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| 1 | Coupled GIMP and CPDI material point method in modelling blast-induced three-dimensional rock fracture显示文摘Three-dimensional rock fracture induced by blasting is a highly complex problem and has received considerable attention in geotechnical engineering.The material point method is firstly applied to treat this challenging task.Some inherent weaknesses can be overcome by coupling the generalized interpolation material point(GIMP)and the convected particle domain interpolation technique(CPDI).For the media in the borehole,unchanged GIMP-type particles are used to guarantee a homogenous blast pressure.CPDITetrahedron type particles are employed to avoid the fake numerical fracture near the borehole for the rock material.A blasting experiment using three-dimensional single-borehole rock was simulated to examine the applicability of the coupled model under realistic loading and boundary conditions.A good agreement was achieved between the simulation and experimental results.Moreover,the mechanism of three-dimensional rock fracture was analyzed.It was concluded that rock particle size and material parameters play an important role in rock damage.The reflected tensile waves cause severe damage in the lower part of the model.Rayleigh waves occur on the top face of the rock model to induce a hoop failure band. | Duanying Wan Meng Wang Zheming Zhu Fei Wang Lei Zhou Ruifeng Liu Weiting Gao Yun Shu Hu Xiao | 2022 | International Journal of Mining Science and Technology2022，32，5： | 2 |
| 2 | Plasmon-mediated photodecomposition of NH3 via intramolecular charge transfer显示文摘As an excellent clean medium for hydrogen storage and fuel cell applications,the photolysis of ammonia via localized surface plasmon could be invoked as a promising route towards significantly reducing the temperature for conventional thermolysis.Here,we explore the underlying microscopic mechanism of ultrafast carrier dynamics in plasmon-mediated NH3 photodecomposition at the single-molecular level using real-time time-dependent density functional theory.The NH_(3)molecule adsorbed on the tip of archetypal magic metal clusters represented by tetrahedral Ag_(2)0 and icosahedral Ag147,splits within a hundred femtoseconds upon laser pulse illumination.We found that the splitting of the first N-H bond is dominated by the intramolecular charge transfer driven by localized surface plasmon.Surprisingly,the phase of laser pulse could modulate the dynamics of charge transfer and thus affect the plasmon-induced bond breaking.These findings offer a new avenue for NH3 decomposition and provide in-depth insights in designing highly efficient plasmon-mediated photocatalysts. | Yimin Zhang Weite Meng Daqiang Chen Lili Zhang Shunfang Li Sheng Meng | 2022 | Nano Research2022，15，5： | 2 |
| 3 | An innovative model for the transient response of a spherical thin-shell transducer and an experimental confirmation显示文摘 | Lin Fa Xin Zhou YuXiao Fa YanDong Zhang JinPeng Mou Meng Liang MaoMao Wang Qi Zhang PengFei Ding WeiTing Feng Hong Yang MeiShan Zhao | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，11： | 1 |
| 4 | Microencapsulated probiotics using emulsification technique coupled with internal or external gelation process显示文摘 | Huiyi Song Weiting Yu Meng Gao Xiudong Liu Xiaojun Ma | 2013 | Carbohydrate Polymers2013，，1： | 1 |
| 5 | Effect of electrokinetic property membrane on bovine serum of charged polyether sulfone albumin fouling behavior显示文摘 | Xiaorong Meng Shanshan Huo Lei Wang Xudong Wang Yongtao Lv Weiting Tang Rui Miao Danxi Huang | 2017 | Frontiers of Environmental Science & Engineering2017，11，2： | 0 |
| 6 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
| 7 | Clinicopathological characteristics and genetic alterations in clear cell carcinoma cells derived from Mullerian duct epithelium of the prostate显示文摘Müllerian duct cysts of the prostate,which are common in young men,are relatively rare clinical complications.Moderately large cysts present with urinary obstruction,urinary tract irritation,subsequent frequent urination,urgency,and dysuria.Larger cysts can compress the seminal vesicles or ejaculatory ducts and cause intractable bloody sperms or obstructive azoospermia.Malignant transformation of Müllerian duct cysts is even rarer.Only 10 cases of Müllerian duct malignancies have been reported in previous studies.[1–9]We reported a case of one patient admitted to our center and discussed the clinicopathologic features,diagnosis. | Shaoan Chen Fengyun Cui Peizhi Zhang Li Chen Wei Song Qingchao Meng Xiude Chen Qinghua Xia Weiting Kang | 2022 | Chinese Medical Journal2022，135，20： | 0 |
| 8 | Parameter calibration of the tensile-shear interactive damage constitutive model for sandstone failure显示文摘The tensile-shear interactive damage(TSID)model is a novel and powerful constitutive model for rock-like materials.This study proposes a methodology to calibrate the TSID model parameters to simulate sandstone.The basic parameters of sandstone are determined through a series of static and dynamic tests,including uniaxial compression,Brazilian disc,triaxial compression under varying confining pressures,hydrostatic compression,and dynamic compression and tensile tests with a split Hopkinson pressure bar.Based on the sandstone test results from this study and previous research,a step-by-step procedure for parameter calibration is outlined,which accounts for the categories of the strength surface,equation of state(EOS),strain rate effect,and damage.The calibrated parameters are verified through numerical tests that correspond to the experimental loading conditions.Consistency between numerical results and experimental data indicates the precision and reliability of the calibrated parameters.The methodology presented in this study is scientifically sound,straightforward,and essential for improving the TSID model.Furthermore,it has the potential to contribute to other rock constitutive models,particularly new user-defined models. | Yun Shu Zheming Zhu Meng Wang Weiting Gao Fei Wang Duanying Wan Yuntao Wang | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，4： | 0 |
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