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| 1 | Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications显示文摘Objective:The programmed cell death-1 receptor/programmed cell death-1 ligand(PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods:Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study.Circulating PD-L1 expression was tested by enzymelinked immunosorbent assay(ELISA).The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results:Expression of PD-L1 in advanced gastric cancer patients was significantly up-regulated compared with health people(P=0.006).The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis(P=0.026 and P=0.041,respectively).Although we didn't find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients(65.6% vs.44.7%,P=0.028).Conclusions:PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis. | Zhixue Zheng Zhaode Bu Xijuan Liu Lianhai Zhang Ziyu Li Aiwen Wu Xiaojiang Wu Xiaojing Cheng Xiaofang Xing Hong Du Xiaohong Wang Ying Hu Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，1： | 37 |
| 2 | LGR5 is a promising biomarker for patients with stage Ⅰ and Ⅱ gastric cancer显示文摘Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance. Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed. Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P<0.001), and more frequently in patients with intestinal type, well-moderate differentiation and stage Ⅰ and Ⅱ (P<0.05). Although we found gastric cancer patients with LGR5 positive expression had a poorer prognosis, it didn't meet statistical significance (P>0.05). LGR5 negative expression was significantly related to the favorable overall survival in stage Ⅰ and Ⅱ gastric cancer patients (P<0.05). Furthermore, patients with high LGR5 expression tended to be more likely to get progression and have poorer progress-free survival (P<0.05). Multivariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage Ⅰ and Ⅱ gastric cancer (P<0.05). Conclusions: Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage Ⅰ and Ⅱ gastric cancer. | Zhaode Bu Zhixue Zheng Lianhai Zhang Ziyu Li Yu Sun Bin Dong Aiwen Wu Xiaojiang Wu Xiaohong Wang Xiaojing Cheng Xiaofang Xing Yingai Li Hong Du Jiafu Ji | 2013 | Chinese Journal of Cancer Research2013，25，1： | 17 |
| 3 | Impact of different benthic animals on phosphorus dynamics across the sediment-water interface显示文摘As a diagenetic progress, bioturbation influences solute exchange across the sediment-water interface (SWI). Different benthic animals have various mechanical activities in sediment, thereby they may have different effects on solute exchange across the SWI. This laboratory study examined the impacts of different benthic animals on phosphorus dynamics across the SWI. Tubificid worms and Chironomidae larvae were introduced as model organisms which, based on their mechanical activities, belong to upward-conveyors and gallery-diffusers, respectively. The microcosm simulation study was carried out with a continuous flow culture system, and all sediment, water, and worms and larvae specimens were sampled from Taihu Lake, China. To compare their bioturbation effects, the same biomass (17.1 g wet weight (ww)/m 2 ) was adopted for worms and larvae. Worms altered no oxygen penetration depth in sediment, while larvae increased the O 2 penetration depth, compared to the control treatment. Their emergence also enhanced sediment O 2 uptake. The oxidation of ferrous iron in pore water produced ferric iron oxyhydroxides that adsorbed soluble reactive phosphorus (SRP) from the overlying water and pore water. Larvae built obviously oxidized tubes with about 2 mm diameter and the maximum length of 6 cm in sediment, and significantly decreased ferrous iron and SRP in the pore water compared to the control and worms treatments. Worms constructed no visually-oxidized galleries in the sediment in contrast to larvae, and they did not significantly alter SRP in the pore water relative to the control treatment. The adsorption of ferric iron oxyhydroxides to SRP caused by worms and larvae inhibited SRP release from sediment. Comparatively, worms inhibited more SRP release than larvae based on the same biomass, as they successively renewed the ferric iron oxyhydroxides rich oxidation layer through their deposition. | Lei Zhang Xiaozhi Gu Chengxin Fan Jingge Shang Qiushi Shen Zhaode Wang Ji Shen | 2010 | Journal of Environmental Sciences2010，22，11： | 14 |
