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| 1 | Phylotranscriptomics in Cucurbitaceae Reveal Multiple Whole-Genome Duplications and Key Morphological and Molecular Innovations显示文摘The ability of climbing plants to grow upward along others to reach the canopy for photosynthesis is hypothesized as a key innovation in flowering plants.Most members of the Cucurbitaceae,a family containing^1000 species and many important crops,are climbers and have characteristic tendrils and pepo fruits.Here,we present 127 newly sequenced transcdptomes and genomes along with other datasets for a total of 136 cucurbits representing all tribes to establish a robust Cucurbitaceae phylogeny containing eight highly resolved major clades.We analyzed whole-genome duplication,diversification dynamics,and ancestral morphologies,and found that after early genome duplication event(s),a burst of diversification and morphological innovations in flower,fruit,and root characters occurred under the climate optimum in the Early Eocene.Species radiation during the Mid-Eocene Climatic Optimum also coincided with several morphological changes shared by 80%of cucurbits.We found that the cucurbit-specific tendril identity gene TEN originated from a paleo-polyploidization event at the origin of the family.Our results support the hypothesis that cucurbit diversifications were probably driven by increased genetic diversity following polyploidizations and by trait morphological innovations under paleo-climate upheavals.Our study provides a phylogenetic framework and new insights into morphological and genomic changes underlying the adaptive evolution of Cucurbitaceae. | Jing Guo Weibin Xu Yi Hu Jie Huang Yiyong Zhao Lin Zhang Chien-Hsun Huang Hong Ma | 2020 | Molecular Plant2020，13，8： | 7 |
| 2 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 3 | A nomogram for individualized estimation of survival among adult patients with adrenocortical carcinoma after surgery:a retrospective analysis and multicenter validation study显示文摘Background:Clinical outcome of adrenocortical carcinoma(ACC)varies because of its heterogeneous nature and reliable prognostic prediction model for adult ACC patients is limited.The objective of this study was to develop and externally validate a nomogram for overall survival(OS)prediction in adult patients with ACC after surgery.Methods:Based on the data from the Surveillance Epidemiology,and End Results(SEER)database,adults patients diagnosed with ACC between January 1988 and December 2015 were identified and classified into a training set,comprised of 404 patients diagnosed between January 2007 and December 2015,and an internal validation set,com-prised of 318 patients diagnosed between January 1988 and December 2006.The endpoint of this study was OS.The nomogram was developed using a multivariate Cox proportional hazards regression algorithm in the training set and its performance was evaluated in terms of its discriminative ability,calibration,and clinical usefulness.The nomogram was then validated using the internal SEER validation,also externally validated using the Cancer Genome Atlas set(TCGA,82 patients diagnosed between 1998 and 2012)and a Chinese multicenter cohort dataset(82 patients diag-nosed between December 2002 and May 2018),respectively.Results:Age at diagnosis,T stage,N stage,and M stage were identified as independent predictors for OS.A nomo-gram incorporating these four predictors was constructed using the training set and demonstrated good calibration and discrimination(C-index 95%confidence interval[CI],0.715[0.679-0.751]),which was validated in the internal validation set(C-index[95%CI],0.672[0.637-0.707]),the TCGA set(C-index[95%CI],0.810[0.732-0.888])and the Chi-nese multicenter set(C-index[95%CI],0.726[0.633-0.819]),respectively.Encouragingly,the nomogram was able to successfully distinguished patients with a high-risk of mortality in all enrolled patients and in the subgroup analyses.Decision