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| 1 | Spatiotemporal dynamics of impervious surface areas across China during the early 21st century显示文摘China has experienced an unprecedented urbanization and industrialization in the past decades. In this research, we examined the dynamics of construction lands and impervious surface areas (ISA) based on land use/cover change and ISA datasets between 2000 and 2008, which were provided by the national resources and environmental remote sensing information platform. The results indicated that the construction areas and ISA increased by 3468.30 and 2212.24 km 2 /a in this period primarily due to the implementation of national macro-development strategies and fast-growing economy. In 2008, ISA accounted for 0.86% of the total land area in China. Urban land areas increased by 43.46% between 2000 and 2008. The annual growth rate of 1788.22 km 2 /a in this period was 2.18 times that in the 1990s. In particular, urban ISA increased by 53.30% between 2000 and 2008 with an annual growth rate of 1348.85 km 2 /a. During the 8 years, the ISA in China increased rapidly, especially in the Beijing-Tianjin-Tangshan Metropolitan Region, Pearl River Delta, Yangtze River Delta, and the western China region. The increasing ISA may influence potentially water environmental quality in the major basins. In particular, the number of subbasins having ISA of greater than 10% increased considerably, which were primarily distributed in the Haihe River, Yangtze River and Pearl River basins. In 2008, 14.42% of the basin areas were affected by the increased ISA. | KUANG WenHui LIU JiYuan ZHANG ZengXiang LU DengSheng XIANG Bao | 2013 | Chinese Science Bulletin2013，58，14： | 59 |
| 2 | Molecular Cytogenetic Characterization of Wheat-Thinopyrum elongatum Addition,Substitution and Translocation Lines with a Novel Source of Resistance to Wheat Fusarium Head Blight显示文摘Thinopyrum elongatum(2n = 2x = 14,EE),a wild relative of wheat,has been suggested as a potentially novel source of resistance to several major wheat diseases including Fusarium Head Blight(FHB).In this study,a series of wheat(cv.Chinese Spring,CS) substitution and ditelosomic lines,including Th.elongatum additions,were assessed for TypeⅡresistance to FHB.Results indicated that the lines containing chromosome 7E of Th.elongatum gave a high level of resistance to FHB,wherein the infection did not spread beyond the inoculated floret.Furthermore,it was determined that the novel resistance gene(s) of 7E was located on the short-arm(7ES) based on sharp difference in FHB resistance between the two 7E ditelosomic lines for each arm.On the other hand,Th.elongatum chromosomes 5E and 6E likely contain gene(s) for susceptibility to FHB because the disease spreads rapidly within the inoculated spikes of these lines. Genomic in situ hybridization(GISH) analysis revealed that the alien chromosomes in the addition and substitution lines were intact,and the lines did not contain discernible genomic aberrations.GISH and multicolor-GISH analyses were further performed on three translocation lines that also showed high levels of resistance to FHB.Lines TA3499 and TA3695 were shown to contain one pair of wheat-Th. elongatum translocated chromosomes involving fragments of 7D plus a segment of the 7E,while line TA3493 was found to contain one pair of wheat-Th.elongatum translocated chromosomes