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| 1 | Value of adipokines in predicting the severity of acute pancreatitis:Comprehensive review显示文摘AIM:To analyze the prognostic value of adipokines in predicting the course,complications and fatal outcome of acute pancreatitis(AP).METHODS:We performed the search of PubMed database and the systemic analysis of the literature for both experimental and human studies on prognostic value of adipokines in AP for period 2002-2012.Only the papers that described the use of adipokines for prediction of severity and/or complications of AP were selected for further analysis.Each article had to contain information about the levels of measured adipokines,diagnosis and verification of AP,to specify presence of pancreatic necrosis,organ dysfunction and/or mortality rates.From the very beginning,study was carried out adhering to the PRISMA checklist and flowchart for systemic reviews.To assess quality of all included human studies,the Quality Assessment of Diagnostic Accuracy Studies tool was used.Because of the high heterogeneity between the studies,it was decided to refrain from the statistical processing or meta-analysis of the available data.RESULTS:Nine human and three experimental studies were included into review.In experimental studies significant differences between leptin concentrations at 24 and 48 h in control,acute edematous and acute necrotizing pancreatitis groups were found(P = 0.027 and P < 0.001).In human studies significant differences between leptin and resitin concentrations in control and acute pancreatitis groups were found.1-3 d serum adiponectin threshold of 4.5 μg/mL correctly classified the severity of 81% of patients with AP.This threshold yielded a sensitivity of 70%,specificity 85%,positive predictive value 64%,negative predictive value88%(area under curve 0.75).Resistin and visfatin concentrations differ significantly between mild and severe acute pancreatitis groups,they correlate with severity of disease,need for interventions and outcome.Both adipokines are good markers for parapancreatic necrosis and the cut-off values of 11.9 ng/mL and 1.8 ng/mL respectively predict the high ranges of radiological scores.However,the review revealed that all nine human studies with adipokines are very different in terms of methodology and objectives,so it is difficult to generalize their results.It seems that concentrations of the leptin and resistin increases significantly in patients with acute pancreatitis compared with controls.Serum levels of adiponectin,visfatin and especially resitin(positive correlation with Acute Physiology and Chronic Health Evaluation Ⅱ,Ranson and C-reactive protein) are significantly different in mild acute pancreatitis and severe acute pancreatitis patients,so,they can serve as a markers for the disease severity prediction.Resistin and visfatin can also be used for pancreatic and parapancreatic necrosis prediction,interventions needs and possible,outcome.CONCLUSION:High levels of adipokines could allow for prediction of a severe disease course and outcome even in small pancreatic lesions on computed tomography scans. | Andrius Karpavicius Zilvinas Dambrauskas Audrius Sileikis Dalius Vitkus Kestutis Strupas | 2012 | World Journal of Gastroenterology2012，18，45： | 20 |
| 2 | Solitary beam propagation in periodic layered Kerr media enables high-efficiency pulse compression and mode self-cleaning显示文摘Generating intense ultrashort pulses with high-quality spatial modes is crucial for ultrafast and strong-field science and can be achieved by nonlinear supercontinuum generation(SCG)and pulse compression.In this work,we propose that the generation of quasi-stationary solitons in periodic layered Kerr media can greatly enhance the nonlinear lightmatter interaction and fundamentally improve the performance of SCG and pulse compression in condensed media.With both experimental and theoretical studies,we successfully identify these solitary modes and reveal their unified condition for stability.Space-time coupling is shown to strongly influence the stability of solitons,leading to variations in the spectral,spatial and temporal profiles of femtosecond pulses.Taking advantage of the unique characteristics of these solitary modes,we first demonstrate single-stage SCG and the compression of femtosecond pulses from 170 to 22 fs with an efficiency>85%.The high spatiotemporal quality of the compressed pulses is further confirmed by highharmonic generation.We also provide evidence of efficient mode self-cleaning,which suggests rich spatiotemporal self-organization of the laser beams in a nonlinear resonator This work offers a route towards highly efficient,simple,stable and highly flexible SCG and pulse compression solutions for state-of-the-art ytterbium laser technology. | Sheng Zhang Zongyuan Fu Bingbing Zhu Guangyu Fan Yudong Chen Shunjia Wang Yaxin Liu Andrius