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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Groundwater Pollution from Underground Coal Gasification显示文摘In situ coal gasification poses a potential environmental risk to groundwater pollution although it depends mainly on local hydrogeological conditions. In our investigation,the possible processes of groundwater pollution origi-nating from underground coal gasification (UCG) were analyzed. Typical pollutants were identified and pollution con-trol measures are proposed. Groundwater pollution is caused by the diffusion and penetration of contaminants generated by underground gasification processes towards surrounding strata and the possible leaching of underground residue by natural groundwater flow after gasification. Typical organic pollutants include phenols,benzene,minor components such as PAHs and heterocyclics. Inorganic pollutants involve cations and anions. The natural groundwater flow after gasification through the seam is attributable to the migration of contaminants,which can be predicted by mathematical modeling. The extent and concentration of the groundwater pollution plume depend primarily on groundwater flow ve-locity,the degree of dispersion and the adsorption and reactions of the various contaminants. The adsorption function of coal and surrounding strata make a big contribution to the decrease of the contaminants over time and with the distance from the burn cavity. Possible pollution control measures regarding UCG include identifying a permanently,unsuitable zone,setting a hydraulic barrier and pumping contaminated water out for surface disposal. Mitigation measures during gasification processes and groundwater remediation after gasification are also proposed. | LIU Shu-qin LI Jing-gang MEI Mei DONG Dong-lin | 2007 | Journal of China University of Mining and Technology2007，17，4： | 36 |
| 3 | Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia显示文摘脉管的光滑的肌肉房间(VSMC ) 的增加的增长和移植是在动脉粥样硬化患者损害的开发的关键事件。Baicalin,导出植物的 flavonoid 混合物,以前被显示了通过多重小径在癌症房间导致 apoptosis 和生长抑制。然而,在 VSMC 增长和心血管的疾病的预防的规定的 baicalin 的潜在的角色仍然保持未经勘探。在这研究,我们证明有 baicalin 的那个预告的处理有一个剂量依赖者 PDGF-BB-stimulated VSMC 增长上的禁止的效果,与增殖的减小伴随了房间原子抗原(PCNA ) 表示。我们也证明导致 baicalin 的生长抑制在在 p27 的激活和增加在刺激 PDGF 的 VSMC 铺平的 cyclin E-CDK2 与减少被联系,它看起来是部分至少由 PDGF 受体尾的封锁调停了(PDGFR 尾) 发信号的细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 。另外, baicalin 也被发现禁止 PDGF-BB 在 VSMC 导致的粘附分子表达式和房间移植。而且,使用一根动物颈动脉动脉的汽球损害模型,我们发现 baicalin 显著地禁止了 neointimal 增生。一起拿,我们的结果在导致生长揭示 baicalin 的新奇功能在汽球损害以后刺激 PDGF 的 VSMC 和压制的 neointimal 增生逮捕,并且建议内在的机制经由 PDGFR 尾 - 的封锁包含在 p27 累积的 cyclin E-CDK2 激活和增加的抑制 ERK1/2 发信号串联。 | Li-Hua Dong Jin-Kun Wen Sui-Bing Miao Zhenhua Jia Hai-Juan Hu Rong-Hua Sun Yiling Wu Mei Han | 2010 | Cell Research2010，20，11： | 30 |
| 4 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 5 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 6 | Determination and dynamics of difenoconazole residues in Chinese cabbage and soil显示文摘一个分析方法用稳固的阶段抽取(SPE ) 被开发为在中国卷心菜和土壤检测 difenoconazole 的残余的清除和煤气的层析。恢复和在中国卷心菜的这个方法的相对标准差是 87.6 鈥 ?9.0% , 1.71 鈥 ?0.50% 分别地;在土壤是 92.4 鈥 ?5.5% , 4.93 鈥 ?0.70% 分别地。在中国卷心菜和土壤的 difenoconazole 残余的进一步的降级被学习评估残余行为和 difenoconazole 的环境安全。在中国卷心菜和土壤的 difenoconazole 的降级率与 6.6 鈥 ?.8 和 54.2 鈥 ? 的一半生活跟随了第一顺序动力学 5.0 天分别地。 | Zhi Hua Wang Tong Yang Dong Mei Qin Yong Gong Ying Ji | 2008 | Chinese Chemical Letters2008，19，8： | 26 |
| 7 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 8 | Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012显示文摘Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31,was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies(RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma(ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma(SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study(Z=17.909,P<0.0001; Z=-6.117,P<0.0001). The RF of ADC increased from 28.72% in 2000-2004,36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas. Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced. | ZOU Xiao Nong LIN Dong Mei WAN Xia CHAO Ann FENG Qin Fu DAI Zhen YANG Gong Huan LV Ning | 2014 | Biomedical and Environmental Sciences2014，27，1： | 19 |
