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| 1 | BZR1 Positively Regulates Freezing Tolerance via CBF-Dependent and CBF-Independent Pathways in Arabidopsis显示文摘冷应力是不利地影响植物生长和开发的一个主要环境因素。C 重复有约束力的 factor/DRE 绑定因素 1 (CBF/DREB1 ) 规章的串联被显示出在对的植物反应起重要作用的 transcriptional 冷。这里,我们证明发信号的 brassinosteroid (BR ) 的二个关键部件调制 Arabidopsis 植物的结冰忍耐。象 GSK3 一样 kinases 的 loss-of-function 异种在 BR 发信号包含了, bin2-3 bil1 bil2,显示出的增加的结冰公差,而 BIN2 的 overexpression 导致了超敏性到结冰,在 non-acclimated 和 acclimated 下面的应力调节。由对比,显示的抄写因素 BZR1 和 BES1 的 gain-of-function 异种提高了结冰忍耐,和一致地冷的处理能导致 dephosphorylated BZR1 的累积。生物化学、基因的分析证明 BZR1 行动 CBF1 和 CBF2 到在上游直接调整他们的表示。而且,我们发现 BZR1 也调整了另外的英国管基因与 CBF 解开了例如 WKRY6, PYL6, SOC1, JMT,和 SAG21,种反应调制到冷应力。一致地, wrky6 异种显示出减少的结冰忍耐。一起拿,我们的结果显示 BZR1 断然调制通过 CBF 依赖、 CBF 独立的小径冻结忍耐的植物。 | Hui Li Keyi Ye Yiting Shi Jinkui Cheng Xiaoyan Zhang Shuhua Yang | 2017 | Molecular Plant2017，10，4： | 37 |
| 2 | Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy显示文摘Genomic instability remains an enabling feature of cancer and promotes malignant transformation.Alterations of DNA damage response(DDR)pathways allow genomic instability,generate neoantigens,upregulate the expression of programmed death ligand 1(PD-L1)and interact with signaling such as cyclic GMPe AMP synthase-stimulator of interferon genes(cGASe STING)signaling.Here,we review the basic knowledge of DDR pathways,mechanisms of genomic instability induced by DDR alterations,impacts of DDR alterations on immune system,and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy. | Minlin Jiang Keyi Jia Lei Wang Wei Li Bin Chen Yu Liu Hao Wang Sha Zhao Yayi He Caicun Zhou | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 12 |
| 3 | COMBINATION STRENTHENING PROCESS OF Ni-W-Ti-SiC COMPOSITE COATING AND NITROCARBURIZATION显示文摘COMBINATIONSTRENTHENINGPROCESSOFNiWTiSiCCOMPOSITECOATINGANDNITROCARBURIZATION①MaKeyi,GuoZhongcheng,WenMingfen,YangXianwanD... | Ma Keyi, Guo Zhongcheng, Wen Mingfen, Yang Xianwan Department of Metallurgy, Kunming University of Science and Technology, Kunming 650093 | 1997 | 中国有色金属学会会刊:英文版1997，7，4： | 8 |
| 4 | Maneuvering Target Tracking in Dense Clutter Based on Particle Filtering显示文摘An improved particle filtering(IPF) is presented to perform maneuvering target tracking in dense clutter.The proposed filter uses several efficient variance reduction methods to combat particle degeneracy,low mode prior probabilities and measure-ment-origin uncertainty.Within the framework of a hybrid state estimation,each particle samples a discrete mode from its poste-rior distribution and the continuous state variables are approximated by a multivariate Gaussian mixture that is updated by an unscented Kalman filtering(UKF).The uncertainty of measurement origin is solved by Monte Carlo probabilistic data associa-tion method where the distribution of interest is approximated by particle filtering and UKF.Correct data association and precise behavior mode detection are successfully achieved by the proposed method in the environment with heavy clutter and very low mode prior probability.The performance of the proposed filter is examined and compared by Monte Carlo simulation over typical target scenario for various clutter densities.The simulation results show the effectiveness of the proposed filter. | YANG Xiaojun XING Keyi FENG Xingle | 2011 | Chinese Journal of Aeronautics2011，24，2： | 8 |
