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| 1 | Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning显示文摘AIM:To assess the relationship between preoperative computed tomography(CT)and postoperative pathological measurements of esophageal tumor length and the prognostic significance of CT tumor length data.METHODS:A retrospective study was carried out in 56 patients who underwent curative esophagogastrectomy.Tumor lengths were measured on the immediate preoperative CT and on the post-operative resection specimens.Inter-and intra-observer variations in CT measurements were assessed.Survival data were collected.RESULTS:There was a weak correlation between CT and pathological tumor length(r=0.30,P=0.025).CT lengths were longer than pathological lengths in 68%(38/56)of patients with a mean difference of 1.67 cm(95%CI:1.18-2.97).The mean difference in measurements by two radiologists was 0.39 cm(95% CI:-0.59-1.44).The mean difference between repeat CT measured tumor length(intra-observer variation) were 0.04 cm(95%CI:-0.59-0.66)and 0.47 cm (95%CI:-0.53-1.47).When stratified,patients not receiving neoadjuvant chemotherapy showed a strong correlation between CT and pathological tumor length(r =0.69,P=0.0014,n=37)than patients that did(r= 0.13,P=0.43,n=19).Median survival with CT tumor length>5.6 cm was poorer than with smaller tumors,but the difference was not statistically significant.CONCLUSION:Esophageal tumor length assessed using CT does not reflect pathological tumor extent and should not be the only modality used for management decisions,particularly for planning radiotherapy. | Karim Sillah Luke R Williams Hans-Ulrich Laasch Azeem Saleem Gillian Watkins Susan A Pritchard Patricia M Price Catharine M West Ian M Welch | 2010 | World Journal of Gastrointestinal Oncology2010，2，4： | 10 |
| 2 | Diffractive Multi-beam Ultra-fast Laser Micro-processing Using a Spatial Light Modulator(Invited Paper)显示文摘Multi-beam ultra-fast laser parallel microprocessing using spatial light modulation is demonstrated in this paper.Diffractive multi-beam patterns are generated with a spatial light modulator(SLM),which is driven by computer generated holograms(CGHs).The CGHs calculated by appropriate algorithms are displayed on the SLM to split an input laser beam to a number of beamlets and digitally manipulate their positions and intensity.The undesired damage by the energetic zero order beam can be avoided by either installing a 4f optical system to block the zero order at the Fourier plane or adding a Fresnel zone lens on the CGH to defocus the zero order at the processing plane.The surface ablation of materials using multi-beam patterns synchronised with a scanning galvanometer system shows flexible and high throughput parallel processing.By tightly focusing the diffractive beams with an objective into transparent materials,high speed dynamic femto-second laser two-dimensional(2D) and three-dimensional(3D) internal structuring is also presented.The results demonstrate the high precision micro-processing with higher efficiency,showing the potential for ultra-fast laser parallel processing in real industrial applications. | Walter Perrie S. P. Edwardson E. Fearon G. Dearden K. G. Watkins | 2009 | 中国激光2009，36，12： | 4 |
