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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Evaluation of cognitive functions,depression,life satisfaction among the elderly receiving visiting nursing services显示文摘 | Won JS Kim KH | 2008 | Taehan Kanho Hakhoe Chi2008，38，1： | 1 |
| 3 | Water saving by shallow intermittent irrigation and growth of rice 显示文摘 | Won JG Choi JS Lee SP | 2005 | Plant Production Science2005，，8： | 1 |
| 4 | Lateral tibial bone mineral density around the level of the proximal tibiofibular joint显示文摘 | Lee YS Won JS Oh WS | 2013 | Knee Surg Sports Traumatol Arthrosc2013，，： | 1 |
| 5 | Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death显示文摘 | Lee JK Won JS Singh AK | 2008 | Neurosci Lett2008，440，3： | 1 |
| 6 | Study on macrophage activation and structural characteristics of purified polysaccharidc from the liquid culture broth of Cordyceps militaris显示文摘 | LEE JS KWON JS WON DP | 2010 | Carbohydr Polym2010，82，3： | 1 |
| 7 | Safety and efficacy of switching anticoagulation to aspirin three months after successful radiofrequency catheter ablation of atrial fibrillation显示文摘 | Uhm JS Won H Joung B | 2014 | Yonsei Med J2014，55，5： | 1 |
| 8 | Involvement of AMP-activatedprotein-kinase(AMPK)in neuronal amyloidogenesis显示文摘 | Won JS Im YB Kim J | 2010 | Biochem Biophys Res Commun2010，399，4： | 1 |
| 9 | Diminished expression of dihydropteridine reductase is a potent biomarker for hy-pertensive vessels显示文摘 | Lee CK Han JS Won KJ | | 0，，21： | 1 |
| 10 | Protective role of S- nitrosoglutathione (GSNO) against cognitive impairment in rat model of chronic cerebral hypoperfusion 显示文摘 | Won JS Kim J Annamalai B | 2013 | J Alzheimers Dis2013，34，3： | 1 |
| 11 | Luteolin induces apoptotic cell death through AIF nuclear translocation mediated by activation of ERK and p38 in human breast cancer cell lines 显示文摘 | Kim MJ Woo JS K won CH | 2012 | Cell BioI Int2012，36，4： | 1 |
| 12 | Statin inhibits kainie acid-induced seizure and associated inflammation and hip- pocampal cell death 显示文摘 | Lee JK Won JS Singh AK | 2008 | Neurosci Lett2008，440，3： | 1 |
| 13 | Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels显示文摘 | Lee CK Han JS Won KJ | 2009 | Proteomics2009，9，21： | 1 |
| 14 | The relations among premenstrual syndrome, menstrual attitude, neuroticism, and stress 显示文摘 | Kim JS Won HT | 1998 | The Korean Journal of Clinical Psychology1998，35，4： | 1 |
| 15 | Percutaneous peritoneovenous shunt creation for the treatment of benign and malignant refractory ascites显示文摘 | Park JS Won JY Park SI | 2001 | J Vasc Interv Radiol2001，12，12： | 1 |
| 16 | Intelligent energy management agent for a parallel hybrid vehicles显示文摘 | Langari R Won JS | 2005 | IEEE Trans Veh Tech2005，5，： | 1 |
| 17 | Kim Kit Evaluation of cognitive functions,depression,lifesatisfaction among the elderly reeeiving visiting nursing services显示文摘 | Won JS | 2008 | Taehan Kanho Hakhoe Chi2008，38，1： | 1 |
| 18 | Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels显示文摘 | Lee CK Han JS Won KJ | 2009 | Proteomics2009，9，21： | 1 |
| 19 | A distinctive pattern ofbeauveria bassiana-biotransformed ginsenoside products triggers mitochondria/ FasL-mediated apoptosis in colon cancer cells显示文摘 | Gum SI Rahman MK Won JS | 2016 | Phytother Res2016，30，1： | 1 |
| 20 | Inhibition of coagulation activation and inflammation by a novel Factor Xa inhibitor synthesized fi'om the earthworm Eisenia andrci 显示文摘 | Joo SS Won TJ Kim JS | 2009 | Biol Pharm Bull2009，32，2： | 1 |
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