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| 1 | Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy显示文摘Genomic instability remains an enabling feature of cancer and promotes malignant transformation.Alterations of DNA damage response(DDR)pathways allow genomic instability,generate neoantigens,upregulate the expression of programmed death ligand 1(PD-L1)and interact with signaling such as cyclic GMPe AMP synthase-stimulator of interferon genes(cGASe STING)signaling.Here,we review the basic knowledge of DDR pathways,mechanisms of genomic instability induced by DDR alterations,impacts of DDR alterations on immune system,and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy. | Minlin Jiang Keyi Jia Lei Wang Wei Li Bin Chen Yu Liu Hao Wang Sha Zhao Yayi He Caicun Zhou | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 12 |
| 2 | A Potential Global Standard Stratotype-Section and Point of the Moscovian Stage(Carboniferous)显示文摘Conodonts 和 fusulinids 是为细分和相关 Bashkirian 和 Moscovian 阶层的二个最广泛地使用的关於生命的组。因为在存在边界定义建议,其各个有劣势之中有许多争论,全球 Moscovian 阶段的底的定义是未定的。Declinognathodus donetzianus 容易在它的 paleogeographic 分发被认出,但是有点限制了。Idiognathoides postsulcatus 是稍微更普遍的,但是它不太容易被识别,它的出现可以是从区域的 diachronous 到区域。Diplognathodus ellesmerensis 容易被认出并且甚至更普遍,但是它通常是稀罕的,它的祖先足够地不被知道。南方贵州的 Naqing 节,华南包含多样的 conodont 在不同 taxa,包括的 Idiognathoides, Idiognathodus, Diplognathodus, Neognathodus, Gondolella 和 Mesogondolella 之中的进化的系。在有众多的过渡形式几乎 Naqing 节的每个系,哪个为华南的前景上演在决定基础 Moscovian 起一个关键作用的表演定义好。 | WANG Xiangdong QI Yuping Lance LAMBERT WANG Zhihao WANG Yue HU Keyi LIN Wei CHEN Bo | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 3 |
| 3 | Carboniferous integrative stratigraphy and timescale of China显示文摘The Carboniferous period lasted about 60 Myr, from ~358.9 Ma to ~298.9 Ma. According to the International Commission on Stratigraphy, the Carboniferous System is subdivided into two subsystems, i.e., Mississippian and Pennsylvanian, including 6 series and 7 stages. The Global Stratotype Sections and Points(GSSPs) of three stages have been ratified, the Tournaisian, Visean, and Bashkirian stages. The GSSPs of the remaining four stages(i.e., the Serpukhovian, Moscovian,Kasimovian, and Gzhelian) have not been ratified so far. This paper outlines Carboniferous stratigraphic subdivision and correlation on the basis of detailed biostratigraphy mainly from South China, and summarizes the Carboniferous chronostratigraphic framework of China. High-resolution biostratigraphic study reveals 37 conodont zones, 24 foraminiferal(including fusulinid) zones, 13 ammonoid zones, 10 brachiopod zones, and 10 rugose coral zones in the Carboniferous of China. The biostratigraphic framework based on these biozones warrants the precise correlation of regional stratigraphy of China(including2 subsystems, 4 series, and 8 stages) to that of the other regions globally. Meanwhile, the Carboniferous chemo-, sequence-,cyclo-, and event-stratigraphy of China have been intensively studied and can also be correlated worldwide. Future studies on the Carboniferous in China should focus on(1) the correlation between shallow-and deep-water facies and between marine and continental facies,(2) high-resolution astronomical cyclostratigraphy, and(3) paleoenvironment and paleoclimate analysis based on geochemical proxies such as strontium and oxygen isotopes, as well as stomatal indices of fossil plants. | Xiangdong WANG Keyi HU Wenkun QIE Qingyi SHENG Bo CHEN Wei LIN Le YAO Qiulai WANG Yuping QI Jitao CHEN Zhuoting LIAO Junjun SONG | 2019 | Science China Earth Sciences2019，62，1： | 2 |