involving the D- and A-genome chromosomes of wheat.Thus,this study has established that the short-arm of chromosome 7E of Th.elongatum harbors gene(s) highly resistant to the spreading of FHB,and chromatin of 7E introgressed into wheat chromosomes largely retained the resistance,implicating the feasibility of using these lines as novel material for breeding FHB-resistant wheat cultivars. | Shulan Fu Zhenling Lv Bao Qi Xiang Guo Jun Li Bao Liu Fangpu Han | 2012 | Journal of Genetics and Genomics2012，39，2： | 35 |
| 3 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 4 | Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes显示文摘背景类型 2 糖尿病是贝它房间 functions.However 的进步损失描绘的长期的疾病,贝它房间功能的评估为试图阐明的临床的 practice.We 昂贵或不方便在胰岛素应答和 fasting 血浆葡萄糖( FPG )的变化之间的协会早为 analysis.The 在有正常的血葡萄糖或多糖症的 1192 个中国个人全部的 diabetes.Methods A 的发展期间被注册 insulinogenic | PANG Can BAO Yu-qian WANG Chen LU Jun-xi JIA Wei-ping XIANG Kun-san | 2008 | Chinese Medical Journal2008，，21： | 34 |
| 5 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 6 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 7 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 8 | Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure显示文摘长期的心失败(CHF ) ,源于各种各样的心血管的疾病(CVD ) 的后果的临床的症候群,逐渐地正在成为病态和死亡的一个全球原因。我们更早证明了洗旅行的一个 4 天的森林能在病人上向附属治疗学的影响提供 CHF。为了进一步调查影响和森林洗澡的最佳的频率的持续时间,与 CHF 在病人摔倒,我们招募了经历了在 4 个星期以后再洗旅行的第一个森林并且也就是,随机把他们分成了二个组的那些对象城市的控制组(城市)和洗组(森林)的森林。在洗旅行的第二个 4 天的森林以后,我们象氧化应力一样在大脑 natriuretic 肽层次,心失败的 biomarker,和稀释煽动性的回答观察了稳定的衰落。因此,这探索研究表明了添加剂好处两次,森林洗澡与 CHF 在老病人摔倒,它能进一步为在 CVD 分析如此的干预的效果铺平道路。 | MAO Gen Xiang CAO Yong Bao YANG Yan CHEN Zhuo Mei DONG Jian Hua CHEN Sha Sha WU Qing LYU Xiao Ling JIA Bing Bing YAN Jing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，2： | 18 |
| 9 | Comparison of Body Mass Index with Body Fat Percentage in the Evaluation of Obesity in Chinese显示文摘Objective To evaluate the present Chinese body mass index(BMI) criteria with body fat percentage(BF%) in determining obesity in Chinese population.Methods A total of 4 907 subjects(age:20-90 yrs) were enrolled in the baseline survey of a longitudinal epidemiological study,and 2 638 of them were reevaluated in 5.5 years later.The Chinese BMI and WHO BF%were used to define obesity,respectively.Results The diagnostic agreement between the Chinese BMI and WHO BF%definitions for obesity was poor for both men(kappa:0.210,95%CI:0.179-0.241) and women(kappa:0.327, 95%CI:0.296-0.358).However,BMI had a good correlation with BF%both in men(r:0.785,P<0,01) and women(r:0.864, P<0.01).The age and sex-adjusted relative risks(RR) for incidence of type 2 diabetes(T2DM) were significantly higher in subjects with intermediate BF%(BF%:20.1%-25%for men,30.1%-35%for women)(RR:2.35,95%CI:1.23-4.48) and high BF%(BF%>25%for men and>35%for women)(RR:2.89,95%CI:1.43-5.81),or in subjects with high BMI(BMI≥28 kg/m^2)(RR:2.46,95%CI:1.31-4.63) when compared to those with low BF%(BF%≤20%for men and≤30%for women) or low BMI(BMI<24 kg/m^2) respectively.No difference in risk could be found in those with intermediate BMI(BMI:24-27.9 kg/m^2)(RR:1.44,95%CI:0.86-2.40),as compared to those with low BMI(BMI<24 kg/m^2),whose BF%ranged widely from 7.8 to 50.3%.Conclusion BMI was correlated with BF%.Both BMI and BF%were associated with high risk for T2DM. However,BMI had its limitations in the interpretation of subjects with BMI between 24 and 27.9 kg/m^2. | CHEN WANG Xu-HONG HOU MING-LIANG ZHANG Yu-QIAN BAO Yu-HUA ZOU WEN-HONG ZHONG KUN-SAN XIANG WEI-PING JIA | 2010 | Biomedical and Environmental Sciences2010，23，3： | 17 |
