-hydroxyisobutyrylation in rice flowers during infection显示文摘The post-translational modification lysine 2-hydroxyisobutyrylation(K_(hib))plays an important role in gene transcription,metabolism,and enzymatic activity.K_(hib)sites have been identified in rice(Oryza sativa).However,the K_(hib)status of proteins in rice flowers during pathogen infection remains unclear.Here,we report a comprehensive identification of K_(hib)-modified proteins in rice flowers,and the changes in these proteins during infection with the fungal pathogen Ustilaginoidea virens.By using a tandem mass tag-based quantitative proteomics approach,we identified 2,891 K_(hib)sites on 964 proteins in rice flowers.Our data demonstrated that 2-hydroxyisobutyrylated proteins are involved in diverse biological processes.K_(hib)levels were substantially reduced upon infection with U.virens.Chromatin immunoprecipitation polymerase chain reaction(PCR)and reverse transcription quantitative PCR analyses revealed that histone K_(hib)is involved in the expression of disease-resistance genes.More importantly,most quantified sites on core histones H3 were downregulated upon U.virens infection.In addition,the histone deacetylases HDA705,HDA716,SRT1,and SRT2 are involved in the removal of K_(hib)marks in rice.HDA705 was further confirmed to negatively regulate rice disease resistance to pathogens U.virens,Magnaporthe oryzae,and Xanthomonas oryzae pv.oryzae(Xoo).Our data suggest that U.virens could modulate K_(hib)in rice flowers during infection. | Xiaoyang Chen Qiutao Xu Yuhang Duan Hao Liu Xiaolin Chen Junbin Huang Chaoxi Luo Dao-Xiu Zhou Lu Zheng | 2021 | Journal of Integrative Plant Biology2021，63，10： | 1 |
| 5 | The difficulty of medical decision-making:should patients be involved?显示文摘Introduction The success or failure of treatment has long been attributed to the doctors alone,but the role of patients in the medical decision-making(MDM)process has often been ignored.As medical development and health needs increase,the desire of patients to participate in MDM continues to grow.This raises the question:should patients be involved in such a highly professional medical activity?How can their involvement bring better clinical benefits? | Junbin Zhou Xiao Xu | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 0 |
| 6 | Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment显示文摘Enzyme-driven micro/nanomotors consuming in situ chemical fuels have attracted lots of attention for biomedical applications.However,motor systems composed by organism-derived organics that maximize the therapeutic efficacy of enzymatic products remain challenging.Herein,swimming proteomotors based on biocompatible urease and human serum albumin are constructed for enhanced antitumor therapy via active motion and ammonia amplification.By decomposing urea into carbon dioxide and ammonia,the designed proteomotors are endowed with self-propulsive capability,which leads to improved internalization and enhanced penetration in vitro.As a glutamine synthetase inhibitor,the loaded L-methionine sulfoximine further prevents the conversion of toxic ammonia into non-toxic glutamine in both tumor and stromal cells,resulting in local ammonia amplification.After intravesical instillation,the proteomotors achieve longer bladder retention and thus significantly inhibit the growth of orthotopic bladder tumor in vivo without adverse effects.We envision that the as-developed swimming proteomotors with amplification of the product toxicity may be a potential platform for active cancer treatment. | Hao Tian Juanfeng Ou Yong Wang Jia Sun Junbin Gao Yicheng Ye Ruotian Zhang Bin Chen Fei Wang Weichang Huang Huaan Li Lu Liu Chuxiao Shao Zhili Xu Fei Peng Yingfeng Tu | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 7 | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys显示文摘Neurological manifestations are frequently reported in the COVID-19 patients.Neuromechanism of SARS-CoV-2 remains to be elucidated.In this study,we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19.In rhesus monkey,SARS-CoV-2 invades the CNS primarily via the olfactory bulb.Thereafter,viruses rapidly spread to functional areas of the central nervous system,such as hippocampus,thalamus,and medulla oblongata.The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons,microglia,and astrocytes in the CNS.Consistently,SARS-CoV-2 infects neuro-derived SK-N-SH,glial-derived U251,and brain microvascular endothelial cells in vitro.To our knowledge,this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model,which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. | Li