| 5 | Electrochemically driven conversion reaction in fluoride electrodes for energy storage devices显示文摘Exploring electrochemically driven conversion reactions for the development of novel energy storage materials is an important topic as they can deliver higher energy densities than current Li-ion battery electrodes.Conversion-type fluorides promise particularly high energy densities by involving the light and small fluoride anion,and bond breaking can occur at relatively low Li activity(i.e.,high cell voltage).Cells based on such electrodes may become competitors to other envisaged alternatives such as Lisulfur or Li-air systems with their many unsolved thermodynamic and kinetic problems.Relevant conversion reactions are typically multiphase redox reactions characterized by nucleation and growth processes along with pronounced interfacial and mass transport phenomena.Hence significant overpotentials and nonequilibrium reaction pathways are involved.In this review,we summarize recent findings in terms of phase evolution phenomena and mechanistic features of(oxy)fluorides at different redox stages during the conversion process,enabled by advanced characterization technologies and simulation methods.It can be concluded that well-designed nanostructured architectures are helpful in mitigating kinetic problems such as the usually pronounced voltage hysteresis.In this context,doping and open-framework strategies are useful.By these tools,simple materials that are unable to allow for substantial Li nonstoichiometry(e.g.,by Li-insertable channels)may be turned into electroactive materials. | Chilin Li Keyi Chen Xuejun Zhou Joachim Maier | 2018 | npj Computational Materials2018，，1： | 8 |
| 6 | A detection method for logic functions suitable for dual-logic synthesis显示文摘Logic functions can be implemented in either AND/OR/NOT-based traditional Boolean(TB) logic or AND/XOR-based Reed-Muller(RM) logic.To the majority of logic functions,it will be beneficial to be partially implemented in both TB logic and RM logic,called dual-logic.In this paper,a detection condition favoring dual-logic synthesis is proposed.A corresponding detection algorithm is developed and implemented in C.The algorithm is applied to test a set of MCNC91 benchmarks for verifying the algorithm.The results show that the proposed algorithm is more efficient than published ones. | Yinshui Xia Fei Sun Keyi Mao | 2009 | Progress in Natural Science:Materials International2009，19，10： | 7 |
| 7 | Optimal deadlock avoidance Petri net supervisors for automated manufacturing systems显示文摘僵局回避问题为与灵活路由生产系统自动化被调查。基于系统的 Petri 网络模型,第一次,这篇论文建议完美的最大的资源转变电路和他们的浸透的状态的概念。这个概念便于实时海角描述和死锁回避 Petri 让监督人赚的系统的开发。僵局作为到达他们的浸透的状态的一些完美的 maximalresource 转变电路被描绘。为生产系统,它不包含中心资源的一个大班,最佳的僵局回避 Petri 网监督人被介绍。为一个一般生产系统,一个方法为减少 systemPetri 网络模型被建议以便减少的模型不包含中心资源并且因此,让最佳的死锁回避 Petri 捕捞监督人。控制减少的 Petri 网模型当时能是使用的著名计算机生产厂商他系统的实时海角监督人。 | Keyi XING Feng TIAN Xiaojun YANG | 2007 | 控制理论与应用(英文版)2007，5，2： | 7 |
| 8 | Co-expression of IL-18 binding protein and IL-4 regulates Th1/Th2 cytokine response in murine collagen-induced arthritis显示文摘我们构造了包含鼠科的白介素( IL )的 recombinant adenoviral 向量 -18 绑定蛋白质( mIL-18BP )和鼠科的 IL-4 ( mIL-4 )熔化基因( AdmIL-18BP/mIL-4 )并且使用一条基因治疗途径在 T-helper1 和 T-helper2 ( Th1/Th2 )在鼠标平衡的 modulating 调查 IL-18BP 和 IL-4 的角色与导致骨胶原的关节炎(中央情报局)。有中央情报局的老鼠 intra-articularly 与 10 被注射(7 ) AdmIL-18BP/mIL-4,或控制侵入人体气管粘膜的病菌的 pfu/6 亩 l,或与控制车辆(缓冲磷酸盐盐) 。在有 AdmIL-18BP/mIL-4 的 intra 关节的基因治疗以后,肿瘤坏死 factor-alpha (TNF-alpha ) 的浆液层次, gamma 干扰素(IFN-gamma ) , IL-4, IL-10,和在有中央情报局的老鼠的 IL-18 被 ELISA IFN-gamma-expressing 和 IL-4-expressing CD4 (+) T 估计从老鼠 splenocytes 的房间被流动 cytometry 监视。有在 1 , 2 ,和 4 显著地在 AdmIL-18BP/mIL-4 的 intraarticular 注射以后显示出的星期的中央情报局的老鼠增加了 IL-4 和 IL-10 的浆液集中( 0.01 根本预定的 P <
指)但是 IFN-gamma 的极大地减少的浆液集中, TNF-alpha ,并且 IL-18 ( 0.01 根本预定的 P <
指)与控制侵入人体气管粘膜的病菌和缓冲磷酸盐的盐的控制组相比。IFN-gamma-producing CD4 (+) T 房间的百分比显著地响应本地 AdmIL-18BP/mIL-4 处理被减少。房间在 AdmIL-18BP/mIL-4 的本地注射以后在 1 个星期显著地增加了的 IL-4-producing CD4 (+) T 的百分比然后在星期 4 回到了正常。这些数据在本地人在 IL-18BP 和 IL-4 的表示上生产的鼠科的中央情报局在 Th1/Th2 不平衡上显示了重要修改效果。有 IL-18BP 和 IL-4 的联合处理是为风湿性关节炎的有希望的潜在的治疗。 | Jianhang Leng Hangping Yao Junya Shen Keyi Wang Guangchao Zhuo Ziwei Wang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 5 |