Baltuska Cheng Jin Chuanshan Tian Zhensheng Tao | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 3 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 4 | Multidisciplinary diagnostic dilemma in differentiating Madelung’s disease—the value of superb microvascular imaging technique:A case report显示文摘BACKGROUND Madelung’s disease,also known as multiple symmetrical lipomatosis,is a rare,underrecognized disorder of fat metabolism that results in unusual accumulation of subcutaneous fat deposits around the neck,shoulders,upper arms,trunk,hips,and upper thighs.Our case demonstrates the importance of differential diagnosis and the value of a superb microvascular imaging technique for suspecting and confirming Madelung’s disease.Timely diagnosis and alcohol abstinence could prevent the progression of growing fatty masses and prevent surgery.CASE SUMMARY A 62-year-old male was admitted to the Rheumatology center complaining of symmetric subcutaneous tumors in the area of the parotid and submandibular salivary glands,small soft masses in the occiput and upper third of the forearm,rashes on calves.A high titer of rheumatoid factor and low concentrations of serum complements were detected.The high-end ultrasound and magnetic resonance imaging examinations of all affected areas of the soft tissues showed predominantly adipose tissue(lipomas)without suspicion of liposarcoma.The biopsy from the small salivary gland revealed no pathology.After evaluating the patient’s clinical presentation(symmetrical lipomatosis,cirrhosis,gynecomastia,anemia,hyperuricemia),Madelung’s disease,type I,along with the psoriatic rash and psoriatic arthritis and secondary liver cirrhosis were established.CONCLUSION Madelung’s disease consists of many co-occurring disorders imitating and overlapping with other conditions.Ultrasonography is the first choice for suspecting and confirming symmetrical lipomatosis. | Goda Seskute Austeja Dapkute Dominyka Kausaite Sandra Strainiene Andrius Talijunas Irena Butrimiene | 2021 | World Journal of Clinical Cases2021，9，21： | 2 |
| 5 | Sustainable consumption progress: should we be proud or alarmed?显示文摘 | Oksana Mont Andrius Plepys | 2007 | Journal of Cleaner Production2007，，4： | 2 |
| 6 | Research on public logistics center as tool for co- operation显示文摘 | Jarzemskis Andrius | 2007 | Transport2007，22，1： | 1 |
| 7 | Attenuated Expression of Profilin-1 Confers Protection From Atherosclerosis in the LDL Receptor–Null Mouse显示文摘 | Giulio R. Romeo Karen S. Moulton Andrius Kazlauskas | 2007 | Circulation Research2007，，4： | 1 |
| 8 | Endogenous motion of liver correlates to the severity of portal hypertension显示文摘BACKGROUND Degree of portal hypertension(PH)is the most important prognostic factor for the decompensation of liver cirrhosis and death,therefore adequate care for patients with liver cirrhosis requires timely detection and evaluation of the presence of clinically significant PH(CSPH)and severe PH(SPH).As the most accurate method for the assessment of PH is an invasive direct measurement of hepatic venous pressure gradient(HVPG),the search for non-invasive methods to diagnose these conditions is actively ongoing.AIM To evaluate the feasibility of parameters of endogenously induced displacements and strain of liver to assess degree of PH.METHODS Of 36 patients with liver cirrhosis and measured HVPG were included in the casecontrol study.Endogenous motion of the liver was characterized by derived parameters of region average tissue displacement signal(dantero,dretro,dRMS)and results of endogenous tissue strain imaging using specific radiofrequency signal processing algorithm.Average endogenous strainμand standard deviationσof strain were assessed in the regions of interest(ROI)(1 cm×1 cm and 2 cm×2 cm in size)and different frequency subbands of endogenous motion(0-10 Hz and 10-20 Hz).RESULTS Four parameters showed statistically significant(P<0.05)correlation with HVPG measurement.The strongest correlation was obtained for the standard deviation of strain(estimated at 0-10 Hz and 2 cm×2 cm ROI size).Three parameters showed statistically significant differences between patient groups with CSPH,but only dretro showed significant results in SPH analysis.According to ROC analysis area under the curve(AUC)of theσROI[0…10Hz,2 cm×2 cm]parameter reached 0.71(P=0.036)for the diagnosis of CSPH;with a cut-off value of 1.28μm/cm providing 73%sensitivity and 70%specificity.AUC for the diagnosis of CSPH forμROI[0…10Hz,1 cm×1 cm]was 0.78(P=0.0024);with a cut-off value of 3.92μm/cm providing 73%sensitivity and 80%specificity.Dretro parameter had an AUC of 0.86(P=0.0001)for the diagnosis of CSPH and 0.84(P=0.0001)for the diagnosis of SPH.A cut-off value of-132.34μm yielded 100%sensitivity for both conditions,whereas specificity was 80%and 72%for CSPH and SPH respectively.CONCLUSION The parameters of endogenously induced displacements and strain of the liver correlated with HVPG and might be used for non-invasive diagnosis of PH. | Sigita Gelman Andrius Sakalauskas Romanas Zykus Andrius Pranculis Rytis Jurkonis Irma Kuliavienė Arūnas Lukoševičius Limas Kupčinskas Juozas Kupčinskas | 2020 | World Journal of Gastroenterology2020，26，38： | 1 |