Jiao Yun Yang Wenhai Yu Yuan Zhao Haiting Long Jiahong Gao Kaiyun Ding Chunxia Ma Jingmei Li Siwen Zhao Haixuan Wang Haiyan Li Mengli Yang Jingwen Xu Junbin Wang Jing Yang Dexuan Kuang Fangyu Luo Xingli Qian Longjiang Xu Bin Yin Wei Liu Hongqi Liu Shuaiyao Lu Xiaozhong Peng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 8 | Target-triggered hairpin-free chain-branching growth of DNA dendrimers for contrast-enhanced imaging in living cells by avoiding signal dispersion显示文摘The development of amplification strategies is one of the central challenges for detection of lowabundance targets. One-to-many(1:M) amplification strategies in which one target lights many signal probes, has improved the detection sensitivity in bulk solution, but with discounted contrast in cell imaging, because the lighted probes are dissociative and dispersible. In this work, a one-to-large(1:L) signaling mechanism, in which the lighted probes were orderly connected to each other, was conceptually proposed to enhance the contrast in cell imaging by avoiding signal dispersion in amplification. Accordingly,target-triggered hairpin-free chain-branching assembly(HFCBA) holds great potential to implement the1:L mechanism, but using it in cell imaging has yet to be demonstrated. As a proof of concept, a group of probes were first programmed to implement mi RNA-21-triggered HFCBA. After transfection of probes,gradually-growing signal flares in cells were monitored along with the growth of DNA dendrimers;and the in situ fluorescence accumulation in HFCBA resulted in highly-enhanced contrast to the surrounding by avoiding signal dispersion in amplification. The contrast-enhanced imaging with signal amplification is significant for biological analysis and molecular medicine. We expect the 1:L mechanism will provide a new thought for high-performance imaging of biomarkers in cells. | Jiaqi Deng Jingyuan Xu Minzhi Ouyang Zhen Zou Yanli Lei Junbin Li Zhihe Qing Ronghua Yang | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 9 | Research Progress in Laboratory of RIB Physics in 2019显示文摘The progress of research going on in Laboratory of Rare Isotope Beam Physics(RIB),Nuclear Physics Research Center,in 2019 is in the following three aspects. | Sun Zhiyu Yang Yanyun Zhang Xueheng Yu Yuhong Wang Shitao Tang Shuwen Hu Jun Hou Suqin Xu Shiwei Yan Duo Fang Fang Zhang Yongjie Bai Zhen Ma Junbin Ma Shaobo | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 10 | Comparative oxidation proteomics analyses suggest redox regulation of cytosolic translation in rice leaves upon Magnaporthe oryzae infection显示文摘Pathogen attack can increase plant levels of reactive oxygen species(ROS),which act as signaling molecules to activate plant defense mechanisms.Elucidating these processes is crucial for understanding redox signaling pathways in plant defense responses.Using an iodo-tandem mass tag(TMT)-based quantitative proteomics approach,we mapped 3362 oxidized cysteine sites in 2275 proteins in rice leaves.Oxidized proteins were involved in gene expression,peptide biosynthetic processes,stress responses,ROS metabolic processes,and translation pathways.Magnaporthe oryzae infection led to increased oxidative modification levels of 512 cysteine sites in 438 proteins,including many transcriptional regulators and ribosomal proteins.Ribosome profiling(Ribo-seq)analysis revealed that the oxidative modification of ribosomal proteins promoted the translational efficiency of many mRNAs involved in defense response pathways,thereby affecting rice immunity.Our results suggest that increased oxidative modification of ribosomal proteins in rice leaves promotes cytosolic translation,thus revealing a novel function of posttranslational modifications.Furthermore,the oxidation-sensitive proteins identified here provide a valuable resource for research on protein redox regulation and can guide future mechanistic studies. | Xiaoyang Chen Qiutao Xu Yaping Yue Yuhang Duan Hao Liu Xiaolin Chen Junbin Huang Lu Zheng | 2023 | Plant Communications2023，4，3： | 0 |
