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| 1 | Active tectonic blocks and strong earthquakes in the continent of China显示文摘The primary pattern of the late Cenozoic to the present tectonic deformation of China is characterized by relative movements and interactions of tectonic blocks. Active tectonic blocks are geological units that have been separated from each other by active tectonic zones. Boundaries between blocks are the highest gradient of differential movement. Most of tectonic activity occurs on boundaries of the blocks. Earthquakes are results of abrupt releases of accumulated strain energy that reaches the threshold of strength of the earth's crust. Boundaries of tectonic blocks are the locations of most discontinuous deformation and highest gradient of stress accumulation, thus are the most likely places for strain energy accumulation and releases, and in turn, devastating earthquakes. Almost all earthquakes of magnitude greater than 8 and 80%-90% of earthquakes of magnitude over 7 occur along boundaries of active tectonic blocks. This fact indicates that differential movements and interactions of active tectonic blocks are the primary mechanism for the occurrences of devastating earthquakes. | ZHANG Peizhen (张培震) DENG Qidong (邓起东) ZHANG Guomin (张国民) MA Jin (马 瑾) GAN Weijun (甘卫军) MIN Wei (闵 伟) MAO Fengying (毛凤英) WANG Qi (王 琪) | 2003 | Science China Earth Sciences2003，46，z2： | 239 |
| 2 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 3 | Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction显示文摘 | Xiao-E Jia Ke Ma Tao Xu Lei Gao Shuang Wu Cong Fu Wenjuan Zhang Zhizhang Wang Kaiyu Liu Mei Dong Changbin Jing Chunguang Ren Zhiwei Dong Yi Chen Yi Jin Qiuhua Huang Xing Chang Min Deng Li Li Lingfei Luo Jun Zhu Yongjun Dang Hung-Chun Chang Leonard I Zon Yi Zhou Saijuan Chen Weijun Pan | 2015 | Cell Research2015，25，8： | 8 |
| 4 | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation显示文摘F 盒子和 WD 重复包含域 7 (FBW7 ) , E3 ubiquitin ligase SCF FBW7 (SKP1, cullin-1 和 FBW7 的建筑群) ,在各种各样的生理、病理学的过程起重要作用。尽管 FBW7 为脉管的开发被要求,它在内皮细胞层的函数尚待被调查。在这研究,我们证明 FBW7 是 endothelial 功能的一个重要管理者,包括 angiogenesis,白血球粘附和 endothelial 障碍正直。用 RNA 干扰,我们发现 FBW7 的弄空显著地在 vitro 并且在 vivo 损害 angiogenesis。我们识别了锌手指抄写因素 Krü象 ppel 一样因素 2 (KLF2 ) 作为在 endothelial 房间的 FBW7 的一个生理的目标。FBW7 击倒表示在 endothelial 房间导致了内长的 KLF2 蛋白质的累积。调停 FBW7 的 KLF2 破坏被显示在二保存 phosphodegrons 经由肝糖 synthase kinase-3 (GSK3 ) 取决于 KLF2 的 phosphorylation。变异这些 phosphodegron 主题废除了 KLF2 的调停 FBW7 的降级和 ubiquitination。调停 siRNA 显示出的 FBW7 击倒 KLF2 是在 endothelial 的规定的 FBW7 的一个必要目标,这工作。而且,调停 FBW7 的 KLF2 降级被显示为在 teratomas 并且在 zebrafish 开发的 angiogenesis 批评。一起拿,我们的学习在 endothelial 房间移植, angiogenesis,发炎和障碍完整的进程为 FBW7 建议一个角色,并且在 vivo 提供新奇卓见进 KLF2 稳定性的规定。 | Rui Wang Yah Wang Ning Liu Chunguang Ren Cong Jiang Kai Zhang Su Yu Yunfei Chen Hui Tang Qi Deng Cong Fu Yingcong Wang Rong Li Mingyao Liu Weijun Pan Ping Wang | 2013 | Cell Research2013，23，6： | 7 |
| 5 | Properties of acrylic resin/nano-SiO2 leather finishing agent prepared viaemulsifierfree emulsion polymerization显示文摘 | Hu Jing Ma Jianzhong Deng Weijun | 2008 | Materials Letters2008，62，17： | 1 |
| 6 | Properties of acrylic resin/nano-SiO2 leather finishing agent prepared via emulsifier-free emulsion pelymerization显示文摘 | Jing Hu Jianzhong Ma Weijun Deng | 2008 | Materials Letters2008，62，： | 1 |
| 7 | Properties ot acryhc resin/nano-SiO2 leather finishing agent prepared via emul- sifier-free emulsion polymerization显示文摘 | Jing Hu Jianzhong Ma Weijun Deng | 2008 | Material Letter2008，62，1718： | 1 |
| 8 | Differential Properties of 4-Coumarate: CoA Ligase Related to Growth Suppression by Chalcone in Maize and Rice显示文摘 | Min-Soo Yun Weijun Chen Fan Deng Yasuhiro Yogo | 2005 | Plant Growth Regulation2005，，2： | 1 |
| 9 | Synt- hesis of alkali - soluble copolymer (butyl acrylate/acrylic acid) and its application in leather finishing agent 显示文摘 | Hu Jing Ma Jianzhong Deng Weijun | 2008 | European Poly- mer Journal2008，44，： | 1 |
| 10 | Properties of acrylic resin/nano - SiO2 leather finishing agent prepared via emul sifter - free emulsion polymerization 显示文摘 | Hu Jing Ma Jianzhong Deng Weijun | 2008 | Materials Letter2008，62，： | 1 |
| 11 | Mesenchymal stromal cells alleviate acute respiratory distress syndrome through the cholinergic anti-inflammatory pathway显示文摘Mesenchymal stromal cells(MSCs)have been considered a promising alternative for treatment of acute respiratory distress syndrome(ARDS).However,there is significant heterogeneity in their therapeutic efficacy,largely owing to the incomplete understanding of the mechanisms underlying the therapeutic activities of MSCs.Here,we hypothesize that the cholinergic antiinflammatory pathway(CAP),which is recognized as a neuroimmunological pathway,may be involved in the therapeutic mechanisms by which MSCs mitigate ARDS.Using lipopolysaccharide(LPS)and bacterial lung inflammation models,we found that inflammatory cell infiltration and Evans blue leakage were reduced and that the expression levels of choline