| 4 | Influencing factors on the preservation of lytic bacteriophage VP3显示文摘Long-term and stable preservation of bacteriophages is of crucial importance.Although many efforts have been made in the past decades to explore the influence of external factors on bacteriophage preservation,there is still little understanding,and a systematic description is lacking.In this study,we explored the influence of different factors on the preservation of lytic bacteriophage VP3,one of the typing bacteriophages of Vibrio cholerae O1 biotype El Tor,and attempted to optimize its preservation.We examined external factors,including temperature,solution,and cryoprotectant,in stable cooling/freezing conditions or alternate cooling/freezing and thawing.We found that whether in Luria-Bertani(LB)medium or SM buffer,in terms of 20-week stable cooling or freezing,−20℃ was the most damaging while 4℃,−80℃,and−196℃ were protective.Thirteen cycles of alternate cooling/freezing and thawing caused a loss in the survival rates of bacteriophages.The addition of cryoprotectant,glycerol(30%,w/v)or dimethyl sulfoxide(DMSO,10%,w/v)significantly improved the survival rates of bacteriophages preserved at−20℃.However,at 4℃,−80℃,and−196℃,the cryoprotectant effect was only slightly positive or even harmful.In summary,for bacteriophage VP3,the best preservation method is to directly preserve the bacteriophage stocks in LB medium at−80℃ or−196℃ instead of storing them in SM buffer or adding cryoprotectant.Our results provided insights into the external influencing factors on bacteriophage VP3 during preservation at low temperature and can be applied to the optimization of bacteriophage preservation in the future. | Yue Xiao Pin Huang Zhenzhou Huang Keyi Yu Yang Song Ning Guo Hang Dai Mengnan Jiang Yi Xu Duochun Wang Qiang Wei | 2022 | Biosafety and Health2022，4，5： | 2 |
| 5 | Application and analysis of RS-485 bus 显示文摘 | Cheng Kai Sun Keyi Cao Wei | 2003 | Journal of Ocean University of China2003，，5： | 1 |
| 6 | Suppression of ETI by PTI priming to balance plant growth and defense through an MPK3/MPK6-WRKYs-PP2Cs module显示文摘Pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)are required for host defense against pathogens.Although PTI and ETI are intimately connected,the underlying molecular mechanisms remain elusive.In this study,we demonstrate that flg22 priming attenuates Pseudomonas syringae pv.tomato DC3000(Pst)AvrRpt2-induced hypersensitive cell death,resistance,and biomass reduction in Arabidopsis.Mitogen-activated protein kinases(MAPKs)are key signaling regulators of PTI and ETI.The absence of MPK3 and MPK6 significantly reduces pre-PTI-mediated ETI suppression(PES).We found that MPK3/MPK6 interact with and phosphorylate the downstream transcription factor WRKY18,which regulates the expression of AP2C1 and PP2C5,two genes encoding protein phosphatases.Furthermore,we observed that the PTI-suppressed ETI-triggered cell death,MAPK activation,and growth retardation are significantly attenuated in wrky18/40/60 and ap2c1 pp2c5 mutants.Taken together,our results suggest that the MPK3/MPK6-WRKYs-PP2Cs module underlies PES and is essential for the maintenance of plant fitness during ETI. | Dacheng Wang Lirong Wei Ting Liu Jinbiao Ma Keyi Huang Huimin Guo Yufen Huang Lei Zhang Jing Zhao Kenichi Tsuda Yiming Wang | 2023 | Molecular Plant2023，16，5： | 1 |
| 7 | Methylation of naphthalene to prepare 2,6-dimethylnaphthalene over acid-dealuminated HZSM - 12 zeolites显示文摘 | Bai Xuefeng Sun Keyi Wu Wei | 2009 | J Mol Catal A :Chem2009，314，： | 1 |
| 8 | A novel method to prepare amorphous alloy catalyst with silver including and KBH4 reducing显示文摘 | Keyi Tao Wei Li | 2004 | Catalysis Communication2004，，： | 1 |
| 9 | Advances in chemical synthesis and application of metal-metalloid amorphous alloy nanoparticulate catalysts显示文摘This paper reviews the advances in the chemical synthesis and application of metal-metalloid amorphous alloy nanoparticles consisting of transition metal(M)and metalloid elements(B,P).After a brief introduction on the history of amorphous alloy catalysts,the paper focuses on the properties and characterization of amorphous alloy catalysts,and recent developments in the solution-phase synthesis of amorphous alloy nanoparticles.This paper further outlines the applica-tions of amorphous alloys,with special emphasis on the problems and strategies for the application of amorphous alloy nanoparticles in catalytic reactions. | WU Zhijie LI Wei ZHANG Minghui TAO Keyi | 2007 | Frontiers of Chemical Science and Engineering2007，1，1： | 1 |