| 4 | Discovery of the Dagele Eclogite in East Kunlun,Western China and Its Zircon SHRIMP U-Pb Ages:New Constrains on the Central Kunlun Suture Zone显示文摘Objective Eclogites are important indicators of ancient plate boundaries or paleosuture zones.Despite their great geological significance,very few investigations have been carried out in the Kunlun region.The Central East Kunlun fault zone was believed to be an Early Paleozoic suture zone,but there has been no reliable evidence for this,though studies on ophiolite,granite,and basic granulite indicate that the Early Paleozoic orogeny occurred in the East Kunlun.This work focused on the Dagele eclogites | DU Wei JIANG Changyi Tang Zhongli XIA Mingzhe XIA Zhaode LING Jinlan ZHOU Wei WANG Bangyao | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 5 |
| 5 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 6 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 7 | Paleoseismologic record of earthquakes along the Wuzunxiaoer section of the Altyn Tagh fault and its implication for cascade rupture behavior显示文摘The Altyn Tagh fault is one of the few great active strike-slip faults in the world. The recurrence characteristics of paleoearthquakes on this fault are still poorly understood due to the lack of paleoseismic records recorded in high-resolution strata. We document a paleoseismic record in a pull-apart basin along the Wuzunxiaoer section of the central Altyn Tagh fault.The high-resolution strata recorded abundant seismic deformations and their sedimentary responses. Four earthquakes are identified based on event evidence in the form of open fissures, thickened strata, angular unconformities, and folds. The occurrence times of the four events were constrained using radiocarbon dating. Event W1 occurred at AD1220–1773, events W2 and W3 occurred between 407 and 215 BC, and event W4 occurred slightly earlier at 1608–1462 BC, indicating clustered recurrence characteristics. A comparison of the earthquake records along the Wuzunxiaoer section with other records along the Xorkoli section suggests that both sections ruptured during the most recent event. | Zhaode YUAN Jing LIU-ZENG You ZHOU Zhigang LI Heng WANG Wenqian YAO Longfei HAN | 2020 | Science China Earth Sciences2020，63，1： | 3 |
| 8 | Diagnostic value of negative enrichment and immune fluorescence in situ hybridization for intraperitoneal free cancer cells of gastric cancer显示文摘Objective:To explore the intraperitoneal free cancer cell(IFCC)detection value of negative enrichment and immune fluorescence in situ hybridization(NEimFISH)on chromosomes(CEN)8/17.Methods:To verify the reliability of NEimFISH,29 gastric cancer tumors,their adjacent tissues and greater omental tissues were tested.Our study then included 105 gastric cancer patients for IFCC.We defined patients as IFCC-positive if a signal was detected,regardless of the detailed cancer cell numbers.A comparison of clinicopathological features was conducted among IFCC groups.We also compared the diagnosis value and peritoneal recurrence predictive value among different detection methods.The comparison of IFCC number was also conducted among different groups.Results:A cutoff of 2.5 positive cells could distinguish all benign tissue samples and 97%of malignant tissue samples in our study.Compared to intestinal gastric cancer,patients with diffuse gastric cancer tended to have more IFCCs(6 vs.4,P=0.002).The IFCC counts were often higher in the lymphovascular invasion positive group than negative group(3 vs.1,P=0.022).All IFCC samples that were considered positive using conventional cytology were also found to be positive using NEimFISH.When compared to conventional cytology and paraffin pathology,NEimFISH had a higher IFCC positive rate(68.9%)and higher one-year peritoneal recurrence predictive value with area under the curve(AUC)of 0.922.Conclusions:Gastric cancer could be effectively diagnosed by NEimFISH.The IFCC number found using NEimFISH on CEN8/17 is closely associated with Lauren type and vascular invasion of cancer.NEimFISH is a reliable detection modality with a higher positive detection rate,higher one-year peritoneal recurrence predictive value and quantitative features for IFCC of gastric cancer. | Anqiang Wang Zhongwu Li Qian Wang Yali Bai Xin Ji Tao Fu Ke Ji Yanwen Xue Tingxu Han Xiaojiang Wu Ji Zhang Yingjie Yang Guobin Xu Zhaode Bu Jiafu Ji | 2019 | Chinese Journal of Cancer Research2019，31，6： | 3 |