| 10 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 11 | The protective effect of the RAS inhibitor on diabetic patients with nephropathy in the context of VEGF suppression显示文摘 | Hai-bing CHEN Jun-xi LU Qing LI Yu-qian BAO Jun-ling TANG Hui-juan LU Kun-san XIANG Wei-ping JIA | 2009 | Acta Pharmacologica Sinica2009，30，2： | 15 |
| 12 | Health Effect of Forest Bathing Trip on Elderly Patients with Chronic Obstructive Pulmonary Disease显示文摘Forest bathing trip is a short,leisurely visit to forest.In this study we determined the health effects of forest bathing trip on elderly patients with chronic obstructive pulmonary disease(COPD).The patients were randomly divided into two groups.One group was sent to forest,and the other was sent to an urban area as control. | JIA Bing Bing YANG Zhou Xin MAO Gen Xiang LYU Yuan Dong WEN Xiao Lin XU Wei Hong LYU XIAO Ling CAO Yong Bao WANG Guo Fu | 2016 | Biomedical and Environmental Sciences2016，29，3： | 15 |
| 13 | Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients^1显示文摘瞄准:这研究的目的是与类型 2 糖尿病在病人与 repaglinide 的治疗学的效果调查 KCNJ11 E23K 和 ABCC8 exon16 3T/C 的协会。方法:有最新诊断的类型的 100 个中国病人的一个总数 2 糖尿病与 repaglinide 被治疗 24 个星期。精氨酸刺激测试被执行评估贝它房间功能。基因变化与 PCR 限制碎片长度多型性被检测。应答者被定义由一比在 fasting 血浆葡萄糖的 25% 减少大或一比在血红素 A1c (HbA1c ) 价值的 20% 减少大(或) 在 24 星期 repaglinide 治疗以后。结果:基线 HbA1c 和 HbA1c 的减少在有 KCNJ11 E23K 变体的 E/K 和 K/K 遗传型的病人是显著地更高的什么时候与 E/E 同质接合体相比(P=0.0103 并且 0.0221,分别地) 。在 2 h 的减少饭后的血浆葡萄糖(2hPG ) 比 E/E 同质接合体(P=0.0367 ) 在 E/K 异质接合体是显著地更大的。处于到在 E 和 K 等位基因之间的 repaglinide 治疗的反应率有重要差别(68%vs 82% , P=0.0324 ) 。在 fasting 胰岛素和对胰岛素抵抗的动态平衡模型评价的变化在有 ABCC8 exon16 的病人是显著地更大的 3 C/C 对 T/C 和 T/T 遗传型(P=0.0372 并且 0.0274,分别地) 。结论:KCNJ11 E23K 变体与 repaglinide 的治疗学的效果被联系。另外, ABCC8 exon16 3T/C 变体的 C/C 同质接合体比 T/C 和 T/T 遗传型在胰岛素敏感对 repaglinide 更好作出回应。 | Ya-yi HE Rong ZHANG Xin-yu SHAO Cheng HU Cong-rong WANG Jun-xi LU Yu-qian BAO Wei-ping JIA Kun-san XIANG | 2008 | Acta Pharmacologica Sinica2008，29，8： | 14 |
| 14 | A new triterpene glycoside from sea cucumber Holothuria leucospilota显示文摘A new triterpene glycoside, leucospilotaside A, along with a known saponin, isolated from sea cucumber Holothuria leucospilota, and its structure was elucidated as 3β-O-[4-O-sodiumsulfate-β-D-quinovopyranosyl-(1→2)-β-D-xylopyranosyl]-holosta-22-ketone-9-en-17α,25α-diol (1) by extensive spectroscopic analysis and chemical methods. Leucospilotaside A (1) has a ketone carbonyl group (22) in the aglycon side chain. | Hua Han Yang Hua Yi Ling Li Xiao Hua Wang Bao Shu Liu Peng Sun Min Xiang Pan | 2007 | Chinese Chemical Letters2007，18，2： | 13 |
| 15 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 16 | THE EFFECTS OF RADIATION STRESS ON WAVE HEIGHTS AND SEA LEVEL IN THE INTERACTION OF COUPLED WAVE-TIDE-SURGE IN THE COASTAL AREA显示文摘Based on coastal high resolution (2′×2′) coupled wave tide surge interaction numerical model, the effects of radiation stress on wave heights and sea level in the coastal area of Huanghe Delta were studied. By comparisons of simulated and measured wave heights and sea level for two mediately strong weather cases, it is demonstrated that the results simulated by coupled wave tide surge model are closer to the measured and particularly in excellent agreement in the extreme values of the wave heights and set up. This