| 9 | Ex vivo adenovirus-mediated gene transfer to corneal graft endothelial cells in mice显示文摘 | Qian Y Leong FL Andrius K | 2004 | Invest Ophthalmol Vis Sci2004，45，： | 1 |
| 10 | Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis 显示文摘 | Andrius B lldar B Liwei F | 2005 | Neuropharmacology2005，49，2： | 1 |
| 11 | Research on dry port concept as intermodal node 显示文摘 | Andrius Jaremskis VASILIAUSKAS A V | 2007 | Transport2007，22，3： | 1 |
| 12 | On the mechanism of contact eliminations: XXX The cracking of butyl-benzenes over silica-alumina catalysts显示文摘 | ANDRIU P MARTIN G NOLLER H | 1971 | Journal of Catalysis1971，21，3： | 1 |
| 13 | Plasma Nogo-A and placental growth factor levels are associated with portal hypertension in patients with liver cirrhosis显示文摘BACKGROUND Clinically significant portal hypertension(CSPH) and severe portal hypertension(SPH) increase the risk for decompensation and life-threatening complications in liver cirrhosis. Pathologic angiogenesis might contribute to the formation of these conditions. Placental growth factor(PlGF) and Nogo-A protein are biomarkers of pathological angiogenesis, but data on their role in liver cirrhosis and portal hypertension is scarce.AIM To determine plasma levels of PlGF and Nogo-A in patients with liver cirrhosis,CSPH, SPH and potential to predict portal hypertension.METHODS A cohort of 122 patients with hepatitis C virus and/or alcohol-induced liver cirrhosis with characterized hepatic venous pressure gradient(HVPG) were included in the study. Demographic data, medical history, Child-Turcotte-Pugh and Model of End Stage liver disease score, clinical chemistry, liver stiffnessvalues were recorded on the day of the procedure prior HVPG measurement. The degree of portal hypertension was determined by the invasive HVPG measurement. Nogo-A and PlGF plasma levels were evaluated using enzyme linked immunosorbent assay. The control group consisted of 30 healthy age-and sex-matched individuals.RESULTS Peripheral PlGF levels were higher and Nogo-A levels were lower in patients with liver cirrhosis(23.20 vs 9.85;P < 0.0001 and 2.19 vs 3.12;P = 0.004 respectively). There was a positive linear correlation between peripheral levels of PlGF and HVPG(r = 0.338, P = 0.001) and negative linear correlation between the peripheral Nogo-A levels and HVPG(r =-0.267, P = 0.007). PlGF levels were higher in CSPH and SPH(P = 0.006;P < 0.0001) whereas Nogo-A levels were lower(P = 0.01;P < 0.033). Area under the curve for the diagnosis of CSPH for PlGF was 0.68(P = 0.003) and for Nogo-A-0.67(P = 0.01);for SPH 0.714(P <0.0001) and 0.65(P = 0.014) respectively. PlGF levels were higher and Nogo-A levels were lower in patients with esophageal varices(P < 0.05). PlGF cut-off value of 25 pg/mL distinguished patients with CSPH at 55.7% sensitivity and76.7% specificity;whereas Nogo-A cut-off value of 1.12 ng/mL was highly specific(93.1%) for the diagnosis of CSPH.CONCLUSION Plasma PlGF levels were higher while Nogo-A levels were lower in patients with liver cirrhosis and portal hypertension. Biomarkers showed moderate predictive value in determining CSPH and SPH. | Sigita Gelman Violeta Salteniene Andrius Pranculis Jurgita Skieceviciene Romanas Zykus Dalius Petrauskas Limas Kupcinskas Ali Canbay Alexander Link Juozas Kupcinskas | 2019 | World Journal of Gastroenterology2019，25，23： | 1 |
| 14 | Sustainable consumption progress: Should we be proud or alarmed?显示文摘 | Oksana Mont Andrius Plepys | 2008 | Journal of Cleaner Production2008，16，4： | 1 |
| 15 | Software Renting-Better Businesss, Better Environment:The Case of Apphcation Service Providing(ASP) 显示文摘 | Andrius Plepys | 2002 | IPU & Atlantic Consulting2002，，4： | 1 |
| 16 | A Novel Strategy to Develop Therapeutic Approaches to Prevent Proliferative Vitreoretinopathy显示文摘 | Steven Pennock Marc-Andre Rheaume Shizuo Mukai Andrius Kazlauskas | 2011 | The American Journal of Pathology2011，，6： | 1 |
| 17 | Efficient high voltage pulser for piezoelectric air coupled transducer显示文摘 | LINAS S ANDRIUS C VYTAUTAS D | 2013 | Ultrasonics2013，53，1： | 1 |
| 18 | Focus on Molecules: Platelet-de-rived Growth Factor C,PDGF-C 显示文摘 | Hetian Lei Andrius Kazlauskas | 2008 | Exp Eye Res2008，86，5： | 1 |
| 19 | Measurement of urban competitiveness in lithuania 显示文摘 | Jurgita Bruneckiene Andrius Guzavicius Renata Cincikaite | 2010 | Inzinerine Ekonomika-Engineering Economics2010，21，5： | 1 |
| 20 | Pharmacological prevention and treatment of vascular dementia:approaches and perspectives显示文摘 | Andrius Baskys Cheng Jin-xiang | | 0，，11： | 1 |
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