| 3 | 肝癌染色体17p13.3区的杂合性缺失分析及缺失区连续克隆群的构建显示文摘目的 检测原发性肝癌在染色体 17p13.3区的杂合性缺失状况 ,确定其共同缺失范围和最小热点缺失范围 ,并获得缺失范围内基因组克隆和构建连续克隆群。方法 应用Southern杂交分析VNTR(variablenumberoftandemrepeat,VNTR)和RFLP标志在肝癌中杂合性缺失 (LOH)状况。应用PCR扩增微卫星标志 ,变性聚丙烯酰胺凝胶电泳分析各个微卫星标志的LOH状况。以微卫星标志为引物 ,经过 3轮PCR筛选阳性基因组克隆。通过检测各位点标志对基因组克隆的反应 ,构建连续克隆群。结果 检测了 5 4份原发性肝癌样品在染色体 17p13.3区 16个位点标志和染色体 17p13.1区的p5 3基因的TP5 3位点标志的LOH情况 ,发现从D17S5位点至D17S34位点间的各个标志都有较高LOH ,频率 >6 3%。而从D17S5位点起、近着丝粒方向的 3个标志LOH率都较低或无LOH。染色体17p13.1的TP5 3标志只有 31%的LOH ,低于染色体 17p13.3区的D17S5至D17S34位点间各标志的LOH率。有 2例肝癌样品在近端粒的D17S34、D17S186 6位点和近着丝粒的D17S5、D17S15 74位点均无LOH ,但在D17S849至D17S15 74间的各位点上均呈LOH或为纯合子。在缺失范围内 ,共筛选了 18个位点的基因组克隆 ,获得了相对应的阳性基因组克隆 ,经过检测各位点对基因组克隆的反应性 ,构建了覆盖 | 赵新泰 万大方 蒋惠秋 何英华 覃文新 Paul Watkins 顾健人 | 2000 | 中华肿瘤杂志2000，22，5： | 4 |
| 4 | GaAsSb/InP异质结晶体三极管显示文摘当x~0.5时,GaAs1-xSbx的晶格与InP衬底匹配,其带隙为0.72 eV,可用于InP衬底上的异质结晶体三极管的基区材料。最近的实验结果表明GaAs0.5Sb0.5/InP的能带为Ⅱ型异质结构:GaAs0.5Sb0.5的导带位于InP导带之上180 meV,其价带位于InP价带之上760 meV,该价带偏置几乎是InGaAs/InP(378 meV)的两倍,这种大的价带偏置有效地阻止了空穴重注入到发射区,并且更重要的是其导带偏置使得电子以弹道方式从GaAs0.5Sb0.5基区发射到InP集电区。因此,从能带工程的角度分析,GaAs0.5Sb0.5是制作基于InP衬底的异质结晶体管(HBT)的理想基区材料。本文简要报道采用金属有机气相外延(MOVPE)生长GaAsSb/InP HBT器件材料。 | 和作现刚 Watkins,SP | 2001 | 固体电子学研究与进展2001，21，1： | 4 |
| 5 | Understanding development and ripening of fruit crops in an‘omics’ era显示文摘Next generation sequencing has revolutionized plant biology.Not only has our understanding of plant metabolism advanced using model systems and modern chromatography,but application of‘omics’-based technology has been widely extended to non-model systems as costs have plummeted and efficiency increased.As a result,important fundamental questions relating to important horticultural crops are being answered,and novel approaches with application to industry are in progress.Here we review recent research advances on development and ripening of fruit crops,how next generation sequencing approaches are driving this advance and the emerging future landscape. | Nigel E Gapper James J Giovannoni Christopher B Watkins | 2014 | Horticulture Research2014，1，1： | 4 |
| 6 | Atorvastatin Reduces the Ability of Clopidogrel to Inhibit Platelet Aggregation: A New Drug–Drug Interaction显示文摘 | Wei C. Lau Lucy A. Waskell Paul B. Watkins Charlene J. Neer Kevin Horowitz Amy S. Hopp Alan R. Tait David G.M. Carville Kirk E. Guyer Eric R. Bates | 2003 | Circulation: Journal of the American Heart Association2003，，1： | 3 |
| 7 | Expression of the Transcription Factors Snail, Slug, and Twist and Their Clinical Significance in Human Breast Cancer显示文摘 | Tracey A. Martin Amit Goyal Gareth Watkins Wen G. Jiang | 2005 | Annals of Surgical Oncology2005，，6： | 3 |
| 8 | Profile of the breast cancer susceptibility marker rs4245739 identifies a role for miRNAs显示文摘Objective:To determine the influence of the single nucleotide polymorphism(SNP)rs4245739 on the binding and expression of micro RNAs and subsequent MDM4 expression and the correlation of these factors with clinical determinants of ER-negative breast cancers.Methods:Find Tar and miRanda were used to detect the manner in which potential micro RNAs are affected by the SNP rs4245739-flanking sequence.RNA sequencing data for ER-negative breast cancer from The Cancer Genome Atlas(TCGA)were used to compare the expression of miR-184,miR-191,miR-193a,miR-378,and MDM4 in different rs4245739 genotypes.Results:Comparison of ER-negative cancer patients with and without the expression of miR-191 as well as profile micro RNAs(miR-184,miR-191,miR-193a and miR-378 altogether)can differentiate the expression of MDM4 among different rs4245739 genotypes.Although simple genotyping alone did not reveal significant clinical relationships,the combination of genotyping and micro RNA profiles was able to significantly differentiate individuals with larger tumor size and lower number of involved lymph nodes(P<0.05)in the risk group(A allele).Conclusions:We present two novel methods to analyze SNPs within 3′UTRs that use:(i)a single miRNA marker expression and(ii)an expression profile of miRNAs predicted to bind to the SNP region.We demonstrate that the application of these two methods,in particular the miRNA profile approach,permits detection of new molecular and clinical features related to the rs4245739 variant in ER-negative breast cancer. | Sumadi Lukman Anwar Wahyu Wulaningsih Johnathan Watkins | 2017 | Cancer Biology & Medicine2017，14，4： | 3 |