curve analysis indicated that the nomogram was clinically useful and applicable.Conclusions:The study presents a nomogram that incorporates clinicopathological predictors,which can accurately predict the OS of adult ACC patients after surgery.This model and the corresponding risk classification system have the potential to guide therapy decisions after surgery. | Jianqiu Kong Junjiong Zheng Jinhua Cai Shaoxu Wu Xiayao Diao Weibin Xie Xiong Chen Chenyi Liao Hao Yu Xinxiang Fan Chaowen Huang Zhuowei Liu Wei Chen Qiang Lv Haide Qin Jian Huang Tianxin Lin | 2019 | Cancer Communications2019，39，1： | 3 |
| 4 | Association of chromosome 7 aneuploidy measured by fluorescence in situ hybridization assay with muscular invasion in bladder cancer显示文摘Background:The preoperative prediction of muscular invasion status is important for adequately treating bladder cancer(BC)but nevertheless,there are some existing dilemmas in the current preoperative diagnostic accuracy of BC with muscular invasion.Here,we investigated the potential association between the fluorescence in situ hybridization(FISH)assay and muscular invasion among patients with BC.A cytogenetic-clinical nomogram for the individualized preoperative differentiation of muscle-invasive BC(MIBC)from non-muscle-invasive BC(NMIBC)is also proposed.Methods:All eligible BC patients were preoperatively tested using a FISH assay,which included 4 sites(chromosome-specific centromeric probe[CSP]3,7,and 17,and gene locus-specific probe[GLP]-p16 locus).The correlation between the FISH assay and BC muscular invasion was evaluated using the Chi-square tests.In the training set,univariate and multivariate logistic regression analyses were used to develop a cytogenetic-clinical nomogram for preoperative muscular invasion prediction.Then,we assessed the performance of the nomogram in the training set with respect to its discriminatory accuracy and calibration for predicting muscular invasion,and clinica usefulness,which were then validated in the validation set.Moreover,model comparison was set to evaluate the discrimination and clinical usefulness between the nomogram and the individual variables incorporated in the nomogram.Results:Muscular invasion was more prevalent in BC patients with positive CSP3,CSP7 and CSP17 status(OR[95%CI],2.724[1.555 to 4.774],P<0.001;3.406[1.912 to 6.068],P<0.001 and 2.483[1.436 to 4.292],P=0.001,respectively).Radiologydetermined tumor size,radiology-determined clinical tumor stage and CSP7 status were identified as independent risk factors of BC muscular invasion by the multivariate regression analysis in the training set.Then,a cytogenetic-clinical nomogram incorporating these three independent risk factors was constructed and was observed to have satisfactory discrimination in the training(AUC 0.784;95%CI:0.715 to 0.853)and validation(AUC 0.743;95%CI:0.635 to 0.850)set.The decision curve analysis(DCA)indicated the clinical usefulness of our nomogram.In models comparison,using the receiver operator characteristic(ROC)analyses,the nomogram showed higher discriminatory accuracy than any variables incorporated in the nomogram alone and the DCAs also identified the nomogram as possessing the highest net benefits at wide range of threshold probabilities.Conclusion:CSP7 status was identified as an independent factor for predicting muscular invasion in BC patients and was successfully incorporated in a clinical nomogram combining the results of the FISH assay with clinical risk factors. | Xiayao Diao Jinhua Cai Junjiong Zheng Jianqiu Kong Shaoxu Wu Hao Yu Hao Huang Weibin Xie Xiong Chen Chengran Huang Lifang Huang Haide Qin Jian Huang Tianxin Lin | 2020 | Cancer Communications2020，40，4： | 3 |
