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| 1 | The European New Car Assessment Programme: A historical review显示文摘 | Michiel van Ratingen Aled Williams Anders Lie Andre Seeck Pierre Castaing Reinhard Kolke Guido Adriaenssens Andrew Miller | 2016 | Chinese Journal of Traumatology2016，19，2： | 3 |
| 2 | Psychosocial mechanisms for the transmission of somatic symptoms from parents to children显示文摘AIM: To examine familial aggregation of irritable bowel syndrome(IBS) via parental reinforcement/modeling of symptoms, coping, psychological distress, and exposure to stress.METHODS:Mothers of children between the ages of8 and 15 years with and without IBS were identified through the Group Health Cooperative of Puget Sound.Mothers completed questionnaires,including the Child Behavior Checklist(child psychological distress),the Family Inventory of Life Events(family exposure to stress),SCL-90R(mother psychological distress),and the Pain Response Inventory(beliefs about pain).Children were interviewed separately from their parents and completed the Pain Beliefs Questionnaire(beliefs about pain),Pain Response Inventory(coping)and Child Symptom Checklist[gastrointestinal(GI)symptoms].In addition,health care utilization data was obtained from the automated database of Group Health Cooperative.Mothers with IBS(n=207)and their 296 children were compared to 240 control mothers and their 335 children,while controlling for age and education.RESULTS:Hypothesis 1:reinforcement of expression of GI problems is only related to GI symptoms,but not others(cold symptoms)in children.There was no significant correlation between parental reinforcement of symptoms and child expression of GI or other symptoms.Hypothesis 2:modeling of GI symptomsis related to GI but not non-GI symptom reporting in children.Children of parents with IBS reported more non-GI(8.97 vs 6.70,P<0.01)as well as more GI(3.24 vs 2.27,P<0.01)symptoms.Total health care visits made by the mother correlated with visits made by the child(rho=0.35,P<0.001 for cases,rho=0.26,P<0.001 for controls).Hypothesis 3:children learn to share the methods of coping with illness that their mothers exhibit.Methods used by children to cope with stomachaches differed from methods used by their mothers.Only 2/16 scales showed weak but significant correlations(stoicism rho=0.13,P<0.05;acceptance rho=0.13,P<0.05).Hypothesis 4:mothers and children share psychological traits such as anxiety,depression,and somatization.Child psychological distress correlated with mother’s psychological distress(rho=0.41,P<0.001 for cases,rho=0.38,P<0.001 for controls).Hypothesis 5:stress that affects the whole family might explain the similarities between mothers and their children.Family exposure to stress was not a significant predictor of children’s symptom reports.Hypothesis 6:the intergenerational transmission of GI illness behavior may be due to multiple mechanisms.Regression analysis identified multiple independent predictors of the child’s GI complaints,which were similar to the predictors of the child’s non-GI symptoms(mother’s IBS status,child psychological symptoms,child catastrophizing,and child age).CONCLUSION:Multiple factors influence the reporting of children’s gastrointestinal and non-gastrointestinal symptoms.The clustering of illness within families is best understood using a model that incorporates all these factors. | Miranda AL van Tilburg Rona L Levy Lynn S Walker Michael Von Korff Lauren D Feld Michelle Garner Andrew D Feld William E Whitehead | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 3 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 4 | The Influence of Total Nodes Examined, Number of Positive Nodes, and Lymph Node Ratio on Survival After Surgical Resection and Adjuvant Chemoradiation for Pancreatic Cancer: A Secondary Analysis of RTOG 9704显示文摘 | Timothy N. Showalter Kathryn A. Winter Adam C. Berger William F. Regine Ross A. Abrams Howard Safran John P. Hoffman Al B. Benson John S. MacDonald Christopher G. Willett | 2011 | International Journal of Radiation Oncology Biology Physics2011，，5： | 2 |