| 10 | Quantitative analysis of the neoni- cotinoid Insecticides imidacloprid and thiamethoxam in fruit juices by enzyme-linked immune sorbent assays 显示文摘 | Xu Ting Wei Keyi Wang Jia | 2010 | Journal of AOAC Interna- tional2010，93，1： | 1 |
| 11 | Development of an enzyme- linked immunosorbent assay specific to Sudan red I显示文摘 | XU Ting WEI Keyi WANG Jia | 2010 | Analytical Biochemistry2010，405，： | 1 |
| 12 | Determination of marbofloxacin residues in beef and pork with an enzyme-linked immunosorbent assay显示文摘 | SHENG Wei XIA Xunfeng WEI Keyi | 2009 | J Agric Food Chem2009，5703，： | 1 |
| 13 | Linking Esports to health risks and benefits:Current knowledge and future research needs显示文摘1.Introduction Electronic sports(Esports),viewed as competitive and organized video gaming,1 are becoming accepted as a form of sports.2-4 Many digital video games associated with Esports are played through various platforms(e.g.,computers,consoles,mobile,streaming,or virtual reality)5 and involve either simulating competitive sports(motion-based)or combative(actionbased)activities.2 Esports have been around for more than 20 years1 and continue to thrive economically as a highly profitable gaming industry.2,6 Thanks to the advances in digital media and online game-streaming or cloud gaming technologies,there has been a rapid increase,on a global scale,in the popularity of Esports worldwide,6 evidenced by the exponential growth in participation,media coverage,viewership,sponsorship,and commercialization. | Keyi Yin Yahua Zi Wei Zhuang Yang Gao Yao Tong Linjie Song Yu Liu | 2020 | Journal of Sport and Health Science2020，9，6： | 1 |
| 14 | Characterization and catalytic application of homogeneous nano-composite oxides ZrO2-Al2O3 显示文摘 | Li Guoran Li Wei Tao Keyi | 2004 | Catalysis Today2004，，93： | 1 |
| 15 | Morphology and hydrodesulfurization activity of CoMo sulfide supported on amorphous ZrO2 nanoparticles combined with Al2O3 显示文摘 | Li Guoran Li Wei Tao Keyi | 2004 | Applied Catalysis A : General2004，273，： | 1 |
| 16 | Catalytic dechlorination of monochlorobenzene with a new type of nanoscale Ni(B)/Fe(B) bimetallic catalytic reductant显示文摘 | Yi Han Wei Li Minghui Zhang Keyi Tao | 2008 | Chemosphere2008，，1： | 1 |
| 17 | A prospective cohort study on serum A20 as a prognostic biomarker of aneurysmal subarachnoid hemorrhage显示文摘BACKGROUND:A20 may be a neuroprotective factor.Herein,we aimed to investigate whether serum A20 levels were associated with disease severity,delayed cerebral ischemia(DCI),and outcome after aneurysmal subarachnoid hemorrhage(aSAH).METHODS:In this prospective cohort study containing 112 aSAH patients and 112 controls,serum A20 levels were quantified.At 90 d poststroke,Modified Rankin Scale(MRS) scores≥3 were defined as a poor outcome.All correlations and associations were assessed using multivariate analysis.RESULTS:Compared with controls,there was a significant elevation of serum A20 levels in patients(median 123.7 pg/mL vs.25.8 pg/mL;P<0.001).Serum A20 levels were independently correlated with Hunt-Hess scores(β 9.854;95% confidence interval [95% CI] 2.481-17.227,P=0.009) and modified Fisher scores(β 10.349,95% CI 1.273-19.424,P=0.026).Independent associations were found between serum A20 levels and poor outcome(odds ratio [OR] 1.015,95%CI 1.000-1.031,P=0.047) and DCI(OR 1.018,95% CI 1.001-1.035,P=0.042).Areas under the curve for predicting poor outcome and DCI were 0.771(95% CI 0.682-0.845) and 0.777(95% CI 0.688-0.850),respectively.Serum A20 levels ≥128.15 pg/mL predicted poor