| 11 | Multisphere Tectonics of the Earth System显示文摘The fundamental theoretical framework of the Multisphere Tectonics of the Earth System is as follows:(1)It intends to extend the geotectonic studies from the crustal and lithospheric tectonics to the multisphere tectonics of the Ear th system as a whole.(2)The global dynamics driven by both the Earth system and the cosmic celestial system:solar energy,multispheric interactions of the Earth system and the combined effects of the motions of celestial bodies in the cosmos syste m are the driving forces of various geological processes.(3)The Continent-Ocean transformation theory:the continent and ocean are two opposite yet unified geological units,which can be transformed into each other;neither continent nor ocean wi ll survive forever;there is no one-way development of continental accretion or ocean extinction;the simple theory of one-way continental accretion is regarded as invalid.(4)The continental crust and mantle are characterized by multiple layers,with different layers liable to slide along the interfaces between them,but corroboration is needed that continents move as a who le or even drift freely.(5)The cyclic evolution theory:the development of Earth’s tectonics is not a uniform change,but a spiral forward evolution,characterized by a combination of non-uniform,non-linear,gradual and catastrophic changes;different evolutionary stages(tectonic cycles)of Earth have distinctive global tectonic patterns and characteristics,one tectonic mo del should not be applied to different tectonic cycles or evolutionary stages.(6)The structure and evolution of Earth are asymmetric and heterogeneous,thus one tectonic model cannot be applied to different areas of the world.(7)The polycyclic evolution of the continental crust:the continental crust is formed by polycyclic tectonics and magmatism,rather than simply lateral or vertical accretion.(8)The role of deep faults:the deep fault zones cutting through different layers of the crus t a nd mantle usually play important roles in tectonic evolution.For example,the present-day mid-ocean ridge fault zones,transform fault zones and Benioff zones outline the global tectonic framework.Different tectonic cycles and stages of Earth’s evolutio n must have their own distinctive deep fault systems which control the global tectonic framework and evolutionary processes during different tectonic cycles and stages.Starting from the two mantle superplumes Jason(Pacific)and Tuzo(Africa),the study of the evolutionary process of the composition and structure of the crust and mantle during the great transformation an d reorganization of the Meso-Cenozoic tectonic framework in China and the other regions of Asia is a good demonstration of theory of Multisphere Tectonics of the Earth System. | REN Jishun NIU Baogui XU Qinqin ZHAO Lei LIU Jianhui LI Shan ZHU Junbin LIU Renyan | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 0 |
| 12 | An l^(1) Regularized Method for Numerical Differentiation Using Empirical Eigenfunctions显示文摘We propose an ?~1 regularized method for numerical differentiation using empirical eigenfunctions. Compared with traditional methods for numerical differentiation, the output of our method can be considered directly as the derivative of the underlying function. Moreover,our method could produce sparse representations with respect to empirical eigenfunctions.Numerical results show that our method is quite effective. | Junbin LI Renhong WANG Min XU | 2017 | Journal of Mathematical Research with Applications2017，37，4： | 0 |
| 13 | Deciphering controversial results of cell proliferation on TiO2 nanotubes using machine learning显示文摘With the rapid development of biomedical sciences,contradictory results on the relationships between biological responses and material properties emerge continuously,adding to the challenge of interpreting the incomprehensible interfacial process.In the present paper,we use cell proliferation on titanium dioxide nanotubes(TNTs)as a case study and apply machine learning methodologies to decipher contradictory results in the literature.The gradient boosting decision tree model demonstrates that cell density has a higher impact on cell proliferation than other obtainable experimental features in most publications.Together with the variation of other essential features,the controversy of cell proliferation trends on various TNTs is understandable.By traversing all combinational experimental features and the corresponding forecast using an exhausted grid search strategy,we find that adjusting cell density and sterilization methods can simultaneously induce opposite cell proliferation trends on various TNTs diameter,which is further validated by experiments.This case study reveals that machine learning is a burgeoning tool in deciphering controversial results in biomedical researches,opening up an avenue to explore the structure-property relationships of biomaterials. | Ziao Shen Si Wang Zhenyu Shen Yufei Tang Junbin Xu Changjian Lin Xun Chen Qiaoling Huang | 2021 | Regenerative Biomaterials2021，8，4： | 0 |
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