acetyltransferase(ChAT)and vesicular acetylcholine transporter(VAChT)in lung tissue were significantly increased 6 hours after MSC infusion.When the vagus nerve was blocked orα7 nicotinic acetylcholine(ACh)receptor(α7nAChR)-knockout mice were used,the therapeutic effects of MSCs were significantly reduced,suggesting that the CAP may play an important role in the effects of MSCs in ARDS treatment.Our results further showed that MSC-derived prostaglandin E2(PGE2)likely promoted ACh synthesis and release.Additionally,based on the efficacy of nAChR andα7nAChR agonists,we found that lobeline,the nicotinic cholinergic receptor excitation stimulant,may attenuate pulmonary inflammation and alleviate respiratory symptoms of ARDS patients in a clinical study(ChiCTR2100047403).In summary,we reveal a previously unrecognized MSC-mediated mechanism of CAP activation as the means by which MSCs alleviate ARDS-like syndrome,providing insight into the clinical translation of MSCs or CAP-related strategies for the treatment of patients with ARDS. | Xiaoran Zhang Xuxia Wei Yiwen Deng Xiaofeng Yuan Jiahao Shi Weijun Huang Jing Huang Xiaoyong Chen Shuwei Zheng Jieying Chen Keyu Chen Ruiming Xu Hongmiao Wang Weiqiang Li Shiyue Li Huimin Yi Andy Peng Xiang | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 12 | Some identities on the Catalan, Motzkin, and Schrooder numbers 显示文摘 | DENG Eva Y P YAN Weijun | 2008 | Discrete Appl Math2008，156，： | 1 |
| 13 | Properties of acrylic resin/ nano-SiO2 leather finishing agent prepared via emulsifier-free emulsion polymerization 显示文摘 | Hu Jing Ma Jianzhong Deng Weijun | 2008 | Materials Letter2008，62，： | 1 |
| 14 | An Intrusion Detection Algorithm for Wireless Networks Based on ASDL显示文摘Wireless networks are more vulnerable to cyberattacks than cable networks. Compared with the misuse intrusion detection techniques based on pattern matching, the techniques based on model checking(MC) have a series of comparative advantages. However, the temporal logics employed in the existing latter techniques cannot express conveniently the complex attacks with synchronization phenomenon. To address this problem, we formalize a novel temporal logic language called attack signature description language(ASDL). On the basis of it, we put forward an ASDL model checking algorithm. Furthermore, we use ASDL programs, which can be considered as temporal logic formulas,to describe attack signatures, and employ other ASDL programs to create an audit log. As a result, the ASDL model checking algorithm can be presented for automatically verifying whether or not the latter programs satisfy the formulas, that is, whether or not the audit log coincides with the attack signatures. Thus,an intrusion detection algorithm based on ASDL is obtained. The case studies and simulations show that the new method can find coordinated chop-chop attacks. | Weijun Zhu Miaolei Deng Qinglei Zhou | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，1： | 1 |
| 15 | Properties of acrylic resin/nano-SiO2 leather finishing agent prepared via emulsi-fier-free emulsion polymerization 显示文摘 | Jing Hu Jianzhong Ma Weijun Deng | 2008 | Materials Letters2008，，62： | 1 |
| 16 | Synthesis of alkali-solu- ble eopolymer (butylacrylate/acrylic acid) and its application in leather finishing agent显示文摘 | Hu Jing Ma Jianzhong Deng Weijun | 2008 | European Polymer Journal2008，44，8： | 1 |
| 17 | Synthesis of alkali - soluble copolymer (butyl acrylate/acryhc acid) and its apphcation in leather finishing agent 显示文摘 | Hu Jing Ma Jianzhong Deng Weijun | 2005 | European Polymer Journal2005，44，8： | 1 |
| 18 | Properties of acrylic resin/nano- SiO2 leather finishing agent prepared via emulsifier-free emulsion polymerization 显示文摘 | Jing Hu Jianzhong Ma Weijun Deng | 2008 | Materials Letters2008，62，： | 1 |
| 19 | Effects of Different Parameters of Electrostatic Field on Removal of Ethylene in Fruit and Vegetable Storage Environment显示文摘[Objectives]The effects of different parameters of electrostatic field on the removal of ethylene from fruit and vegetable storage environment were studied. [Methods]The high voltage electrostatic field technology was used to simulate the removal of ethylene from fruit and vegetable storages, and its influencing factors were tested and analyzed. [Results] The removal effect of needle-plate electrodes was better than that of needle electrodes. The removal effect of ethylene at high voltage was better than that at low voltage. The length of gas chamber was positively correlated with the time required for ethylene removal. Increasing the voltage could produce more ozone, thus improving the removal effect of ethylene. [Conclusions] This study provides theoretical basis and technical support for the use of high-voltage electrostatic field to remove ethylene in controlled atmosphere storages. | Weijun CHEN Wenting DAI Zhuangsheng WU Xiaojuan WANG Hao DENG Qiang ZHANG | 2023 | Agricultural Biotechnology2023，12，1： | 0 |
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