| 9 | Laparoscopic vs.open lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction:An exploratory,observational,prospective,IDEAL stage2b cohort study(CLASS-10 study)显示文摘Objective:This study aims to verify the feasibility and efficacy of laparoscopic lower mediastinal lymphadenectomy for Siewert typeⅡ/Ⅲadenocarcinoma of esophagogastric junction(AEG).Setting:An exploratory,observational,prospective,cohort study will be carried out under the Idea,Development,Exploration,Assessment and Long-term Follow-up(IDEAL)framework(stage 2 b).Paritcipants:The study will recruit 1,036 patients with cases of locally advanced AEG(Siewert typeⅡ/Ⅲ,clinical stage cT2-4 aN0-3 M0),and 518 will be assigned to either the laparoscopy group or the open group.Interventions:Patients will receive lower mediastinal lymphadenectomy along with either total or proximal gastrectomy.Primary and secondary outcome measures:The primary endpoint is the number of lower mediastinal lymph nodes retrieved,and the secondary endpoints are the surgical safety and prognosis,including intraoperative and postoperative lower-mediastinal-lymphadenectomy-related morbidity and mortality,rate of rehospitalization,R0 resection rate,3-year local recurrence rate,and 3-year overall survival.Conclusions:The study will provide data for the guidance and development of surgical treatment strategies for AEG.Trial registration number:The study has been registered in ClinicalTrials.gov(No.NCT04443478). | Shuangxi Li Xiangji Ying Fei Shan Yongning Jia Zhemin Li Kan Xue Rulin Miao Yinkui Wang Zhaode Bu Xiangqian Su Ziyu Li Jiafu Ji | 2022 | Chinese Journal of Cancer Research2022，34，4： | 3 |
| 10 | Identification of lymph node metastasis by computed tomography in early gastric cancer显示文摘Objective:Lymph node status is critical when selecting treatment methods for patients with early gastric cancer(EGC).The aim of this study was to assess the diagnostic value of computed tomography(CT)for detection of lymph node metastasis(LNM)in patients with EGC.Methods:We retrospectively analyzed patients who had pathologically confirmed EGC between November2010 and January 2019.After 1:1 propensity score matching,65 patients with LNM and 65 patients without LNM were retained for comparison.The long diameter(LD)and short diameter(SD)of all visualized lymph nodes in all stations were recorded.The diagnostic value of LNM was assessed with receiver operating characteristic analysis.Results:Among 130 patients,we found a total of 558 lymph nodes on the CT images.Among the diagnostic indicators,the number,sum of LD and sum of SD of lymph nodes greater than 3 mm had better discrimination.The areas under the curve were all greater than 0.75.As for different regions,the optimal cutoff values of number,the sum of LD and sum of SD were determined as follows:overall,≥4,19.9 mm and 13.5 mm;left gastric artery basin,≥3,15.7 mm and 8.6 mm;right gastroepiploic artery basin,≥2,8.6 mm and 7.0 mm.Conclusions:CT is valuable for diagnosing LNM in EGC patients.The number,sum of LD and sum of SD of lymph nodes greater than 3 mm are preferable indicators.Different regional lymph nodes have different optimal criteria for predicting LNM in ECG patients. | Jingtao Wei Yinan Zhang Zhilong Wang Xiaojiang Wu Ji Zhang Zhaode Bu Jiafu Ji | 2021 | Chinese Journal of Cancer Research2021，33，6： | 2 |
| 11 | AVHRR satellite remote sensing and shipboard measurements of the thermal plume from the Daya Bay, nuclear power station, China 显示文摘 | Tang Danling Kester R D Wang Zhaoding | 2003 | Remote Sensing of Environment2003，84，： | 1 |
| 12 | AVHRR satellite remote sensing and shipboard measurements of the thermal plume from the Daya Bay, nuclear power station, China显示文摘 | DanLing Tang Dana R Kester Zhaoding Wang Jiansheng Lian Hiroshi Kawamura | 2002 | Remote Sensing of Environment2002，，4： | 1 |
| 13 | AVHRR satellite remote sensing and shipboard measurements of the thermal plume from the Daya Bay, nuclear power station, China显示文摘 | DanLing Tang Dana R Kester Zhaoding Wang Jiansheng Lian Hiroshi Kawamura | 2002 | Remote Sensing of Environment2002，，4： | 1 |
| 14 | Parameters of the AD 849 earthquake east of Baotou City in Inner Mongolia and the adjustion of the potential seismic sources zone spatial distribution functions显示文摘According to volume 18(Xuanzong Ji Tang)of the historical book entitled the Old Book of Tang,the Hetao area of Inner Mongolia experienced a large earthquake in AD 849.However,previous work on that earthquake contains many discrepancies regarding its epicenter location,magnitude,deaths,and intensity.While exploring active faults in Baotou City,the present authors mapped the Daqing Mountain piedmont fault geologically.Based on previous work,several seismic deformation traces of more than 1000 years ago were found,and dating tests were conducted.The research showed the Daqing Mountain piedmont fault zone to be the seismogenic structure of the AD 849 earthquake.The length of earthquake surface rupture zone was around 80 km,and the macro epicenter was located in the active fault.The