| 5 | Comparison of magnetic resonance and endoscopic retrograde cholangiopancreatography in malignant pancreaficobiliary obstruction显示文摘 | STEVE K LAWRENCE H WILLIAM R el al | 1999 | Arch Surg1999，134，： | 1 |
| 6 | The carcinogenic action of 4-aminodiphenyl and 3:2'-dimethyl-4-amino-diphenyl 显示文摘 | Walpole AL Williams MH Roberts DC | 1952 | Br J Ind Med1952，9，4： | 1 |
| 7 | Laparoscopic versus open- component separation: A comparative analysis in a porcine model显示文摘 | Rosen MJ Williams C Jin J el al | 2007 | AmJ Surg2007，194，3： | 1 |
| 8 | DNA Polymorphisms Amplified by Arbitary Primers are Useful as Genetic Markers显示文摘 | Williams J G Kubelik A R Livak J el al | 1990 | Nucleic Acid Research1990，，18： | 1 |
| 9 | Comparison of wear of ultra high molecular weight polyethylene acetabular cups against alumina ceramic and chromium nitride coated femoral heads显示文摘 | Galvin AL Williams S Hatto P | 2005 | Wear2005，295，2： | 1 |
| 10 | DNA Polymorphisms Amplified by Arbitary Primers are Useful as Genetic Markers显示文摘 | Kubelik A R Livak J el al | 1990 | Nucleic Acid Research1990，，18： | 1 |
| 11 | Delta Protocadherin 10 is Regulated by Activity in the Mouse Main Olfactory System显示文摘 | Williams EO Sickles HM Dooley AL | | 0，，： | 1 |
| 12 | Contrast-enhanced CT colonography in recurrent colorectal carcinoma:feasibility of simultaneous evaluation for metastatic disease,local recurrence,and metachronous neoplasia in colorectal carcinoma显示文摘 | Fletcher J G Daniel JC William R K et al | 2002 | American Journal of Roentgenology2002，178，： | 1 |
| 13 | Early and later vocalization skills in children with and without cleft pal- ate显示文摘 | Seherer NJ Williams AL Proctor-Williams K | 2008 | Int J Pediatr Otorhinolaryngol2008，72，6： | 1 |
| 14 | Compaision of patient ABO/RH/Ktyping by a column agglutination system and convertionl tube methods显示文摘 | William son KP et al | 1993 | Transfion1993，，： | 1 |
| 15 | Preliminaryanalysis of a randomized trial comparing microemulsioncyclosporine and tacrolimus for recipients of renal transplantsfrom non-heart-beating donors显示文摘 | Williams ST Knight AL White SA | 2000 | Transplant Proc2000，32，3： | 1 |
| 16 | Simulating soil C dynamics with EPIC: Model description and testingagainst long-term data 显示文摘 | Izaurralde R C Williams J R McGill W B e( al | 2006 | Ecological Modelling2006，192，： | 1 |
| 17 | Factors Associated With Mortality and Reoperation in 377 Children With Total Anomalous Pulmonary Venous Connection显示文摘 | Tara Karamlou Rebecca Gurofsky Eisar Al Sukhni John G. Coles William G. Williams Christopher A. Caldarone Glen S. Van Arsdell Brian W. McCrindle | 2007 | Circulation2007，，12： | 1 |
| 18 | A comparative study for improving the mechanical properties of cold bituminous emulsion mixtures with cement and waste materials显示文摘 | HASSAN Al Nageim SHAKIR Falih Al-Busaltan WILLIAM Atherton | 2012 | Construction and Building Materials2012，26，： | 1 |
| 19 | Factors affectingthe completion of intraperitoneal chemotherapy in women with ovariancan c e r显示文摘 | WILLIAM R ROBINSON MD BEYER i e t al | 2010 | Int J Gynecol Cancer2010，20，1： | 1 |
| 20 | Prognostic implica-tions of abnormalities in renal function in patients with acute coro-nary syndromes显示文摘 | Al Suwaidi J Reddan D N Williams K | 2002 | Circulation2002，106，8： | 1 |
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