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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | The vegetation of a New Zealand dune slack 显示文摘 | Sykes MT Wilson JB | 1987 | Vegetatio1987，71，： | 1 |
| 3 | Parental transmission of type 2 diabetes: the Framingham Offspring Study 显示文摘 | Meigs JB Cupples LA Wilson PW | 2000 | Diabetes2000，49，12： | 1 |
| 4 | Community structure and assembly rules in a dune slack : Variance in richness, guild proportionality, biomass constancy and dominance/diversity relations 显示文摘 | Wilson JB Gitay H | 1995 | Vegetatio1995，116，： | 1 |
| 5 | Three-dimensional image reconstruction in conventional and confocal microscopes显示文摘 | Wilson T Tan JB | 1993 | Bioimaging1993，，1： | 1 |
| 6 | A retrospective review of 1349 cases of sebaceous carcinoma显示文摘 | Dasgupta T Wilson LD Yu JB | 2009 | Cancer2009，115，： | 1 |
| 7 | Fasting and postchallenge glycemia and cardiovasculr disease risk:The Framingham Offspring Study显示文摘 | Meigs JB Nathan DM D'Agostino RB Wilson PWF | 2002 | Diabetes Care2002，25，7： | 1 |
| 8 | Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham offspring Studies显示文摘 | Wilson PWF Nathan DM | 2003 | Diabetes2003，8，： | 1 |
| 9 | Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 151,211 adults in 31 prospective studies显示文摘 | Kostis JB Wilson AC Folsom AR | 2007 | Am J Epidemiol2007，166，8： | 1 |
| 10 | Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study 显示文摘 | Wilson PW Meigs JB Sullivan L | 2007 | Arch Intern Med2007，167，10： | 1 |
| 11 | Revision tibiotalar arthrodesis显示文摘 | Easley ME Montijo HE Wilson JB | 2008 | Journal of Bone and Joint Surgery-American Volume2008，，06： | 1 |
| 12 | Shoot competition and root competition显示文摘 | Wilson JB | 1988 | J Appl Ecol1988，25，1： | 1 |
| 13 | The Framingham Offspring Study显示文摘 | Meigs JB D Agostino RBSr Wilson PW et aL Risk variable clustering in the insulin resistance syndrome | 1997 | Diabetes1997，46，： | 1 |
| 14 | primary tracheal carcinoma显示文摘 | AI Urdaneta JB Yu and LD Wilson | 2011 | Am J Clin Oncol2011，34，1： | 1 |
| 15 | Prevalence and character-istics of the metabolic syndrome in the san antonio heart and fram-ingham offspring studies显示文摘 | Meigs JB Wilson PW Nathan DM | 2003 | Diabetes2003，52，： | 1 |
| 16 | Population based cancer registry analysis of primary tracheal carcinoma 显示文摘 | Urdaneta AI Yu JB Wilson LD | 2011 | Am J Clin Oncol2011，34，1： | 1 |
| 17 | Evaluation of microvascular decompression and partial sensory rhizotomy in 252 cases of trigeminal neuralgia显示文摘 | Bederson JB Wilson CB | 1989 | J Neurosurg1989，71，： | 1 |
| 18 | The distribution of bacterial lipopolysaccharide (endotoxin) in relation to periodontally involved root surfaces 显示文摘 | Moore J Wilson M Kieser JB | 1986 | J Clin Periodontol1986，13，8： | 1 |
| 19 | Hyperinsulinemia, hyperglycemia and impaired hemostasis: The Framingham Offspring Study显示文摘 | Meigs JB Mittleman MA Nathan DM Tofler GH Singer DE Murphy-Sheehy PM Lipinska I D'Agostino RB Wilson PW | 2000 | JAMA2000，283，： | 1 |
| 20 | Antiviral and antitumor compounds from tunicates显示文摘 | Rinehart KL Jr Gloer JB Wilson GR | 1983 | Fed Proc1983，42，1： | 1 |
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