| 9 | Changes in Waist Circumference and Abdominal Obesity among Chinese Adults over a Ten-year Period显示文摘Objective The aim of this study was to describe changes in waist circumference(WC) and prevalence of abdominal obesity over a period of 10 years among Chinese adults in different socio-economic status(SES). Methods Data derived from the China Nutrition and Health Surveillance during 2002 and 2010-2012. We calculated the mean WC and the prevalence of abdominal obesity by gender, place of residence, SES indicators(education, income, and marital status), and body mass index(BMI) categoriesand used pooled t-tests to assess the differences between the two time periods. Results 26.0% of men and 25.3% of women had abdominal obesity in 2010-2012. The age-adjusted mean WC increased by 2.7 cm among men and 2.1 cm among women; the age-adjusted prevalence of abdominal obesity increased by 7.7% among men and 5.3% among women. The rising trends were observed in all subgroups except for a negative growth in high-income women. People living in rural areas with low education and income and with a BMI of 18.5 to 23.9 kg/m^2 had a greater absolute and relative increase in WC. People living in rural areas with low income had a greater relative increase in abdominal obesity. Conclusion The mean WC and prevalence of abdominal obesity among Chinese adults have increased during the past 10 years. Gender differences were noted using various SES indicators. | ZHAI Yi FANG Hong Yun YU Wen Tao YU Dong Mei ZHAO Li Yun LIANG Xiao Feng ZHAO Wen Hua | 2017 | Biomedical and Environmental Sciences2017，30，5： | 19 |
| 10 | YAP promotes osteogenesis and suppresses adipogenic differentiation by regulatingβ-catenin signaling显示文摘YAP(yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP's function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis.YAP is selectively expressed in osteoblast(OB)-lineage cells. Conditionally knocking out Yap in the OB lineage in mice reduces cell proliferation and OB differentiation and increases adipocyte formation, resulting in a trabecular bone loss. Mechanistically, YAP interacts with β-catenin and is necessary for maintenance of nuclear β-catenin level and Wnt/β-catenin signaling. Expression of β-catenin in YAP-deficient BMSCs(bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis. | Jin-Xiu Pan Lei Xiong Kai Zhao Peng Zeng Bo Wang Fu-Lei Tang Dong Sun Hao-han Guo Xiao Yang Shun Cui Wen-Fang Xia Lin Mei Wen-Cheng Xiong | 2018 | Bone Research2018，6，2： | 19 |
| 11 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 12 | Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure显示文摘长期的心失败(CHF ) ,源于各种各样的心血管的疾病(CVD ) 的后果的临床的症候群,逐渐地正在成为病态和死亡的一个全球原因。我们更早证明了洗旅行的一个 4 天的森林能在病人上向附属治疗学的影响提供 CHF。为了进一步调查影响和森林洗澡的最佳的频率的持续时间,与 CHF 在病人摔倒,我们招募了经历了在 4 个星期以后再洗旅行的第一个森林并且也就是,随机把他们分成了二个组的那些对象城市的控制组(城市)和洗组(森林)的森林。在洗旅行的第二个 4 天的森林以后,我们象氧化应力一样在大脑 natriuretic 肽层次,心失败的 biomarker,和稀释煽动性的回答观察了稳定的衰落。因此,这探索研究表明了添加剂好处两次,森林洗澡与 CHF 在老病人摔倒,它能进一步为在 CVD 分析如此的干预的效果铺平道路。 | MAO Gen Xiang CAO Yong Bao YANG Yan CHEN Zhuo Mei DONG Jian Hua CHEN Sha Sha WU Qing LYU Xiao Ling JIA Bing Bing YAN Jing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，2： | 18 |
| 13 | Study of angiogenesis induced by metastatic and non-metastatic liver cancer by corneal micropocket model in nude mice显示文摘METHODSCornealmicropocketswerecreatedinnudemice.Tumortissuesandlivertissueswereimplantedintothecornealmicropockets.Angiogenes... | SUN Hui Chuan, LI Xiao Ming, XUE Qiong, CHEN Jun, GAO Dong Mei and TANG Zhao You | 1999 | World Journal of Gastroenterology1999，5，2： | 17 |
| 14 | Microwave Exposure Impairs Synaptic Plasticity in the Rat Hippocampus and PC12 Cells through Over-activation of the NMDA Receptor Signaling Pathway显示文摘Objective The aim of this study is to investigate whether microwave exposure would affect the N-methyl-D-aspartate receptor(NMDAR) signaling pathway to establish whether this plays a role in synaptic plasticity impairment. Methods 48 male Wistar rats were exposed to 30 m W/cm2 microwave for 10 min every other day for three times. Hippocampal structure was observed through H&E staining and transmission electron microscope. PC12 cells were exposed to 30 m W/cm2 microwave for 5 min and the synapse morphology was visualized with scanning electron microscope and atomic force microscope. The release of amino acid neurotransmitters and calcium influx were detected. The expressions of several key NMDAR signaling molecules were evaluated. Results Microwave exposure caused injury in rat hippocampal structure and PC12 cells, especially the structure and quantity of synapses. The