| 9 | Quantitative biochemical and ultrastructural comparison of mitochondrial permeability transition in isolated brain and liver mitochondria: evidence for reduced sensitivity of brain mitochondria 显示文摘 | Sarah BB Watkins SC Hastings TG | 2000 | Exp Neurol2000，16，： | 3 |
| 10 | A two-pass procedure for the calculation of heat transfer in recirculating turbulent flow显示文摘 | Goory A M Watkins C B Aung W | 1983 | Number Heat Transfer1983，6，3： | 3 |
| 11 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 3 |
| 12 | Variations in zonal fruit starch concentrations of apples – a developmental phenomenon or an indication of ripening?显示文摘Patterns of starch hydrolysis in stem,equatorial,and calyx zones of‘Honeycrisp’and‘Empire’apples(Malus sylvestris(L.)Mill var.domestica(Borkh.)Mansf.)during maturation and ripening,and in‘Gala’apples in response to propylene or 1-methylcyclopropene(1-MCP)treatments after harvest,were studied.Differences in zonal starch concentrations were found for‘Empire’and‘Gala’fruits,but not for‘Honeycrisp’.During maturation and ripening of‘Empire’,the concentration of starch was highest in the calyx end and lowest in the stem region.Differences in rates of starch hydrolysis among zones were not detected.‘Honeycrisp’and‘Empire’had the highest concentration of sorbitol in the calyx region,whereas it was highest in the stem-end region in‘Gala’.The distribution differences of glucose,fructose,and sucrose were similar in all three cultivars;higher fructose and glucose concentrations in the stem region,and higher sucrose concentrations in the calyx end of the fruit.Postharvest treatment of‘Gala’with propylene did not affect the internal ethylene concentration of the fruit but 1-MCP markedly inhibited it.Starch concentrations were highest in the calyx end but gradients of starch among zones were not changed by postharvest treatment.The rate of hydrolysis was slowed by 1-MCP treatment,but was unaffected by propylene.Postharvest treatments influenced sorbitol,glucose,and fructose concentrations.Patterns of starch concentration among the zones did not confirm differences in ripening,but reflected its uneven distribution throughout the fruit during development.Therefore,measured differences in zonal starch are most likely related to starch accumulation during fruit development,rather than differences in rates of starch degradation during ripening. | Franziska C Doerflinger William B Miller Jacqueline F Nock Christopher B Watkins | 2015 | Horticulture Research2015，2，1： | 3 |
| 13 | 舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者安全性的评价:随机双盲临床研究显示文摘目的评价舒更葡糖钠用于ASA分级Ⅲ或Ⅳ级高风险手术患者术后拮抗神经肌肉阻滞的安全性。尤其着重评估了心脏不良事件以及其他预先指定的临床关注不良事件的影响。方法符合ASA分级Ⅲ或Ⅳ级标准的患者,根据ASA分级和神经肌肉阻滞剂(罗库溴铵或维库溴铵)进行随机分组,新斯的明/格隆溴铵组:中度神经肌肉阻滞;舒更葡糖钠2 mg/kg组,中度神经肌肉阻滞;舒更葡糖钠4 mg/kg组,深度神经肌肉阻滞;舒更葡糖钠16 mg/kg组,深度神经肌肉阻滞(仅罗库溴铵)。主要研究终点包括治疗期间窦性心动过缓、窦性心动过速和其他心律失常的发生情况。结果344例患者进入随机化分配,331例患者接受了治疗[61%为男性,BMI(28.5±5.3)kg/m^(2),年龄(69±11)岁]。舒更葡糖钠2 mg/kg组治疗期间窦性心动过缓发生率显著降低,舒更葡糖钠2 mg/kg组和4 mg/kg组治疗期间窦性心动过速发生率显著降低(P<0.05)。4组间治疗期间其他心律失常发生率比较差异无统计学意义(P>0.05)。结论ASA分级Ⅲ或Ⅳ级高风险手术患者使用舒更葡糖钠拮抗罗库溴铵或维库溴铵诱导的中度和深度神经肌肉阻滞的安全性良好。 | W.Joseph Herring Yuki Mukai Aobo Wang Jeannine Lutkiewicz John F.Lombard Li Lin Molly Watkins David M.Broussard Manfred Blobner | 2022 | 中华麻醉学杂志2022，42，1： | 3 |