| 9 | Statistical analysis of mesoscale eddy propagation velocity in the South China Sea deep basin显示文摘Using mesoscale eddy trajectory product derived from satellite altimetry data from 1993 to 2017,this study analyzes the statistical characteristics of spatiotemporal distribution of mesoscale eddy propagation velocities(C)in the South China Sea(SCS)deep basin with depths>1000 m.Climatologically,the zonal propagation velocities(cx)are westwards in the whole basin,and the meridional velocities(cy)are southwards in the northwestern basin,and northwards in the southeastern basin.The variation of cy with longitude is consistent with that of the background meridional currents with correlation coefficient R2 of 0.96,while the variation of cx is related both to the background zonal currents andβeffect.The propagation velocities characterize significant seasonality with the minimum magnitude occurring in summer and the maximum in winter for cx and C.Interannually,larger values of cx and cy mostly occurred in La Ni?a years in the negative phase of the Pacific Decadal Oscillation(PDO).Mesoscale eddies move fast at the beginning and end of their life span,i.e.,at their growth and dissipation periods,and slowly during their stable'midlife'period.This trend is negatively correlated with the rotating tangential velocity with R2 of–0.93.Eddies with extreme propagation velocities are defined,which are slower(faster)than 1.5 cm/s(15.4 cm/s)and take 1.5%(1.9%)of the total eddies.The extremely slow-moving(fastmoving)eddies tend to appear in the middle(on the edge)of the basin,and mostly occur in summer(winter).The mechanism analysis reveals that the spatiotemporal distributions of the propagation velocities of mesoscale eddies in the SCS are modulated by the basin-scale background circulation. | Runqi Huang Lingling Xie Quanan Zheng Mingming Li Peng Bai Keyi Tan | 2020 | Acta Oceanologica Sinica2020，39，11： | 4 |
| 10 | Vertical shaking table tests on the structure with viscoelastic multi-dimensional earthquake isolation and mitigation devices显示文摘The viscoelastic multi-dimensional earthquake isolation and mitigation device is a new kind of passive control device, which can perform its 'name-giving' task of earthquake isolation and earthquake mitigation simultaneously. In order to quantify its vertical earthquake isolation and mitigation effect on structures, firstly, shaking table tests on steel frame structures with and without the devices were carried out; secondly, analysis on dynamic characteristics and dynamic responses of the structures was also performed; furthermore, the finite element analytical results and the experimental results were compared. It can be shown from the analytical and experimental results that the devices have noticeable earthquake isolation and mitigation effect in the vertical direction. | XU ZhaoDong SHI BenQiang WU KeYi ZENG Xiao | 2009 | Science China(Technological Sciences)2009，52，10： | 4 |
| 11 | Robust Deadlock Avoidance Policy for Automated Manufacturing System With Multiple Unreliable Resources显示文摘This work studies the robust deadlock control of automated manufacturing systems with multiple unreliable resources. Our goal is to ensure the continuous production of the jobs that only require reliable resources. To reach this goal, we propose a new modified Banker's algorithm(MBA) to ensure that all resources required by these jobs can be freed. Moreover,a Petri net based deadlock avoidance policy(DAP) is introduced to ensure that all jobs remaining in the system after executing the new MBA can complete their processing smoothly when their required unreliable resources are operational. The new MBA together with the DAP forms a new DAP that is robust to the failures of unreliable resources. Owing to the high permissiveness of the new MBA and the optimality of the DAP, it is tested to be more permissive than state-of-the-art control policies. | Jianchao Luo Zhiqiang Liu Shuogang Wang Keyi Xing | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，3： | 4 |