| 5 | Investigation of plasmonic whispering gallery modes of graphene equilateral triangle nanocavities显示文摘In this paper, a graphene-based equilateral triangle nanocavity is proposed and numerically investigated. The relationship between the mode characteristics and the nanocavity parameters, such as the geometry of nanocavity and the chemical potential of graphene, is systematically explored. A high-order plasmonic WGM(whispering gallery mode) with a high quality factor of 147.93 is obtained in our nanocavity with a wavelength of around 1.415 μm in free space, with a corresponding Purcell factor as high as 7.067×108. The proposed plasmonic WGM nanocavity could be a key component of the high density plasmonic integrated circuits due to its ultra-compactness and performances. | Yixin HUANG Weibin QIU Shangxin LIN Jing ZHAO Houbo CHEN Jia-Xian WANG Qiang KAN Jiao-Qing PAN | 2016 | Science China(Information Sciences)2016，59，4： | 2 |
| 6 | Tetrahydrobenzo[5]helicenediol derivatives as additives for efficient proline-catalyzed asymmetric List-Lerner-Barbas aldol reactions of bulky aldehyde substrates显示文摘Tetrahydrobenzo[5]helicenediol(THB-[5]HDIOL) derivatives as additives for the efficient prolinecatalyzed asymmetric List-Lerner-Barbas(LLB) aldol reactions of bulky aldehyde substrates was described. It was found that with dibromo-substituted helical diols P-4 a/M-4 a as additives, the prolinecatalyzed LLB aldol reaction of 9-anthraldehyde and acetone gave the product in 83% yield and 99% ee.Transition state models revealed an edge-to-face p-p stacking between the anthracenyl group in TS(R)and the phenyl group of the additive, which might result in the high enantioselectivity. | Lei Fang Weibin Lin Chuanfeng Chen | 2018 | Chinese Chemical Letters2018，29，8： | 1 |
| 7 | Characteristics of Oil Sources from the Chepaizi Swell,Junggar Basin,China显示文摘到目前为止 Chepaizi 的油来源上没有普通意见在 Junggar 盆胀大。因此,决定小径系统和烃移植的趋势是困难的,并且这在油气体累积模式的学习导致困难。在这份报纸,在从 Chepaizi 的油的氮混合物分发的学习被执行以便分类在学习区域在不同水库存储的油的来源岩石。然后,从一样的来源的油的移植特征被使用氮混合物参数调查。在从一样的来源的一组油 / 油沙样品的氮混合物的结果显示在 Chepaizi 套住的油胀大经历了明显的垂直迁居。与增加迁居距离, carbazoles 的数量和索引有一个常规变化模式(在一种好线性关系中) 。由使用氮混合物技术, Chepaizi 的分析油 / 油沙样品能被分类进二个组。一个人是在白垩纪的水库床上存储的样品并且第三级,并且这些油来自主要有白垩纪岩石的小数量的侏罗记来源岩石;其它在侏罗记存储的那些,二叠、含碳的床,和他们从二叠的来源被发源。另外,从一座上面的侏罗记水库(井 Ka 6 ) 的油的一件样品,从侏罗记煤来源岩石被产生,从那些有完全不同的氮混合物分布上述二组样品,它从 mudstone 来源被产生。因为从油移植的分别的影响,有不同结构和极性的氮混合物的数量和比率随着增加移居的距离定期变化,并且作为结果,与一样的来源一起的样品在内容和比率跟随一种好线性关系,当不同来源的油样品由于他们的来源岩石的不同有机物类型有显然不同的氮混合物分发时。油来源学习的这些结论是相同的,那些由另外的 geochemical 简历标记获得了。因此,氮混合物具有在油类型分类和油 / 来源关联的大意义。 | LIU Luofu KUANG Jun WANG Ping CHEN Zhijun WANG Weibin ZHAO Yande WU Lin JIN Jun WANG Weili MENG Jianghui ZHOU Jieli LIU Guodong | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 1 |
| 8 | Enantioselective catalysis with homochiral metalorganic frameworks显示文摘 | MA Liqing ABNEY C LIN Weibin | 2009 | Chem Soc Rev2009，38，： | 1 |
| 9 | Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches显示文摘Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS. | Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang | 2020 | Asian Journal of Urology2020，7，3： | 1 |
| 10 | Effects of strontium in modified biomaterials显示文摘 | Weibin Zhang Yuhui Shen Haobo Pan Kaili Lin Xiaoguo Liu Brian W. Darvell William W. Lu Jiang Chang Lianfu Deng Deping Wang Wenhai Huang | 2010 | Acta Biomaterialia2010，，2： | 1 |
| 11 | A multi-band atomic candle with microwave-dressed Rydberg atoms显示文摘Stabilizing important physical quantities to atom-based standards lies at the heart of modern atomic,molecular and optical physics,and is widely applied to the field of precision metrology.Of particular importance is the atom-based microwave field amplitude stabilizer,the so-called atomic candle.Previous atomic candles are realized with atoms in their ground state,and hence suffer from the lack of frequency band tunability and small stabilization bandwidth,severely limiting their development and potential applications.To tackle these limitations,we employ microwave-dressed Rydberg atoms to realize a novel atomic candle that features multi-band frequency tunability and large stabilization bandwidth.We demonstrate amplitude stabilization of microwave field from C-band to Ka-band,which could be extended to quasi-DC and terahertz fields by exploring abundant Rydberg levels.Our atomic candle achieves stabilization bandwidth of 100 Hz,outperforming previous ones by more than two orders of magnitude.Our simulation indicates the stabilization bandwidth can be further increased up to 100 kHz.Our work paves a route to develop novel electric field control and applications with a noise-resilient,miniaturized,sensitive and broadband atomic candle. | Yafen Cai Shuai Shi Yijia Zhou Jianhao Yu Yali Tian Yitong Li Kuan Zhang Chenhao Du Weibin Li Lin Li | 2023 | Frontiers of physics2023，18，1： | 1 |
