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| 1 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 2 | Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer显示文摘 | Anne Fl?rcken Joachim Kopp Antje van Lessen Kamran Movassaghi Anna Takvorian Korinna J?hrens Markus M?bs Constanze Sch?nemann Birgit Sawitzki Karl Egerer Bernd D?rken Antonio Pezzutto J?rg Westermann | 2013 | Human Vaccines & Immunotherapeutics2013，，： | 2 |
| 3 | Role of left ventricular stiffness in heart failure with normal ejection fraction 显示文摘 | Westermann D Kasner M Steendijk P | 2008 | Circulation2008，117，16： | 1 |
| 4 | Acute pancreatitis in rat: effect of sodium taurocholate, CCK- 8, and Sec on pancreatic micoacirculation 显示文摘 | Plusczyk T Westermann S Rathgeb D | 1997 | Am J Physiol1997，272，： | 1 |
| 5 | The role of NT-proBNP in the diagnostics of isolated diastolic dysfunction: correlation with echocardiographic and invasive measurements显示文摘 | TSCHOPE C KASNER M WESTERMANN D | 2005 | Eur Heart J2005，26，： | 1 |
| 6 | Molecular ecology of anaerobic reactor systems显示文摘 | Hofman-Bang J Zheng D Westermann P | 2003 | Advances Biochemical Engineering/Biotechnol2003，48，6： | 1 |
| 7 | Pretreatment with statin at- tenuates the cardiotoxicity of Doxorubiein in mice显示文摘 | Riad A Bien S Westermann D | 2009 | Cancer Res2009，69，2： | 1 |
| 8 | Additional lack of iNOS attenuates diastolic dysfunction in aged ET- 1 transgenic mice显示文摘 | Kalk P Westermann D Herzfeld S | 2008 | Can J Physiol Pharmacol2008，86，6： | 1 |
| 9 | The role of NT-proBNPin the diagnostics of isolated diastolic dysfunction: correlation with echocardiographic and invasive measurements显示文摘 | Tschope C Kasner M Westermann D | 2005 | Eur Heart J2005，26，21： | 1 |
| 10 | Utility of Doppler echocardioguaphy and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal eieetion fraction: a comparative Doppler-conductance catheterization study显示文摘 | Kasner M Westermann D Steendij KP | 2007 | Circulation2007，116，6： | 1 |
| 11 | Utility of Doppler echocardiographyand tissue Doppler imaging in the estima-tion of diastolic function in heart failurewith normal ejection fraction: a eompa-rative Doppler-conductance catheteriza-tion study 显示文摘 | Kasner M Westermann D Steendijk P etal | 2007 | Circutation2007，116，6： | 1 |
| 12 | Up-regulation of PPAR gamma in myocardial infarction 显示文摘 | FLIEGNER D WESTERMANN D RIAD A | 2008 | Eur J Heart Fail2008，10，1： | 1 |
| 13 | Nitrogen placement,row spacing,and furrow irrigation water positioning effects on corn yield显示文摘 | LEHRSCH G A SOJKA R E WESTERMANN D T | 2000 | Agronomy Journal2000，92，6： | 1 |
| 14 | Up-regulation of PPARγ in myocardial infarction显示文摘 | Fliegner D Westermann D Riad A | 2008 | Eur J Heart Fail2008，10，1： | 1 |
| 15 | Nitrogen placement, row spacing, and furrow irrigation water positioning effects显示文摘 | Lehrsch G A Sojka R E Westermann D T | 2000 | Agron J2000，92，： | 1 |
| 16 | Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction:a comparative Doppler-conductance catheterization study显示文摘 | Kasner M Westermann D Steendijk P | 2007 | Circulation2007，116，： | 1 |
| 17 | Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angio- tensin type 1 receptor antagonism显示文摘 | Westermann D Rutschow S Jager S | 2007 | Diabetes2007，56，： | 1 |
| 18 | Cardiac inflamma- tion contributes to changes in the extraeellular matrix in patients with heart failure and normal ejection fraction显示文摘 | Westermann D Lindner D Kasner M | 2011 | Circ Heart Fail2011，4，1： | 1 |
| 19 | Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler-conductance catheterization study显示文摘 | Kasner M Westermann D Steendijk P | 2007 | Circulation2007，116，6： | 1 |
| 20 | Additional lack of iNOS attenuates diastolic dysfunction in aged ET-1 transgenicmice显示文摘 | Kalk P Westermann D Herzfeld S etal | 2008 | Can J Physiol Pharmacol2008，86，6： | 1 |
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