| 12 | Global perspectives and future research directions for the phytoremediation of heavy metal-contaminated soil:A knowledge mapping analysis from 2001 to 2020显示文摘In total,9,552 documents were extracted from the Web of Science Core Collection and subjected to knowledge mapping and visualization analysis for the field of phytoremediation of HM-contaminated soil(PHMCS)with CiteSpace 5.7 R3 software.The results showed that(1)the number of publications increased linearly over the studied period.The top 10 countries/regions,institutions and authors contributing to this field were exhibited.(2)Keyword co-occurrence cluster analysis revealed a total of 8 clusters,including“Bioremediation,”“Arsenic,”“Biochar,”“Oxidative stress,”“Hyperaccumulation,”“EDTA,”“Arbuscular mycorrhizal fungi,”and“Environmental pollution”clusters(3)In total,334 keyword bursts were obtained,and the 25 strongest,longest duration,and newest keyboard bursts were analyzed in depth.The strongest keyword burst test showed that the hottest keywords could be divided into 7 groups,i.e.,“Plant bioremediation materials,”“HM types,”“Chelating amendments,”“Other improved strategies,”“Bioremediation characteristics,”“Risk assessment,”and“Other.”Almost half of the newest topics had emerged in the past 3 years,including“biochar,”“drought,”“health risk assessment,”“electrokinetic remediation,”“nanoparticle,”and“intercropping.”(4)In total,9 knowledge base clusters were obtained in this study.The studies of Ali et al.(2013),Blaylock et al.(1997),Huang et al.(1997),van der Ent et al.(2013),Salt et al.(1995),and Salt(1998),which had both high frequencies and the strongest burst scores,have had the most profound effects on PHMCS research.Finally,future research directions were proposed. | Kehui Liu Xiaojin Guan Chunming Li Keyi Zhao Xiaohua Yang Rongxin Fu Yi Li Fangming Yu | 2022 | Frontiers of Environmental Science & Engineering2022，16，6： | 4 |
| 13 | Horizontal shaking table tests and analysis on structures with multi-dimensional earthquake isolation and mitigation devices显示文摘The viscoelastic multi-dimensional earthquake isolation and mitigation device is a new kind of passive control device, which has both earthquake isolation and earthquake mitigation abilities. In order to quantify the horizontal earthquake isolation and mitigation effect of this device on structures, shaking table tests on structures with and without the devices and the corresponding analysis on earthquake isolation and mitigation properties are carried out. It can be shown from the experimental and analytical results that the device has both earthquake isolation and earthquake mitigation effects on structures in horizontal direction, and its horizontal earthquake mitigation coefficients can be referred to those of the rubber bearing earthquake isolation structure. | ZhaoDong Xu Xiao Zeng KeYi Wu AiQun Li QingYang Xu | 2009 | Science China(Technological Sciences)2009，52，7： | 3 |
| 14 | Growing Operational Use of FY-3 Data in the ECMWF System显示文摘This paper reviews the data quality and impact of observations from the FY-3 satellite series used operationally in the ECMWF system. This includes data from the passive microwave radiometers MWHS-1, MWHS-2 and MWRI, as well as observations from the radio occultation receiver GNOS. Evaluations against background equivalents show that the quality of the observations is broadly comparable to that of similar instruments on other polar-orbiting satellites, even though biases for the passive microwave observations can be somewhat larger and more complex for some channels. An observing system experiment shows that the FY-3 instruments jointly contribute significantly to the forecast skill in the ECMWF system. Positive impact of up to 2% is seen for most variables out to the day-2 forecasts over hemispheric scales, with significant benefits for total column water vapor or for temperature and wind in the stratosphere out to day 4. | Niels BORMANN David DUNCAN Stephen ENGLISH Sean HEALY Katrin LONITZ Keyi CHEN Heather LAWRENCE Qifeng LU | 2021 | Advances in Atmospheric Sciences2021，38，8： | 3 |