| 12 | Ultra-compact tunable graphene-based plasmonic multimode interference power splitter in mid infrared frequencies显示文摘In this paper, we propose graphene-based plasmonic multimode interference power splitters with ultra-compact size working in mid infrared range. Further, the arbitrary-ratio 1×2 power splitter with a size of 140 nm×232 nm, where the splitting ratio can be tuned continuously from 1:1 to 100:0, is numerically demonstrated. Meanwhile, the graphene-based arbitrary-ratio 1×2 power splitters with different frequencies and chemical potentials are also investigated. The proposed multimode interference structure with a deep nanoscale footprint might be a fundamental component of the future high density integrated plasmonic circuit or on-chip plasmonic interconnect techniques. | Pingping QIU Weibin QIU Zhili LIN Houbo CHEN Yixin TANG Jiaxian WANG Qiang KAN Jiaoqing PAN | 2017 | Science China(Information Sciences)2017，60，8： | 1 |
| 13 | Human Recombinant PLD2 Can Repress p65 Activity of Guinea Pigs of Chronic Asthma in vivo显示文摘这篇文章是在畿尼猪的长期的气喘在原子抄写因素 p65 的表示上在 vivo 调查人的 recombinant phospholipase D2 (rhPLD2 ) 的效果。在由 rhPLD2 与长期的气喘对待畿尼猪以后,粗略的原子抽取是有为 pulmo 织物的活动的 TransAM 抄写因素试金工具包的 assayed 原子抄写因素 p65。与健康畿尼猪相比,在长期的气喘的畿尼猪的原子抄写因素 p65 的活动比控制组的高得多。当畿尼猪被长期的气喘攻击时,我们的结果证明 rhPLD2 显著地压抑 p65 的活动。细胞与分子的免疫学。2006; 3 (4 ): 307-310。 | Ling Zhu Weibin Zou Chuanxing Yu Junjin Lin Xiaoli He | 2006 | Cellular & Molecular Immunology2006，3，4： | 1 |
| 14 | Fast spin squeezing by distance-selective long-range interactions with Rydberg molecule dressing显示文摘We propose a Rydberg molecule dressing scheme to create strong and long-ranged interactions at selective distances. This is achieved through laser coupling ground-state atoms off-resonantly to an attractive molecular curve of two interacting Rydberg atoms. Although dephasing due to Rydberg state decay occurs in all dressing schemes, an advantage of the molecule dressing is that a large ratio of dressed interaction to dephasing rate can be realized at large atomic separations. In an optical lattice or tweezer setting, we show that the strong interaction permits the fast generation of spin squeezing for several tens of dressed atoms.The proposed setting offers a new route to study complex many-body dynamics and to realize quantum information processing with non-convex long-range interactions. | Huaizhi Wu Xin-Yu Lin Zong-Xing Ding Shi-Biao Zheng Igor Lesanovsky Weibin Li | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 0 |
| 15 | ACTIVATION OF TRICOBALT CLUSTERS AND SYNTHESIS OF TRICOBALT CLUSTERS CONTAINING PHOSPHINE LIGANDS显示文摘A successful method of activation, in which trimethylamine oxide is used to activate the tricobalt carbonyl clusters at room temperature, has been reported in this paper. A series of tricobalt clusters containing monodentate phosphine ligand PPh3 and bidentate phosphine ligand dppm (bis(diphenylphosphino)methane) have also been synthesized by making use of the quasi-coordinatively unsaturated clusters (μ3-CR)Co3(CO)9-n(MeCN)n(R=Me, Ph, H, Cl,n=1, 2). The structures of these clusters reported in this paper have been characterized by IR, NMR and MS. | Liu Jiachu, Wang Weibin, Cong Aizhen, Lu Getan, Lin Xiuqin(Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China) | 1990 | 分子催化1990，4，S1： | 0 |
