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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Diabetes,oxidative stress and antioxidants:a review J 显示文摘 | Maritim AC Sanders RA Watkins JB | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 3 | Nonnutritive Sucking during garage feeding enhances growth and matura- tion in premature infants显示文摘 | Bembaum JC Pereira GR Watkins JB | 1983 | Pediatrics1983，71，1： | 1 |
| 4 | Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats显示文摘 | Marritim AC Sanders RA Watkins JB | 2003 | J Nutr Biochem2003，14，： | 1 |
| 5 | Diabe- tes, oxidative stress, and antioxidants: a review 显示文摘 | Maritim AC Sanders RA Watkins JB 3rd | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 6 | Diabetes, oxidative stress, and antioxidants: a review显示文摘 | Maritim AC Sanders RA Watkins JB 3rd | 2003 | J BiochemMol 7oxicol2003，71，： | 1 |
| 7 | Genomics and metabolomics as markers for the interaction of diet and health: Lessons from lipids 显示文摘 | German JB Roberts MA Watkins SM | 2003 | J Nutr2003，133，6： | 1 |
| 8 | Nonnutritive sucking during garage feeding enchances growth and maturation in premature infants显示文摘 | Bembaum JC Pereira GR Watkins JB | 1983 | Pediatrics1983，71，1： | 1 |
| 9 | Nonnut- ritive Sucking during gavage feeding enhances growth and maturation in premature infants显示文摘 | Bembaum JC Pereira GR Watkins JB | 1983 | Pediatries1983，71，1： | 1 |
| 10 | Diabetes,Oxidative stress, and antioxidants:a review显示文摘 | Maritim AC Sanders RA Watkins JB | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 11 | Diabetes,oxidative stress,and antioxidants:a review显示文摘 | Maritim AC Sanders RA Watkins JB | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 12 | Diabetes, Oxidative Stress, and Antioxidants : A Review显示文摘 | AC Maritim RA Sanders JB Watkins | 2003 | J Biochem Molecular Tocicology2003，17，1： | 1 |
| 13 | Diabetes, oxidative stress, and antioxidant: a review 显示文摘 | MaritimAC Sanders RA Watkins llI JB | 2003 | J Biochem Mol Toxical2003，17，1： | 1 |
| 14 | Diabetes,oxidativestress,and antioxidants:a review显示文摘 | Maritim AC Sanders RA Watkins JB 3rd | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 15 | Diabetes, oxidative stress, and antioxidants: A review 显示文摘 | Maritim AC Sanders RA Watkins JB 3rd | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 16 | Diabetes,oxidative stress,andantioxidants:a review显示文摘 | MaritimAC Sanders RA Watkins JB | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 17 | Diabetes, oxidative stress,and antioxidants: a review 显示文摘 | Maritim AC Sanders RA Watkins JB 3rd | 2003 | J Biochem Mol Toxicol2003，17，1： | 1 |
| 18 | Diabetes, oxidative stress,and antioxidants:a review显示文摘 | Maritim AC Sanders RA Watkins JB | 2003 | Biochem Mol Toxicol2003，17，1： | 1 |
| 19 | Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats显示文摘 | Sanders RA Rauscher FM Watkins JB 3rd | 2001 | J Biochem Mol Toxicol2001，15，3： | 1 |
| 20 | Diabetes, oxidative stress, and antioxidants : a review 显示文摘 | Marttim AC Sanders RA Watkins JB 3rd | 2003 | J Biochem Mol Toxico12003，17，1： | 1 |
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