| 15 | A Potential Global Standard Stratotype-Section and Point of the Moscovian Stage(Carboniferous)显示文摘Conodonts 和 fusulinids 是为细分和相关 Bashkirian 和 Moscovian 阶层的二个最广泛地使用的关於生命的组。因为在存在边界定义建议,其各个有劣势之中有许多争论,全球 Moscovian 阶段的底的定义是未定的。Declinognathodus donetzianus 容易在它的 paleogeographic 分发被认出,但是有点限制了。Idiognathoides postsulcatus 是稍微更普遍的,但是它不太容易被识别,它的出现可以是从区域的 diachronous 到区域。Diplognathodus ellesmerensis 容易被认出并且甚至更普遍,但是它通常是稀罕的,它的祖先足够地不被知道。南方贵州的 Naqing 节,华南包含多样的 conodont 在不同 taxa,包括的 Idiognathoides, Idiognathodus, Diplognathodus, Neognathodus, Gondolella 和 Mesogondolella 之中的进化的系。在有众多的过渡形式几乎 Naqing 节的每个系,哪个为华南的前景上演在决定基础 Moscovian 起一个关键作用的表演定义好。 | WANG Xiangdong QI Yuping Lance LAMBERT WANG Zhihao WANG Yue HU Keyi LIN Wei CHEN Bo | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 3 |
| 16 | Joint state and parameter estimation in particle filtering and stochastic optimization显示文摘In this paper, an adaptive estimation algorithm is proposed for non-linear dynamic systems with unknown static parameters based on combination of particle filtering and Simultaneous Perturbation Stochastic Approximation (SPSA) technique. The estimations of parameters are obtained by maximum-likelihood estimation and sampling within particle filtering framework, and the SPSA is used for stochastic optimization and to approximate the gradient of the cost function. The proposed algorithm achieves combined estimation of dynamic state and static parameters of nonlinear systems. Simulation result demonstrates the feasibility and efficiency of the proposed algorithm. | Xiaojun YANG Keyi XING Kunlin SHI Quan PAN | 2008 | 控制理论与应用(英文版)2008，6，2： | 2 |
| 17 | Close-to-nature and Value-oriented Forest Management in Harbin City, China显示文摘The paper came up with the basic principles, technology system, planning and forest governance system of close-to-nature and value-oriented forest management on the basis of discussions on its concept and theoretical foundation, and finally introduced initial effects of close-to-nature and value-oriented forest management implemented in Harbin. | WU Keyi Harbin Forestry Bureau, Harbin 150076, P. R. China | 2010 | Chinese Forestry Science and Technology2010，9，1： | 2 |
| 18 | Determining the critical size of a rabbit rib segmental bone defect model显示文摘In order to establish and standardize the rabbit rib segmental bone defect model,it is of vital importance to determine rabbit rib critical size defect(CSD).According to the general time needed for spontaneous long-bone regeneration,three-month observation period was set to determine the CSD.The rabbit rib segmental bone defects with different sizes from 1 to 5cm with or without periosteum were performed in the eighth rib of 4-month-old male New Zealand rabbits and underwent Xray examinations at the 4th,8th and 12th weeks postoperatively.The gross and histological examinations at postoperative week 12 were evaluated,which showed that the critical sizes in the rabbit rib models with and without periosteum were 5 and 2 cm,respectively.This study provides prerequisite data for establishing rabbit rib CSD model and evaluating bonematerials using this model. | Fengzhen Liu Kun Chen Lei Hou Keyi Li Dawei Wang Bin Zhang Xiumei Wang | 2016 | Regenerative Biomaterials2016，3，5： | 2 |