deformation center was located at 40.6°N,110.2°E.By collecting and analyzing more historical data about the AD 849 earthquake,reinterpreting some existing historical data,and re-examining the contradictory numbers of deaths in the historical data,the present analysis concludes that around 10,000 people were dead.It is suggested that this earthquake had a magnitude of 7½.According to the revised seismic parameters and the paleoearthquake recurrence period of the Daqing Mountain piedmont fault,the boundary of some potential seismic sources zone in the Baotou area are adjusted and the recurrence period of M8 and M7.5 are re-calculated. | Ji Wang Zhanwu Gao Wei Xu Zhaode Yuan Zhicheng Liu Xiaoliang Zhang | 2019 | Earthquake Science2019，32，3： | 0 |
| 15 | Geochemical characteristics and provenance analysis of Lower Jurassic Badaowan Formation in Changji area of Xinjiang,China显示文摘Based on the field survey of Lower Jurassic Badaowan Formation(Fm.)in Changji area of Xinjiang,China,the authors studied the sedimentary environment and provenance characteristics using the analyses of stratigraphic profiles,sedimentary structures,petrography,zircon U-Pb chronology and geochemistry.The results show that Badaowan Fm.deposited in fluvial to swamp shallow-deeplacustrine sedimentary facies deposition.Contents of Sr and ratios of Sr/Cu,Sr/Ba,Th/U,SiO_(2)/Al_(2)O_(3),V/(V+Ni),V/Cr,and Cu/Zn together indicate that Badaowan Fm.was deposited in an oxygen-poor transitional freshwater environment,under humid climatic conditions.Geochemical characteristics and Q–F–L,Qm–E–Lt,Th–Co–Zr/10,La–Th–Sc,and Th–Sc–Zr/10 discrimination diagrams indicate that the tectonic setting of the source area was a continental island arc environment.Lithological composition,Th/U ratios,and Co/Th–La/Sc,La/Th–Hf,and La/Yb–REE discrimination diagrams show that the source rocks of Badaowan Fm.were upper-crust felsic volcanic rocks.U-Pb dating of detrital zircons yields ages of 1542.3±15.0 to 232.9±3.3 Ma and mostly in the ranges of 470–410 and 370–280 Ma.A comparison of these ages with the age data from different blocks of crystalline rock in Tianshan Mountains area reveals that the sedimentary rocks in the Badaowan Fm.were sourced predominantly from the central and subordinately from the southern Tianshan Mountains during Early Jurassic. | LIU Zhanjin XIA Zhaode LIU Yunhua DU Jinhua WANG Shuo ZHANG Yunfei GAO Jinghui | 2023 | Global Geology2023，26，2： | 0 |
| 16 | Double-tract reconstruction is superior to esophagogastrostomy in controlling reflux esophagitis and enhancing quality of life after proximal gastrectomy:Results from a prospective randomized controlled clinical trial in China显示文摘Objective:The aim of this study was to prospectively compare double-tract reconstruction(DTR)and esophagogastrostomy(EG)after proximal gastrectomy(PG)regarding the incidence of reflux esophagitis,quality of life(QOL),nutritional status and surgical safety.Methods:This study was a randomized controlled trial.Patients eligible for PG were enrolled and randomly assigned to the EG group and DTR group.The characteristics of patients,parameters for surgical safety,incidence of reflux esophagitis,nutrition status and QOL were collected and compared between the two groups.Univariate analysis and multivariate analysis were performed to determine the significant factors affecting the incidence of reflux esophagitis after PG.Results:Thirty-seven patients of the EG group and 36 patients of the DTR group were enrolled.The incidence of reflux esophagitis was significantly lower in the DTR group than in the EG group(8.3%vs.32.4%,P=0.019).The DTR group demonstrated a more favorable QOL than the EG group after PG.The nutritional status was balanced within the EG group and the DTR group.The operation time was longer in the DTR group than in the EG group(191 min vs.221 min,P=0.001),while surgical safety was similar in the two groups.Conclusions:Our research demonstrated that DTR is superior to EG after PG in terms of the incidence of reflux esophagitis and provides a more satisfactory QOL without increasing surgical complications or sacrificing nutritional status. | Yinan Zhang Hongtao Zhang Yan Yan Ke Ji Ziyu Jia Heli Yang Biao Fan Anqiang Wang Xiaojiang Wu Ji Zhang Jiafu Ji Xin Ji Zhaode Bu | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