| 14 | Drug-Induced Liver Injury Network (DILIN) Prospective Study: Rationale, Design and Conduct显示文摘 | Fontana Robert J Watkins Paul B Bonkovsky Herbert L Chalasani Naga Davern Timothy Serrano Jose Rochon James | 2009 | Drug Safety2009，，1： | 2 |
| 15 | Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States显示文摘 | Naga Chalasani Robert J. Fontana Herbert L. Bonkovsky Paul B. Watkins Timothy Davern Jose Serrano Hongqiu Yang James Rochon | 2008 | Gastroenterology2008，，6： | 2 |
| 16 | Do medical students studying in the United Kingdom have an adequate factual knowledge of basic life support?显示文摘BACKGROUND: Healthcare professionals have a duty to maintain basic life support(BLS) skills. This study aims to evaluate medical students' factual knowledge of BLS and the training they receive.METHODS: A cross-sectional, closed-response questionnaire was distributed to the fi rst-and fourth-year students studying at institutions in the United Kingdom. The paper questionnaire sought to quantify respondent's previous BLS training, factual knowledge of the BLS algorithm using five multiple choice questions(MCQs), and valuate their desire for further BLS training. Students received 1 point for each correctly identifi ed answer to the 5 MCQ's.RESULTS: A total of 3,732 complete responses were received from 21 medical schools. Eighty percent(n=2,999) of students completed a BLS course as part of their undergraduate medical studies. There was a signifi cant difference(P<0.001) in the percentage of the fourth-year students selecting the correct answer in all the MCQ's compared to the fi rst-year students except in identifyingthe correct depth of compressions required during CPR(P=0.095). Overall 10.3%(95% CI 9.9% to 10.7%) of respondents correctly identified the answer to 5 MCQ's on BLS: 9% of the first-year students(n=194) and 12% of the fourth-year students(n=190). On an institutional level the proportion of students answering all MCQ's correctly ranged from 2% to 54% at different universities. Eighty-one percent of students(n=3,031) wished for more BLS training in their curriculum.CONCLUSION: Factual knowledge of BLS is poor among medical students in the UK. There is a disparity in standards of knowledge across institutions and respondents indicating that they would like more training. | Robert D.Willmore Damjan Veljanoski Feray Ozdes Bethan Stephens James Mooney Seamus G.Crumley Arpan Doshi Philippa Davies Shreya Badhrinarayanan Emily Day Kristian Tattam April Wilson Nathan Crang Lorna Green Craig A.Mounsey Howell Fu Joseph Williams Michelle S.D'souza Dhanya Sebastian Liam A.Mcgiveron Matthew G.Percy James Cohen Imogen J.John Alice Lethbridge Imogen Watkins Omar Amin Mubasher A.Qamar John Gerrard Hanrahan Emily Cramond-Wong | 2019 | World Journal of Emergency Medicine2019，10，2： | 2 |
| 17 | Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats显示文摘 | Clark RS Chen J Watkins SC | 1997 | J Neurosci1997，17，91： | 2 |
| 18 | Recent developments in titanium alloy application in the energy industry显示文摘 | R.W Schutz H.B Watkins | 1998 | Materials Science & Engineering A1998，，1： | 2 |
| 19 | 原位肝移植术后成功进行内镜下吻合口狭窄治疗:胆总管狭窄的复发率 | Alazmi W.M. Fogel E.L. Watkins J.L. G. Lehman 程妍 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，11： | 2 |
| 20 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
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