study shows that the radiation stress can increase the wave heights maximally to 67cm and sea level to 40cm. It is also found that there are areas of over 50cm wave height increase and an area of over 20cm sea level increase in the Huanghe Delta coastal area, and this find may be very important in engineering. For this reason, it is suggested that in the practical engineering application, the coupled wave tide surge interaction numerical model should be prefered. | Lin Xiang, Yin Bao shu, Hou Yi jun, Su Jing zhi, Cheng Ming hua Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China | 2003 | Journal of Hydrodynamics2003，15，1： | 12 |
| 17 | Influence of up-regulation of Notch ligand DLL4 on biological behaviors of human gastric cancer cells显示文摘AIM: To investigate the potential roles of Delta-like ligand 4 (DLL4) on the biological behavior of gastric cancer cells and its molecular mechanisms. METHODS: A recombinant eukaryotic expression vector containing human DLL4 gene was constructed and transfected into the human gastric cancer cell line SGC7901. Clones with up-regulated DLL4 were selected and amplified. The effect of DLL4 up-regulation on gastric cancer cell growth was assessed using cell growth assay. The migration and invasion were assessed using a transwell migration assay and matrigel invasion assay. Matrix metalloproteinases were detected using the zymogram technique. Cells were implanted subcutaneously into male BALB/c nu/nu mice. Tumor volumes were then calculated and compared. DLL4 staining in the implanted tumor was performed using immunohistochemistry technique. RESULTS: Growth curves over a six-day time course showed significantly promoted cell proliferation of SGC7901 cells with up-regulated DLL4. DLL4 up-regulation in SGC7901 cells promoted the migration (205.4 ± 15.2 vs 22.3 ± 12.1, P < 0.05) and invasion (68.8 ± 5.3 vs 18.2 ± 6.0, P < 0.05) in vitro and tumorigenicity in vivo (2640.5 ± 923.6 mm 3 vs 1115.1 ± 223.8 mm 3 , P < 0.05). Furthermore, significantly increased mRNA level and increased secretion of matrix metalloproteinase-2 (MMP-2) proenzyme were observed in SGC7901 cells with up-regulated DLL4. However, increased MMP-9 mRNA level but decreased extracellular MMP-9 proenzyme level was observed. CONCLUSION: Our observations indicated a mechanism by which activation of DLL4-mediated Notch signaling promotes the expression and secretion of MMP-2 proenzyme and influences the progress of gastric cancer. | Guo-Gang Li Lan Li Chao Li Long-Yun Ye Xiao-Wen Li Da-Ren Liu Qi Bao Yi-Xiong Zheng Da-Peng Xiang Li Chen Jian Chen | 2013 | World Journal of Gastroenterology2013，19，28： | 12 |
| 18 | Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014显示文摘Background:H7N9 continues to cause human infections and remains a pandemic concern.Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation,including infectious disease prevention and control investment.However,there are limited data on such impacts.Methods:Hospitalized laboratory-confirmed H7N9 patients or their families in Jiangsu Province of China were interviewed.Patients’direct medical costs of hospitalization were derived from their hospital bills.A generalized linear model was employed to estimate the mean direct medical costs of patients with different characteristics.Results:The mean direct cost of hospitalization for H7N9 was estimated to be¥71060(95%CI,48180–104820),i.e.,US$10996(95%CI,7455–16220),and