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| 1 | Competition between collective oblate rotation and non-collective prolate K isomerism in neutron-rich tungsten isotopes显示文摘Recent experiments open up the possibility to investigate oblate rotation-aligned states and prolate high-K isomers in neutron-rich tungsten isotopes.In the present work,we perform the projected-shell-model calculations for A ~ 190 tungsten nuclei.The 190 W results are compared with experimental data.The observed 8 + isomer is assigned as a two-quasiproton K π = 8 + configuration.Low-lying high-K four-quasiparticle states are predicted.Of particular interest is the prediction of the K π = 20 + state in 190,192 W,which may form a long-lived spin trap.In competition with the prolate high-K states,rotational alignment leads to near-yrast collective oblate rotation. | JIAO ChangFeng SHI Yue XU FuRong SUN Yang WALKER P M | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，9： | 5 |
| 2 | Wilson’s disease显示文摘 | Aftab Ala Ann P Walker Keyoumars Ashkan James S Dooley Michael L Schilsky | 2007 | The Lancet . 2007 (9559)2007，，9559： | 3 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 5 | Biology of Trichogramma ostriniae (Hymenoptera: Trichogrammatidae) reared on Ostriniae nubilalis (Lepidoptera: Pyralidae) and survey for additional hosts显示文摘 | HOFFMANN M P WALKER D L SHELTON A M | 1998 | Entomophaga1998，40，： | 2 |
| 6 | The role of periodic agitation and water addition in managing moisture limitations during high-solids aerobic decomposition显示文摘 | Walker L P Nock T D Gossett J M VanderGheynst J S | 1999 | Process Biochemistry1999，34，： | 2 |
| 7 | HFE gene in primary and secondary hepatic iron overload显示文摘从世袭 haemochromatosis 不同,肝的铁超载是在几长期的肝疾病的普通发现。许多研究调查了流行,分发和过量的可能的贡献角色在 non-haemochromatotic 的肝的铁长期的肝疾病。确实,一些作者在除世袭 haemochromatosis 以外的肝疾病建议了铁移动。然而,第二等的铁超载的致病仍然保持不清楚。高 Fe (HFE ) 基因被含有,但是报导数据是争论的。在这篇文章,我们在铁动态平衡关于 HFE 蛋白质的细胞的角色总结当前的概念。我们在长期的丙肝,肝炎 B,含酒精、非酒精的脂肝疾病和迟发性皮肤卟啉症关于流行,肝的分发和铁超载的可能的治疗学的含意考察文学的当前的地位。我们在这些肝疾病关于 HFE 基因变化的角色讨论证据。最后,我们在除 haemochromatosis 以外的肝疾病总结铁超载的普通、特定的特征。 | Giada Sebastiani Ann P Walker | 2007 | World Journal of Gastroenterology2007，13，35： | 2 |
| 8 | 重型柴油机达到欧4和欧5标准的排放控制方案显示文摘现代柴油机是最通用的车辆动力之一。柴油机因较高的燃油经济性和扭矩得以长期用于全球重型车辆。此外,如今的涡轮增压小型高速柴油机有很高的动力性,以及优异的驱动性,加上很低的CO2排放,使得柴油机驱动的轻型车也越来越多。然而,只有当柴油车的废气排放满足日益严格的排放法规,它才可能被接受。在美国,重型柴油车和轻型柴油车要满足2007年开始生效的严格的排放法规,必须加装颗粒过滤器。从2010年起,排放法规将进一步收紧,这些车辆还必须加装NOx控制系统。欧洲与美国相似,先是欧4、欧5,最终将实施欧6排放法规。实际上,这样的目标意味着NOx和颗粒排放要比之前降低多达90%。评述了世界范围内重型柴油车为满足现行以及即将实施的欧6排放法规所使用的废气排放控制装置,以及控制策略的发展,探讨了有助于满足重型车法规要求的柴油机氧化催化器、通流式颗粒过滤器以及NOx控制催化器(选择性催化还原系统)的应用,并给出了不同控制方案的比较分析。 | Chatterjee S【美】 Walker A P【美】 Blakeman P G【美】 章海峰(译) 刘巽俊(校) | 2009 | 国外内燃机2009，，2： | 2 |
| 9 | Testosterone activates mitogen- activated protein kinase and the cAMP responses dement binding protein transcription factor in Sertoli cells 显示文摘 | Fix C Jordan C Cano P Walker WH | 2004 | Proc Natl Acad Sci USA2004，，10： | 1 |
| 10 | Growth of Listeria monocytogenes at refrigeration temperatures显示文摘 | WALKER S J ARCHER P BANKS J G | 1990 | J Appl Bacteriol1990，68，： | 1 |
| 11 | Characterization of the bovine pregnancy-associated glycoprotcin gone family-analysisof gene sequences, regulatory regions within the promoter and expression of selected genes 显示文摘 | Telugu B P Walker A M Green J A et el | 2009 | BMC Genomics2009，10，： | 1 |
| 12 | Atmospheric transport and wet deposition of ammonium in North Carolina 显示文摘 | Walker J T Aneja V P Dickey D A | 2000 | Atmospheric Environment2000，34，20： | 1 |
| 13 | The effect of temperature and relative humidity on population growth of three Liposcelis infesting stored products in tropical countries 显示文摘 | Ree D P Walker A G | 1990 | Bolletin of Entom Res1990，80，： | 1 |
| 14 | SGrid: A Service- Oriented Model for the Semantic Grid显示文摘 | Li M van Santen P Walker D W | 2004 | Future Generation Computer Systems2004，20，1： | 1 |
| 15 | Assimilation of remotely sensed data for improved latent and sensible heat flux prediction: A comparative synthetic study 显示文摘 | Pipunic R C Walker J P Western A | 2008 | Remote Sensing of Environ- ment2008，112，4： | 1 |
| 16 | Biological invasion by Myricafaya in Hawai'i: plant demography, nitrogen fixation, ecosystem effects显示文摘 | VITOUSEK P M WALKER L R | 1989 | Ecological Monographs1989，59，： | 1 |
| 17 | Gesta-tiona| diabetesmellitus: clinical predictors and long-term risk o{ developing type 2 diabetes: a retrospect{ve cohort study using survival analysis显示文摘 | Lee AJ Hiseock RJ Wein P Walker SP Permeze|M | 2007 | Diabetes Care2007，30，： | 1 |
| 18 | Competency assessment: methods for development and implementation in nursing education 显示文摘 | Redman R W Lenburg C B Hinton Walker P | 1999 | Online Journal of Issues in Nursing1999，4，2： | 1 |
| 19 | The role of sleep in cognition and emotion 显示文摘 | Walker M P | 2009 | Ann N Y Acad Sci2009，1156，3： | 1 |
| 20 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
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