| 17 | Vertical physicochemical parameter distributions and health risk assessment for trace metals in water columns in eastern Lake Tanganyika, Tanzania显示文摘The vertical distributions of trace metals and physicochemical parameters in water columns in Kigoma Bay and Kungwe Bay in eastern Lake Tanganyika, Tanzania, were studied. The Al, Ba, Ca, Co,K, Mg, Mn, Mo, Na, Sn, Sr, and V concentrations were low and varied very little with depth. The toxic heavy metal(As, Cr, Cu, Ni, Pb, and Zn) concentrations were relatively high in the surface water, and the Cu, Ni, Pb, and Zn concentrations decreased with depth. Principal component and cluster analyses indicated that the metals in the lake had three main sources. Al, Ba, Ca, Co, Cu, Cr, Mn, Sr, Sn, and V were found to be geogenic; As, Cr, Cu, Mo, Ni, Pb, Sn and Zn anthropogenic; and As, Ca, Co, Mg, and Na biogenic.Human health risk assessments were performed, and it was found that trace metals in the water at most of the sampling sites would cause no potential adverse ef fects or non-carcinogenic health risks through dermal contact or ingestion. However, trace metals in surface water in Kungwe Bay could have certain adverse ef fects on human health through the ingestion pathway(the total hazard quotient for ingestion(ΣHQi ng)was 1.75(a value >1 was de?ned as possibly indicating adverse ef fects). The Pb HQi ng for surface water in Kungwe Bay was 1.50 and contributed >80% of the ΣHQ_(ing_, implying that Pb pollution is a water quality and safety problem that needs to be carefully monitored and the potential sources identi?ed. | SHEN Qiushi ZHANG Lu Ismael Aaron KIMIREI WANG Zhaode GAO Qun CHEN Shuang YU Cheng | 2019 | Journal of Oceanology and Limnology2019，37，1： | 0 |
| 18 | Pan-cancer tumor-infiltrating T cells: A great hallmark in cancer immunology research显示文摘As one of the most promising tools for deep analyses of tumor characteristics, single-cell RNA sequencing(sc RNAseq) is well welcomed for the great advantages of analyzing tumor features at single cell levels(1). However, the substantial gap between clinical practice and basis research on sc RNA-seq still could not be ignored. | Anqiang Wang Zhaode Bu | 2022 | Chinese Journal of Cancer Research2022，34，2： | 0 |
| 19 | CULTIVATION OF S&T TALENTS FOR THE NEXT CENTURY显示文摘In recent years, the research institutes under the CAS Shanghai Branch have emphasized the training of S&T talents, energized the restructuring of their system of personnel affairs and adopted a lot of effective measures conducive to producing prodigies, leading to remarkable results. This article gives a detailed exposition of these changes. | Wang Zhaode(Shanghai Branch of the CAS) | 1998 | Bulletin of the Chinese Academy of Sciences1998，12，4： | 0 |
| 20 | Correlation between imaging features on computed tomography and combined positive score of PD-L1 expression in patients with gastric cancer显示文摘Objective:To explore the correlation between computed tomography(CT)features and combined positive score(CPS)of programmed cell death ligand 1(PD-L1)expression in patients with gastric cancer(GC).Methods:This study reviewed an institutional database of patients who underwent GC operation without neoadjuvant chemotherapy between December 2019 and September 2020.The CPS results of PD-L1 expression of postoperative histological examination were recorded by pathology.Baseline CT features were measured,and their correlation with CPS 5 or 10 score groups of PD-L1 expression was analyzed.Results:Data for 153 patients with GC were collected.Among them,124 were advanced GC patients,and 29were early GC patients.None of the CT features significantly differed between CPS groups with a cutoff score of 5and a score of 10 in patients with early GC.In advanced GC,the presence of lymph nodes with short diameters>10mm was significantly different(P=0.024)between the CPS<5 and CPS≥5 groups.CT features such as tumor attenuation in the arterial phase,long and short diameter of the largest lymph node,the sum of long diameter of the two largest lymph nodes,the sum of short diameter of the two largest lymph nodes,and the presence of lymph nodes with short diameters>10 mm significantly differed between the CPS<10 and CPS≥10 groups in advanced GC.The sensitivity,specificity and area under receiver operating characteristic(ROC)curve of logistic regression model for predicting CPS≥10 was 71.7%,50.0%and 0.671,respectively.Microsatellite instability(MSI)status was significantly different in CPS groups with cutoff score of 5 and 10 in advanced GC patients.Conclusions:CT findings of advanced GC patients with CPS≥10 showed greater arterial phase enhancement and larger lymph nodes.CT has the potential to help screen patients suitable for immunotherapy. | Zhilong Wang Yinkui Wang Xiaoting Li Yanling Li Zhaode Bu Zhongwu Li Yingshi Sun Jiafu Ji | 2022 | Chinese Journal of Cancer Research2022，34，5： | 0 |
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