ratio of glutamic acid and gamma-aminobutyric acid neurotransmitters was increased and the intracellular calcium level was elevated in PC12 cells. A significant change in NMDAR subunits(NR1, NR2 A, and NR2B) and related signaling molecules(Ca2+/calmodulin-dependent kinase II gamma and phosphorylated c AMP-response element binding protein) were examined. Conclusion 30 m W/cm2 microwave exposure resulted in alterations of synaptic structure, amino acid neurotransmitter release and calcium influx. NMDAR signaling molecules were closely associated with impaired synaptic plasticity. | XIONG Lu SUN Cheng Feng ZHANG Jing GAO Ya Bing WANG Li Feng ZUO Hong Yan WANG Shui Ming ZHOU Hong Mei XU Xin Ping DONG Ji YAO Bin Wei ZHAO Li PENG Rui Yun | 2015 | Biomedical and Environmental Sciences2015，28，1： | 16 |
| 15 | Cr^(Ⅵ) adsorption on four typical soil colloids: equilibrium and kinetics显示文摘It is observed that the adsorption of chromium are greater on kaolinite minerals, red soil (R) and laterite (L) colloids than that on montmorillonite, indicotic black (IB) and yellow brown (YB) soil colloids. The adsorption process of Cr Ⅵ on these media can be further described by Langmuir or Freundlich equation quite well. The adsorption reaction of Cr Ⅵ is fast, and the adsorption equilibrium can be reached within the first two hours in moderate temperature. The adsorption quantity of Cr Ⅵ to kaolinite mineral increased with the increasing pH in the range of 2.0 to 7.0, then decreased at higher pH. But it showed some consistence among the four soil colloids. The lower the pH, the stronger the adsorption. The possible mechanisms are further discussed here. Meanwhile the influence of temperature on Cr Ⅵ adsorption on different soil colloid and clay minerals are also investigated. | ZHOU Dong\|mei, CHEN Huai\|man * (LMCP, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China) | 2000 | Journal of Environmental Sciences2000，12，3： | 15 |
| 16 | Genotypic Characterization of Methicillin-resistant Staphylococcus aureus Isolated from Pigs and Retail Foods in China显示文摘Objective To investigate the genotypic diversity of Methicillin-resistant Staphylococcus aureus(MRSA) isolated from pigs and retail foods from different geographical areas in China and further to study the routes and rates of transmission of this pathogen from animals to food. Methods Seventy-one MRSA isolates were obtained from pigs and retail foods and then characterized by multi-locus sequencing typing(MLST), spa typing, multiple-locus variable number of tandem repeat analysis(MLVA), pulsed-field gel electrophoresis(PFGE), and antimicrobial susceptibility testing. Results All isolated MRSA exhibited multi-drug resistance(MDR). Greater diversity was found in food-associated MRSA(7 STs, 8 spa types, and 10 MLVA patterns) compared to pig-associated MRSA(3 STs, 1 spa type, and 6 MLVA patterns). PFGE patterns were more diverse for pig-associated MRSA than those of food-associated isolates(40 vs. 11 pulse types). Among the pig-associated isolates, CC9-ST9-t899-MC2236 was the most prevalent clone(96.4%), and CC9-ST9-t437-MC621(20.0%) was the predominant clone among the food-associated isolates. The CC9-ST9 isolates showed significantly higher antimicrobial resistance than other clones. Interestingly, CC398-ST398-t034 clone was identified from both pig-and food-associated isolates. Of note, some community-and hospital-associated MRSA strains(t030, t172, t1244, and t4549) were also identified as food-associated isolates. Conclusion CC9-ST9-t899-MC2236-MDR was the most predominant clone in pigs, but significant genetic diversity was observed in food-associated MRSA. Our results demonstrate the great need for improved surveillance of MRSA in livestock and food and effective prevention strategies to limit MDR-MRSA infections in China. | WANG Wei LIU Feng ZULQARNAIN Baloch ZHANG Cun Shan MA Ke PENG Zi Xin YAN Shao Fei HU Yu Jie GAN Xin DONG Yin Ping BAI Yao LI Feng Qin YAN Xiao Mei MA Ai Guo XU Jin | 2017 | Biomedical and Environmental Sciences2017，30，8： | 13 |
| 17 | The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator显示文摘 | Ling Li Mei Dong Xiao-Guang Wang | 2016 | Chinese Medical Journal2016，，4： | 12 |