| 19 | Carboniferous integrative stratigraphy and timescale of China显示文摘The Carboniferous period lasted about 60 Myr, from ~358.9 Ma to ~298.9 Ma. According to the International Commission on Stratigraphy, the Carboniferous System is subdivided into two subsystems, i.e., Mississippian and Pennsylvanian, including 6 series and 7 stages. The Global Stratotype Sections and Points(GSSPs) of three stages have been ratified, the Tournaisian, Visean, and Bashkirian stages. The GSSPs of the remaining four stages(i.e., the Serpukhovian, Moscovian,Kasimovian, and Gzhelian) have not been ratified so far. This paper outlines Carboniferous stratigraphic subdivision and correlation on the basis of detailed biostratigraphy mainly from South China, and summarizes the Carboniferous chronostratigraphic framework of China. High-resolution biostratigraphic study reveals 37 conodont zones, 24 foraminiferal(including fusulinid) zones, 13 ammonoid zones, 10 brachiopod zones, and 10 rugose coral zones in the Carboniferous of China. The biostratigraphic framework based on these biozones warrants the precise correlation of regional stratigraphy of China(including2 subsystems, 4 series, and 8 stages) to that of the other regions globally. Meanwhile, the Carboniferous chemo-, sequence-,cyclo-, and event-stratigraphy of China have been intensively studied and can also be correlated worldwide. Future studies on the Carboniferous in China should focus on(1) the correlation between shallow-and deep-water facies and between marine and continental facies,(2) high-resolution astronomical cyclostratigraphy, and(3) paleoenvironment and paleoclimate analysis based on geochemical proxies such as strontium and oxygen isotopes, as well as stomatal indices of fossil plants. | Xiangdong WANG Keyi HU Wenkun QIE Qingyi SHENG Bo CHEN Wei LIN Le YAO Qiulai WANG Yuping QI Jitao CHEN Zhuoting LIAO Junjun SONG | 2019 | Science China Earth Sciences2019，62，1： | 2 |
| 20 | Influencing factors on the preservation of lytic bacteriophage VP3显示文摘Long-term and stable preservation of bacteriophages is of crucial importance.Although many efforts have been made in the past decades to explore the influence of external factors on bacteriophage preservation,there is still little understanding,and a systematic description is lacking.In this study,we explored the influence of different factors on the preservation of lytic bacteriophage VP3,one of the typing bacteriophages of Vibrio cholerae O1 biotype El Tor,and attempted to optimize its preservation.We examined external factors,including temperature,solution,and cryoprotectant,in stable cooling/freezing conditions or alternate cooling/freezing and thawing.We found that whether in Luria-Bertani(LB)medium or SM buffer,in terms of 20-week stable cooling or freezing,−20℃ was the most damaging while 4℃,−80℃,and−196℃ were protective.Thirteen cycles of alternate cooling/freezing and thawing caused a loss in the survival rates of bacteriophages.The addition of cryoprotectant,glycerol(30%,w/v)or dimethyl sulfoxide(DMSO,10%,w/v)significantly improved the survival rates of bacteriophages preserved at−20℃.However,at 4℃,−80℃,and−196℃,the cryoprotectant effect was only slightly positive or even harmful.In summary,for bacteriophage VP3,the best preservation method is to directly preserve the bacteriophage stocks in LB medium at−80℃ or−196℃ instead of storing them in SM buffer or adding cryoprotectant.Our results provided insights into the external influencing factors on bacteriophage VP3 during preservation at low temperature and can be applied to the optimization of bacteriophage preservation in the future. | Yue Xiao Pin Huang Zhenzhou Huang Keyi Yu Yang Song Ning Guo Hang Dai Mengnan Jiang Yi Xu Duochun Wang Qiang Wei | 2022 | Biosafety and Health2022，4，5： | 2 |
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