| 16 | Stabilizing iridium sites via interface and reconstruction regulations for water oxidation in alkaline and acidic media显示文摘Exploring effective iridium(Ir)-based electrocatalysts with stable iridium centers is highly desirable for oxygen evolution reaction(OER).Herein,we regulated the incorporation manner of Ir in Co_(3)O_(4)support to stabilize the Ir sites for effective OER.When anchored on the surface of Co_(3)O_(4)in the form of Ir(OH)_6 species,the created Ir-OH-Co interface leads to a limited stability and poor acidic OER due to Ir leaching.When doped into Co_(3)O_(4)lattice,the analyses of X-ray absorption spectroscopy,in-situ Raman,and OER measurements show that the partially replacement of Co in Co_(3)O_(4)by Ir atoms inclines to cause strong electronic effect and activate lattice oxygen in the presence of Ir-O-Co interface,and simultaneously master the reconstruction effect to mitigate Ir dissolution,realizing the improved OER activity and stability in alkaline and acidic environments.As a result,Ir_(lat)@Co_(3)O_(4)with Ir loading of 3.67 wt%requires 294±4 mV/285±3 mV and 326±2 mV to deliver 10 mA cm^(-2)in alkaline(0.1 M KOH/1.0 M KOH)and acidic(0.5 M H_(2)SO_(4))solution,respectively,with good stability. | Weibin Chen Yanhui Song Lei Li Junjie Guo Zhan Lin | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 17 | Synthesis and biological evaluation of piperidyl benzimidazole carboxamide derivatives as potent PARP-1 inhibitors and antitumor agents显示文摘We have synthesized a series of compounds based on a piperidyl benzimidazole carboxamide structure,and tested their PARP-1 inhibitory activity,as well as cellular inhibitory activity.Some of them show great potency as PARP-1 inhibitors and antitumor activity,which are valuable for further research.In addition,the predicted ADME properties and proposed binding mode with PARP-1 of the compounds were obtained via computational simulation. | Xinwei Zhang Cunlong Zhang Lin Tang Kuan Lu Huan Zhao Weibin Wu Yuyang Jiang | 2020 | Chinese Chemical Letters2020，31，1： | 0 |
| 18 | Nuclear phylogeny and insights into wholegenome duplications and reproductive development of Solanaceae plants显示文摘Solanaceae,the nightshade family,have2700 species,including the important crops potato and tomato,ornamentals,and medicinal plants.Several sequenced Solanaceae genomes show evidence for wholegenome duplication(WGD),providing an excellent opportunity to investigate WGD and its impacts.Here,we generated 93 transcriptomes/genomes and combined them with 87 public datasets,for a total of 180 Solanaceae species representing all four subfamilies and 14 of 15 tribes.Nearly 1700 nuclear genes from these transcriptomic/genomic datasets were used to reconstruct a highly resolved Solanaceae phylogenetic tree with six major clades.The Solanaceae tree supports four previously recognized subfamilies(Goetzeioideae,Cestroideae,Nicotianoideae,and Solanoideae)and the designation of three other subfamilies(Schizanthoideae,Schwenckioideae,and Petunioideae),with the placement of several previously unassigned genera.We placed a Solanaceae-specific whole-genome triplication(WGT1)at81 million years ago(mya),before the divergence of Schizanthoideae from other Solanaceae subfamilies at73 mya.In addition,we detected two gene duplication bursts(GDBs)supporting proposed WGD events and four other GDBs.An investigation of the evolutionary histories of homologs of carpel and fruit developmental genes in 14 gene(sub)families revealed that 21 gene clades have retained gene duplicates.These were likely generated by the Solanaceae WGT1 and may have promoted fleshy fruit development.This study presents a well-resolved Solanaceae phylogeny and a new perspective on retained gene duplicates and carpel/fruit development,providing an improved understanding of Solanaceae evolution. | Jie Huang Weibin Xu Junwen Zhai Yi Hu Jing Guo Caifei Zhang Yiyong Zhao Lin Zhang Christopher Martine Hong Ma Chien-Hsun Huang | 2023 | Plant Communications2023，4，4： | 0 |
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