| 18 | Fine-Tuning of MiR528 Accumulation Modulates Flowering Time in Rice显示文摘In plants,microRNA (miRNA) functions in the post-transcriptional repression of target mRNAs have been well explored.However,the mechanisms regulating the accumulation of miRNAs remain poorly under.stood.Here,we report that distinct mechanisms regulate accumulation of a monocot-specific miRNA,rice (Oryza sativa) miR528.At the transcriptional level,miR528 accumulated to higher levels in older plants than in young seedlings and exhibited aging-modulated gradual accumulation and diurnal rhythms in leaves;at the post-transcriptional level,aging also modulated miR528 levels by enhancing pri-miR528 alter.native splicing.We found that miR528 promotes rice flowering under long-day conditions by targeting RED AND FAR-RED INSENSITIVE2 (OsRFI2).Moreover,natural variations in the MIR528 promoter region caused differences in miR528 expression among rice varieties,which are correlated with their different binding affinities with the transcription factor OsSPL9 that activates the expression of miR528.Taken together,our findings reveal rice plants have evolved sophisticated modes fine-tuning miR528 levels and provide insight into the mechanisms that regulate MIRNA expression in plants. | Rongxin Yang Pingchuan Li Hailiang Mei Dong Wang Jing Sun Chao Yang Lili Hao Shouyun Cao Chengcai Chu Songnian Hu Xianwei Song Xiaofeng Cao | 2019 | Molecular Plant2019，12，8： | 12 |
| 19 | Left atrial appendage morphology in patients with atrial fibrillation in China: implications for stroke risk assessment from a single center study显示文摘 | Kong Bin Liu Yu Hu He Wang Lei Fan Yang Mei Yang Liu Wanli Liao Jiafen Liu Dan Xing Dong Huang He | 2014 | Chinese Medical Journal2014，，24： | 12 |
| 20 | Comparative analyses of leaf anatomy of dicotyledonous species in Tibetan and Inner Mongolian grasslands显示文摘Knowledge of the leaf anatomy of grassland plants is crucial for understanding how these plants adapt to the environment. Tibetan alpine grasslands and Inner Mongolian temperate grasslands are two major grassland types in northern China. Tibetan alpine grasslands occur in high-altitude regions where the low temperatures limit plant growth. Inner Mongolian temperate grasslands are found in arid regions where moisture is the limiting factor. Few comparative studies concerning the leaf anatomy of grassland plants of the Tibetan Plateau and Inner Mongolian Plateau have been conducted. We examined leaf characteristics at 71 sites and among 65 species, across the alpine grasslands of the Tibetan Plateau and the temperate grasslands of the Inner Mongolian Plateau. We compared the leaf structures of plants with different life forms and taxonomies, and their adaptation to arid or cold environments. We explored relationships among leaf features and the effects of climatic factors (i.e., growing season temperature and precipitation) on leaf characteristics. Our results showed that (i) there were significant differences in leaf anatomy between Tibetan alpine and Inner Mongolian temperate grasslands. Except for mesophyll cell density, the values obtained for thickness of leaf tissue, surface area and volume of mesophyll cells were larger on the Tibetan Plateau than on the Inner Mongolian Plateau. (ii) Within the same family or genus, leaf anatomy showed significant differences between two regions, and trends were consistent with those of whole species. (iii) Leaf anatomy of woody and herbaceous plants also showed significant differences between the regions. Except for mesophyll cell density, the values obtained for the thickness of leaf tissue, and the surface area and volume of mesophyll cells were larger in herbaceous than in woody plants. (iv) Leaf anatomical traits changed accordingly. Total leaf thickness, thicknesses of lower and upper epidermal cells, and surface area and volume of mesophyll cells were positively correlated, while mesophyll cell density was negatively associated with those traits. (v) Growing season temperature had stronger effects on leaf anatomy than growing season precipitation. Although the communities in Tibetan and Inner Mongolian grasslands were similar in appearance, leaf anatomy differed; this was probably due to the combined effects of evolutionary adaptation of plants to environment and environmental stress induced by climatic factors. | MA JianJing JI ChengJun HAN Mei ZHANG TingFang YAN XueDong HU Dong ZENG Hui HE JinSheng | 2012 | Science China(Life Sciences)2012，55，1： | 12 |
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