outcome,with a sensitivity of 73.9% and specificity of 74.2%,and A20 levels ≥160.55 pg/mL distinguished the risk of DCI with65.5% sensitivity and 89.2% specificity.Its ability to predict poor outcome and DCI was similar to those of Hunt-Hess scores and modified Fisher scores(both P>0.05).CONCLUSION:Enhanced serum A20 levels are significantly associated with stroke severity and poor clinical outcome after aSAH,implying that serum A20 may be a potential prognostic biomarker for aSAH. | Tian Yan Ziyin Chen Shengdong Zou Zefan Wang Quan Du Wenhua Yu Wei Hu Yongke Zheng Keyi Wang Xiaoqiao Dong Shuangyong Dong | 2023 | World Journal of Emergency Medicine2023，14，5： | 0 |
| 18 | Mid-infrared broadband optical frequency comb generated in MgF_2 resonators显示文摘Microresonator-based optical frequency combs are broadband light sources consisting of equally spaced and coherent narrow lines,which are extremely promising for applications in molecular spectroscopy and sensing in the mid-infrared(MIR)spectral region.There are still great challenges in exploring how to improve materials for microresonator fabrication,extend spectral bandwidth of parametric combs,and realize fully stabilized soliton MIR frequency combs.Here,we present an effective scheme for broadband MIR optical frequency comb generation in a MgF_(2) crystalline microresonator pumped by the quantum cascade laser.The spectral evolution dynamics of the MIR Kerr frequency comb is numerically investigated,revealing the formation mechanism of the microresonator soliton comb via scanning the pump-resonance detuning.We also experimentally implement the modulation instability state MIR frequency comb generation in MgF_(2) resonators covering from 3380 nm to 7760 nm.This work proceeds microresonator-based comb technology toward a miniaturization MIR spectroscopic device that provides potential opportunities in many fields such as fundamental physics and metrology. | WEI WU QIBING SUN YI WANG YU YANG XIANSHUN MING LEI SHI KEYI WANG WEI ZHAO LEIRAN WANG | 2022 | Photonics Research2022，10，8： | 0 |
| 19 | Hydrogenation of furfuryl alcohol to tetrahydrofurfuryl alcohol on NiB/SiO_(2) amorphous alloy catalyst显示文摘NiB/SiO2 amorphous alloy catalyst was prepared by power electroless plating method and characterized by induction coupled plasma(ICP),Brunauer–Emmett–Teller method(BET),transmission electron microscope(TEM)and X-ray diffraction(XRD)techniques.The catalytic perfor-mance of NiB/SiO2 was investigated for the hydrogenation of furfuryl alcohol(FA)to tetrahydrofurfuryl alcohol(THFA).The effects of operational conditions,such as reaction tem-perature,pressure,and stirring rate were carefully studied.The proper conditions were determined as the following:pressure 2.0 MPa,temperature 120°C and stirring rate 550 r/min.A typical result with FA conversion of 99%and THFA selectivity of 100%was obtained under such conditions,which was close to that over Raney Ni. | SONG Yun LI Wei ZHANG Minghui TAO Keyi | 2007 | Frontiers of Chemical Science and Engineering2007，1，2： | 0 |
| 20 | An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy显示文摘Two red-emissive luminogens(TPTH and TPTB) with typical aggregation-induced emission characteristics were developed. By introducing the heavy atom of Br at the end of alkyl chain, TPTB exhibited higher reactive oxygen species generation efficiency through both types I and II pathways. Due to its excellent biocompatibility and proper lipophilicity, TPTB could be used for long-term cell membrane staining and this staining ability was independent of the change of plasma membrane potential. Furthermore, TPTB could ablate the cancer cells through cell membrane-targeted photodynamic therapy. | Hailing Zhao Nan Li Caixia Ma Zhengwei Wei Qiya Zeng Keyi Zhang Na Zhao Ben Zhong Tang | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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