was¥12060(US$1861),¥136120(US$21001)and¥218610(US$33728)for those who had mild or severe symptoms or who died,respectively.The principal components of the total fees differed among patients with different disease severity,although medication fees were always the largest contributors.Disease severity,proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient’s direct medical cost of hospitalization.Conclusions:The direct medical costs of hospitalized patients with H7N9 are significant,and far surpass the annual per capita income of Jiangsu Province,China.The influencing factors identified should be taken into account when developing related health insurance policies and making health resource allocation.Trial registration:Not applicable.This is a survey study with no health care intervention implemented on human participants. | Xiang Huo Li-Ling Chen Lei Hong Lun-Hui Xiang Fen-Yang Tang Shan-Hui Chen Qiang Gao Cong Chen Qi-gang Dai Chuan-Wu Sun Ke Xu Wen-Jun Dai Xian Qi Chang-Cheng Li Hui-Yan Yu Yin Zhou Hao-Di Huang Xing-Yang Pan Chang-sha Xu Ming-Hao Zhou Chang-Jun Bao | 2016 | Infectious Diseases of Poverty2016，5，1： | 10 |
| 19 | Effects of ABCA1 variants on rosiglitazone monotherapy in newly diagnosed type 2 diabetes patients显示文摘现在的学习的目的是调查在 R219K 之间的关系, M883I ,并且ATP有约束力的盒子 transporter 亚科 A 的 R1587K 变体第一号( ABCA1 )基因和反应到在有类型 2 diabetes.Methods 的最新诊断的病人的 rosiglitazone 治疗:没有反多糖症药的历史的 105 个糖尿病的病人的一个总数为 48 与 rosiglitazone ( 4 或 8 mg 日报)被对待星期。三非同义的变体 R219K, M883I,和 R1587K,是在所有 patients.Results 的 genotyped : 93 个病人完成了全部学习。ABCA1 的 R219K 变体为治疗失败与 2.04 的每等位基因机会比率在 rosiglitazone 反应上有效果(P < 0.05 ) 。RR 同质接合体在胰岛素敏感度的指示物有更好的改进,在抗胰岛素性的动态平衡模型评价索引由显著地更大的减少决定了 -2.39 ± 0.46 对 -0.69 ± 0.51,P<0.05) 。没有遗传型显型协会为 M883I 和 R1587K.Conclusion 被检测: ABCA1 的 R219K 变体与 rosiglitazone.The RR 同质接合体的治疗学的效果被联系比次要的 K 等位基因搬运人以胰岛素敏感度改进有更好的回答到 rosiglitazone 治疗。ABCA1 基因的既不 M883I 也不 R1587K 变体与 rosiglitazone 反应被联系。 | Jie WANG Yu-qian BAO Cheng HU Rong ZHANG Cong-rong WANG Jun-xi LU Wei-ping JIA Kun-san XIANG | 2008 | Acta Pharmacologica Sinica2008，29，2： | 10 |
| 20 | Bipolar charged aerosol agglomeration and collection by a two-zone agglomerator显示文摘In older to collect fine particles more efficiently, a new type electrostatic agglomerator with two zones was developed. The distinguishing feature of this electrostatic agglomerator is that the particles are bipolarly charged and coagulated in the same alternating electric field simultaneously. The silica flour with 2 μm mass median diameter and the smoke from burning wood powder were used as test aerosol. The comparison experimental results have shown that when the mean electric field is 4 kV/cm the collection efficiency of the new electrostatic agglomerator was 98.2% for silica flour and 67.4% for wood powder smoke. Under the same experimental condition, the collection efficiency of the electrostatic agglomerator with three zones was 97.4% for collecting silica flour and the collection efficiency of the electrostatic precipitator was 56.3% for wood powder smoke. | XIANG Xiao dong 1, CHEN Bao zhi 1, COLBECK I 2 (1. School of Resource and Civil Engineering, Northeastern University, Shenyang 110006, China. 2. Institute for Environmental Research, Department of Biological and Chemical Sciences, University of Es | 2001 | Journal of Environmental Sciences2001，13，3： | 9 |
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