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27篇 您的检索式:作者名="Weigert G"
    题名 作者 年代 出处 被引量
1Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis.Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler 2006World Journal of Gastroenterology2006,12,34:4
2Agent-Based Interbay System Control for a Single-Loop Semiconductor Manufacturing Fab 显示文摘Wang K J Lin J T Weigert G 2007Production Planning & Control2007,18,2:1
3Intravitreal bevaeiznmab (Avastin) therapy versus photodynamic therapy plus intravitreal triamcinolone for neovascular age-related macular degeneration: 6-month results of a prospective, randomised, controlled clinical study 显示文摘Weigert G Michels S Seau S 2008Br J Ophthalmol2008,92,3:1
4Tungsten carbides as alternative electrocatalysts:from surface science studies to fuel cell evalua-tion显示文摘STOTTLEMYER A L WEIGERT E C CHEN G 2011Ind Eng Chem Res2011,50,:1
5Inhibition of GTP eyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-1ike polarization of tumor associated maerophages 显示文摘PICKERT G LIM H Y WEIGERT A 2013Int J Cancer2013,132,3:1
6Agent-based interbay system control for a single-loop semiconductor manufacturing fab(')显示文摘WANG K J LIN J T WEIGERT G 0,,02:1
7Effects of high- dose prednisolone on optic nerve head blood flow in patients with acute optic neuritis 显示文摘Kircher K Weigert G Resch H 2008Graefes Arch Clin Exp Oph- thalmol2008,246,:1
8Evaluation of hard gelatin capsules and hydroxypropyl methylcellulose containing ampicillin显示文摘WEIGERT G G INEU A P GOMES P 2012Quin Nova2012,35,2:1
9Optimization of manufacturing process by distributed simulation显示文摘Weigert G Horn S Werner S 2006International Journal of Production Research2006,44,:1
10Evaluation of anterior chamber inflammatory activity in eyes treated with intravitreal bevacizumab显示文摘Kiss C Michels S Prager F Weigert G Geitzenauer W Schmidt-Erfurth U 2006Retina2006,26,8:1
11Optimisation approaches for batch scheduling in semiconductor manufacturing显示文摘KLEMMT A WEIGERT G WERNER S 2011European Journal of Industrial Engineering2011,5,3:1
12Agent-based inter-bay system control for a single-loop semiconductor manufacturing fab显示文摘Wang K J Lin J T Weigert G 2007Production Planning & Control2007,18,2:1
13Documenting completeness, speciesarea relations, and the specials-abundance distribution of a regional flora 显示文摘Miller R I Weigert R G 1989Ecology1989,70,1:1
14Regulation of choroidal blood flow during combined changes in intraoeular pressure and arterial blood pressure显示文摘Polska E Simader C Weigert G 2007Invest Ophthalmol Vis Sci2007,48,:1
15Intravitreal bevacizumab (Avastin) therapy versus photodynamic therapy plus intravitreal triamcinolone for neovascular age-related macular degeneration: 6-month results of a prospective, randomized, controlled clinical study显示文摘WEIGERT G MICHELS S SACU S 2008Br J Ophthalmol2008,92,:1
16Effect of unspecific inhibition of cyclooxygenase by indomethacin on retinal and choroidal blood flow显示文摘Weigert G Berisha F Resch H 0,,03:1
17Choroidal hemodynamic changes during isometric exercise inpatients with inactive central serous chorioretinopathy 显示文摘Tittl M Maar N Polska E Weigert G Stur M Schmetterer L 2005In-vest Ophthalmol Vis Sci2005,46,12:1
18CX^sub 3^CR1-dependent renal macrophage survival promotes Candida control and host survival显示文摘Lionakis Michail S Swamydas Muthulekha Fischer Brett G Plantinga Theo S Johnson Melissa D Jaeger Martin Green Nathaniel M Masedunskas Andrius Weigert Roberto Mikelis Constantinos Wan Wuzhou Lee Chyi-Chia Richard Lim Jean K Rivollier Aymeric 2013Journal of Clinical Investigation2013,,12:1
19Response of retinal vessels and retrobulbar hemodynamics to intravitreal anti-VEGF treatment in eyes with branch retinal vein occlusion 显示文摘SACU S PEMP B WEIGERT G 2011Invest Ophthalmol Vis Sci2011,52,6:1
20Optimization of manufacturing process by distributed simulation显示文摘Weigert G Horn S Werner S 2006International Journal of Production Research2006,44,:1
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